• BMB Reports
• /
• v.55 no.3
• /
• pp.148-153
• /
• 2022

Etoposide is a chemotherapeutic medication used to treat various types of cancer, including breast cancer. It is established that pulsed electromagnetic field (PEMF) therapy can enhance the effects of anti-cancer chemotherapeutic agents. In this study, we investigated whether PEMFs influence the anti-cancer effects of etoposide in MCF-7 cells and determined the signal pathways affected by PEMFs. We observed that co-treatment with etoposide and PEMFs led to a decrease in viable cells compared with cells solely treated with etoposide. PEMFs elevated the etoposide-induced PARP cleavage and caspase-7/9 activation and enhanced the etoposide-induced down-regulation of survivin and up-regulation of Bax. PEMF also increased the etoposide-induced activation of DNA damage-related molecules. In addition, the reactive oxygen species (ROS) level was slightly elevated during etoposide treatment and significantly increased during co-treatment with etoposide and PEMF. Moreover, treatment with ROS scavenger restored the PEMF-induced decrease in cell viability in etoposide-treated MCF-7 cells. These results combined indicate that PEMFs enhance etoposide-induced cell death by increasing ROS induction-DNA damage-caspase-dependent apoptosis.

• Korean Journal of Digital Imaging in Medicine
• /
• v.12 no.1
• /
• pp.65-69
• /
• 2010

High energy electron beams were to concentrically dose inside a tumor and more energy is a shape decreased of dose. Therefore, it is useful to radiation therapy of a tumor. Also high energy electron beams ionized into collision with a atom in structure material of tissue and it has big changes to dose distribution by multiple scattering. The study had to establish characteristic of electron beams from interaction of electron beams and materials. Experiment method was to measure dependence of electron beam central axis for depth dose curve, field flatness and symmetry and field size dependence. The results were able to evaluate data for a datum pint of electron beam. Also radiotherapy has to be considered for not only energy pencil of lines but characteristic, electron guide and isodose curves distribution.

• Journal of Korean Medical Ki-Gong Academy
• /
• v.1 no.1
• /
• pp.95-109
• /
• 1996

To investigate anti-stress effects of Manual Kigong, Manual-Apparatus Combined Kikong, and Systemic Kigong, this experiments were performed changing of plasma catecholaminess and serum cortisol measured. Also using D.I.T.I(Digital Infrared Thermongraphy Imaging), Pulse Analyzer, Electric Current on Neurometer, and Digital Flicker on Testing-Stressed. And following results were abtained. 1) Menual-Appartus Combined Kikong decreased significantly increasing concentration of plasma epinephrine and norepinephrine level in Testing-stressed. 2) Manual Kigong decreased increasing concentration of serum cortisol level in Testing-stressed. 3) Manual Kigong and Manual-Aparatues Combined Kikong increased decreasing thermomerty on the palm's center caused Testing-stressed. 4) All of three treats are small change in SET(Systolic Ejection Time) by Pulse Analyzer caused Testing-stressed. 5) More changes of Electric Current on the Neurometer Diagnosis caused Testing-stressed are as followed. Manual-Apparatus Combined Kikong >Systemic Kigong >Manual Kigong From the results, it may be concluded that Manual-Apparatus Combined Kikong Theraphy having more anti-stress effects than Manual Theraphy. Systemic Kigong Therapy.

• Journal of Digital Convergence
• /
• v.11 no.10
• /
• pp.373-378
• /
• 2013

Web accessibility should be guaranteed regardless of disability in current information society. Automatic tools are needed to evaluate a huge number of web sites. Five pre-developed web accessibility evaluation tools are selected and experimenting results are compared and analyzed in this paper. The research results will be very helpful for users who are selecting a web accessibility evaluation tool.

• Journal of Korean Medical Ki-Gong Academy
• /
• v.14 no.1
• /
• pp.52-62
• /
• 2014

Objective : The aim of this study is to analyze the effectiveness of Korean Medicine treatment on post-hysterectomy syndrome patients by thermographic change during treatment. Methods : 5 female patients who had a hysterectomy within a year were treated with Korean Medicine concluding acupuncture, herbal medicine, cupping therapy, herbal bath. We evaluated the thermographic differences by checking Digital Infrared Thermal Imaging(D.I.T.I.) at CV17(膻中), CV4(關元), ST3(巨髎), BL15(心兪), and BL23(腎兪). Results : In consequence of Korean Medicine Treatment for 3 weeks, thermographic differences between CV17(膻中) and CV4(關元), ST3(巨髎) and CV4(關元), BL15(心兪), and BL23(腎兪) tended to decrease. Conclusion : After Korean Medicine treatment, thermographic differences between upper body and lower body tended to decrease cause shangrexiahanzheng(上熱下寒證) made by hysterectomy became moderated.

• Proceedings of the Korean Society of Computer Information Conference
• /
• 2023.01a
• /
• pp.65-68
• /
• 2023

4차 산업혁명과 메타버스와 같이 빠르게 변화하는 정보화 시대에서 디지털 사각지대에 놓인 '디지털 소외 계층'들이 존재하고 있다. 특히 고령자 같은 경우엔 빠르게 변화된 사회 속에서 보장받아야 할 디지털 교육을 받지 못하여 이제는 당연하게 누려야 할 편리함까지 놓치고 있다. 본 논문에서는 이런 문제들을 해결하기 위한 효과적인 디지털 교육 방안으로 '놀이'와 '게임' 그리고 '컴퓨터'를 융합시킨 'e스포츠'를 통해 디지털 치료제로서 제안하고자 한다. 이는 단순한 '교육'이 아닌 새로운 실버 콘텐츠로 접근하여 노인들의 또 다른 문화로 개척하며 디지털 소외 문제를 해결하는 것과 동시에 고령자들에게 'e스포츠'의 발전과 인식개선에도 기대해 본다.

• International Journal of Advanced Culture Technology
• /
• v.12 no.3
• /
• pp.427-433
• /
• 2024

This study aims to develop a personalized music digital therapeutic based on MBTI personality types and apply it to depression treatment. In the data collection stage, participants' MBTI personality types and music preferences were surveyed to build a database, which was then preprocessed as input data for the KNN model. The KNN model calculates the distance between personality types using Euclidean distance and recommends music suitable for the user's MBTI type based on the nearest K neighbors' data. The developed system was tested with new participants, and the system and algorithm were improved based on user feedback. In the final validation stage, the system's effectiveness in alleviating depression was evaluated. The results showed that the MBTI personality type-based music recommendation system provides a personalized music therapy experience, positively impacting emotional stability and stress reduction. This study suggests the potential of nonpharmacological treatments and demonstrates that a personalized treatment experience can offer more effective and safer methods for treating depression.

• Journal of Korean Medical Ki-Gong Academy
• /
• v.5 no.1
• /
• pp.1-21
• /
• 2001

• The Journal of Korean Society for Radiation Therapy
• /
• v.25 no.1
• /
• pp.87-90
• /
• 2013

Purpose: Introducing CR (Computed Radiography) system created a process of printing therapy irradiation images and converting the degree of enlargement. This is to increase job efficiency and contribute to work improvement using a computerized method with home grown software to simplify this process, work efficiency. Materials and Methods: Microsoft EXCEL (ver. 2007) and VISUAL BASIC (ver. 6.0) have been used to make the software. A window for each shield block was designed to enter patients' treatment information. Distances on the digital images were measured, the measured data were entered to the Excel program to calculate the degree of enlargement, and printouts were produced to manufacture shield blocks. Results: By computerizing the existing method with this program, the degree of enlargement can easily be calculated and patients' treatment information can be entered into the printouts by using macro function. As a result, errors in calculation which may occur during the process of production or errors that the treatment information may be delivered wrongly can be reduced. In addition, with the simplification of the conversion process of the degree of enlargement, no copy machine was needed, which resulted in the reduction of use of paper. Conclusion: Works have been improved by computerizing the process of block production and applying it to practice which would simplify the existing method. This software can apply to and improve the actual conditions of each hospital in various ways using various features of EXCEL and VISUAL BASIC which has already been proven and used widely.

• Journal of Korea Entertainment Industry Association
• /
• v.15 no.4
• /
• pp.325-335
• /
• 2021

Chronic diseases have been increasing recently as the average life expectancy of humans has been extended, and this trend has caused problems such as the widespread demand for health and rehabilitation services and rising medical costs. In order to solve this problem, the community-based rehabilitation has been developed and strengthened in Korea and gradually promoted since 2019. It is important to secure access to clients who want to use services to revitalize community-based rehabilitation. So in this study, as part of the community-based rehabilitation, intends to devise smartphone applications designs and develop a prototype to secure access to community-based occupational therapy services based on occupation and activities. For Occupational Therapy Practice Framework (OTPF), International Classification of Functioning, Disability and Health (ICF), and Allen Diagnostic Module-2 (ADM-2) were used to devise and categorize occupation and activity based application content, and link OTPF, ICF, and ADM-2 through prior research analysis and expert meetings. The derived content was visualized through literature review and activity analysis, and was implemented to enable direct playback within the application using the YouTube API, and finally developed a prototype application. The Android Studio 3.5.2 for Windows 64-bit was used to build the application prototype. In further research, converging various digital technologies for user convenience and additionally researching community-based occupational therapy service providers opinions and service user satisfaction will improve accessibility to community-based occupational therapy services for clients who have difficulty occupational performance in the community.