• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.22 no.2
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• pp.235-240
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• 2013

This paper presents a disposable microfluidic infusion pump using the restoring force of elastomeric membrane of Polydimethylsiloxane. Microfluidic infusion pump consists of hydraulic resistance control part, elastomeric blister actuator part, drug inlet and outlet. Expanded elastomeric blister actuator continuously pushes liquid in the chamber to outlet. At same time, microchannel diameter near the outlet was controlled by thin elastomeric membrane in hydraulic resistance control part. Eventually flow rate of infused liquid is controlled by air pressure. In experimental study, the amount of the filled liquid in the blister is precisely controlled by the height of the blister. Flow rate of infused liquid could be controlled, that is, controlled release of the drug over time was possible by adjusting hydraulic resistance and restoring pressure with the blister actuator.

• Journal of the Korean Society of Manufacturing Technology Engineers
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• v.24 no.1
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• pp.81-86
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• 2015

This paper presents a disposable passive suction pump that uses the restoring force of an elastomeric chamber for liquid transportation in a microfluidic system. The proposed suction pump can be operated by finger pressure without any peripheral equipment. To adjust the generated suction pressure, five different displacements of the suction chamber ceiling, two different chamber shapes, and five different elastic moduli of the elastomer were considered. For a cylindrical chamber with a 5 mm height and 5 mm radius, the generated suction pressure and flow rate increased almost linearly up to about 31 kPa and $160.8{\mu}L/min$, respectively, depending on the chamber deformation. A maximum suction pressure of $42.9{\pm}0.7kPa$ was obtained for a hemispherical chamber with a 2.1 mm height and 5 mm radius.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.32 no.9
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• pp.720-727
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• 2008

Microfluidic single chip integrating thermopneumatic micropump and micro check valve are developed. The micropump and micorvalve are made of biocompatible materials, glass and PDMS, so as to be applicable to the biochip. By using the passive-type check valve, backward flow and fluid leakage are blocked and flow control is stable and precise. The chip is composed of three PDMS layers and a glass substrate. In the chip, flow channel and pump chamber were made on the PDMS layers by the replica molding technique and pump heater was made on the glass substrate by Cr/Au deposition. Diameter of the pump chamber is 7 mm and the width and depth of the channel are 200 and $180{\mu}m$, respectively. The PDMS layers chip and the heater deposited glass chip are combined by a jig and a clamp for pumping operation, and they are separable so that PDMS chip is used as a disposable but the heater chip is able to be used repeatedly. Pumping performance was simulated by CFD software and investigated experimentally. The performance was the best when the duty ratio of the applied voltage to the heater was 33%.