• Molecules and Cells
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• v.26 no.4
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• pp.329-337
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• 2008

Src-family kinases are critically involved in the control of cytoskeleton organization and in the generation of integrin-dependent signaling responses, inducing tyrosine phosphorylation of many signaling and cytoskeletal proteins. Activity of the Src family of tyrosine kinases is tightly controlled by inhibitory phosphorylation of a carboxy-terminal tyrosine residue, inducing an inactive conformation through binding with its SH2 domain. Dephosphorylation of C-ter tyrosine, as well as its deletion of substitution with phenylalanine in oncogenic Src kinases, leads to autophosphorylation at a tyrosine in the activation loop, thereby leading to enhanced Src activity. Beside this phophorylation/dephosphorylation circuitry, cysteine oxidation has been recently reported as a further mechanism of enzyme activation. Mounting evidence describes Src activation via its redox regulation as a key outcome in several circumstances, including growth factor and cytokines signaling, integrin-mediated cell adhesion and motility, membrane receptor cross-talk as well in cell transformation and tumor progression. Among the plethora of data involving Src kinase in physiological and pathophysiological processes, this review will give emphasis to the redox component of the regulation of this master kinase.

• Proceedings of the Korea Information Processing Society Conference
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• 2000.04a
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• pp.797-802
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• 2000

컴포넌트 지향 소프트웨어 개발은 독립적이고 확장성 있는 재사용 부품을 만들어 표준화되고 신뢰성 있는 소프트웨어 모듈 조립에 의한 것이며, 개발비용과 시간을 줄이고 유지보수를 용이하게 한다. 이러한 컴포넌트는 여러 가지 도메인 상에서 제공될 수 있도록 기존의 컴포넌트 생성을 위한 방법론이 제시되어져 왔다. 본 논문에서는 비즈니스 도메인을 기반으로 요구사항에서부터 분석 및 설계, 구현, 그리고 실행에 이르는 분산형 비즈니스 컴포넌트를 생성하는 개발 프로세스를 제시하여, 확장된 형태의 4가지 비즈니스 컴포넌트(attribute, operation, facility, package)를 얻어낼 수 있도록 하며, 분산형 컴포넌트는 웹을 기반으로 세분화한 시스템 관리를 단순하게 하고, 비즈니스 컴포넌트의 재사용성을 높이고 유지보수를 줄이며, 컴포넌트간의 통합을 쉽게 한다. 또한, 사용자가 원하는 실세계의 비즈니스 개념을 올바르게 적용할 수 있으며, 단일 개념의 단순한 형태로 사용자가 원하는 내용을 쉽게 변화시킬 수 있도록 하여 미숙한 재사용자들이 빠르고 효과적으로 활용할 수 있도록 한다.

• Journal of the Korea Institute of Information and Communication Engineering
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• v.13 no.2
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• pp.253-260
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• 2009

This paper, mathematically analyzes the performance of newly proposed TR-UWB system which the frequency components of a UWB pulse were processed so that the system could be implemented with ADCs of a few MHz sampling rate, and presents the comparison with an existing frequency-domain based TR-UWB system. The comparison is mainly based on the SNR ratio which depends on the mean and the variance of the frequency components. We also shows that the simulation results to support the theoretical analysis where the comparison is made under the IEEE 802.15.3a channel model as well as AWGN channel.

• Pediatric Gastroenterology, Hepatology & Nutrition
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• v.22 no.6
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• pp.501-510
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• 2019

Nonalcoholic fatty liver disease (NAFLD) is the most common cause of chronic liver disease in children. The global prevalence of pediatric NAFLD from general populations is 7.6%. In obese children, the prevalence is higher in Asia. NAFLD has a strong heritable component based on ethnic difference in the prevalence and clustering within families. Genetic polymorphisms of patatin-like phospholipase domain-containing protein 3 (PNPLA3), transmembrane 6 superfamily member 2, and glucokinase regulatory protein (GCKR) are associated with the risk of NAFLD in children. Variants of PNPLA3 and GCKR are more common in Asians. Alterations of the gut microbiome might contribute to the pathogenesis of NAFLD. High fructose intake increases the risk of NAFLD. Liver fibrosis is a poor prognostic factor for disease progression to cirrhosis. Magnetic resonance spectroscopy and magnetic resonance proton density fat fraction are more accurate for steatosis quantification than ultrasound. Noninvasive imaging methods to assess liver fibrosis, such as transient elastography, shear-wave elastography, and magnetic resonance elastography are useful in predicting advanced fibrosis, but they need further validation. Longitudinal follow-up studies into adulthood are needed to better understand the natural history of pediatric NAFLD.

• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.556-564
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• 2021

Numerous spatial and transform-domain-based conventional denoising algorithms struggle to keep critical and minute structural features of the image, especially at high noise levels. Although neural network approaches are effective, they are not always reliable since they demand a large quantity of training data, are computationally complicated, and take a long time to construct the model. A new framework of enhanced hybrid filtering is developed for denoising color images tainted by additive white Gaussian Noise with the goal of reducing algorithmic complexity and improving performance. In the first stage of the proposed approach, the noisy image is refined using a high-dimensional non-local means filter based on Principal Component Analysis, followed by the extraction of the method noise. The wavelet transform and SURE Shrink techniques are used to further culture this method noise. The final denoised image is created by combining the results of these two steps. Experiments were carried out on a set of standard color images corrupted by Gaussian noise with multiple standard deviations. Comparative analysis of empirical outcome indicates that the proposed method outperforms leading-edge denoising strategies in terms of consistency and performance while maintaining the visual quality. This algorithm ensures homogeneous noise reduction, which is almost independent of noise variations. The power of both the spatial and transform domains is harnessed in this multi realm consolidation technique. Rather than processing individual colors, it works directly on the multispectral image. Uses minimal resources and produces superior quality output in the optimal execution time.

• Nuclear Engineering and Technology
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• v.51 no.5
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• pp.1279-1288
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• 2019

The vortex-type fluidic diode (FD) is a key safety component for inherent safety in various advanced reactors such as the sodium fast reactor (SFR) and the molten salt reactor (MSR). In this study, topology optimization is conducted to optimize the design of the vortex-type fluidic diode. The optimization domain is simplified to 2-dimensional geometry for a tangential port and chamber. As a result, a design with a circular chamber and a restrictor at the tangential port is obtained. To verify the new design, experimental study and computational fluid dynamics (CFD) analysis were conducted for inlet Reynolds numbers between 2000 and 6000. However, the results show that the performance of the new design is no better than the original reference design. To analyze the cause of this result, detailed analysis is performed on the velocity and pressure field using flow visualization experiments and 3-D CFD analysis. The results show that the discrepancy between the optimization results in 2-D and the experimental results in 3-D originated from exclusion of an important pressure loss contributor in the optimization process. This study also concludes that the junction design of the axial port and chamber offers potential for improvement of fluidic diode performance.

• Parasites, Hosts and Diseases
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• v.59 no.1
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• pp.67-76
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• 2021

Legionella pneumophila is an opportunistic pathogen that survives and proliferates within protists such as Acanthamoeba spp. in environment. However, intracellular pathogenic endosymbiosis and its implications within Acanthamoeba spp. remain poorly understood. In this study, RNA sequencing analysis was used to investigate transcriptional changes in A. castellanii in response to L. pneumophila infection. Based on RNA sequencing data, we identified 1,211 upregulated genes and 1,131 downregulated genes in A. castellanii infected with L. pneumophila for 12 hr. After 24 hr, 1,321 upregulated genes and 1,379 downregulated genes were identified. Gene ontology (GO) analysis revealed that L. pneumophila endosymbiosis enhanced hydrolase activity, catalytic activity, and DNA binding while reducing oxidoreductase activity in the molecular function (MF) domain. In particular, multiple genes associated with the GO term 'integral component of membrane' were downregulated during endosymbiosis. The endosymbiont also induced differential expression of various methyltransferases and acetyltransferases in A. castellanii. Findings herein are may significantly contribute to understanding endosymbiosis of L. pneumophila within A. castellanii.

• Journal of the Microelectronics and Packaging Society
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• v.29 no.1
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• pp.1-6
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• 2022

The mobile device industry demands much higher levels of integration and lower costs coupled with a growing awareness of the complete system's configuration. A subsystem module package is similar to a board-level circuit that integrates a system function in a package beyond a System-in-Package (SiP) design. It is an advanced IC packaging solution to enhance the PDN and achieve a smaller form factor. Unlike a system-level design with a decoupling capacitor, a subsystem module package system needs to redefine the role of the capacitor and its configuration for PDN performance. Specifically, the design of package's form factor should include careful consideration of optimal PDN performance and the number of components, which need to define the decoupling capacitor's value and the placement strategy for a low impedance profile with associated cost benefits. This paper will focus on both the static case that addresses the voltage (IR) drop and AC analysis in the frequency domain with three specific topics. First, it will highlight the role of simulation in the subsystem module design for the PDN. Second, it will compare the performance of double-sided component placement (DSCP) motherboards with the subsystem module package and then prove the advantage of the subsystem module package. Finally, it will introduce three-terminal decoupling capacitor (decap) configurations of capacitor size, count and value for the subsystem module package to determine the optimum performance and package density based on the cost-effective model.

• International Journal of Computer Science & Network Security
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• v.24 no.5
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• pp.79-88
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• 2024

The information retrieval domain deals with the retrieval of unstructured data such as text documents. Searching documents is a main component of the modern information retrieval system. Locality Sensitive Hashing (LSH) is one of the most popular methods used in searching for documents in a high-dimensional space. The main benefit of LSH is its theoretical guarantee of query accuracy in a multi-dimensional space. More enhancement can be achieved to LSH by adding a bit to its steps. In this paper, a new Dynamic Locality Sensitive Hashing (DLSH) algorithm is proposed as an improved version of the LSH algorithm, which relies on employing the hierarchal selection of LSH parameters (number of bands, number of shingles, and number of permutation lists) based on the similarity achieved by the algorithm to optimize searching accuracy and increasing its score. Using several tampered file structures, the technique was applied, and the performance is evaluated. In some circumstances, the accuracy of matching with DLSH exceeds 95% with the optimal parameter value selected for the number of bands, the number of shingles, and the number of permutations lists of the DLSH algorithm. The result makes DLSH algorithm suitable to be applied in many critical applications that depend on accurate searching such as forensics technology.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.37 no.6
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• pp.22-31
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• 2000

In this paper, we propose a method for removing noise components in the feature extraction process for robust speech recognition. This method is based on blind separation using independent component analysis (ICA). Given two noisy speech recordings the algorithm linearly separates speech from the unwanted noise signal. To apply ICA as closely as possible to the feature level for recognition, a new spectral analysis is presented. It modifies the computation of band energies by previously averaging out fast Fourier transform (FFT) points in several divided ranges within one met-scaled band. The simple analysis using sample variances of band energies of speech and noise, and recognition experiments showed its noise robustness. For noisy speech signals recorded in real environments, the proposed method which applies ICA to the new spectral analysis improved the recognition performances to a considerable extent, and was particularly effective for low signal-to-noise ratios (SNRs). This method gives some insights into applying ICA to feature levels and appears useful for robust speech recognition.