• 약학회지
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• 제43권6호
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• pp.696-702
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• 1999

The first and versatile total synthesis of isopimarol diterpene has been achieved via stereoselective construction of C-13 quaternary carbon unit as a key step. Isopimarol diterpene was synthesized from the known decalone in 17% overall yield of 16 steps.

• 생명과학회지
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• 제10권1호
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• pp.107-113
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• 2000

UV-B와 도열병병원균 접종들의 환경 스트레스에 의한 벼의 POD, SOD및 Diterpene cyclase등의 활성 변화를 조사하여 해 본 결과, 일품벼에서 POD 와 SOD활성이 가장 놓았고, 도열병진전에 따른 PDO활성은 감수성 품종인 일품과 화성은 증가하였으나 저항성 품종인 다산은 감소하였다. 키토산 처리에의한 SOD의 활성 변화는 처리 농도가 높을수록 증가하였다. 키토산 처리후 14일에서의 감수성품종인 화성의 SOD활성은 무처리 식물체에 비하여 높았다. UV-B조사 시간이 길수록 감수성품종인 일폼의 POD활성은 감소하였고, 저항성 품종인 다산은 증가하였다. 특히UV-B의 조사시간에 따른 다산의 POD활성은 차가 없었으나, 화성의 활성은 40분 조사처리시 2배 놓았다 UV-B처리에 비해 p.oryzae를 접종시는 diterpene cyclase의 활성이 놓아졌으며, 병원균 접종후 5일까지 효소활성이 검진적으로 증가하였다.

• 약학회지
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• 제16권2호
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• pp.65-72
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• 1972

A new diterpene glycoside, $C_{26}H_{44}O_{8}{\cdot}H_{2}O, $ m.p. <$225-6^{\circ}, [{\alpha}]_D^{20}=-48^{\circ}$ (0.1% in EtOH) was isolated from methylalcohol extract of Siegesbeckia pubescens $M_{AKINO}$ which has been used as a folk remedy for hypertensive in Korea and its chemical structure was established as (III).

• 한국자원식물학회지
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• 제19권6호
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• pp.660-664
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• 2006

The aerial part of Siegesbeckia pubescens (Compositae) has been used to treat rheumatoid arthritis and hypertension in the Oriental medicine. This crude drug has been used without process (SP-0) or with three times-process of steaming and drying (SP-3) or the nine times of that process (SP-9). To search for the antinociceptive anti-inflammatory components from this crude drug, activity-directed fractionation was performed on this crude drug. Since the $CHCl_3$ extract was shown to have a more potent effect than other extracts, it was subjected to silica gel & ODS column chromatography to yield two diterpene compounds (1). Compound 1 was structurally identified as ent-16 (H, 17-hydroxykauran-19-oic acid, which were tentatively named siegeskaurolic acid A. A main diterpene, siegeskaurolic acid A was tested for the antiiflammatory antinociceptive effects using both hot plate- and writhing anti-nociceptive assays and carrageenan-induced anti-inflammatory assays in mice and rats. Pretreatment with siegeskaurolic acid A (20 and 30mg/kg) significantly reduced the stretching episodes, action time of mice and carrageenan-induced edema. These results support that siegeskaurolic acid is a main diterpene responsible for antinociceptive and antiiflammatory action of S. pubescens. In addition, the assays on SP-0, SP-3 and SP-9 produced the experimental results that SP-9 had more significant effects than other two crude drugs. These results suggest that the processing on the original plant may lead to the higher pharmacological effect.

• Archives of Pharmacal Research
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• 제9권3호
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• pp.189-191
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• 1986

The effects of diterpene acids (i. e. pimaradienoic acid, kaurenoic acid, hydroxy cembratrienoic acid and dihydroxycembratetraenoic acid) on malondialdehyde generation by rat platelets in response to thrombin were studied. All the compounds inhibited the generation of MDA.

• 생약학회지
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• 제18권2호
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• pp.103-106
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• 1987

Two diterpene alkaloids were isolated from Aconitum napiforme which is a native plant in Korea, and identified as hypaconitine and mesaconitine by UV, IR, MS and NMR data.

• Natural Product Sciences
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• 제10권2호
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• pp.59-62
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• 2004

A novel chlorinated diterpene quinone methide; chlorosmaridione (7-chloro-11-hydroxy-abeita-7,9(11),13-triene-6,12-diode) was isolated from petroleum ether extract of the stems of Rosemarinus officinalis L. growing in Egypt. In addition, ${\beta}-sitosterol$, stigmasterol, lupeol acetate, ${\alpha}-amyrin,\;{\beta}-amyrin$, lupeol, acetyloleanolic acid, acetylursolic acid taxodione, horminone, and cryptotanshinone were also identified. Chemical structures of the isolated compounds have been elucidated on the bases of physical, chemical, and spectral data including IR, UV, MS, 1D-and 2D-NMR spectra.

• Bulletin of the Korean Chemical Society
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• 제34권12호
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• pp.3840-3842
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• 2013

• 생약학회지
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• 제4권2호
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• pp.63-65
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• 1973

A component, $C_{20}H_{32}O_3$, m.p. $207.5^{\circ}$, was isolated from Siegesbeckia pubescens $M_{AKINO}$. This compound was identified as $17-hydroxy-16{\beta}-(-)-kauran-19-oic\;acid$, using spectroscopies and synthesizing various derivatives of the compound.

• 생약학회지
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• 제19권3호
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• pp.181-187
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• 1988

$Two\;C_{19}-diterpene\;alkaloids$ were isolated from the root of Aconitum psedolaeve var. erectum Nakai, and identified as lycoctonine and septentriodine by UV, IR, MS and NMR data.