• Journal of computational fluids engineering
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• v.11 no.4 s.35
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• pp.39-47
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• 2006

In this paper, the authors developed a multidimensional interpolation method inside a finite volume cell in the computation of high-order accurate numerical flux such as the fifth order WEND (weighted essentially non-oscillatory) scheme. This numerical method starts from a simple Taylor series expansion in a proper spatial order of accuracy, and the WEND filter is used for the reconstruction of sharp nonlinear waves like shocks in the compressible flow. Two kinds of interpolations are developed: one is for the cell-averaged values of conservative variables divided in one mother cell (Type 1), and the other is for the vertex values in the individual cells (Type 2). The result of the present study can be directly used to the cell refinement as well as the convective flux between finer and coarser cells in the Cartesian adaptive grid system (Type 1) and to the post-processing as well as the viscous flux in the Navier-Stokes equations on any types of structured and unstructured grids (Type 2).

• Korean Journal of Head & Neck Oncology
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• v.20 no.2
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• pp.198-201
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• 2004

Neuroendocrine carcinomas are rare neoplasms of the hypopharynx. Neuroendocrine neoplasms are divided into four main types : carcinoid, atypical carcinoid, small cell carcinoma and paraganglioma. The diagnosis is primarily based on light microscopy and should be confirmed by immunohistochemical investigation. Small cell neuroendocrine carcinoma of the hypopharynx is extremely uncommon tumor and surgical results for this tumor have been disappointing. Chemotherapy and radiotherapy currently appear the most effective forms of therapy. We report our case of small cell neuroendocrine carcinoma of the hypopharynx with the brief review of literatures.

• The Journal of the Korean dental association
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• v.52 no.12
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• pp.726-733
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• 2014

The gingiva consists of an epithelial layer and an underlying connective tissue layer. The oral epithelium is a keratinized, stratified, squamous epithelium. The epithelium can be divided into the following cell layer: basal layer, prickle cell layer, granular cell layer and keratinized cell layer. The desquamative disease of gingiva means exfoliative diseases of epithelial layer on the gingiva. The chronic desqumative gingivitis is usually related to the dematologic disorders that produce cutaneous and mucous membrane blisters. The cicatricial pemphigoid and lichen planus are representative diseases of the dermatologic cases. Patients may be asymptomatic or symptomatic. When symptomatic, their complaints range from a mild burning sentation to an severe pain. The clinical examination must be considered with a thorough history, and routine histologic and immunofluorescence studies. A systemic approach needs to achieve accurate diagnosis and treatment of the gingival desquamative diseases.

• IMMUNE NETWORK
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• v.5 no.3
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• pp.179-185
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• 2005

Background: Psoriasis is a multifactorial autoimmune skin disease with a pathogenesis that has remained obscure. Recently, T cells bearing natural killer receptors (NKRs) were precisely and strongly targeted as new putative pathogenic immunocytes in psoriasis. Among NKRs, killer cell immunoglobulin-like receptor (KIR) is the major molecule recognizing HLA class I allotypes and might be closely related to psoriasis. Methods: To investigate the association of KIR genotype and patients with psoriasis in Korean, we defined the 14 KIR genotypes in 96 patients with psoriasis and 86 healthy controls using PCR-SSP methods. Results: The frequencies of KIR2DS4 and KIR3DL1 were significantly decreased in psoriasis compared with controls (RR=0.21, p<0.02). When patients were divided into two subgroups at the age of onset, type I (<30 years) and type II ($({\geq}30$ years) respectively, these phenomena were similarly observed independent of groups divided (type I: RR=0.26, p<0.005; type II: RR=0.14, p<0.0006). When the patients were divided into subgroups according to the age of onset and family history, the frequencies of KIR2DS4, KIR3DL1, and KIR2DS3 were significantly decreased in type I compared with type II psoriasis (3DL1, 2DS4: p<0.004; 2DS3: p<0.04) and were significantly decreased in psoriasis without family history compared to with family history (3DL1, 2DS4: p<0.007; 2DS3: p<0.05). The frequency of haplotype combination BB was significantly increased in psoriasis compared with controls (RR=2.74, p<0.009). Conclusion: These results suggest that KIR genotype is a factor for the occurrence and development of psoriasis and in future how combinations of HLA and KIR genes influence psoriasis needs to be defined.

• The Transactions of the Korean Institute of Power Electronics
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• v.23 no.3
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• pp.217-224
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• 2018

In this study, the optimal design methods of soft-switching cell for high-voltage DC-DC converter (HDC) of fuel cell electric vehicles (FCEVs) is proposed for high efficiency and high power density. The appropriate soft-switching cell for FCEVs is chosen by analyzing the losses of HDC which adopts soft-switching cell. The proposed optimal design methods for the soft-switching cell are divided into two purposes which are improvement of efficiency and power density. Two kinds of design methods enable to improve fuel efficiency and cost, respectively. The proposed design methods are validated with the experimental results based on the specification and hardware used in actual FCEVs.

• Journal of Communications and Networks
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• v.15 no.1
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• pp.8-14
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• 2013

For alleviating the low spectrum efficiency problem of orthogonal frequency division multiplexing (OFDM), due to the strong inter-cell-interference (ICI) at cell's edge, we introduce comb-spectrum code division multiple access (CS-CDMA) into broadband OFDM system at downlink channel for enabling the use of entire spectrum for seamless coverage. In addition, we develop a new method, called orthogonal cell code (OCC) scheme, to assist CS-CDMA for nullifying the ICI from contiguous cells. In system operation, each of the conventional cells is divided into an outer cell and an inner cell, and a mobile station (MS) should access to the CS-CDMA when it is in the outer cell and access to OFDM when it is in the inner cell. This study investigates the spectrum efficiency of using CS-CDMA and makes a comparison with that of long term evolution (LTE) in the following cases; (1) under an assumption of perfect channel state information and (2) based on channel estimates at a MS station. The results show the great advantage of utilizing the proposed system.

• The Journal of Korea Institute of Information, Electronics, and Communication Technology
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• v.11 no.4
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• pp.394-400
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• 2018

A heterogenous network is the one of key technologies for 5G, where one cell is divided into small cells in order to extend coverage and support high data rates. Divided cells aggravates the intercell interference problem as the cell edge increases. In order to avoid the intercell interference, it is the best to allocate the different spectrum for each cells. However, it also decreases the spectral efficiency. Therefore, the trade-off between the spectral efficiency gain and the signal quality loss by the interference should be considered for an efficient spectrum sharing in the heterogenous network. The adaptive modulation is the method to change the transmitted bit according to the channel quality, which is adopted as the standard in the most practical communication systems. It should be considered to applied the performance analysis into the practical systems. In this paper, the overall cell data rates is analyzed for the heterogenous network under the adaptive modulation. The Monte Carlo simulation results verify the correctness of the analysis.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• v.27 no.6
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• pp.535-542
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• 2001

The purpose of this study was to examine the mRNA levels of TNF-${\alpha}$ and IL-6 in the cell lines of normal oral keratocyte and oral squamous cell carcinoma. Total RNA was extracted from these cell lines, observed under UV light, developed by radiographic films of PCR products via reverse transcriptase polymerase chain reaction(RT-PCR) amplication, and measured with densitometer. Each mRNA level of these cell lines divided by ${\beta}$-actin mRNA level was compared to that of normal control group. The results were as follows: 1. Higher mRNA expression of TNF-${\alpha}$ than IL-6 in the normal oral epithelial cell line. 2. In general, expression of mRNA of IL-6 appeared 3-4 times more in tumor cell lines than in control group. 3. mRNA expression of TNF-${\alpha}$ showed variable expression in tumor cell lines, unlike normal cell line. 4. There are no special connections between differentiation of oral cancer cell lines and mRNA expression of TNF-${\alpha}$ and IL-6. From the above results, expression of mRNA of IL-6 in the cell lines of squamous cell carcinoma used in this study has higher than the normal oral epithelial cell line, but there are no relationship between the differentiation of oral cancer cell lines and the expression of mRNA of TNF-${\alpha}$ and IL-6.

• The korean journal of orthodontics
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• v.24 no.1 s.44
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• pp.105-114
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• 1994

The movement of teeth during orthodontic treatment requires bone remodeling process of bone formation and bone resolution. To find out the changes occuring in the cell itself, mechanical stress was applied to the cell populations involved in the bone metabolism. Bone tissue cell populations were isolated from fetal rat calvaria and divided into OC and OB groups. Following results were obtained from measuring the changes in acid & alkaline phosphatease activity, cyclic AMP and $PGE_2$ production in time lapse after the application of mechanical stress. 1. In case of the marker enzyme of specific bone tissue cell, acid phosphatase activity was high in OC group and alkaline phosphatase activity was high in OB group. 2. After the mechanical stress was applied, acid phosphatase activity was decreased in both OC and OB groups and alkaline phosphatase activity was increase in OB group. 3. When the mechanical stress was applied for 15, 30 and 60 minutes, the production of $PGE_2$ increased in both OC and OB groups, as the time span increased. 4. When the mechanical stress was applied for 20 and 40 minutes, the production of $PGE_2$ increased in both OC and OB groups, as the time span increased.

• Journal of Nutrition and Health
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• v.36 no.7
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• pp.661-666
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• 2003

The study was designed to compare the anti-carcinogenic effect of conjugated linoleic acid (CLA) isomers on colon carcinogenesis in 1,2-dimethylhydrazine (DMH)-treated rats by determining the levels of apoptosis, cell proliferation, eicosanoids and 1,2-diacylglycerol (DAG) in colonic mucosa. Sixty male Sprague Dawley rats were randomly divided into 3 groups depending on the types of CLA isomers, i.e. BT group (no CLA contained), CLA-C group (cis-9, trans11 isomer contained), and CLA- T group (trans-10, cis-12 isomer contained). The experimental diet was composed of protein at 20%, carbohydrate at 56.2%, and fat at 14.5% including 0.8% CLA isomers by weight. The experimental diet was fed for 14 weeks with the initiation of intramuscular injection of DMH, which was injected twice a week for 6 weeks to give total dose of l80mg per kg body weight. Two CLA isomers (c9t11 and t10c12) significantly increased the relative percentage of apoptosis but reduced cell proliferation in mucosal cell and also the levels of PGE$_2$, TXB$_2$, and DAG in colonic mucosa. However, there was no significant differences in anti-carcinogenic effect between c9t11 isomer and t10c12 isomer. Overall, colon carcinogenesis could be significantly inhibited by CLA isomers by increasing apoptosis and reducing cell proliferation, the levels of eicosanoids and DAG in colonic mucosa.