• Korean Journal of Pharmacognosy
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• v.20 no.1
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• pp.6-9
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• 1989

A new aromatic amide, methyl-N-(3-carbamoylpropionyl) anthranilate was isolated for the first time as a natural compound and one known $C_{19}-diterpene\;alkaloid$, avadharidine was also obtained from the root of Aconitum pseudolaeve var. erectum. The\;LD_{50}$ values of water extract and MeOH extract of the root of Aconitum pseudolaeve var. erectum in mice were 1. 23 g (13. 6 g crude drug) and 0. 77 g(5. 13 g crude drug)/kg, p.o., respectively.

• Bulletin of the Korean Chemical Society
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• v.29 no.9
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• pp.1839-1842
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• 2008

• Journal of Physiology & Pathology in Korean Medicine
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• v.17 no.4
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• pp.1112-1115
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• 2003

The diterpene acid 1 was isolated from the roots of Anisotome lyallii(Apiaceae/Umbelliferae). The structure of the compound was elucidated as anisotomenoic acid 1 on the basis of spectroscopic methods. This compound was evaluated against P388 murine leukaemia and B 16/F10 melanoma cells.

• YAKHAK HOEJI
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• v.17 no.4
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• pp.179-216
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• 1973

Diterpenoid늬 연구현황은 본인의 회갑기념논문집에 기재한바 있으나 그후 수년이 경과하여 많은 논문이 발표되어 있으므로 입수된 문헌범위내에서 이를 보충하여 천연 diterpene의 분포, 생합성, 생물학적 중요성 및 이용에 관한 연구등에 대하여 이하 기술코저 한다.

• Proceedings of the PSK Conference
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• 2000.10a
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• pp.238.1-238.1
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• 2000

• Proceedings of the Korean Society of Plant Biotechnology Conference
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• 2005.11a
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• pp.411-411
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• 2005

• Archives of Pharmacal Research
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• v.18 no.3
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• pp.217-218
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• 1995

• The Journal of Korean Medicine
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• v.36 no.4
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• pp.74-79
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• 2015

Objectives: Here we investigated the anti-lipogenic potential of kaurenoic acid (KA), a diterpene derived from Aralia continentalis, in a cellular model of non-alcoholic fatty liver disease. Methods: HepG2 cells were treated with palmitate for 24h to induce intracellular lipid accumulation. To assess the influence of KA on steatotic HepG2 cells, various concentration of KA was co-administered. After palmitate treatment, Intracellular triglyceride content was measured. Expression level of several lipogenic genes, sterol regulatory element-binding transcription factor-1c (SREBP-1c), acetyl-CoA carboxylase (ACC), fatty acid synthase (FAS), and stearoyl-CoA desaturase-1 (SCD-1) were measured using Western-blot analyses or RT-PCR. Results: Palmitate markedly increased intracellular triglyceride level and expression of related lipogenic genes in HepG2 cells, and which was relieved by co-administered KA. Conclusions: It is conceivable that that KA may have a pharmacological potential to reduce lipid accumulation in non-alcoholic fatty liver disease.

• Natural Product Sciences
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• v.4 no.1
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• pp.42-44
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• 1998

Aromatic esters named benzyl-2,6-dimethoxy and benzyl-2,3,5,6-tetramethoxybenzoates along with previously reported compounds were isolated from aerial parts of Blainvillea latifolia.

• Proceedings of the Plant Resources Society of Korea Conference
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• v.18 no.1
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• pp.130-133
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• 2005