• Health Policy and Management
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• v.1 no.1
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• pp.116-135
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• 1991

Few studies have been conducted on the detailed routes of medical care utilization under the National Health Insurance. This study was undertaken to identify the utilization patte군 of health care facilities among industrial workers and their dependents. One of the largest health insurance association was purposively chosen for this objective. The association had 345, 757 members as of 31 December, 1990. The study sample of 297, 948 subjects have been drawn from the membership pool on the basis of their continuous membership status during 1 January through 31 December 1990. This study has tried to identify differential utilization patterns between acute and chronic conditions, and among standard income classes. All the diagnoses were recoded in a manner to achieve the objective of this study. As for acute diseases, most age group had used one medical facility as much as by 60% except the age group of 1-4, This young age group had used over three different health facilities as much as by 10.9-15.8%. The finding suggests that some policy measures by sought for remedying the excessive/inappropriate use of services. In addition, mid-income classes(between 17 and 48) were more likely to use multiple sources of care than lower income classes(between 1 and 16) and upper income classes(above 49). This study has revealed that chronic cases are more likely to pursue multiple sources of care, however those with chronic conditions tend to use single health facility more than those with acute conditions(67.9% versus 52.4%). As many as 12.2% have visited more than three health facilities in chronic conditions, but 5.9% for acute conditions. The most likely source of care was primary clinics for both acute and chronic conditions. Compared with the role of general hospital, small-size hospitals found to play a minimal role in the care and referral of patients. This indicates the need of strengthening the function of small-size hospitals. While a minor cross utilization of western medicine and pharmacy was noted, no significant boundary crossing was identified between western medicine and oriental medicine, or between pharmacy and oriental medicine. It is too early to confirm that whether there is substitutability or cross utilization among these alternative sources of care. A further study is needed to identify these relationship.

• Environmental Mutagens and Carcinogens
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• v.23 no.1
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• pp.11-15
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• 2003

Gap junctional intercellular communication (GJIC) plays a key role during development, process of tissue differentiation, and in maintenance of adult tissue homeostasis. Neural stem cells leading to formation of cell clusters termed 'neurospheres', can differentiate into neurons, oligodendrocytes, and astrocytes. We investigated the expression levels and distribution of connexin43 (Cx43) and connexin32 (Cx32), abundant gap junctional protein in neural cells and in neurospheres isolated from rat fetus embryonic day (ED) 17. During differentiation of neurospheres, expression of Cx43 and 32 were increased time-dependently within 72 h, and then decreased at 7 day in western blot analysis. TPA-induced inhibition of GJIC was confirmed by decreased fluorescence by SL/DT assay, and induced hyperphosphorylation of Cx43 while no changes in Cx32 levels in western blot assay. Our results indicate that GJIC may be a crucial role in the differentiation of neuronal stem cell. And this GJIC can be inhibited by TPA through the hyperphosphorylation of Cx43.

• The Korean Journal of Ecology
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• v.16 no.3
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• pp.239-259
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• 1993

The vegetation types and distributional characteristics of the forest vegetation on Mt. Ilwol were investigated by the Z-M school method. Geographical distribution of the vegetation was a central/montane(CEMO) type of the Korean Peninsula subtype. The forest was classified into five vegetation units: Artemisio-Quercetum mongolicae (Artemisio-Quercetum typicum subass. nov., Artemsio-Quercetum pinetosum dens~florae subass. nov. ). Lychno-Quercetum mongolicae (Lychno-Quercetum Calamagrostetosum arundinaceae subass. nov.. Lychno-Quercetum ligularetosum f~scherii subass. nov.), Fraxinus rhynchophylla community, Quercus variabilis community and Larix leptolepis afforestation. Species with percentage constance degree more than 61% are Quercus mongolica (89.5%, V), Lespedeza maximowiczii (73.7%, IV), Isodon japonicus(73.7%, IV), Fraxinus rhynchophylla (68.%, IV), Arlemisia stolonifera (65, 8%, IV), etc. Artemisio-Quercetum mongolicae was chiefly distributed on the ridge lines of low altitudes (570~700m) and on the ground with exposed rocks in sloping surface (800~1, 000m). Both Fraxinus sievoldiana and Rhododendrou schlippenbachii of the Artemisio-Quercetum mongolicae showed a predominant condition all over the subtree and shrub layers. Of Artemisio-Quercetum pinetosum densifloraes, Pinus densiflora becomes powerful over the tree layer and, on the other hand, Quercus mongolica over the subtree layer. Lychno-Quercetum mongolicae was distributed somewhat on the humid region of the high altitude area (840~1.200m). Fraxinus rhynchophylla community was chiefly distributed in the vicinity of the ravines. Quereus rariabilis community was distributed at subxeric slope on southeast side of the mountain. Larix leptolepis has been reforested at the ecotone between Artemisio-Quercetum mongolicae and Lychno-Quercetum mongolicae. Percentage cover degrees of the subtree layer In Lychno-Quercetum mongolicae, Quereus rariabilis community and Larix leptolepis afforestation were relatively low, 15.3%, 5% and 2.5%, respectively.The contents of moisutre and organic matter in the soil were much higher in Luchno-Quercetum monogolicae and Larix leptolepis afforestaion than in the other communities. Contents o Ca, Mg, K and the available phosphorus were relaively high compared with forests of the other area. This result seems to be influenced by a forest fire. As the altitude increases, the moisure content in the forest soil also increases.

• Journal of Labour Economics
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• v.40 no.1
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• pp.1-36
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• 2017

This study aimed to analyze influencing factors to increase the wage differential between large enterprise and subcontracted small-medium enterprises by using panel data composed of 19 manufacturing industries for 16 years from 1999 to 2014. According to the results of analysis, in large enterprises the elasticity of substitution between the labor inputs and the subcontracted product supplies from small-medium enterprises was significantly less than 1. So, the increase in wages of workers of large enterprises, whose degree of employment protection was relatively high, seemed to increase the share of wage cost in total cost and was resulted to decrease the cost share of subcontracted product supplies significantly. This was interpreted to be able to exert a negative influence upon the price of subcontracted product supplies and the wages of workers in subcontracted small-medium enterprises, and, therefore, to increase the wage differentials between large enterprises and subcontracted small-medium enterprises. Furthermore, it was also found that the increases in the labor union participation rate at large enterprises and the openness rate of the industry concerned were contributing to make such effects much stronger significantly. In order to mitigate the wage differentials and the polarizing trend in labor market, we can suggest to establish a certain kind of flexible wage system and to introduce co-bargaining practices with the workers of subcontracted small-medium enterprises within large enterprises, and also for the workers of small-medium enterprises, to prepare new social systems to upgrade their human resources and job skills drastically.

• Journal of the Korean Institute of Illuminating and Electrical Installation Engineers
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• v.22 no.4
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• pp.1-12
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• 2008

The aim of this study is to investigate the sensitivity evaluation of human beings in reacting to the correlated color temperature of the optical properties of white LED lighting. For the sake of this study, white light-emitting diode modules have been fabricated their correlated color temperature have been measured, test cabinets for the sensitivity evaluation have been constructed with the white LED modules, and their sensitivity reactions on the test cabinets have been evaluated and analyzed. The sensitivity reaction has been evaluated by the semantic differential method with 15 selected questions, and the reliability and the content validity of their lighting have been analyzed to 3 factors which foe the activity as the first factor, the stability as the second one, the potency as the third one, respectively. For the data analysis on the sensitivity reaction, the dependent variable is the score of the sensitivity evaluation and the independent one is the correlated color temperature of the test module. The results of this study is as follows: In the case of the sensitive evaluation on the activity and the potency in the white LED lighting compared with the fluorescent lamp, the subjects have made higher mark on $MA_3$ with 8,300[K], and in the factor of the stability, they have made higher mark on $MA_1$ with 3,800[K].

• Composites Research
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• v.12 no.3
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• pp.75-83
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• 1999

The thermal properties of carbon/phenolic and silica/phenolic ablative composites were investigated by measuring the heat capacity, thermal diffusivity and thermal conductivity. The heat capacities of carbon/ phenolic and silica/phenolic composites were calculated from differential scanning calorimeter curve. The thermal diffusivities of carbon/phenolic and silica/phenolic composites were measured by the laser flash method with varying laminated direction, i.e., with laminar direction and across laminar direction. The thermal diffusivities decreased with increasing temperature. The thermal conductivities of carbon/phenolic and silica/phenolic composites were calculated using the heat capacity, density and thermal diffusivity. The thermal conductivities increased with increasing temperature. The thermal conductivity of with laminar direction is two times higher than that of across-laminar direction in carbon/phenolic composite due to the directionality of thermal conductivity of carbon fiber. The thermal conductivities of two dimensional fiber reinforced composites were analyzed using the conductivities of constituents and volume fraction of each constituent. The thermal conductivities of carbon fiber and silica fiber were calculated from thermal conductivities of carbon/phenolic and silica/phenolic composites. The thermal conductivities of carbon/phenolic and silica/phenolic composites at RT were predicted from thermal conductivities of fiber and resin with varying the volume fraction of fiber.

• Journal of Physiology & Pathology in Korean Medicine
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• v.28 no.3
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• pp.303-309
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• 2014

The fruit of Gleditsia sinensis has been extensively used as a key ingredient of an herbal remedy for the treatment of various inflammatory diseases in traditional Korean Medicine. However, the reason of using the fruit of G. sinensis for the remedy is unclear. Since Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) is a key anti-inflammatory transcription factor, which is activated by the fruit of G. sinesis, we examined whether other plant parts of G. sinensis are also capable of suppressing inflammatory responses by activating Nrf2. Water extracts of various parts of G. sinensis were prepared and tested for Nrf2 activation by reporter assay and western blot analysis. Our results show that the hull of G. sinensis is the most potent in activating Nrf2. Sequential organic solvent extraction of the hull show that all the fractions had a higher potency in activating Nrf2 than the water extract, albeit differential degrees. The hull originated from Korea in general activated Nrf2 strongly compared to that of China. Chloroform fraction of the hull was further examined, showing that the fraction induced nuclear localization of Nrf2, indicative of activated Nrf2, and Nrf2-dependent gene expression including NAD(P)H dehydrogenase quinone 1 (NQO-1), glutamate-cysteine ligase catalytic subunit (GCLC), and heme oxygenase - 1 (HO-1). Therefore, our results show that, among other plant parts examined in this study, the hull of G. sinensis is the most potent, providing the experimental basis for the use of the hull of G. sinensis as an active ingredient for an anti-inflammatory remedy.

• Journal of Sericultural and Entomological Science
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• v.53 no.1
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• pp.44-49
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• 2015

We characterized tissue specific-expressed genes in the posterior silk gland of Bombyx mori using by the Annealing Control Primer based differential display-PCR manner. In this study, we isolated 34 differentially expressed PCR amplicons, which one of these was identified as a novel transcript named as ACP-16 (366 bp), its expression was observed only in the posterior silk glands by Northern blot analysis. To determine promoter region of the ACP-16, we isolated and analyzed a phage DNA having 1.7 kb-long genome DNA including the open reading flame and 5'- upstream untranslated region of the ACP-16 gene from a genomic DNA library. We have estimated a promoter region of the ACP-16 gene by a web promoter prediction engine, which locates -750 ~ -165 from translation initiation site (ATG, +1). ACP-16 gene is necessary to more studies about critical biological role in order to apply the silkworm's transgenic system.

• Journal of Pharmaceutical Investigation
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• v.39 no.1
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• pp.29-36
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• 2009

Since the quality of final products is significantly affected by the homogeneity of powder mixture, the powder blending process has been regarded as one of the critical pharmaceutical unit processes, especially for solid dosage forms. Accordingly, the monitoring to determine a blending process' end-point based on a faster and more accurate in-line/on-line analysis has attracted enormous attentions recently. Among various analytical tools, NIR (near-infrared) spectroscopy has been extensively studied for PAT (process analytical technology) system due to its many advantages. In this study, NIR spectroscopy was employed with an optical fiber probe for the in-line monitoring of fluid-bed blending process. The position of the probe, the ratio of binary powder mixture, the powder size differential and the back-flush period of the shaking bag were examined as principal process parameters. During the blending process of lactose and mannitol powders, NIR spectra were collected, corrected, calibrated and analyzed using MSC and PLS method, respectively. The probe position was optimized. A reasonable end-point was predicted as 1,500 seconds based on 5% RSD value. As a consequence, it was demonstrated that the blending process using a fluid-bed processor has several advantages over other methods, and the application of NIRS with an optical fiber probe as PAT system for a fluid-bed blending process could be high feasible.

• Applied Biological Chemistry
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• v.42 no.3
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• pp.240-245
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• 1999

The starches were isolated from normal (Mudeung) and waxy (Chalssal) hull-less barleys which contained similar contents of ${\beta}-glucan$ and amylose. Their water binding capacity, swelling power and solubility were analyzed. Scanning electron microscopy showed most starch granules had predominant lense shape granules. The particle size of starch granules was in the range of $0.1{\sim}30\;{\mu}m$. The higher pasting temperature was found for $Mudeung(84^{\circ}C)$ than for $Chalssal(61.5^{\circ}C)$. However, Mudeung barley had a lower peak viscosity(535 BU) than that of Chalssal(1,510 BU). Differential scanning calorymetry analysis showed that To and Tp for two starches were 57.0, $60.6^{\circ}C$ for Mudeung, and were 57.0 and $62.2^{\circ}C$ for Chalssal, respectively. Enthalpy changes were 7.9 and 13.2 J/g for Mudeung and Chalssal, respectively.