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Clinical, Histopathological and Molecular Characteristics of Metastatic Breast Cancer in North-Eastern Kazakhstan: a 10 Year Retrospective Study

  • Abiltayeva, Aizhan;Moore, Malcolm A;Myssayev, Ayan;Adylkhanov, Tasbolat;Baissalbayeva, Ainur;Zhabagin, Kuantkan;Beysebayev, Eldar
    • Asian Pacific Journal of Cancer Prevention
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    • v.17 no.10
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    • pp.4797-4802
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    • 2016
  • Background: Breast cancer (BC) is the top cancer among women worldwide and has been the most frequent malignancy among Kazakhstan women over the past few decades. Information on clinical and histopathological features of metastatic breast cancer (MBC), as well as the distribution of molecular subtypes is limited for Kazakh people. Materials and Methods: The present observational retrospective study was carried out at Regional Oncologic Dispensaries in the North-East Region of Kazakhstan (in Semey and Pavlodar cities). Сlinical and histopathological data were obtained for a total of 570 MBC patients in the 10 year period from 2004-2013, for whom data on molecular subtype were available for 253. Data from hospital charts were entered into SPSS 20 for analysis by one-way ANOVA analysis of associations of different variables with 1-5 year survival. Pearson correlation and linear regression models were used to examine the relation between parameters with a p-value < 0.05 considered statistically significant. Results: No significant relationships were evident between molecular subtype and survival, site of metastases, stage or ethnicity. Young females below the age of 44 were slightly more likely to have triple negative lesions. While the ductal type greatly predomonated, luminal A and B cases had a higher percentage with lobular morphology. Conclusions: In this select group of metastatice brease cancer, no links were noted for survival with molecular subtype, in contrast to much of the literature.

Repeated Cropping based on Deep Learning for Photo Re-composition (사진 구도 개선을 위한 딥러닝 기반 반복적 크롭핑)

  • Hong, Eunbin;Jeon, Junho;Lee, Seungyong
    • Journal of KIISE
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    • v.43 no.12
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    • pp.1356-1364
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    • 2016
  • This paper proposes a novel aesthetic photo recomposition method using a deep convolutional neural network (DCNN). Previous recomposition approaches define the aesthetic score of photo composition based on the distribution of salient objects, and enhance the photo composition by maximizing the score. These methods suffer from heavy computational overheads, and often fail to enhance the composition because their optimization depends on the performance of existing salient object detection algorithms. Unlike previous approaches, we address the photo recomposition problem by utilizing DCNN, which shows remarkable performance in object detection and recognition. DCNN is used to iteratively predict cropping directions for a given photo, thus generating an aesthetically enhanced photo in terms of composition. Experimental results and user study show that the proposed framework can automatically crop the photo to follow specific composition guidelines, such as the rule of thirds.

A Study on Simulation of Cavity and Relaxation Zone Using Finite Element Method (유한요소법을 이용한 지반 공동 및 이완영역 모사에 관한 연구)

  • You, Seung-Kyong;Kim, Joo-Bong;Han, Jung-Geun;Hong, Gi-Gwon;Yun, Jung-Mann;Lee, Kang-Il
    • Journal of the Korean Geosynthetics Society
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    • v.16 no.4
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    • pp.67-74
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    • 2017
  • In order to prevent the ground subsidence accidents caused by the occurrence of underground cavity, it is necessary to evaluate the mechanical characteristics in the relaxation zone of the underground cavity. Also, the relaxation zone including underground cavity be appropriately reinforced. This paper described analysis results based on finite element method that was conducted to analyze the mechanism for occurrence of the relaxation zone around the underground cavity. The finite element analysis applied in forced displacement was carried out to simulate the underground cavity and relaxation zone, and then there were compared with previous research results. The analysis results showed that the void distribution of soil around the underground cavity has figured out. As a result, the area of the relaxation zone could be quantitatively presented by reduction characteristics of the shear stress.

A Study on the Impact of IT Investment on Demand for Labor (IT투자가 노동수요에 미치는 영향에 관한 연구)

  • Hong, Hyo Jin;Hong, Pilky;Lee, Young Soo
    • Informatization Policy
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    • v.17 no.4
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    • pp.44-60
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    • 2010
  • Under the continuing economic growth without increase in employment, issues regarding the impact of IT investment on demand for labor have been continuously raised. Under the circumstance, this study carried out an empirical analysis on the impact of IT investment on employment with a sample of 498 businesses whose domestic sales for the period of six years from 2003 to 2008 are KRW 100 billion or above. The result of the analysis found that IT investment increases employment in most of the industries except for some of the service sectors. In the manufacturing industry, more IT investment increased employment but decreased the flexibility in demand for labor; therefore, IT investment has a substitutional relationship with low-skilled labor and a complementary relationship with high-skilled labor. In the areas of electricity, gas and construction, employment increased as IT investment increased, with the greatest flexibility in demand for labor. In the service industry, increase in IT investment led to more employment and higher flexibility in producer services only. On the other hand, there was no meaningful relationship found between IT investment and employment in the areas of distribution services and social services.

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The Effects of Mobile Social Commerce Characteristics on the Purchase Intention -Focusing on the Mediating Effects of Shopping Values- (모바일 소셜 커머스 특성이 구매의도에 미치는 영향 -쇼핑가치의 매개효과를 중심으로-)

  • Choi, Beet-Na;Han, Kyung-Il
    • Journal of Digital Convergence
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    • v.16 no.8
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    • pp.89-98
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    • 2018
  • The emergence of the mobile commerce market as a new megatrend, mobile shopping is becoming an important distribution channel in the domestic online shopping market. The purpose of this study is to classify shopping values perceived by mobile social commerce users into a utilitarian value and a hedonic value explained and to empirically examine the effects of social commerce characteristics on the purchase intention and shopping values in mobile social commerce. conclusion, this implies that site providers and sellers need to try to supply cheaper and more economical products than those offline and provide the most effective and optimum information and service so sellers and consumers can exchange messages with each other and create meanings.

Priority Data Handling in Pipeline-based Workflow (파이프라인 기반 워크플로우의 우선 데이터 처리 방안)

  • Jeon, Wonpyo;Heo, Daeyoung;Hwang, Suntae
    • KIISE Transactions on Computing Practices
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    • v.23 no.12
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    • pp.691-697
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    • 2017
  • Volcanic ash has been predicted to be the main source of damage caused by a potential volcanic disaster around Mount Baekdu and the regions of the Korean peninsula. Computer simulations to predict the diffusion of volcanic ash should be performed according to prevalent meteorological situations within a predetermined time. Therefore, a workflow using pipelining is proposed to parallelize the software used for this computation. Due to the nature of volcanic calamities, the simulations need to be carried out for various plausible conditions given that the parameters cannot be precisely determined during the simulations, even at the time of a volcanic eruption. Among the given conditions, computations need to be first performed for the condition with the highest probability so that a response to the volcanic disaster can be provided using these results. Further action can then be performed later based on subsequent results. The computations need to be performed using a volcanic disaster damage prediction system on a computing server with limited computing performance. Hence, an optimal distribution of the computing resources is required. We propose a method through which specific data can be provided first to the proposed pipeline-based workflow.

Efficient Locality-Aware Traffic Distribution in Apache Storm (Apache Storm에서 지역성을 고려한 효율적인 트래픽 분배)

  • Son, Siwoon;Lee, Sanghun;Moon, Yang-Sae
    • KIISE Transactions on Computing Practices
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    • v.23 no.12
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    • pp.677-683
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    • 2017
  • Apache Storm is a representative real-time distributed processing system, which is able to process data streams quickly over distributed servers. Storm currently provides several stream grouping methods to distribute data traffic to multiple servers. Among them, the shuffle grouping may cause a processing delay problem and the local-or-shuffle grouping used to solve the problem may cause the problem of concentrating the traffic on a specific node. In this paper, we propose the locality-aware grouping to solve the problems that may arise in the existing Storm grouping methods. Experimental results show that the proposed locality-aware grouping is considerably superior to the existing shuffle grouping and the local-or-shuffle grouping. These results show that the new grouping is an excellent approach considering both the locality and load balancing which are limitations of the existing Storm.

A Study on the Construction Plan of Smart Fish Farm Platform in the Future (미래 스마트 양식 플랫폼의 구축방안에 대한 연구)

  • Choi, Joowon;Lee, Jongsub;Kim, Youngae;Shin, Yongtae
    • KIPS Transactions on Computer and Communication Systems
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    • v.9 no.7
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    • pp.157-164
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    • 2020
  • As the consumption of fishery products continues to increase, aquaculture industry has emerged instead of fishing industry facing limitations of fish stock resources. Recently, smart fish farming industry has rapidly developed through convergence with 4th Industrial Revolution technology. Accordingly, it is important to derive a future model of smart fish farming platforms in order to secure the superiority of the aquaculture industry and the technology standard hegemony. In this study, the future direction of smart fish farm platform was derived through the analysis of environment related to politics, economy, society, and technology related to smart fish farming by applying PEST methodology of macro-environment analysis. It is expected that it will help the public and industrial circles in planning and implementing related projects by including the entire process of value chain of aquaculture industry of breeding, production, management and distribution, and by presenting advanced models based on artificial intelligence and digital twin.

A study of new business creation on digital contents industries (디지털콘텐츠 산업분석을 통한 기술사엄화 기회창출 연구)

  • Park, Dong-Un;Kim, Eun-Sun;Park, Young-Seo
    • Proceedings of the Korea Contents Association Conference
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    • 2006.11a
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    • pp.759-762
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    • 2006
  • Historically, internet is the fastest growing media together with the ICT development and the key of the development is contents. Digital contents indicate information which covers voice, DB, game, publications and music etc. and the areas have been creating new technology business opportunities. The value chain of digital contents consists of production, collection, processing, services, connection and navigation and is expected to be reorganized around business players of production and distribution areas. This paper presents on those changes occurring in business environment and examples of business models, and further provides industries and academias with technology commercialization strategies.

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Study on the Sheet Rolling by a Rigid-Plastic Finite Element Method Considering Large Deformation Formulation (강소성 대변형 유한요소법을 이용한 판재 압연연구)

  • 김동원;홍성인
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.15 no.1
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    • pp.145-153
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    • 1991
  • A numerical simulation of the nonsteady state rolling process in the plane strain condition is presented in the basis of the rigid-plastic finite element method by considering large deformation. In order to apply the large deformation theory to the numerical method for sheet rolling problems, constitutive equation relating 2nd-Piola Kirchhoff stress and Lagrangian strain which reflect geometrical nonlinearity is used. To confirm the validity of the developed algorithm, the analysis of the neutral flow region, roll separating force, torque, pressure and stress/strain distributions on the workpiece is conducted from the bite of the material until the steady state is reached. The computed results of the roll force and torque in the present finite element analysis are lower than those corresponding to small strain theory. The pressure distribution at the work piece-roll interface is found to show the typical 'friction hill' type only. The peak value in near the neutral region, however, is good agrements with the existing results. the neutral region, however, is good agrements with the existing results. The frictional force at the roll interface provide detailed information about the neutral point where the shear forces change direction. In addition, the analysis also includes the effect and influence of material condition, strip thickness, work roll diameter, as well as roll speed and lubricant on each deformation process.