• Toxicological Research
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• v.30 no.3
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• pp.179-184
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• 2014

Xenobiotics causing a variety of toxicity in biological systems could be classified as two types, inorganic and organic chemicals. It is estimated that the organic xenobiotics are responsible for approximately 80~90% of chemical-induced toxicity in human population. In the class for toxicology, we have encountered some difficulties in explaining the mechanisms of toxicity caused especially by organic chemicals. Here, a simple flowchart was introduced for explaining the mechanism of toxicity caused by organic xenobiotics, as the central dogma of molecular biology. This flowchart, referred to as a central dogma, was described based on a view of various aspects as follows: direct-acting chemicals vs. indirect-acting chemicals, cytochrome P450-dependent vs. cytochrome P450-independent biotransformation, reactive intermediates, reactivation, toxicokinetics vs. toxicodynamics, and reversibility vs. irreversibility. Thus, the primary objective of this flowchart is to help better understanding of the organic xenobiotics-induced toxic mechanisms, providing a major pathway for toxicity occurring in biological systems.

• Journal of architectural history
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• v.12 no.4 s.36
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• pp.7-26
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• 2003

This article works on the development process of the Buddhist Temple with two pagodas in the Eastern Asia. in 7-8th centuries. This study was motivated from the observation that why there are many the Buddhist Temple having two pagodas only around the late 7th century, roughly around 670 A.D.. This period corresponds to the Silla Dynasty(in Korean History) and Hakuho Period(in Japan History) among the Eastern Asia while the composition of the temple being changed as Buddhism spreads out from China. The results of this study are the followings. The appearance of the Buddhist Temple having two pagodas was resulted from the representation of the Ideology in Botabpum(dogma of pagoda security) of the Saddharmapundarika Sutra, that is to say, two Buddhas sit side by side and iconography of Esoteric Buddhism dogma supports the spirit for defending one's country. Buddhist Temple having two pagodas in China had separate tab-won(areas with pagodas outer temple building block). Buddhist Temple having two pagodas in Korea had begun with sacheunwangsa temple in Unified-Silla. But it had two pagodas with inner temple area instead of outer. This was different from the composition of China. It can be related to the layout of the temple haying two pagodas in East-Jin(in China History) and the sculpture of two pagodas in Ungang-stonecave(in China). Thus the layout of the Buddhist Temple having two pagodas in Silla had been originated from that of China, but was developed to the main temple layout on her own accord. As Japanese Temple having two pagodas had been influenced diplomatically, it had two pagodas inner area as like the layout in Shilla. But later under the influence of Tang it was modified to the layout having them in separate area. And this influence can be seen for example Tangchojaesa temple. For the more, We call see that the diplomatic trends according to the policies in East asia affected to Buddhism and then naturally also to the layout of the Buddhist Temple.

• Korean Institute of Interior Design Journal
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• no.10
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• pp.11-20
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• 1997

This paper, based on the surveys on 43 cases in whole Korea, aims to analyze the architectural principles extracted from the religious dogmas and to propose the direction of the expression of tradition in Korean religious architecture. Buddhist temples in the modern cities. Catholic churches, Anglican churches, Protestant churches have similar problems and attitudes on the expression of traditiov. They have not yet various subjects on the expression of tradition as 'tradition' is not distinguished from 'transmission'. It is not caused only by the general phase of Korean modern architecture, but also by the lack of the practical theology which extract architectural principles from religious dogma and history. I proposed 'Architectural vocabulary', 'Architectural syntax', 'Architectural idea', and 'Symbolization of interior space' , 'Architectural zeitgeist' as the ideal approach.

• Electronics and Telecommunications Trends
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• v.32 no.2
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• pp.29-36
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• 2017

본고에서는 바이오 기술(BT: Bio Technology)의 주요 소재인 DNA(DeoxyriboNucleic Acid, 디옥시리보핵산)를 정보기술(IT: Information Technology)과 나노 기술(NT: Nano Technology)에 적용한 세 가지 DNA 응용 기술 동향에 대해 소개하였다. 먼저 1958년 프랜시스 크릭(Francis Crick)이 주장한 센트럴 도그마(Central Dogma)의 출발점인 DNA의 구조와 기능에 대해 최대한 자세히 소개하였고, DNA의 염기 서열 방식을 이용한 DNA 저장장치에 관해 설명하였다. 그다음 장에서는 DNA의 자기 조립(Self-Assembly) 능력과 자기 복제 능력 및 다른 분자를 인식하여 결합하는 특성을 정보기술에 적용한 DNA 컴퓨터에 대해 설명하였다. 마지막으로, 나노 단위의 DNA 구조를 응용한 나노 기술 중에서 다양한 나노구조물을 만드는 기술인 DNA 오리가미 기술에 대해 설명하였다.

• Koreanishche Zeitschrift fur Deutsche Sprachwissenschaft
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• v.1
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• pp.263-286
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• 1999

In diesem Aufsatz handelt es sich um den Stand der wissen­schaftlichen Forschung unter dem sprachimperialistischen Zeitalter. Dazu mochte ich folgende Punkte zur Diskussion bringen: Erstens, wissen­schaftliche Erkenntnisse sol1en nicht nur zur akademischen Bildung, sondern auch zur gesellschaftlichen Praxis beitragen, sonst haben sie in der Zukunft keine Chance zum $\"{U}berleben$. Zweitens, alle $m\"{o}glichen$ Formen der Diskrimination auf der wissenschaftlichen $B\"{u}hne$, sei es politisch, regional, epistemologisch oder semiotisch, mussen sofort, und zwar von Grund ab abgeschafft werden. Drittens, die germanistische Linguistik soll eine akkumulierende Wissenschaft werden. Dabei darf man nicht $mi{\ss}verstehen$: mein Vorschlag ist kein Dogma, sondern ein $pers\"{o}nliches\;Gespr\"{a}chsangebot$, dessen Grundlage in der Diskurs- und Textwissenschaft liegt. Aber damit hoffe ich mindestens, das $k\"{o}nnte$ zur Reflexion $\"{u}ber\;den\;zuk\"{u}nftigen$ Stand unseres Faches und zur Verbesserung cler $gegenw\"{a}rtigen$ Situation beitragen.

• Journal of Plant Biology
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• v.16 no.1_2
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• pp.23-29
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• 1973

The effect of phosphorus nutrition on the content of deoxyribonucleic acid(DNA), ribonucleic acid(RNA), crude protein and plant growth of soybean plant(Glycine max, Merr.) was studied. Yields of the above-and under-ground parts of the soybean plant in terms of dry weight, the amounts of crude protein, RNA and DNA continued to increase with increasing phosphorus supply. The amounts of RNA and crude protein were highest in the leaf tissues where most intensive growth was taking place. The relationships among DNA, RNA, crude protein and plant growth appeared to consist of the central dogma which has immortalized, while DNA in plant tissue was subject to charges cuased by external environmental facters such as phosphorus nutrition.

• Journal of Pharmaceutical Investigation
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• v.20 no.4
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• pp.179-191
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• 1990

A central dogma of pharmacology is that only unbound drug is capable of translocation across biological membrane. Thus, hepatic uptake is assumed to be solely determined by the unbound concentration of the diffusible moiety at the surface of the liver cell. However, an increasing number of experimental observations with xenobiotics that are normally very extensively bound to plasma proteins (>99%) appear to be inconsistent with these assumptions. This suggested that in addition to progressive spontaneous dissociation within the liver sinusoids and space of Disse, direct interactions of the albumin-drug complex at the plasma membrane may facilitate dissociation of the complex. To explain this phenomena. called albumin-mediated uptake, 4 mechanisms have been suggested. The validity of such hypotheses needs to be examined by the further study. Because albumin-mediated uptake has also been observed to occur in other plasma proteins, protein-mediated uptake rather than albumin-mediated uptake seems to be acceptable.

• Journal of Korean Neurosurgical Society
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• v.64 no.3
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• pp.346-358
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• 2021

Secondary neurulation is a morphological process described since the second half of the 19th century; it accounts for the formation of the caudal spinal cord in mammals including humans. A similar process takes place in birds. This form of neurulation is caused by the growth of the tail bud region, the most caudal axial region of the embryo. Experimental work in different animal species leads to questioning dogmas widely disseminated in the medical literature. Thus, it is clearly established that the tail bud is not a mass of undifferentiated pluripotent cells but is made up of a juxtaposition of territories whose fate is different. The lumens of the two tubes generated by the two modes of neurulation are continuous. There seem to be multiple cavities in the human embryo, but discrepancies exist according to the authors. Finally, the tissues that generate the secondary neural tube are initially located in the most superficial layer of the embryo. These cells must undergo internalization to generate the secondary neurectoderm. A defect in internalization could lead to an open neural tube defect that contradicts the dogma that a secondary neurulation defect is closed by definition.

• Journal of the Daesoon Academy of Sciences
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• v.24_2
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• pp.1-55
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• 2015

Haewonsangsaeng(解冤相生; the resolution of grievances and mutual beneficence) along with sininjohwa(神人調化; harmonious union of divine beings and human beings) belongs to the mid-stage of the Four Tenets. Thus, it is a core factor to achieve creative conjunction of the virtues of yin and yang and realization of the Dao in the world. It is very significant that Daesoonjinrihoe includes haewonsangsaeng in its dogma. Daoism has focused on the resolution of grievances with haewonseokgyeol(解怨釋結) from the beginning of its foundation. Haewon(解冤; the resolution of grievances) is the important matter which Chinese Daoism has paid attention to. This study compares the similarities and differences between Haewon thoughts of Daesoonjinrihoe and Daoism in order to help promote communication of Korean and Chinese culture.

• Journal of the Daesoon Academy of Sciences
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• v.24_2
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• pp.57-82
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• 2015

Grievance resolution, gratitude and mutual beneficence are not only an essential dogma of Daesoonjinrihoe but also a major issue which Chinese Confucian scholars have been concerned about. In this context, this study compares the perspectives of grievance resolution, gratitude, mutual beneficence based on basic scriptures of Daesoonjinrihoe and ancient Chinese Confucianism. With nurture and benevolence as core thoughts, the ways of ruling the world in righteousness and proprieties have common characteristics of Daesoonjinrihoe and Confucianism. The Heavenly Way, which is rather an abstract conception, is perceived as a Confucianism ultimate ground. Because Confucianism does what is right for nurture, embracing rationality, the religious aspects are not clearly defined, it is the difference between Daesoonjinrihoe and Chinese Confucianism. In this regard, this study compares similarities and differences between the two cultures to promote mutual understanding.