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Reproductive Toxicity of DA-125, A New Anthracycline Anticancer Agent: Teratogenicity Study in Rabbits (새로운 안트라사이클린계 항암제 DA-125의 생식독성연구: 토끼 최기형시험)

  • 정문구;김종춘;한상섭;노정구
    • Biomolecules & Therapeutics
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    • v.3 no.1
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    • pp.47-53
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    • 1995
  • DA-125, a new anthracycline antitumor antibiotic, was administered at dose levels of 0, 0.2, 0.6 and 1.8 mg/kg/day intravenously to pregnant New Zealand White rabbits from day 6 through 18 of gestation. The does were subjected to the caesarean section on day 28 of gestation. Effects of test agent on general toxicity of does and embryonic development of F1 fetuses were examined. At 1.8 mg/kg, the organ weight for ovary of does was significantly decreased. The decrease in the number of corpus lutea, implantations and litter size, and the increase in the rate of resorptions were also observed. In addition, various types of external, visceral and skeletal malformations occurred in fetuses at an incidence of 7.7, 7.7 and 20.6%, respectively. The results show that the no effect dose levels (NOELs) of DA-125 are 0.6 mg/kg/day for does and F1 fetuses.

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Forecasting volatility via conditional autoregressive value at risk model based on support vector quantile regression

  • Shim, Joo-Yong;Hwang, Chang-Ha
    • Journal of the Korean Data and Information Science Society
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    • v.22 no.3
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    • pp.589-596
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    • 2011
  • The conditional autoregressive value at risk (CAViaR) model is useful for risk management, which does not require the assumption that the conditional distribution does not vary over time but the volatility does. But it does not provide volatility forecasts, which are needed for several important applications such as option pricing and portfolio management. For a variety of probability distributions, it is known that there is a constant relationship between the standard deviation and the distance between symmetric quantiles in the tails of the distribution. This inspires us to use a support vector quantile regression (SVQR) for volatility forecasts with the distance between CAViaR forecasts of symmetric quantiles. Simulated example and real example are provided to indicate the usefulness of proposed forecasting method for volatility.

A Study on the application of new railroad transportation facilities (철도 신물류운송방식의 적용성 검토)

  • 방연근;문대섭;정병현
    • Proceedings of the KSR Conference
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    • 2001.10a
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    • pp.62-73
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    • 2001
  • The scope of this study is focused on the survey of new logistics transportation systems in railroad and case studies of new systems such as piggyback system, bi-modal system swapbody, and double stack train(DST). Piggyback system, bi-modal system, swapbody, and double stack train are reviewed in term of technological validity and economic validity in Korea. Piggyback - trailer does pass loaded weight limits but does not pass train limits and can not utilize the existing freight cars. Piggyback - cargo trunk does pass all the criteria and could be developed by a domestic technology. But this study suggests to expand the length of train cars to 18.300mm for accommodation of two cargo trucks. Bi-modal system and swapbody do also pass. Double stack train could only pass the loaded weights and does not meet the train limit and the possibility of using existing freight cars. Domestic technology could not development DST, due to civil engineering construction limits and low standard height of electric line, which could not afford to operate DST.

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The Development Plan for the Reliability Centred Maintenance of Electric Multiple Unit (신뢰성기반의 전동차 유지보수체계 개발방안 연구)

  • Lee, Woo-Dong
    • Proceedings of the KSR Conference
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    • 2007.05a
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    • pp.974-979
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    • 2007
  • From '1994 Gwacheon accident of the Electric Multiple Unit(EMU)' till '2004 Seoul subway 2 lines Guui station accident', the accident is increasing at day and the service demand of the citizen is coming to be various. But it does not deal with technical or operation side demands. There is a possibility of saying that the accident of the EMU or deficit operation is caused by the RCM. The EMU where the efficiency is good though does the time passes and it becomes old anger and does not display that efficiency not only the cause of formation accident does becomes. The breakdown about under occurring before getting up an accident, appropriately shifting the parts is to a maintenance very the pending question fact which is important is a possibility of doing. From there is by an EMU, RCM in reliability base grudge is a tool of confirms an improvement point and the place where it judges. From the research which it sees will present about technical development plan of RCM.

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Analysis on the Structure of Defect Consulting Report in Apartment Building (공동주택 하자감정서의 구성체계 분석)

  • Park, Jun-Mo;Seo, Deok-Suk;Kim, Ok-Kyue;Park, Gil-Bum
    • Proceedings of the Korean Institute of Building Construction Conference
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    • 2013.05a
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    • pp.166-167
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    • 2013
  • There has been a defect dispute of apartment building in Korea. The defect dispute is complicated by main issues and details of dispute. It is yet to be solved. Meanwhile, a judge does not a inspection and analysis, but, related field expert who contracted professional engineer does. As a result, defect consulting report that an important judgment is used in a defect dispute. Therefore, this study does research on structure of defect consulting report. A defect consulting report has same items, irrespective of a defect consultant as a result that check 7 indexes about 10 cases. It has different structure's details depending on each defect consultants. And, it inserts new detail or deletes existing detail, does not show clear distinction.

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Milk yield and kit development of four breeds of rabbit in Ibadan, Nigeria

  • Jimoh, Olatunji Abubakar;Ewuola, Emmanuel Olabisi
    • Journal of Animal Science and Technology
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    • v.59 no.12
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    • pp.25.1-25.7
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    • 2017
  • Background: Rabbit breeding with high performance imported ones would be of benefit for genetic diversity and improvement of performance in domestic rabbit breeds. The rearing of more productive rabbit breeds could be pathway to improve the productivity and reduce the production cost. Maternal nutritional status exert a great influence on reproductive functions of does, which may expand from conception, through gestation and parturition and development of kits to puberty. Methods: Four breeds of rabbit were evaluated for their parturition, weaning and pubertal differences among the rabbit population in Ibadan, Nigeria. The breed consist of Fauve De Bourgogne (FDB), Chinchilla (CHA), British Spot (BS) and New Zealand White (NZW) rabbits. A total of 60 bucks and 360 does consisting of 15 bucks and 90 does per breed were mated in 6 mating cycles, three each of natural mating and artificial insemination. All does were synchronized for estrus with 20 IU pregnant mare serum gonadotropin 48 h prior to mating. The does after parturition were assessed for milk yield (g) and kit survival rate (%) till weaning, weight changes of kits from birth to puberty. At puberty, the pubertal age (days) and weight (g) of the offspring were assessed. Result: Results obtained reveals that British Spot doe had highest milk yield among the breeds which significantly increased growth of kit and weight at weaning in British Spot rabbits. Survival rates of Chinchilla kits were significantly (p < 0.05) higher than Fauve de Bourgogne, British Spot and New Zealand White kits. Puberty attainment of the rabbits indicates that British spot does and Fauve de Bourgogne bucks are early maturing. Conclusion: Chinchilla shows high kit survivability and British spot has highest milk yield among the four breeds of rabbit.

Effect of Strategic Feed Supplementation during Gestation on Intake, Blood-biochemical Profile and Reproductive Performance of Goats

  • Rastogi, Ankur;Dutta, Narayan;Sharma, K.
    • Asian-Australasian Journal of Animal Sciences
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    • v.16 no.12
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    • pp.1725-1731
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    • 2003
  • Effect of strategically supplemented pregnancy allowance was ascertained during different phases of gestation on the reproductive performance of does. Gravid does (18) were allotted to 3 dietary treatments HH, HL and LH in a completely randomized block design. All does were provided wheat straw ad libitum and supplemented with concentrate mixture at the rate of $20g/kgW^{0.75}$ from 0-60 days post-mating. Subsequently, HH group was given concentrate at the rate of $40g/kgW^{0.75}$ from 61 d post-mating to term. HL group was offered concentrate from 61-90 d post-mating and 121d post mating to term at the rate of $20g/kgW^{0.75}$ and from 91-120 d post-mating at the rate of $40g/kgW^{0.75}$. LH group was provided with concentrate from 61 to 120 d post-mating and 121 to term at the rate of 20 g and $40g/kgW^{0.75}$, respectively. Mean total dry matter and concentrate intake ($g/kgW^{0.75}$) was significantly higher on HH in comparison to comparable intake of HL and LH treatments, however, wheat straw followed the reverse trend. Haematological and biochemical parameters except serum glucose, total serum protein and A:G ratio did not differ significantly among dietary treatments. The gross gain in weight, products of pregnancy at 21 weeks of gestation, pregnant does average daily gain, birth weight of kids and survivability of kids were significantly lower in treatment HL in comparison to comparable values for HH and LH treatments. The net gain in gravid does was significantly higher in treatment HH than the comparable values obtained in HL and LH treatments. The last month of pregnancy was found to be nutritionally most sensitive period of gestation for native goats.

A Study on Ontology of Digital Photo Image Focused on a Simulacre Concept of Deleuze & Baudrillard (디지털 사진 이미지의 존재론에 관한 연구 -들뢰즈와 보드리야르의 시뮬라크르 개념을 중심으로)

  • Gwon, Oh-sang
    • Cartoon and Animation Studies
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    • s.51
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    • pp.391-411
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    • 2018
  • The purpose of this thesis is to examine ontology of digital photo image based on a Simulacre concept of Gilles Deleuze & Jean Baudrillard. Traditionally, analog image follows the logic of reproduction with a similarity with original target. Therefore, visual reality of analog image is illuminated, interpreted, and described in a subjective viewpoint, but does not deviate from the interpreted reality. However, digital image does not exist physically but exists as information that is made of mathematical data, a digital algorithm. This digital image is that newness of every reproduction, that is, essence of subject 'once existing there' does not exist anymore, and does not instruct or reproduce an outside target. Therefore, digital image does not have the similarity and does not keep the index instruction ability anymore. It means that this digital image is converted into a virtual area, and this is not reproduction of already existing but display of not existing yet. This not-being of digital image changes understanding of reality, existence, and imagination. Now, dividing it into reality and imagination itself is meaningless, and this does not make digital image with technical improvement but is a new image that is basically completely different from existing image. Eventually, digital image of the day passes step to visualize an existent target, nonexistent things have been visualized, and reality operates virtually. It means that digital image does not reproduce our reality but reproduces other reality realistically. In other words, it is a virtual reproduction producing an image that is not related to a target, that is to say Simulacre. In the virtually simulated world, reality has an infinite possibility, and it is not a picture of the past and present and has a possibility as the infinite virtual that is not fixed, is infinitely mutable, and is not actualized yet.

Analysis of Developing Contents of 2005 Renault Samsung Motors Corporate Brochure (2005 르노삼성자동차 Corporate Brochure Contents 개발 분석)

  • Suh, Kyong-Won
    • The Journal of the Korea Contents Association
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    • v.7 no.4
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    • pp.241-249
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    • 2007
  • This article addresses considerations, processes of drawing concepts and design approaches in compiling a corporate brochure set in the practice of editorial design. A well-made brochure does not simply refer to listings of the current state of a company and a fantastic visualization of their visions. It necessarily involves the utilization of strategic core keywords appropriate to the industry, proper and classy metaphors that fit the target, a certain harmony between direct and indirect narratives, and bringing all of these aspects under the hat of creative and purposeful design in a single brochure. Thus, it also calls for variety and changes to captivate the eye when leafing through brochures. 1. Does the brochure reflect accurate diagnoses on the position of the market environment, the industry and their needs? 2. Does it offer solutions to given tasks, does it claim to be able to solve problems a company may have, does it satisfy their expectations, and does it cover the topics in an in-depth manner? 3. Referring to questions 1 & 2, does it address existing cases of competitors, leading players and global trends? 4. Does it have an appropriate design language that can communicate intrinsic issues and global trends as well as appropriate rhetorical visual aids that stand out?