• Journal of Digital Convergence
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• v.20 no.3
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• pp.481-486
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• 2022

This study verified the influence of distributive justice on burnout and inspected the mediating effect of empowerment of personnel in rehabilitation facilities. We surveyed 321 personnel in facilities of Daejeon and Chungnam areas. The main methods are structural equation model analysis and confirmatory factor analysis. The important analysis result is that distributive justice influenced burnout negatively and mdiating effect of empowerment was identified. According to analysis results, some measurements were proposed to reduce personnels' burnout. For increasing distribution fairness, compensation by objective evaluation of ability and workload, establishment of transparent compensation system, improvement of working conditions of irregular workers are required. In order to improve empowerment, leadership education for managers and operation of related programs, voluntary participation of employees in programs, provision of supervision and education of empowerment are needed.

• Journal of Genetic Medicine
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• v.20 no.1
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• pp.6-14
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• 2023

Fabry disease (FD), a rare X-linked lysosomal storage disorder, is caused by mutations in the α-galactosidase A gene gene encoding α-galactosidase A (α-Gal A). The functional deficiency of α-Gal A results in progressive accumulation of neutral glycosphingolipids, causing multi-organ damages including cardiac, renal, cerebrovascular systems. The current treatment is comprised of enzyme replacement therapy (ERT), oral pharmacological chaperone therapy and adjunctive supportive therapy. ERT has been introduced 20 years ago, changing the outcome of FD patients with proven effectiveness. However, FD patients have many unmet needs. ERT needs a life-long intravenous therapy, inefficient bio-distribution, and generation of anti-drug antibodies. Migalastat, a pharmacological chaperone, augmenting α-Gal A enzyme activity only in patients with mutations amenable to the therapy, is now available for clinical practice. Furthermore, these therapies should be initiated before the organ damage becomes irreversible. Development of novel drugs aim at improving the clinical effectiveness and convenience of therapy. Clinical trial of next generation ERT is underway. Polyethylene glycolylated enzyme has a longer half-life and potentially reduced antigenicity, compared with standard preparations with longer dosing interval. Moss-derived enzyme has a higher affinity for mannose receptors, and seems to have more efficient access to podocytes of kidney which is relatively resistant to reach by conventional ERT. Substrate reduction therapy is currently under clinical trial. Gene therapy has now been started in several clinical trials using in vivo and ex vivo technologies. Early results are emerging. Other strategic approaches at preclinical research level are stem cell-based therapy with genome editing and systemic mRNA therapy.

• Journal of the Society of Naval Architects of Korea
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• v.60 no.4
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• pp.266-277
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• 2023

In this study, fundamental research is conducted for the generation technique and analysis of multi-directional irregular waves in the Deep Ocean Engineering Basin (DOEB). A three-dimensional boundary element method-based numerical tank is implemented to perform wave generation simulations, and directional spectrum estimation is carried out using the results of simulations. The wave generation technique of the Snake type wave maker, generating multi-directional irregular waves, is implemented using the Fast Fourier Transform (FFT) and Inverse Fast Fourier Transform (IFFT) algorithms. The wave generation technique is validated by comparing the wave spectrum from simulations and experiments. A Maximum Likelihood Method (MLM) based estimation code is developed for estimating the directional wave spectra. The multi-directional irregular waves are tested in the DOEB and the numerical tank, and directional wave spectra obtained from two methodologies are estimated and compared. A correction procedure for the directional distribution of multi-directional waves is established, and the possibility of correcting the directional spreading function using the numerical tank is validated.

• Journal of the Korean Society of Food Culture
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• v.24 no.3
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• pp.256-266
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• 2009

The purpose of this study was to determine conditions of dining behaviors, sleep patterns, rates of obesity and intake of snacks and self-purchased snacks deriving from the lack of sleep in academic high school students. The anthropometric characteristics, height and weight (p<0.05), and the distribution of obesity index (p<0.001) showed significant differences between males and females. Dining scores for both male and female students decreased as the frequency of day time napping increased. Although, there was no significant difference in obesity-related "lack of sleep" between males and females, the rate of "being overweight" was slightly higher in female students who indicated that they experienced a "lack of sleep" than female students that indicated "no lack of sleep". While, whether intake of snacks and self-purchased snacks or not, day time napping frequency affected not to male students. However, the frequency of day time napping among females who ate snacks one or more times a day was higher (p<0.05), and a greater frequency of eating self-purchased snacks correlated with a greater frequency of day napping (p<0.01). Consequently, lack of sleep was identified as one of the factors increasing the frequency of intake of snacks and self-purchased snacks in females. Thus, this study suggests that dining behavior guidance should be given along with systematic and continual nutrition education so that the intake of snacks and self-purchased snacks can be moderated to optimize the physical and mental growth and development of adolescents.

• Korean Journal of Environmental Agriculture
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• v.42 no.2
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• pp.104-111
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• 2023

As apple trees mature, it is important to maintain good light distribution within the canopy to produce marketable fruits. Tree thinning is the selective removal of a proportion of trees growing in the orchard to provide more growing space and a good light environment for the remaining trees. This study was conducted over 3 years (14-16 years after planting) to investigate the influence of tree thinning on vegetative growth, yield, fruit quality, and blooming in the 14 years old slender spindle 'Fuji'/M.9 apple trees planted with the tree space of 3.2×1.2 m. The trees were placed in a control group (no thinning; 260 trees per 10 a) or a tree thinning group (thinned 50% of the control; 130 trees per 10 a). The tree thinning successfully improved light penetration, yield per tree, fruit red color, and yield efficiency for 3 years, and the tree thinning controlled the occurrence of biennial bearing. However, tree thinning significantly decreased accumulated yield per 10 a compared with the control. The vegetative growth, yield per tree, soluble solid contents, and blooming were not clear by the occurrence of biennial bearing in the control. These results indicated that tree thinning was a good method for improving light penetration and preventing biennial bearing in the old 'Fuji'/M.9 high-density apple orchards.

• The Bulletin of The Korean Astronomical Society
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• v.45 no.1
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• pp.59.2-59.2
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• 2020

Disks around protostars are the birthplace of planets. The first step toward planet formation is grain growth from ㎛-sized grains to mm/cm-sized grains in a disk, particularly in dense regions. In order to study whether grains grow and segregate at the protostellar stage, we investigate the ALMA Band 3 (3.1 mm) and 7 (0.87 mm) dust continuum observations of the protostellar disk WL 17 in ρ Ophiuchus L1688 cloud. As reported in a previous study, the Band 3 image shows substructures: a narrow ring and a large central hole. On the other hand, the Band 7 image shows different substructures: a non-axisymmetric ring and an off-center hole. The two-band observations provide a mean spectral index of 2.3, which suggests the presence of mm/cm-sized large grains. Its non-axisymmetric distribution may imply dust segregation between small and large grains. We perform radiative transfer modeling to examine the size and spatial distributions of dust grains in the WL 17 disk. The best-fit model suggests that large grains (>1 cm) exist in the disk, settling down toward the midplane, whereas small grains (~10 ㎛) well mixed with gas are distributed off-center and non-axisymmetrically in a thick layer. The low spectral index and the modeling results suggest that grains rapidly grow at the protostellar stage and that grains differently distribute depending on sizes, resulting in substructures varying with observed wavelengths. To understand the differential grain distributions and substructures, we discuss the effects of the protoplanet(s) expected inside the large hole and the possibility of gravitational instability.

• Analytical Science and Technology
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• v.20 no.1
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• pp.10-16
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• 2007

This research was designed to investigate the formations of hazardous air pollutants in the MSWs pyrolysis-gasification-melting process. In this survey, PCDDs/PCDFs (polychlorinated dibenzo-p-dioxins and polychlorinated dibenzofuran) were investigated in the two facilities (A and B facilities). In A facility, the PCDDs/DFs concentrations were 0.88, 2.29, 0.16 ng I-TEQ/$m^3$ respectively on the secondary incinerator, boiler and stack. In B facility, the PCDDs/PCDFs concentrations were 0.22, 0.05 ng I-TEQ/$m^3$ respectively on the pyrolysis-gasification-melting furnace and stack. The concentrations of PCDDs/PCDFs increased due to resynthesis during cooling process in the both facilities. High concentrations of PCDDs/PCDFs isomers were founded as 2, 3, 4, 7, 8-PeCDF, 2, 3, 4, 6, 7, 8-HxCDF and 1, 2, 3, 6, 7, 8-HxCDF orderly in A facility, and 2, 3, 4, 7, 8-PeCDF, 1, 2, 3, 7, 8-PeCDD and 2, 3, 4, 6, 7, 8-HxCDF orderly in B facility.

• Steel and Composite Structures
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• v.46 no.6
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• pp.773-791
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• 2023

Connections with damage concentrated to pre-selected components can enhance seismic resilience for moment resisting frames. These pre-selected components always yield early to dissipate energy, and their energy dissipation mechanisms vary from one to another, depending on their position in the connection, geometry configuration details, and mechanical characteristics. This paper presents behaviour insights on two types of beam-to-beam connections that the angles were designed as energy dissipation components, through the results of experimental study and finite element analysis. Firstly, an experimental programme was reviewed, and key responses concerning the working mechanism of the connections were presented, including strain distribution at the critical section, section force responses of essential components, and initial stiffness of test specimens. Subsequently, finite element models of three specimens were established to further interpret their behaviour and response that were not observable in the tests. The moment and shear force transfer paths of the composite connections were clarified through the test results and finite element analysis. It was observed that the bending moment is mainly resisted by axial forces from the components, and the dominant axial force is from the bottom angles; the shear force at the critical section is primarily taken by the slab and the components near the top flange. Lastly, based on the insights on the load transfer path of the composite connections, preliminary design recommendations are proposed. In particular, a resistance requirement, quantified by a moment capacity ratio, was placed on the connections. Design models and equations were also developed for predicting the yield moment resistance and the shear resistance of the connections. A flexible beam model was proposed to quantify the shear resistance of essential components.

• Wind and Structures
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• v.36 no.3
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• pp.161-174
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• 2023

The analytical model of tornado vortices plays an essential role in tornado wind description and tornado-resistant design of civil structures. However, there is still a lack of guidance for the selection and application of tornado analytical models since they are different from each other. For single-cell tornado vortices, this study conducts a comparative study on the velocity characteristics of the analytical models based on numerically simulated tornado-like vortices (TLV). The single-cell stage TLV is first generated by Large-eddy simulations (LES). The spatial distribution of the three-dimensional mean velocity of the typical analytical tornado models is then investigated by comparison to the TLV with different swirl ratios. Finally, key parameters are given as functions of swirl ratio for the direct application of analytical tornado models to generate full-scale tornado wind field. Results show that the height of the maximum radial mean velocity is more appropriate to be defined as the boundary layer thickness of the TLV than the height of the maximum tangential mean velocity. The TLV velocity within the boundary layer can be well estimated by the analytical model. Simple fitted results show that the full-scale maximum radial and tangential mean velocity increase linearly with the swirl ratio, while the radius and height corresponding to the position of these two velocities decrease non-linearly with the swirl ratio.

• Journal of the Korean Society of Food Culture
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• v.23 no.6
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• pp.820-833
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• 2008

The study analyzed the body shape perception, weight control attitude, nutrition knowledge, and dietary habits of 529 high school students in Jeju surveyed from January 14-18, 2008 according to students' body shape satisfaction, with the aim of providing basic nutritional education data to aid in appropriate weight control for high school students. The data were analyzed by descriptive analysis, T-test, Chi-square test, ANOVA, and Pearson's correlation coefficients, using the SPSS Win 12.0 program. The body mass index (BMI) of subjects was in the normal range. With regard to weight distribution, 59.4% of subjects showed normal weight and girls were significantly more underweight than boys. More girls considered themselves to be fatter than boys and tended to be increasingly dissatisfied with their body shape. Both boys and girls were more interested in weight control for obesity and were significantly less satisfied with their body shape. Efforts at weight control and reduction had occurred significantly more often for girls than for boys. Dietary attitude scores were significantly higher in girls than boys. BMI positively correlated to weight control concern and nutrition knowledge positively correlated to dietary attitude. BMI negatively correlated to the body shape satisfaction, which in turn negatively correlated to food ingestion disorders. Therefore, it is necessary to develop a systematic nutrition educational program that can induce changes in dietary behavior and increase accurate perception and satisfaction of body shape.