• Journal of Physiology & Pathology in Korean Medicine
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• v.32 no.4
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• pp.217-225
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• 2018

This study was to investigate the relationship between ultrasonographic examination and pattern identification classification on cinical studies in chinese medicine. We searched clinical studies related correlation between ultrasonographic examination and pattern identification classification in chinese medicine, that published from 2013 to 2016 in China National Knowledge Infrastructure (CNKI) databases by keywords, 'ultrasound(超?)', 'chinese medicine(中?)', 'syndrome differentiation (辨?)'. Seventeen studies were found. There were 7 studies of gynecological diseases including polycystic ovary syndrome and uterine myoma, 5 studies of fatty liver, 3 studies of arthritis, and 1 studie of thyroid nodule and lymphadenopathy respectively. As a result, ii is thought that there was a certain degree of correlation between the change of the ultrasonographic image and the pathological types according to traditional chinese medicine (TCM) syndrome differentiation and ultrasonographic examination could be used as secondary means for the TCM syndrome differentiation classification. In conclusion, by using ultrasonograph device in a medicinal way of TCM and traditional korean medicine (TKM), it is thought that more detailed and accurate diagnosis and treatment are possible and the evidence for reasonableness of syndrome differentiation in TCM and TKM its validity can be secured.

• Korean Journal of Child Studies
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• v.34 no.5
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• pp.115-126
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• 2013

The purpose of this study was to investigate the relationship between self-differentiation and covert narcissism with organization citizenship behavior on the part of teachers in childcare centers. The subjects consisted of 522 teachers who worked in childcare centers in Daegu and Gyeongbuk Province. The data collected were analyzed by means of Pearson's correlation, and hierarchical regression, using SPSS Win 19.0. The results were as follows. (1) Self-differentiation was positively associated with organization citizenship behavior. However when covert narcissism was operating as control, self-differentiation was not associated with organization citizenship behavior. (2) Covert narcissism was negatively associated with organization citizenship behavior. (3) Between both covert narcissism and self-differentiation, only covert narcissism was associated with organization citizenship behavior. (4) There were observable interactional effects between self-differentiation and covert narcissism to organization citizenship behavior.

• Tissue Engineering and Regenerative Medicine
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• v.15 no.6
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• pp.751-760
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• 2018

BACKGROUND: Bone tissue engineering based on pluripotent stem cells (PSCs) is a new approach to deal with bone defects. Protocols have been developed to generate osteoblasts from PSCs. However, the low efficiency of this process is still an important issue that needs to be resolved. Many studies have aimed to improve efficiency, but developing accurate methods to determine efficacy is also critical. Studies using pluripotency to estimate efficacy are rare. Telomerase is highly associated with pluripotency. METHODS: We have described a quantitative method to measure telomerase activity, telomeric repeat elongation assay based on quartz crystal microbalance (QCM). To investigate whether this method could be used to determine the efficiency of in vitro osteogenic differentiation based on pluripotency, we measured the pluripotency pattern of cultures through stemness gene expression, proliferation ability and telomerase activity, measured by QCM. RESULTS: We showed that the pluripotency pattern determined by QCM was similar to the patterns of proliferation ability and gene expression, which showed a slight upregulation at the late stages, within the context of the general downregulation tendency during differentiation. Additionally, a comprehensive gene expression pattern covering nearly every stage of differentiation was identified. CONCLUSION: Therefore, this assay may be powerful tools for determining the efficiency of differentiation systems based on pluripotency. In this study, we not only introduce a new method for determining efficiency based on pluripotency, but also provide more information about the characteristics of osteogenic differentiation which help facilitate future development of more efficient protocols.

• Journal of Korean Traditional Oncology
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• v.26 no.1
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• pp.1-15
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• 2021

Objective: The aim of this review is to analyze the studies using syndrome differentiation questionnaire in cancer patients. Methods: We searched electronic databases including Pubmed, google scholar, Cochrane library, CNKI, KISS, RISS and OASIS. Key words used for searching were cancer, Korean medicine, pattern identification, and questionnaire. Studies using a symptom differentiation questionnaire to cancer patients were selected. Results: 35 studies were enrolled. A total of 17 questionnaires was used. Most of the types of included studies were observational studies, followed by randomized controlled trials (RCTs) and validation studies. The purposes of using questionnaires were rrelation analysis, outcome measurement, evaluating adverse events, subgroup analysis, and questionnaire development. The most used questionnaire was Body Constitution Questionnaire (BCQ), and it was used 8 times, Questionnaire for the Sasang Constitution Classification II (QSCC II) was used 5 times, Constitution in Chinese Medicine Questionnaire (CCMQ), TCM-Symptom Complex Differentiation Questionnaire (TCM-SCDQ), Yin Deficiency Questionnaire were used 4 times, and Qi Blood Yin Yang Deficiency Questionnaire was used twice. BCQ is a questionnaire diagnosing and evaluating yang deficiency, yin deficiency, and blood stasis. It has high reliability, validity, and optimal cut-off value. Conclusion: BCQ is the most used syndrome differentiation questionnaire in cancer-related studies. So, BCQ could be recommended in syndrome differentiation-related cancer studies.

• Korean Journal of Child Studies
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• v.28 no.6
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• pp.119-133
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• 2007

The subjects of this study were composed of 620 $5^{th}$ and $6^{th}$ grade children in Pusan City and their parents. Both parents completed the Differentiation of Self Inventory(DSI : Skowron & Friedlander, 1998). Children completed the DSI, the Personal Authority in the Family System Questionnaire (Bray et al., 1984), and the Youth Self-Report (Archenbach, 1991). These measures were translated into Korean and adapted for children and parents; their validity was established through a preliminary survey of content validity and reliability. Results showed no meaningful correlation between parent's self-differentiation and children's self-differentiation or between parents' self-differentiation total and children's level of problem behaviors. However, Intergenerational Family Relationship and Children's Self-Differentiation influenced children's internalizing and externalizing of problem behavior.

• Journal of Society of Preventive Korean Medicine
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• v.19 no.1
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• pp.61-70
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• 2015

Objective : The aim of this study is to investigate the features of clinical trial which used symptom differentiation on cancer patients Method : Electronic databases including Ovid-Medline, Ovid-EMBASE, and Cochrane library were searched. Search terms incorporating the concepts of cancer, herbal medicine, clinical trial were used. Articles described using symptom differentiation in methods were selected. Results : Twelve studies used symptom differentiation for prescribing herbal medicine to cancer patients. A total of 36 symptom differentiation were used. The kind of the herbal medicines was varied as much as the kind of symptom differentiation. Conclusion : Most of herbal medicines used for cancer patients focused on quality of life or adverse events rather than tumor size. Symptom differentiation and herbal medicine used in selected studies were too diverse to categorize. To use standardized symptom differentiation, symptom differentiation instrument should be developed and reliability test and validity test are needed.

• International Journal of Human Ecology
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• v.10 no.1
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• pp.47-59
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• 2009

This study investigates the relationship of self-differentiation with individualism and collectivism among college students. Special focus was on whether distinctions between vertical and horizontal individualism and collectivism were more useful in examining the relationship with self-differentiation. The results reveal that different aspects of individualism and collectivism were differently related to self-differentiation, indicating that self-differentiation was negatively associated with all aspects of collectivism and with vertical individualism, but positively with horizontal individualism. This study proved that four distinct constructs were more useful in explaining the effects on self-differentiation. The implications of the findings are discussed for clinicians and future research.

• Journal of Families and Better Life
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• v.34 no.4
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• pp.111-125
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• 2016

The purpose of this study was to model the relations between male and female university students' self-differentiation, rejection sensitivity, and interpersonal anxiety. Questionnaires from 502 university students in Seoul were analysed. The findings are as follows. Firstly, self-differentiation, rejection sensitivity, and interpersonal anxiety were significantly different according to gender. Secondly, the level of differentiation from family regression was higher for both male and female students. And the lower the rejection sensitivity experiencing in vertical relations became, and the lower the rejection sensitivity on horizontal relations was, the lower the interpersonal anxiety became. Thirdly, it was confirmed that for male students, differentiation from family regression affected rejection sensitivity on horizontal relations, and for females, differentiation from emotional reactivity affected ejection sensitivity on both horizontal and vertical relations. Finally, rejection sensitivity played a full mediation parameter when self-differentiation affected interpersonal anxiety, and it was demonstrated differences by gender. This study was meaningful in that it confirmed the relations between male and female university students' self-differentiation, rejection sensitivity, and interpersonal anxiety.

• Korean Journal of Child Studies
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• v.23 no.6
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• pp.65-79
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• 2002

The present study surveyed both the parents of 130 children with psychopathology and the parents of 240 normal children. children were between 2 and 12 years of age. No differences were found between parents in self-differentiation or in family function by type of disorder. Parents of children with psychopathology were lower than parents of normal children in self-differentiation; this was particularly evident in cognitive function-emotional function, and emotional cut-off. Patents of children with psychopathology were lower than parents of normal children in terms of family function. Multiple regression analyses indicated that parent's self-differentiation, children's psychopathology, and parent's education level had a significant influence on family function. The regression model explained 52% of the variance.

• Asian-Australasian Journal of Animal Sciences
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• v.31 no.9
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• pp.1507-1515
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• 2018

Objective: In the poultry industry, the most important economic traits are meat quality and carcass yield. Thus, many studies were conducted to investigate the regulatory pathways during muscle differentiation. To gain insight of muscle differentiation mechanism during growth period, we identified and validated calcium-related genes which were highly expressed during muscle differentiation through mRNA sequencing analysis. Methods: We conducted next-generation-sequencing (NGS) analysis of mRNA from undifferentiated QM7 cells and differentiated QM7 cells (day 1 to day 3 of differentiation periods). Subsequently, we obtained calcium related genes related to muscle differentiation process and examined the expression patterns by quantitative reverse-transcription polymerase chain reaction (qRT-PCR). Results: Through RNA sequencing analysis, we found that the transcription levels of six genes (troponin C1, slow skeletal and cardiac type [TNNC1], myosin light chain 1 [MYL1], MYL3, phospholamban [PLN], caveolin 3 [CAV3], and calsequestrin 2 [CASQ2]) particularly related to calcium regulation were gradually increased according to days of myotube differentiation. Subsequently, we validated the expression patterns of calcium-related genes in quail myoblasts. These results indicated that TNNC1, MYL1, MYL3, PLN, CAV3, CASQ2 responded to differentiation and growth performance in quail muscle. Conclusion: These results indicated that calcium regulation might play a critical role in muscle differentiation. Thus, these findings suggest that further studies would be warranted to investigate the role of calcium ion in muscle differentiation and could provide a useful biomarker for muscle differentiation and growth.