• Journal of Korean Institute of Industrial Engineers
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• v.37 no.4
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• pp.390-399
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• 2011

Generally the life-cycle cost of complex systems composed of several sub systems or equipments such as train, aircraft weapon systems is spent much more during operation and maintenance phase than development phase. The maintenance cost for maintaining the availability and extending the life span of systems comprise a large proportion of systems operation cost. The cycle of preventive maintenance affects operation and maintenance cost a lot. In this study we introduce a way minimizing life-cycle cost of systems by calculating more reliable preventive maintenance period than the results of previous study using systems reliability data considered the reliability and failure effect ratio of sub-systems or components. We can solve the preventive maintenance period problem known as NP-Hard as quick as possible by using modified genetic algorithm than using other models introduced in previous study.

• Korean Journal of Computational Design and Engineering
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• v.18 no.1
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• pp.28-35
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• 2013

Product Life cycle Management (PLM) is an indispensable tool for manufactures to develop competitive products in an efficient way. This enlarges the number of participants for product development who should understand PLM for their supporting activities. However, burdens for developing example products, maintaining complex PLM systems and training prerequisite skills for engineering tools such as CAD systems prohibit an efficient introductory course to PLM. This paper proposes a comprehensive introductory course to PLM that bases on general product development process. In addition, it enables participants to build their example products with familiar Lego blocks and to construct 3D CAD assembly models by using predefined 3D elements. The PLM system for the course provides an intuitive and simple user environment for participants to specify their parts lists, associated 3D CAD models, and product structure of example products. Experiences on a class of the course show it is a valid and efficient education and training method for the PLM introduction.

• Journal of Internet Computing and Services
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• v.20 no.3
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• pp.69-75
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• 2019

The safety and performance of medical device software is managed through life-cycle processes, which represent the entire process of research and development (R&D). The life-cycle process of medical device software is represented by an international standard called IEC 62304, ISO/IEC 12207. In order to license the product, the manufacturer must have document artifacts that comply with the IEC 62304 standard. However, these standards only describe the content of the activity and do not provide a method or procedure for documentation. Therefore, this paper suggests R&D documentation guidelines that assist medical device software developers to have R&D documents conforming to the standards. For this purpose, this study identifies the requirements related to documentation among the requirements existing in the standard and extracts them in the form of guidelines showing only the core information of the requirements. In addition, through the Web framework implemented based on this research, the developer can evaluate whether the technical documents are written in accordance with the R&D document guidelines. Medical device software manufacturers can efficiently produce high-quality research and development documents through R&D documentation guidelines, and they can have standards-compliantresearch and development documentation required for licensing procedures.

• The KIPS Transactions:PartD
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• v.18D no.6
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• pp.493-500
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• 2011

The trends of technical terms express the changes of particular subjects in a specific research field over time. However, the amount of academic literature and patent data is too large to be analyzed by human resources. In this paper, we propose a method that can detect and analyze the trends of terms by modeling the life cycle of the terms. The proposed method is composed of the following steps. First, the technical terms are extracted from academic literature data, and the TDVs(Term Dominance Values) of terms are computed on a periodic basis. Based on the TDVs, the life cycles of terms are modeled, and technical terms with similar temporal patterns of the life cycles are classified into the same trends class. The experiments shown in this paper is performed by exploiting the NDSL academic literature data maintained by KISTI.

• Journal of Life Science
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• v.16 no.4
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• pp.598-604
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• 2006

The $Ca^{2+}-activated$ neutral protease calpain induced proteolysis has been suggested to play a role in certain cell growth regulatory proteins. Cyclin proteolysis is essential for cell cycle progression. D-type cyclins, which form an assembly with cyclin-dependent kinases (cdk4 and cdk6), are synthesized earlier in G1 of the cell cycle and seem to be induced in response to external signals that promote entry into the cell cycle. Here we show that cyclin D3 protein levels are regulated at the posttranscriptional level by calpain protease. Treatment of human breast carcinoma MDA-MB-231 cells with lovastatin and actinomycin D resulted in a loss of cyclin D3 protein that was completely reversible by the peptide aldehyde calpain inhibitor, LLnL. The specific inhibitor of the 26S proteasome, lactacystin, the lysosome inhibitors, ammonium chloride and chloroquine, and the serine protease inhibitor, phenylmethylsulfonylfluoride (PMSF), did not block the degradation of cyclin D3 by lovastatin and actinomycin D. Results of in vitro degradation of cyclin D3 by purified calpain showed that cyclin D3 protein is degraded in a $Ca^{2+}-dependent$ manner, and the half-life of cyclin D3 protein was dramatically increased in LLnL treated cells. These data suggested that cyclin D3 protein is regulated by the $Ca^{2+}-activated$ protease calpain.

• Biomedical Science Letters
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• v.15 no.2
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• pp.147-152
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• 2009

Lycopus lucid us Turcz is well known as traditional Chinese medicine, and it has been shown to exhibit antiinflammatory, -allergic and -oxidative effect. However, its anti-cancer properties have not been examined yet. In this study, we investigated the effect of the methanol extract of Lycopus lucid us Turcz on anti-cancer effect in MCF-7 human breast cancer cells. Treatment of Lycopus lucidus Turcz extract induced apoptosis and inhibition of cell proliferation in dose- and time-dependent manner. Apoptosis in the MCF-7 cells was characterized with the changes in nuclear morphology; decrease of Bcl-2 and caspase-7 expression; and increase of cleaved poly ADP-ribose polymerase(PARP). Furthermore, treatment of Lycopus lucidus Turcz extract caused the down-regulation of cell cycle-related protein including, cdk4, cyclin D1 and E2F-1. These results suggest that Lycopus lucidus Turcz might have the therapeutic value against human breast cancer cells.

• The Journal of Society for e-Business Studies
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• v.4 no.2
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• pp.177-196
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• 1999

The current process of weapon system R&D has lots of problems that the phase is complex, the concept of integration and/or connection of related data is laked and don't be digitalized. To solve these problems we should establish the R&D CALS system and to do this, analysis the R&D process is necessary. In this paper, We suggested weapon system R&D CALS concept and model, and analysed R&D process with ARIS Toolset and proposed the new R＆D process and operation scenarios with CALS concept.

• Proceedings of the Korean Society of Crop Science Conference
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• 2022.10a
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• pp.134-134
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• 2022

Mungbean is used for not only seed but sprout, so, consumption of mungbean has been on the rise in Korea. Life cycle of mungbean tends to be short among Legume. For that reason, Mungbean can be harvested for various cropping system and season per regions and farmers regardless of sowing date and harvesting date. So, Prior research is needed about growth characters and life cycle of mungbean per sowing period. Mungebean cultivar 'Dahyun' and 'Sanpo' supplied by Korea Agriculture Technology Promotion Agency(KOAT) is cultivated in wagner pot. Sowing period is proper time of seeding in Jeollanam-do and Gyeongsangnam-do that is major cultivation region of mungbean in korea from early May to mid July every 2 weeks. Length at maturity stage tends to increase from early May(sowing date: 4^th May) to early July(sowing date: 5^th July), but after that, It tends to decrease from mid July(sowing date: 19^th July). Number of branches and nods shows a similar trend. Length of pod has no tendency and no difference per sowing date. Number of pod per plants has also no tendency per sowing date. Test plots sowing in late May has the most number of pods.(Sanpo 22.9pods, Dahyun 16.8) Number of seeds per pod tends to increase to late May and Test plots sowing in mid July has the most number of seed per pod. In case of sowing at early May, Days of emergence is 7d. its summation of temperature is 132.2℃. After that, it tends to decrease to mid June. After mid June, Days of emergence is fixed to 3d. Average temperature growing up in this season, Summation of temperature from sowing to emergence takes the lowest point in test plots sowing in mid June.(Sanpo 88.6℃, Dahyun 88.6) Days of flowering tends to fasten from early May to mid July. Two cultivar shows same level. Days of maturity tends to fasten to mid June, after that tends to slow. In case that many research results about growth characters and life cycle mungbean per sowing period are drawn, it is expected that it result in increase of cultivation area and income of farmer.

• Journal of Microbiology and Biotechnology
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• v.29 no.9
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• pp.1453-1459
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• 2019

Zeaxanthin is an important pigment in the photo-protection mechanism of microalgae. However, zeaxanthin epoxidase, an enzyme involved in the accumulation and conversion of zeaxanthin, has not been extensively studied in microalgae. In this work, we report the expression pattern of zeaxanthin epoxidase in Dunaliella tertiolecta (DtZEP) at different light and diverse salinity conditions. To confirm the responsiveness to light conditions, the ZEP expression pattern was investigated in photoperiodic (16 h of light and 8 h of dark) and continuous (24 h of light and 0 h of dark) light conditions. mRNA expression levels in photoperiodic conditions fluctuated along with the light/dark cycle, whereas those in continuous light remained unchanged. In varying salinity conditions, the highest mRNA and protein levels were detected in cells cultured in 1.5 M NaCl, and ZEP expression levels in cells shifted from 0.6 M NaCl to 1.5 M NaCl increased gradually. These results show that mRNA expression of DtZEP responds rapidly to the light/dark cycle or increased salinity, whereas changes in protein synthesis do not occur within a short period. Taken together, we show that DtZEP gene expression responds rapidly to light irradiation and hyperosmotic stress. In addition, ZEP expression patterns in light or salinity conditions are similar to those of higher plants, even though the habitat of D. tertiolecta is different.

• 한국항공운항학회:학술대회논문집
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• 2015.11a
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• pp.179-182
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• 2015

DO-278A는 소프트웨어 인증 절차를 제공할 목적으로 만들어진 것은 아니지만, 소프트웨어 개발 절차를 설명하는 것으로 지상용 항공장비의 소프트웨어를 만드는데 적절한 역할을 수행할 수 있다. 대체적으로, 수명주기증거품(life cycle evidence)을 통해 프로세스가 정확하고 적합하게 이행되었다는 것을 증명할 수 있다면 소프트웨어는 적합성을 확인을 받을 수 있다. 본 논문에서는 국토부 R&D로 개발되고 있는 항공기 지상이동유도 및 통제시스템(Advanced-Surface Movement Guidance & Control System, A-SMGCS)의 소프트웨어 개발 및 검증에 DO-278A 절차를 적용한 방안을 제시하고자 한다.