• Proceedings of the Korean Vacuum Society Conference
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• 2013.08a
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• pp.249-249
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• 2013

Surface-enhanced Raman spectroscopy (SERS) is a sensitive approach to detect and to identify a variety of molecules. To enhance the Raman signal, optimization of the gap between nanostructures is quite important. One-dimensional materials such as nanowires, nanotubes, and nanograsses have great potential to be used in SERS due to their unique sizes and shape dependent characteristics. In this study we investigate a simple way to fabricate SERS substrates based on randomly grown copper oxide (CuO) nanowires. CuO nanograss is fabricated on pre-cleaned Cu foils. Cu oxidized in an ammonium ambient solution of 2.5 M NaOH and 0.1 M $(NH_4)_2S_2O_8$ at $4^{\circ}C$ for 10, 30, and 60 minutes. Then, Cu(OH)2 nanostructures are formed and dried at $180^{\circ}C$ for 2 h. With the drying process, the Cu(OH)2 nanostructure is transformed to CuO nanograss by dehydration reaction. CuO nanograss are grown randomly on Cu foil with the average length of 10 ${\mu}m$ and the average diameter of a 100 nm. CuO nanograsses are covered by Ag with various thicknesses from 10 to 30 nm using a thermal evaporator. Then, we immerse uncoated and Ag coated CuO nanowire samples of various oxidation times in a 0.001M methanol-based 4-mercaptopyridine (4-Mpy) in order to evaluate SERS enhancement. Raman shift and SERS enhancement are measured using a Raman spectrometer (Horiba, LabRAM ARAMIS Spectrometer) with the laser wavelength of 532 nm. Raman scattering is believed to be enhanced by the interaction between CuO nanograss and Ag island film. The gaps between Ag covered CuO nanograsses are diverse from <10 nm at the bottom to ~200 nm at the top of nanograsses. SERS signal are improved where the gaps are minimized to near 10s of nanometers. There are many spots that provide sufficiently narrow gap between the structures on randomly grown CuO nanograss surface. Then we may find optimal enhancement of Raman signal using the mapping data of average results. Fabrication of CuO nanograss based on a solution method is relatively simple and fast so this result can potentially provide a path toward cost effective fabrication of SERS substrate for sensing applications.

• Korean Journal of Microbiology
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• v.41 no.4
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• pp.262-268
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• 2005

Intoxication of murine macrophages (RAW 264.7) with the anthrax lethal toxin (LeTx 100 ng/ml) results in profound alterations in the host cell gene expression. The role of LeTx in mediating these effects is unknown, largely due to the difficulty in identifying and assigning function to individual proteins. In this study, we have used two-dimensional polyacrylamide gel electrophoresis to analyze the protein profile of murine macrophages treated with the LeTx, and have coupled this to protein identification using MALDI-TOF mass spectrometry. Interpretation of the peptide mass fingerprint data has relied primarily on the ProFound database. Among the differentially expressed spots, cleaved mitogen-activated protein kinase kinase (Mek1) and glucose-6-phosphate dehydrogenase were increased in the LeTx treated macrophages. Mek1 acts as a negative element in the signal transduction pathway, and G6PD plays the role for the protection of the cells from the hyper-production of active oxygen. Our results suggest that this proteomic approach is a useful tool to study protein expression in intoxicated macrophages and will contribute to the identification of a putative substrate for LeTx.

• Journal of Biomedical Engineering Research
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• v.24 no.6 s.81
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• pp.515-522
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• 2003

Pharynx is a system transporting foods by peristaltic motion(contraction and expansion movement! into the esophagus and functioning as airway passages. In this study, structural changes of pharyngeal dysfunction are analyzed by biomechanical model using CT and FEM(finite clement method). Loading condition was assumed that equal pressure was loaded sequentially to inside of pharyngeal tissue. In order to analyze the pharyngeal muscular dysfunction by biomechanical model. the pharyngeal dysfunctions was classified into 3 cases. Taking into account the clinical complication by neuromuscular symptoms such as pharyngeal dysfunction after stroke. we assumed that a change of material property is caused by muscular tissue stiffness. A deformation of cross sectional area of the pharynx is analyzed increasing the stiffness $25\%,\;50\%,\;75\%$ in each case on the basis of stress-strain relationship. Based on three-dimensional reconstruction of pharyngeal structure using limited factor - techniques and the optimization procedure by means of inverse dynamic approach. the biomechanical model of the human pharynx is implemented. The results may be used as clinical index illustrating the degree of pharyngeal muscular dysfunction. This study may be used as useful diagnostic model in discovering early deglutitory impediment caused by physiological or pathological pharyngeal dysfunction.

• Journal of KIISE:Databases
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• v.36 no.6
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• pp.476-485
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• 2009

In sensor networks, many methods have been proposed to process in-network aggregation effectively. Unlike general aggregation queries, skyline query processing compares multi-dimensional data for the result. Therefore, it is very difficult to process the skyline queries in sensor networks. It is important to filter unnecessary data for energy-efficient skyline query processing. Existing approach like MFTAC restricts unnecessary data transitions by deploying filters to whole sensors. However, network lifetime is reduced by energy consumption for many false positive data and filters transmission. In this paper, we propose a bottom up filtering-based skyline query processing algorithm of in-network for reducing energy consumption by filters transmission and a PBFiltering technique for improving performance of filtering. The proposed algorithm creates the skyline filter table (SFT) in the data gathering process which sends from sensor nodes to the base station and filters out unnecessary transmissions using it. The experimental results show that our algorithm reduces false positives and improves the network lifetime over the existing method.

• Journal of the Korea Society of Computer and Information
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• v.25 no.6
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• pp.109-117
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• 2020

An edutainment system aims to help learners to recognize problems effectively, grasp and classify important information needed to solve the problems and convey the contents of what they have learned. Edutainment contents can be usefully applied to education and training in the both scientific and industrial areas. Our present work proposes an edutainment system that can be applied to a drug discovery process including virtual screening by using intuitive multi-modal interfaces. In this system, a stereoscopic monitor is used to make three-dimensional (3D) macro-molecular images, with supporting multi-modal interfaces to manipulate 3D models of molecular structures effectively. In this paper, our system can easily solve a docking simulation function, which is one of important virtual drug screening methods, by applying gaming factors. The level-up concept is implemented to realize a bio-game approach, in which the gaming factor depends on number of objects and users. The quality of the proposed system is evaluated with performance comparison in terms of a finishing time of a drug docking process to screen new inhibitors against target proteins of human immunodeficiency virus (HIV) in an e-drug discovery process.

• Tunnel and Underground Space
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• v.29 no.4
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• pp.262-279
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• 2019

In the engineering barriers of high-level radioactive waste disposal, gases could be generated through a number of processes. If the gas production rate exceeds the gas diffusion rate, the pressure of the gas increases and gases could migrate through the bentonite buffer. Because people and the environment can be exposed to radioactivity, it is very important to clarify gas migration in terms of long-term integrity of the engineered barrier system. In particular, it is necessary to identify the hydro-mechanical mechanism for the dilation flow, which is a very important gas flow phenomenon only in medium containing large amounts of clay materials such as bentonite buffer, and to develop and validate new numerical approach for the quantitative evaluation of the gas migration phenomenon. Therefore, in this study, we developed a two-phase flow model considering the mechanical damage model in order to simulate the gas migration in the engineered barrier system, and validated with 1D gas flow modelling through saturated bentonite under constant volume boundary conditions. As a result of numerical analysis, the rapid increase in pore water pressure, stress, and gas outflow could be simulated when the dilation flow was occurred.

• Journal of Korea Water Resources Association
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• v.54 no.5
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• pp.335-345
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• 2021

The one-dimensional solute transport models have been developed for recent decades to predict behavior and fate of solutes in rivers. Transient storage model (TSM) is the most popular model because of its simple conceptualization to consider the complexity of natural rivers. However, the TSM is highly dependent on its parameters which cannot be directly measured. In addition, the TSM interprets the late-time behavior of concentration curves in the shape of an exponential function, which has been evaluated as not suitable for actual solute behavior in natural rivers. In this study, we suggested a stochastic approach to the solute transport analysis. We delineated the model development and model application to a natural river, and compared the results of the proposed model to those of the TSM. To validate the proposed model, a tracer test was carried out in the 4.85 km reach of Gam Creek, one of the first-order tributaries of Nakdong River, South Korea. As a result of comparing the power-law slope of the tail of breakthrough curves, the simulation results from the stochastic storage model yielded the average error rate of 0.24, which is more accurate than the 14.03 and 1.87 from advection-dispersion model and TSM, respectively. This study demonstrated the appropriateness of the power-law residence time distribution to the hyporheic zone of the Gam Creek.

• Journal of the Korean Academy of Esthetic Dentistry
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• v.29 no.2
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• pp.103-117
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• 2020

A beautiful smile has a great impact on the quality of life. It gives you confidence, and makes you function with a positive attitude, which will eventually bring the joy and happiness to daily lives. As dental practitioners, our mission is to bring back the bright smile of the people who come to see us. Restoring masticatory function is one thing but one should always remember that the esthetics should always come first in any kind of restorative procedures. When treating complex rehabilitation cases, treatment planning is probably the most important step before you start any dental procedures. Obviously, esthetics should be the ultimate goal of the treatment and one should approach a case step by step to achieve an optimal result. For the past few years, "digital smile design" has been introduced in the field of dentistry. It can be applied by using various methods and tools. In this article, a very basic form of 2-dimensional digital smile designing was utilized to treat a complete mouth rehabilitation case. We will discuss how the DSD concept can be applied to your daily practice with a simple photograph and photoshop.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.35 no.2
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• pp.73-82
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• 2022

The study presents a three-dimensional approach to simulate the nonlinear behavior of a 72 m long Ultra High Performance Fiber Reinforced Concrete (UHPFRC) pre-stressed box girder for a pedestrian bridge in Busan, South Korea. The concrete damage plasticity (CDP) model is adopted to model the non-linear behavior of the UHPFRC material, in which the material properties are obtained from uniaxial compressive and tensile tests. The simulation model based on the proposed stress-strain curve is validated by the results of four-point bending model tests of a 50 m UHPFRC pre-stressed box girder. The results from the simulation models agree with the experimental observations and predict the flexural behavior of the 50 m UHPFRC pre-stressed box girder accurately. Afterward, the validated model is utilized to investigate the flexural behavior of the 72 m UHPFRC pre-stressed box girder. Here, the load-deflection curve, stress status of the girder at various load levels, and connection details is analyzed. The load-deflection curve is also compared with design load to demonstrate the great benefit of the slender UHPFRC box girder. The obtained results demonstrate the applicability of the nonlinear finite element method as an appropriate option to analyze the flexural behavior of pre-stressed long-span girders.

• Journal of Korea Water Resources Association
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• v.54 no.11
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• pp.943-953
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• 2021

The propagation of impact wave induced by landslide and debris flow occurred on the slope of lake, reservoir and bays is a three-dimensional natural phenomenon associated with strong interaction of debris flow and water flow in complex geometrical environments. We carried out 3D numerical modeling of such impact wave in a bay using a multiphase turbulence flow model and a rheology model for non-Newtonian debris flow. Numerical results are compared with previous experimental result to evaluate the performance of present numerical approach. The results underscore that the reasonable predictions of both thickness and speed of debris flow head penetrating below the water surface are crucial to accurately reproduce the maximum peak height and free surface profiles of impact wave. Two predictions computed using different initial debris flow thicknesses become different from the instant when the peaks of impact waves fall due to the gravity. Numerical modeling using relatively thick initial debris flow thickness appears to well reproduce the water surface profile of impact wave propagating across the bay as well as wave run-up on the opposite slope. The results show that the maximum run-up height on the opposite slope is not sensitive to the initial thickness of debris flows of same total volume. Meanwhile, appropriate rheology model for debris flow consisting of inviscid particle only should be employed to more accurately reproduce the debris flow propagating along the channel bottom.