• 대한전기학회:학술대회논문집
• /
• 대한전기학회 2000년도 하계학술대회 논문집 A
• /
• pp.66-68
• /
• 2000

The Eigen analysis in large power system provides much useful information that is not got in nose curve. The branch participation factor is not quantitative information and is an indirect method calculating incremental change in branch reactive loss. But the Eigen sensitivity analysis to each mode is direct and provides of quantitative information but this method because of needing much time is used in large power system. In this paper the Hessenberg method is used to obtaining dominant eignvalues and corresponding eigenvectors of Jacobian matrix. Ranking the critical contingencies is done by computing the Eigen sensitivity of each dominant eignvalues for changes of each line. The proposed algorithm is tested on the New England 30-bus system and KEPCO system in the year of 2000, which comprises of 791-bus and 2500-branches.

• 대한인간공학회지
• /
• 제17권1호
• /
• pp.11-22
• /
• 1998

When grasping a movable object or making an object move, humans feel kinesthetic sense. The kinesthetic sense is the human sense that the human feels in response to the motion acted on him. The objective of the paper is to transform the kinesthetic sense associated with the human arm into the quantified data that are useful from the engineering viewpoint. A 2-dimensional motion generator composed of two linear motors was developed to provide various motion patterns. It can change its stiffness and damping values on the real-time basis by properly regulating the force generated by the linear motors. Based on Taguchi method, the most dominant factors to affect the kinesthetic sense were investigated. Also, a reference function adequate to quantify the kinesthetic sense was found. Based on this function, the effects of changes in stiffness and damping on the kinesthetic sense were investigated. Various tests show that the damping is a more dominant factor than the stiffness in forming the kinesthetic sense.

• 한국정밀공학회:학술대회논문집
• /
• 한국정밀공학회 2003년도 춘계학술대회 논문집
• /
• pp.1434-1437
• /
• 2003

Sometimes open holes are required for the function and the weight reduction of structure and machinery. However, the serious stress concentration occurs because of the geometric discontinuity caused by the holes and cutting section. In this study, it is attempted to obtain the stress concentration coefficients of the inner surface of the hole boundary by changing the position and the shape of holes on the homogeneous isotropic plate. And the effects on the plate are investigated. The results show that the stress level becomes low and the distribution area widens the position of stress concentration changes as the ratio a/b increases and change to a circle. And as the ratio a/l decreases, the stress concentration reduces. As the plate with three holes. the stress $\sigma$$\_$x/ and $\tau$$\_$xy/ of hole 1,3 becomes high, especially $\sigma$$\_$x/ dominant and high.

• 연구논문집
• /
• 통권33호
• /
• pp.157-165
• /
• 2003

New titanium alloys with a low elastic modulus have been developed for biomedical applications to avoid the stress shielding effect of the artificial prosthesis. The newly developed alloys contained the transition elements like Zr, Hf, Nb, Ta which were non-cytotoxicity elements and $\beta$ stabilizers. In the present paper the elastic moduli of Ti-xM containing Zr, Hf, Nb, Ta were evaluated by measuring the acoustic velocity (PEG). The effectiveness of the alloying elements for lowering the elastic modulus was investigated. In addition, the dominant factors for the low modulus were discussed. Ta was the most effective in lowering the elastic modulus of the alloys. The effectiveness of Hf was not acceptable for decreasing the elastic modulus. The dominant factor was the lattice parameter for Zr, and the poisson's ratio for Nb, Ta, respectively.

• Journal of Microbiology
• /
• 제45권4호
• /
• pp.297-304
• /
• 2007

The detection of virulence factors of Aeromonas is a key component in determining potential pathogenicity because these factors act multifunctionally and multifactorially. In this study water samples were collected from a trout farm on a seasonal basis, and diseased fish and Aeromonas species were isolated and identified. For rapid detection of six virulence factors of isolated Aeromonas, a hexaplex-polymerase chain reaction (hexaplex-PCR) assay was used. The detected virulence factors include aerolysin (aer), GCAT (gcat), serine protease (ser), nuclease (nuc) lipase (lip) and lateral flagella (laf). The dominant strain found in our isolates was Aeromonas sobria, and the dominant virulence factors were aer and nuc for all seasons. We confirmed that A. sobria and two of the virulence genes (aer and nuc) are related. We proposed a method by which one can identify the major strains of Aeromonas: A. hydrophila, A. sobria, A. caviae, and A. veronii, using hexaplex-PCR.

• Journal of Genetic Medicine
• /
• 제17권1호
• /
• pp.34-38
• /
• 2020

The term dopa-responsive dystonia (DRD) is used to describe a group of neurometabolic disorders, which are characterized by dystonia, and are typically associated with diurnal fluctuations and respond to levodopa treatment. Autosomal dominant DRD (DYT5a, MIM# 128230) is caused by a heterozygous mutation in the GTP cyclohydrolase 1 (GCH1) gene (MIM# 600225). GCH1 encodes an enzyme, which is involved in the biosynthesis of tetrahydrobiopterin, an essential co-factor for tyrosine hydroxylase. Herein, we report the case of a 16-year-old girl who was diagnosed with DYT5a. She exhibited additional unusual clinical features, including intellectual disability, depression, multiple skeletal anomalies, and short stature, which are not commonly observed in patients with DYT5a. The patient harbored a heterozygous missense variant, c.539A>C, p.Gln180Pro, in the GCH1 gene, which was identified by targeted gene panel analysis using next-generation sequencing.

• Biomolecules & Therapeutics
• /
• 제32권3호
• /
• pp.291-300
• /
• 2024

Autosomal dominant polycystic kidney disease (ADPKD), a congenital genetic disorder, is a notable contributor to the prevalence of chronic kidney disease worldwide. Despite the absence of a complete cure, ongoing research aims for early diagnosis and treatment. Although agents such as tolvaptan and mTOR inhibitors have been utilized, their effectiveness in managing the disease during its initial phase has certain limitations. This review aimed to explore new targets for the early diagnosis and treatment of ADPKD, considering ongoing developments. We particularly focus on cell polarity, which is a key factor that influences the process and pace of cyst formation. In addition, we aimed to identify agents or treatments that can prevent or impede the progression of renal fibrosis, ultimately slowing its trajectory toward end-stage renal disease. Recent advances in slowing ADPKD progression have been examined, and potential therapeutic approaches targeting multiple pathways have been introduced. This comprehensive review discusses innovative strategies to address the challenges of ADPKD and provides valuable insights into potential avenues for its prevention and treatment.

• 한국환경복원기술학회지
• /
• 제11권6호
• /
• pp.91-103
• /
• 2008

The purpose of this study is to compare the satisfaction of the urban parks and to classify and assess the environmentally-friendly behaviors in the urban parks. For this purpose, the park user's behaviors and satisfactions were surveyed in 10 parks in Seoul and its suburb area. Parks are divided into 2 types, the walking-distance parks and the metropolitan parks, by time to reach, visit frequency and visit purpose. The park users are generally satisfied with the facilities, but not satisfied with some specific items, such as cultural facilities, accommodations for the handicapped, safety facilities and sports facilities. The environmentally-friendly behaviors are positively assessed in general, but the behavior of the natural experience was negatively assessed. The environmentally-friendly behaviors in the urban parks are classified into 2 factors; the experience factor and the activity factor. The parks are categorized into 3 types by these factors. For type I parks, the experience factor is dominant, but the activity factor is relatively low. For type II parks, the both factors are low and the parks are necessary to improve. And type III parks are positively assessed in the aspect of the environmentally-friendly behaviors, even though some park are necessary to complement.

• Structural Engineering and Mechanics
• /
• 제12권4호
• /
• pp.409-428
• /
• 2001

The characteristics of dynamic wheel loads of heavy vehicles running on bridge and rigid surface are investigated by using three-dimensional analytical model. The simulated dynamic wheel loads of vehicles are compared with the experimental results carried out by Road-Vehicles Research Institute of Netherlands Organization for Applied Scientific Research (TNO) to verify the validity of the analytical model. Also another comparison of the analytical result with the experimental one for Umeda Entrance Bridge of Hanshin Expressway in Osaka, Japan, is presented in this study. The agreement between the analytical and experimental results is satisfactory and encouraging the use of the analytical model in practice. Parametric study shows that the dynamic increment factor (DIF) of the bridge and RMS values of dynamic wheel loads are fluctuated according to vehicle speeds and vehicle types as well as roadway roughness conditions. Moreover, there exist strong dominant frequency resemblance between bounce motion of vehicle and bridge response as well as those relations between RMS values of dynamic wheel loads and dynamic increment factor (DIF) of bridges.

• Bulletin of the Korean Chemical Society
• /
• 제20권11호
• /
• pp.1329-1334
• /
• 1999

The curing characteristics of diglycidyl ether of bisphenol A (DGEBA) with diaminodiphenylmethane (DDM) as a curing agent were studied using differential scanning calorimetry (DSC), rheometrics mechanical spectrometry (RMS), and dielectric analysis (DEA). The isothermal curing kinetics measured by DSC were well represented with the generalized auto-catalytic reaction model. With the temperature sweep, the inverse relationship between complex viscosity measured by RMS and ionic conductivity obtained from DEA was established indicating that the mobility of free ions represented by the ionic conductivity in DEA measurement and the chain segment motion as revealed by the complex viscosity measured from RMS are equivalent. From isothermal curing measurements at several different temperatures, the ionic conductivity contribution was shown to be dominant in the dielectric loss factor at the early stage of cure. The contribution of the dipole relaxation in dielectric loss factor became larger as the curing further proceeded. The critical degrees of cure, at which the dipolar contribution in the dielectric loss factor starts to appear, increases as isothermal curing temperature is increased. The dielectric relaxation time at the same degree of cure was shorter for a sample cured at higher curing temperature.