• Genomics & Informatics
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• 제8권2호
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• pp.90-93
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• 2010

A-kinase-anchoring proteins (AKAPs) are scaffold proteins which compartmentalize protein kinase A (PKA, cAMP-dependent protein kinase) and other enzymes to specific subcellular sites. The spatiotemporal control of these enzymes by AKAPs is important for cellular function like cell growth and development etc. Hence, it is important to understand the basic function of AKAPs and their functional domains. However, diverse names, function, cellular localizations and many members of AKAPs increase difficulties when researchers search appropriate AKAPs for their experimental purpose. Nevertheless, there was no previous AKAPs-related database regardless of their important cellular functions and difficulty of finding appropriate AKAPs. So, we developed AKAPs database (AKAPDB), which contains their sequence information, functions and other information derived from prediction programs and other databases. Therefore, we propose that AKAPDB can be an important tool to researchers in the related fields. AKAPDB is available via the internet at http://plaza3.snu.ac.kr/akapdb/.

• 스마트미디어저널
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• 제8권3호
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• pp.88-94
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• 2019

가축 질병 발생시 신속하게 대처를 하지 못할 경우 그 피해가 막대하기 때문에 가축 질병은 축산업에서 매우 중요한 이슈이다. 가축 질병 발생으로 인한 문제를 해결하기 위해서는 가축 질병상태를 조기에 진단하고 체계적이며 과학적인 가축 사양기술의 개발이 필요하지만 국내에는 이러한 기술에 대한 연구가 미흡한 실정이다. 본 논문에서는 클라우드 컴퓨팅을 활용한 가축 질병 예찰 및 축사 통합 관제 시스템을 제안하고자 한다. 제안하는 시스템은 WSN과 어플리케이션을 통해 수집된 가축 및 축사관련 정보들을 데이터를 컬럼 지향 데이터베이스인 하둡 HBase를 이용하여 저장하고 관리하며, 맵리듀스 모델을 통한 병렬처리를 통해 가축 질병 예찰 및 축사 통합 관제 서비스를 제공한다. 또한 REST 기반의 웹서비스 제공을 통해 사용자는 PC, 모바일 기기 등 다양한 플랫폼으로 서비스를 제공받을 수 있다.

• 디지털콘텐츠학회 논문지
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• 제19권3호
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• pp.587-593
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• 2018

증후군감시는 감염병 발생 초기에 나타날 수 있는 임상적 증상 발생동향을 감시하여 감염병의 발생을 가능한 조기에 인지하기 위해 고안된 감시체계이다. 한국 질병관리본부에서는 응급실 기반의 증후군감시시스템을 개발하였으며, 현 시스템의 기능을 강화하고자 국외 증후군감시 조기경보시스템에 관한 문헌조사를 하였다. 본 논문에서는 국외 증후군감시 조기경보시스템 운영현황을 설명, 비교하여 한국의 응급실 기반 증후군감시를 위한 조기경보시스템의 개선에 필요한 근거자료를 마련하였다.

• 디지털콘텐츠학회 논문지
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• 제19권9호
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• pp.1795-1801
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• 2018

질환의 원인을 규명하기 위해 전장유전체 연관분석 (GWAS; Genome-Wide Association Study) 연구가 활발히 진행되고 유전체 레벨의 단일염기다형성 (SNP; Single-nucleotide polymorphism)이 많이 밝혀지고 있다. 그러나 단일염기다형성의 연관분석을 통해 질환이 발병하는 생물학적 메카니즘을 이해하기 어렵기 때문에 유전자, 생물학적 패스웨이 및 질환 등의 연관성 분석이 이전보다 더욱 중요하다. 본 논문에서는 단일염기다형성과 관련된 유전자와 패스웨이, 질환 정보를 검색하여 통합 분석하는 서비스를 제공하는 PRaDA 웹 시스템을 제안하였다. PRaDA는 사용자로부터 입력받은 유의한 몇몇의 단일염기다형성들과 관련된 유전자 및 패스웨이 뿐만 아니라, 유의하지 않은 다수의 단일염기다형성 집합의 간접적인 영향을 파악하기 위해 기능적으로 근접한 패스웨이를 검색하고 통계적 분석을 실행한다. 사용자들은 PRaDA가 제공하는 통합된 정보를 통해 질병의 전반적인 이해를 할 수 있다.

• 인터넷정보학회논문지
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• 제18권5호
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• pp.55-60
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• 2017

The pulmonary function test (PFT) is an essential data source for evaluating the effect of drugs on the lungs or the status of lung function. However, the numeric values of PFT cannot be easily used for clinical studies without labor-intensive manual efforts, because PFTs are usually recorded as image files. This study was aimed at constructing a de-identified, open-access PFT database with various clinical information. For constructing the PFT database, optical character recognition (OCR), regular expression, and the parsing technique were used to extract alphanumeric data from the PFT images in a Korean tertiary teaching hospital. This longitudinal observational database contains 413,000 measurements of PFT from 183,000 patients.

• 한국생물정보학회:학술대회논문집
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• 한국생물정보시스템생물학회 2005년도 BIOINFO 2005
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• pp.407-411
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• 2005

KUGI (Korean UniGene Information) database contains the annotation information of the cDNA sequences obtained from the disease samples prevalent in Korean. A total of about 157,000 5'-EST high throughput sequences collected from cDNA libraries of stomach, liver, and some cancer tissues or established cell lines from Korean patients were clustered to about 35,000 contigs. From each cluster a representative clone having the longest high quality sequence or the start codon was selected. We stored the sequences of the representative clones and the clustered contigs in the KUGI database together with their information analyzed by running Blast against RefSeq, human mRNA, and UniGene databases from NCBI. We provide a web-based search engine fur the KUGI database using two types of user interfaces: attribute-based search and similarity search of the sequences. For attribute-based search, we use DBMS technology while we use BLAST that supports various similarity search options. The search system allows not only multiple queries, but also various query types. The results are as follows: 1) information of clones and libraries, 2) accession keys, location on genome, gene ontology, and pathways to public databases, 3) links to external programs, and 4) sequence information of contig and 5'-end of clones. We believe that the KUGI database and search system may provide very useful information that can be used in the study for elucidating the causes of the disease that are prevalent in Korean.

• 한국경영과학회:학술대회논문집
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• 대한산업공학회/한국경영과학회 2004년도 춘계공동학술대회 논문집
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• pp.9-12
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• 2004

Developing an efficient knowledge base construction mechanism as an input method for expert systems (ES) development is of extreme importance due to the fact that an input process takes a lot of time and cost in constructing an ES. Most ES require experts to explicit their tacit knowledge into a form of explicit knowledge base with a full sentence. In addition, the explicit knowledge bases were composed of strict grammar and keywords. To overcome these limitations, this paper proposes a knowledge conceptualization and construction mechanism for automated knowledge acquisition, allowing an efficient decision. To this purpose, we extended traditional knowledge map (KM) construction process to dynamic knowledge map (DKM) and combined this algorithm with relational database (RDB). In the experiment section, we used medical data to show the efficiency of our proposed mechanism. Each rule in the DKM was characterized by the name of disease, clinical attributes and their treatments. Experimental results with various disease show that the proposed system is superior in terms of understanding and convenience of use.

• 한국의사학회지
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• 제33권2호
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• pp.89-104
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• 2020

The purpose of this research is to build a database structure that can be useful for evidence-based medical practices by constructing the knowledge related to oriental medicine in the classical literature knowledge in a form that can utilize new forms of information technology. As a method, "database" is used as a keyword to search published studies in the field of oriental medicine, research is conducted on classic literature knowledge, and studies describing the contents of the data structure are found and analyzed. In conclusion, the original text DB for the preservation of the original texts and the presentation of the supporting texts should include 'Contents Text', 'Tree Structure', 'Herbal Structure', 'Medicine Manufacture', and 'Disease Structure' tables. In order to search, calculate, and automatically extract expressions written in the original text of the old literature, the tool DB should include 'Unit List', 'Capacity Notation List', 'CUI', 'LUI', and 'SUI' tables. In addition, In order to manage integrated knowledge such as herbal, medicine, acupuncture, disease, and literature, and to implement a search function such as comparison of similarity of control composition, the knowledge DB must contain 'dose-controlled medicine name', 'dose-controlled medicine composition', 'relational knowledge', 'knowledge structure', and 'computational knowledge' tables.

• 대한예방한의학회지
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• 제25권3호
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• pp.25-37
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• 2021

Objectives : To investigate the effectiveness of Korean Medicine services use on the all-cause mortality and incidence of Parkinson's disease(PD) in elderly patients with chronic disease based on the National Health Insurance Service Corhort Database (elderly), called as the NHIS-senior. Methods : This study was a retrospective cohort analysis conducted using the NHIS-senior. Patients with chronic diseases over 65 years old who were not diagnosed PD during 2007-2009 were identified. The case group was defined as patients who used both Korean Medicine and Western Medicine services and the control group consisted of patients who used Western Medicine service only. The all-cause mortality and incidence of PD was analyzed using the Cox proportional hazard model after a propensity score matching(PSM) with a 1:1 ratio. Results : After PSM, the cohort included 47,546 subjects (23,773 in the case group, 23,773 in the control group). Sex, age, comorbidity, severity of disability, and neurology medical service utilization were adjusted in both groups. The mortality was 0.668 times (95% C.I.: 0.646-0.690) lower in the case group than the control group, which was statistically significant (p<0.001). The incidence of PD was 1.051 times (95% C.I.: 0.962-1.148) higher in the case group than the control group, which was not statistically significant(p=0.272). Conclusion : It was not obvious that the use of both Korean Medicine service and Western Medicine services for prevention of PD is benefitial than using only Western Medicine. But it would be possible that using both Korean Medicine and Western Medicine services decreases the mortality than using Western Medicine alone.

• Molecules and Cells
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• 제43권10호
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• pp.880-888
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• 2020

Inherited peripheral neuropathy is a heterogeneous group of peripheral neurodegenerative disorders including Charcot-Marie-Tooth disease. Many peripheral neuropathies often accompany impaired axonal construction and function. To study the molecular and cellular basis of axon-defective peripheral neuropathy, we explore the possibility of using Caenorhabditis elegans, a powerful nematode model equipped with a variety of genetics and imaging tools. In search of potential candidates of C. elegans peripheral neuropathy models, we monitored the movement and the body posture patterns of 26 C. elegans strains with disruption of genes associated with various peripheral neuropathies and compiled a database of their phenotypes. Our assay showed that movement features of the worms with mutations in HSPB1, MFN2, DYNC1H1, and KIF1B human homologues are significantly different from the control strain, suggesting they are viable candidates for C. elegans peripheral neuropathy models.