• 한국임상약학회지
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• 제1권1호
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• pp.31-36
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• 1991

Tobramycin is one of the most frequently selected agents for pharmacokinetic drug monitoring because of its narrow therapeutic index and essential role for the management of serious infections, especially gram-negative infections. Its pharmacokinetic parameters are dependent on race, sex, age, ideal body weight. disease states, and etc. Therefore, to schedule the dosing of tobramycin, the individual pharmacokinetic parameters such as half-life and volume of distribution are needed. However, these pharmacokinetic parameters have never been reported in Koreans. The purposes of this study were to evaluate the volume of distribution of tobramycin in cancer patients who had normal renal function, to compare the mean values of Vd reported in the literature, and to compare the measured half-life with the expected half-life based on ABW, LBW, and IBW, respectively. Venous blood samples were collected just before and thirty minutes after dosing during steady state. Serum tobramycin concentrations were determined by $TD_x$ (fluorescence immunoassay). IBW were measured by the method of Devine: and LBW were measured by the method of Hallynck. Creatinine clearances (CLcr) of the patients were estimated using the Cockcroft and Gault equation. Elimination rate constants (kel) were determined using the Welling and Craig equation. Infusion rate (ko), volume of distribution (Vd), and half-life $(t_{1/2})$ were determined using the Saw chuk and Zaske equation. The volume of distribution Was $27\%$ greater than the Schentag's study (0.26 vs 0.33 l/kg), but the half-life was similar to the Levy's study. The predicted half-lives based on IBW were the closest to actual half-lives (1.85 vs 2.01 hr).

• 한국임상약학회지
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• 제12권1호
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• pp.7-12
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• 2002

Pharmacokinetic parameters and dosage of aminoglycosides (AGs) were studied retrospectively in 36 patients with neutropenic fever after stem cell transplantation in Seoul National University Hospital from July 1996 to June 2001. AGs pharmacokinetic parameters were calculated with steady-state peak and trough serum drug concentrations by the method of Sawchuk and Zaske et at. The calculated aminoglycosides volume of distribution and clearance were greater than population value $(0.36\pm0.06\;L/kg,\;116\pm32\;ml/min/1.73\;m^2,\;respectively)$. The average dosage of aminoglycosides required to maintain optimal serum AGs concentration was also greater than recommended dose in insert paper. The average dosage of amikacin was $11\pm2.1$ mg/kg every 12 hours (In case of tobramycin, $2.09\pm0.37$ mg/kg every 8 hours or $2.59\pm0.20$ mg/kg every 12 hours). The relationship between AGs volume of distribution and sex, serum albumin (g/dl), body mass index $(kg/m^2)$, body weight change $(\%)$, the amount of fluid inpu (ml/kg/day), the degree of hematocrit decrease $(\%)$ were studied respectively. Univariate anlysis revealed that body mass index $(kg/m^2)$, the amount of fluid input (ml/kg/day) and the degree of hematocrit decrease $(\%)$ had significant correlation with aminoglycosides volume of distribution. But sex, serum albumin, body weight change $(\%)$ had no significant correlation with aminoglycosides volume of distribution.

• 대한교통학회지
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• 제25권4호
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• pp.109-121
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• 2007

자료결측의 심각성은 현실적으로 거의 대부분의 조사에서 발생한다. 비단 교통분야뿐만 아니라 인문사회 분야나 기상학, 생물학, 지구과학 등 모든 분야에서 인력식이든 기계식이든 조사 방식에 관계없이 발생한다. 교통자료 수집장비에서의 자료결측의 발생은 현실적으로 불가피한 현상으로 볼 수 있으며, 이와 같은 자료 수집과정에서 발생하는 결측을 신뢰성있게 추정하여 보정하였던 선행연구의 대부분은 교통량 자료의 결측값 보정시 통계적 검증없이 시간적인 임의의 종속성만 고려함으로서, 보정 성능이 떨어지는 단점을 노출하고 있다. 이들 연구에서 적용했던 기법들 또한, 교통량 자료가 가지고 있는 가장 큰 특징인 주기적 순환성(periodic circularity)이 제대로 반영되지 못함으로서 적용상 한계를 노출하고 있다. 본 연구는 현실적으로 거의 대부분의 조사과정에서 발생하는 자료결측의 심각성에 대한 인식을 토대로 대안으로 순환분포모형을 제안하였다. 이러한 자료결측 현상에 대응하고자 하였던 기존의 ad-hoc 또는 heuristic 보정 기법과 모형 기반 및 알고리즘 기반의 보정 기법에 관한 선행 연구의 고찰을 통하여 이들 기법들의 한계점을 확인하였다.

• Journal of Korean Neurosurgical Society
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• 제52권5호
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• pp.435-440
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• 2012

Objective : The purpose of this study is to find the optimal stiffness and volume of bone cement and their biomechanical effects on the adjacent vertebrae to determine a better strategy for conducting vertebroplasty. Methods : A three-dimensional finite-element model of a functional spinal unit was developed using computed tomography scans of a normal motion segment, comprising the T11, T12 and L1 vertebrae. Volumes of bone cement, with appropriate mechanical properties, were inserted into the trabecular core of the T12 vertebra. Parametric studies were done by varying the volume and stiffness of the bone cement. Results : When the bone cement filling volume reached 30% of the volume of a vertebral body, the level of stiffness was restored to that of normal bone, and when higher bone cement exceeded 30% of the volume, the result was stiffness in excess of that of normal bone. When the bone cement volume was varied, local stress in the bony structures (cortical shell, trabecular bone and endplate) of each vertebra monotonically increased. Low-modulus bone cement has the effect of reducing strain in the augmented body, but only in cases of relatively high volumes of bone cement (>50%). Furthermore, varying the stiffness of bone cement has a negligible effect on the stress distribution of vertebral bodies. Conclusion : The volume of cement was considered to be the most important determinant in endplate fracture. Changing the stiffness of bone cement has a negligible effect on the stress distribution of vertebral bodies.

• 대한교통학회지
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• 제13권1호
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• pp.167-183
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• 1995

The objective of study is to evaluate highway capaicty estimation alternative and to develop capacity from statistical distribution of observed traffic flow. Speed-Volume relation is analyzed from vehicle's headway distribution eliminating the long headway by confidence intervals 99%, 95%, 90%. Capacity estimate alternatives were evaluated from 95% , 90%, 85% level of cummulative distribution of observed hourly traffic flow adjusted to confidence intervals. The result of investigation revealed that maximum hourly rate of flow is 2, 130pcu at confidence interval of 995, 2, 233pcu at 95%, 2, 315pcu at 90% respectively. Compared to the capacity of 2, 200pcu per hour per lane used in HCM and KHCM(Korea Highway Capacity Manual), capa챠y appears to correspond to confidence interval of 95%. Using the traffic flow rate at confidence interval of 95% the maximum hourly flow rate is 2, 187pcu at 95% of cummulative volume distribution, 2, 153pcu at 90%, 2, 215pcu at 85%. The study suggests that raional capacity esimation alternative is to take the 95% of cummulative distribution of observed hourly traffic flow at 95% confidence headway interval eliminating 5% long headway.(i.e. 95-95 rule)

• 한국자동차공학회논문집
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• 제12권3호
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• pp.10-18
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• 2004

It is well known that the stratified charge combustion has many kind of advantages to combustion characteristics, such as higher thermal efficiency and less CO, NOx levels than conventional homogeneous mixture combustion. Although this combustion can be caused low fuel consumption, it is produced the high unburned hydrocarbon and soot levels because of different equivalence ratio in the combustion chamber. Moreover it has a lot of possibility of low output and misfire if the mixture gas would not be in existence around the spark plug. In this paper, fundamental studies for stratified combustion were carried out using a constant volume combustion chamber. The effect of locally mixture gas distribution according to control the direct injection and premixed injection in the chamber were examined experimentally. In addition, the effects of turbulence on stratified charge combustion process were observed by schlieren photography.

• International Journal of Automotive Technology
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• 제3권3호
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• pp.95-99
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• 2002

The characteristics of soot vaporization induced by a high-energy Pulsed laser were studied in an ethylene-air laminar flame. A system consisting of two pulsed lasers was used for the experiments. The pulse from the first laser was used to vaporize the soot particles, and the delayed pulse from the second laser was used to measure the residual soot volume fraction. Laser-induced soot vaporization was characterized according to the initial particle size distribution. The results indicated that soot particles could not be completely vaporized simply by introducing a high intensity laser pulse. Residual soot volume fractions present after vaporization appeared to be insensitive to the initial soot particle size distribution. Since the soot vaporization effect is more pronounced in the region of high soot concentrations, this laser-induced soot vaporization technique may be a very useful tool for measuring major species in highly sooting flame.

• 한국시스템다이내믹스연구
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• 제12권3호
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• pp.67-86
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• 2011

This study shows the reduction effect of freight volume by the supply chain redesign for the alliance of distributors with system dynamics simulation. The as-is model is composed of 3 independent companies which one has 3 distribution centers (DCS) and 24 agents, another has 1 dc and 9 agents, the other has 3 DCS and 15 agents each. The to-be model is an integrated logistics model and composed of 1 company having 5 areal DCS and 38 agents. Each agent in the same area is integrated with each other. Two models have same demands but very different result. As a result, the freight volume between DCS and agents is reduced by 33.55%. This case study will be useful to analyze the similar cases about the logistics integration by supply chain redesign.

• 천문학회보
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• 제45권1호
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• pp.29.3-29.3
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• 2020

Cosmology is a study to understand the origin, fundamental property, and evolution of the universe. Nowadays, many observational data of galaxies have become available, and one needs large-volume numerical simulations with good quality of the spatial distribution for a fair comparison with observation data. On the other hand, since galaxies' evolution is affected by both gravitational and baryonic effects, it is nontrivial to populate galaxies only by N-body simulations. However, full hydrodynamic simulations with large volume are computationally costly. Therefore, alternative galaxy assignment methods to N-body simulations are necessary for successful cosmological studies. In this talk, I would like to introduce the MBP-galaxy abundance matching. This novel galaxy assignment method agrees with the spatial distribution of observed galaxies between 0.1Mpc ~ 100Mpc scales. I also would like to introduce mock galaxy catalogs of the Horizon Run 4 and Multiverse simulations, large-volume cosmological N-body simulations done by the Korean community. Finally, I would like to introduce some recent works with those mock galaxies used to understand our universe better.

• 한국해양환경ㆍ에너지학회지
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• 제12권4호
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• pp.255-263
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• 2009

본 연구는 부산연안에 기 시설된 인공어초에 대해서 현재 시설현황을 분석하고 조사된 결과를 바탕으로 시설된 단위어초의 유효공용적율 평가 연구를 수행하였다. 본 연구를 통해 획득되어진 연구결과는 다음과 같이 요약할 수 있다. 부산연안의 연도별 인공어초시설 추이를 살펴본 결과, 단위어초수와 시설면적은 1997년부터 2004년까지 큰 폭의 변동 경향을 나타내었다. 하지만 시설물량에서는 2003년이후 급격하게 감소된 결과를 나타내었는데 강제어초 및 세라믹어초 등 다양한 어초가 사용됨에 따라서 나타난 패턴이라 할 수 있다. 기장군 해역에 시설되어 있는 어초는 2,777개로 89%의 확인율을, 해운대 남구해역은 7,691개로 어초 확인율은 84.9%, 사하 강서해역에의 확인량은 사각형어초의 경우 905개로서 96%, 그 외 어초는 모두 100%이었다. 부산연안에 시설된 인공어초의 경우 그 보존상태가 약 85%이상으로서 매우 양호한 상태를 나타내고 있음을 알 수 있으며 해저 지반조건에 따라서 다소 침하, 이탈, 망실 등 약 15%의 손실이 발생하였다.