• Journal of Acupuncture Research
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• v.15 no.2
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• pp.157-171
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• 1998

In order to study the effect of direct moxibustion on depressed immune response and thyroid hormone in rats exposed to cold stress, Sprague-Dawley male rats were put in the horizontal refrigerator by $-10^{\circ}C$ for 14 days and thereafter $-18^{\circ}C$ for 11 days(control group). Sample I group was treated by daily direct moxibustion to bilateral Shinsu(BL23) from the 22nd day to the 25th day for 4 days under the same condition with the control group. Sample II group was treated by daily direct moxibustion to bilateral non-acupoints near the root of the tail from the 22nd day to the 25th day for 4 days under the same condition with the control group. And RBC, WBC, CD4+ T cell count, T3, T4 and TSH were measured. The results were as follows; 1. RBC increased with statistical significance in the sample I and sample II groups compared with the control group. 2. WBC increased with statistical significance in the sample I group, but there was not any significance in the sample II group compared with the control group. 3. Lymphocyte increased with statistical significance both in the sample I and sample II groups compared with the control group. 4. CD4+ T cell count increased with statistical significance both in the sample I and sample II groups compared with the control group. 5. T3, T4 and TSH increased respectively with statistical significance in the sample I and sample II groups compared with the control group.

• Proceedings of the Korea Concrete Institute Conference
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• 2008.04a
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• pp.177-180
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• 2008

SHCC shows the high energy tolerance capacity due to the interfacial bonding of the fibers to the cement matrix. For effective material design and application of SHCC, it is needed to investigate the damage process and micro-fracture mechanism of cement matrix reinforced with different types of fibers. The objective of this paper is to investigate the direct tensile response of cement composites reinforced with single and hybrid fibers using acoustic emission(AE) technique. In this study, the correlations between AE signal and result of the direct tensile response of SHCC. For these purposes, three kinds of fibers were used: PET1.5%, PET1.0+PE0.5%, PET1.0%+PVA0.5%. The result of the direct tensile response of SHCC, for the same volume fraction of fibers, ultimate strength of PET-PE specimen was 2.7 times higher than specimens with PET fibers. And from AE signal value, AE event numbers and cumulative energy were different according to kind of fiber because of the different material properties of reinforced fiber.

• Proceedings of the Earthquake Engineering Society of Korea Conference
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• 2003.03a
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• pp.110-117
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• 2003

The result of recent seismic hazard analysis indicates that the ground motion response spectra for Korean nuclear power plant site have relatively large high frequency acceleration contents. In the ordinary seismic fragility analysis of nuclear power plant structures and equipments, the safety margin of design ground response spectrum is directly used as a response spectrum shape factor. The effects of input response spectrum shape on the floor response spectrum were investigated by performing the direct generation of floor response spectrum from the ground response spectrum. The safety margin included in the design ground response spectrum should be considered as a floor response spectrum shape factor for the seismic fragility analysis of the equipments located in a building.

• Journal of Institute of Control, Robotics and Systems
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• v.13 no.10
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• pp.990-999
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• 2007

We deal with second order NMP(Non-Minimum Phase) systems which are difficult to control with conventional methods because of their inherent characteristics of undershoot. In such systems, reducing the undesirable undershoot phenomenon makes the response time of the systems much longer. Moreover, it is impossible to control the magnitude of undershoot in a direct way and to predict the response time. In this paper, we propose a novel two sliding mode control scheme which is capable of determining the magnitude of undershoot and thus the response time of NMP systems a priori. To do this, we introduce two sliding lines which are in charge of control in turn. One is used to stabilize the system and achieve asymptotic regulation eventually like the conventional sliding mode methods and the other to stably control the magnitude of undershoot from the beginning of control until the state meets the first sliding line. This control scheme will be proved to have an asymptotic regulation property. The computer simulation shows that the proposed control scheme is very effective and suitable for controlling the second order NMP system because it can decide the magnitude of undershoot in a direct and stable way and reduce the response time compared with the conventional ones.

• Journal of Internet Computing and Services
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• v.9 no.3
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• pp.103-117
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• 2008

General customer uses internet, SMS(Short Message Service), ATM(Automated Teller Machine), DM(Direct Mail), and telephony services, etc, for service of big businesses and small and medium enterprises, securities, financial institutions, bank. In particular, the case of Fire insurance & Securities, financial institutions, banks must meet Real-Time constrain control through QoS(Quality of Service) ensure. In this paper, we design and implement a system model about Fault-Tolerance IVR(Interactive Voice Response) of Multi Channel Service based on CRM(Customer Relationship Management) environment for the first inbound position of customer. The proposed model can be widely used in Large-scale Customer Response service.

• Transactions of the Korean Society of Mechanical Engineers B
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• v.30 no.11 s.254
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• pp.1101-1106
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• 2006

To investigate a relation between fine scale eddies and particle dispersion in a near-wall turbulence, direct numerical simulations of turbulent channel flow laden particle are performed for $Re_{\tau}$=180. The motions of 0,8 million particles are calculated for several particle response times ($t_p$) which is the particle response time based on stokes’ friction law. The number density of particles has a tendency to increase with approaching the near-wall regions ($y^+$<20) except for cases of very small and large particle response times (i.e. $t_p$=0.02 and 15). Near the wall, the behavior and distribution of particles are deeply associated with the fine scale eddies, and are dependent on particle response times and a distance from the wall. The Stokes number that causes preferential distribution in turbulence is changed by a distance from the wall. The influential Stokes number based on the Burgers' vortex model is derived by using the time scale of the fine scale eddies. The influential Stokes number is also dependent on a distance from the wall and shows large value in the buffer layer.

• Computers and Concrete
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• v.21 no.4
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• pp.355-365
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• 2018

Five previously-tested reinforced concrete frames were modelled using a nonlinear finite element analysis procedure to demonstrate the accurate response simulations for seismically-deficient frames through pushover analyses. The load capacities, story drifts, and failure modes were simulated. This procedure accounts for the effects of shear failures and the shear-axial force interaction, and thus is suitable for modeling seismically-deficient frames. It is demonstrated that a comprehensive analysis method with a capability of simulating material constitutive response and significant second-order mechanisms is essential in achieving a satisfactory response simulation. It is further shown that such analysis methods are invaluable in determining the expected seismic response, safety, and failure mode of the frame structures for a performance-based seismic evaluation. In addition, a new computer program was developed to aid researchers and engineers in the direct displacement-based seismic design process by assessing whether a frame structure meets the code-based performance requirements by analyzing the analysis results. As such, the proposed procedure facilitates the performance-based design of new buildings as well as the numerical assessment and retrofit design of existing buildings. A sample frame analysis was presented to demonstrate the application and verification of the approach.

• Structural Engineering and Mechanics
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• v.72 no.2
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• pp.203-216
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• 2019

Reliability analysis of composite structures considering random variation of involved parameters is quite important as composite materials revealed large statistical variations in their mechanical properties. The reliability analysis of such structures by the first order reliability method (FORM) and Monte Carlo Simulation (MCS) based approach involves repetitive evaluations of performance function. The response surface method (RSM) based metamodeling technique has emerged as an effective solution to such problems. In the application of metamodeling for uncertainty quantification and reliability analysis of composite structures; the finite element model is usually formulated by either classical laminate theory or first order shear deformation theory. But such theories show significant error in calculating the structural responses of composite structures. The present study attempted to apply the RSM based MCS for reliability analysis of composite shell structures where the surrogate model is constructed using higher order shear deformation theory (HSDT) of composite structures considering the uncertainties in the material properties, load, ply thickness and radius of curvature of the shell structure. The sensitivity of responses of the shell is also obtained by RSM and finite element method based direct approach to elucidate the advantages of RSM for response sensitivity analysis. The reliability results obtained by the proposed RSM based MCS and FORM are compared with the accurate reliability analysis results obtained by the direct MCS by considering two numerical examples.

• Korean Journal of Clinical Pharmacy
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• v.32 no.3
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• pp.191-203
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• 2022

Background: Direct-acting antivirals are recommended for the treatment of chronic hepatitis C virus in Korea. However, evaluation of direct-acting antiviral regimens in a real-world setting is limited. The aims of this study were to investigate the effectiveness and safety of direct-acting antiviral treatment in Korean patients infected with chronic hepatitis C virus genotype 1b or 2 at a tertiary care hospital. Methods: This was a retrospective study conducted with patient data obtained between August 2015 and August 2019 at Jeonbuk National University Hospital. The primary effectiveness endpoint was sustained virological response 12 weeks post-treatment (SVR12) via intention-to-treat (ITT) and modified intention-to-treat (mITT) analyses. Results: Of the 270 patients, 47.0% were infected with genotype 1b and 53.0% with genotype 2. ITT analysis revealed that SVR12 was achieved in 78.9% of all patients, 77.2% in genotype 1b patients, and 80.4% in genotype 2 patients. Of the 21.1% of all patients who did not achieve SVR12, the majority of treatment failures were non-virologic failures (19.7%). mITT analysis revealed that SVR12 was achieved in 98.2% of all patients, 98.0% in genotype 1b patients, and 98.3% in genotype 2 patients. Almost half of all patients experienced one or more adverse events (43.3%), leading to 2.6% discontinuing scheduled treatment. The most common adverse event was anemia. Conclusions: Direct-acting antiviral-based treatment regimens showed high effectiveness and safety. Non-virological factors, such as premature treatment discontinuation due to adverse events or loss of follow-up, were the major disruptors in achieving SVR12.

• Gut and Liver
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• v.12 no.6
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• pp.694-703
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• 2018

Background/Aims: Limited data exist comparing the safety and efficacy of direct-acting antivirals (DAAs) in hepatitis C virus (HCV) monoinfected and HCV/human immunodeficiency virus (HIV) coinfected patients in the real-world clinic practice setting. Methods: All HCV monoinfected and HCV/HIV coinfected patients treated with DAAs between January 2014 and October 2017 in community clinic settings were retrospectively analyzed. Pretreatment baseline patient characteristics, treatment efficacy, factors affecting sustained virologic response at 12 weeks (SVR12) after treatment, and adverse reactions were compared between the groups. Results: A total of 327 patients were included in the study, of which 253 were HCV monoinfected, and 74 were HCV/HIV coinfected. There was a statistically significant difference observed in SVR12 when comparing HCV monoinfection and HCV/HIV coinfection (94% and 84%, respectively, p=0.005). However, there were no significant factors identified as a predictor of a reduced response. The most common adverse effect was fatigue (27%). No significant drug interaction was observed between DAA and antiretroviral therapy. None of the patients discontinued the treatment due to adverse events. Conclusions: In a real-world setting, DAA regimens have lower SVR12 in HCV/HIV coinfection than in HCV monoinfection. Further studies involving a higher number of HCV/HIV coinfected patients are needed to identify real predictors of a reduced response.