• Asian Pacific Journal of Cancer Prevention
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• v.16 no.7
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• pp.2923-2928
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• 2015

Background: Gallbladder carcinoma (GBC) has been stated as an Indian disease, with the highest number of cases being reported from certain districts of northeast India, which has an ethnically distinct population. Unfortunately there are no scientific reports on the underlying molecular mechanisms associated with the pathogenesis of the disease from this region. Aim: The present study evaluated the role of differential expression of human telomerase reverse transcriptase (hTERT) in the development of gall bladder anomalies. Materials and Methods: Blood and tissue samples were collected from patients undergoing routine surgical resection for clinically proven cases of gallbladder disease {cholelithiasis (CL, n=50), cholecystitis (CS, n=40) and GBC (n=30) along with adjacent histopathologically proved non-neoplastic controls (n=15)} with informed consent. Whole blood was also collected from age and sex matched healthy controls (n=25) for comparative analysis. Differential hTERT mRNA expression was evaluated by semi-quantitative rt-PCR and real-time PCR based analysis using ${\beta}$-actin as an internal control. Evaluation of differential hTERT protein expression was studied by Western blot analysis and immunoflourescence. Statistical analysis for differential expression and co-relation was performed by SPSSv13.0 software. Results: Gallbladder anomalies were mostly prevalent in females. The hTERT mRNA and protein expression increased gradiently from normal

• Fire Science and Engineering
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• v.15 no.1
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• pp.108-115
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• 2001

In this paper, we analyzed the properties change of electric wire when the thermal stress was applied to 600V grade polyvinyl chloride insulated wire (IV). In the structure analysis, normal wire has the properties of direction on the surface, but in case of deteriorated wire at above $400^{\circ}c$, it formed the carbide, the crack and the crystal. The surface composition rate of normal wire was Cu : 100%, but the section composition of the deteriorated wire at $800^{\circ}c$ showed Cu : 78.89%, O : 21.11%. In result of analyzing the differential scanning calory of copper wire, the new reaction peak was observed on the deteriorated wire at above $700^{\circ}c$. In case of the deteriorated wire as $150^{\circ}c$ at the differential thermal analysis, an endothermic reaction appeared at $264^{\circ}c$ lower than the reactive point of normal wire. The occupation rate of oxygen according to the deterioration of copper wire is about 20% at $500^{\circ}c$.

• Asian Pacific Journal of Cancer Prevention
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• v.14 no.11
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• pp.6331-6335
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• 2013

Objective:To evaluate the performance of combined quantitative analysis of thyroid blood flow and static imaging data in the differential diagnosis of thyroid nodules. Method: Thyroid blood flow and static imaging were performed in 165 patients with thyroid nodules. Patients were divided into a benign thyroid nodule group (BTN, n=135) and a malignant thyroid nodule group (MTN, n=30) based on the results of post-surgical pathologic examination. Carotid artery thyroid transit times (CTTT), perfusion ratio of thyroid nodule blood/thyroid blood (TNB/TB), and perfusion ratio of thyroid nodule blood/carotid artery blood (TNB/CAB) were measured using thyroid blood flow imaging. The ratios between thyroid nodule and ipsilateral submandibular gland (TN/SG) and thyroid nodule and normal thyroid tissue (TN/T) were measured from thyroid static imaging. The differences between the BTN and MTN groups were compared. Results: 1) CTTT was markedly lower in the MTN group than the BTN group, the difference being statistically significant. 2) TNB/TB and TNB/CAB were both significantly higher in MTN than BTN groups. 3) TN/T was significantly lower in MTN group than BTN group. 4) TN/SG was lower in MTN group than BTN group, but the difference was not statistically significant. 5) Using the combination of CTTT and TN/T, the sensitivity, specificity and accuracy were 93.1%, 95.3% and 94.9% respectively for the diagnosis of MTN. Using the combination of CTTT, TNB/TB and TN/T, the sensitivity, specificity and accuracy changed to 89.7%, 100%, and 98.1% respectively. 6) Correlation analysis demonstrated a significant correlation between TN/T and TNB/TB (r=-0.384, P=0.036) and TNB/CAB (r=-0.466, P=0.009) in the MTN group. Conclusion: The combination of quantitative markers from thyroid blood flow and thyroid static imaging had high specificity and accuracy in differential diagnosis of benign and malignant thyroid nodules, thus providing an important imaging diagnostic approach.

• Toxicological Research
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• v.25 no.1
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• pp.35-40
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• 2009

TCDD (2,3,7,8-tetrachlorodibenzo-p-dioxin) and related halogenated aromatic hydrocarbons elicit a diverse spectrum of biochemical and toxic responses in laboratory animals and mammalian cells in culture. Toxicity and carcinogenicity of TCDD is well established but the molecular mechanism is still poorly understood. Here, we found the noble responsive genes to TCDD using the differential display analysis. Treatment of HepG2 cells with TCDD showed a significantly different mRNA expression pattern from the untreated cells in differential display analysis. The differentially displayed bands were isolated and used as probes in dot blot and Northern blot analyses. Of thirty-five isolated differentially displayed bands, only two bands were confirmed as positive in dot blot and Northern blot analyses. The nucleotides sequences of these clones were analyzed and the search of Genebank database revealed that one clone is highly homologous with RanBP2 (Ras-related nuclear protein binding protein2; 92%) and the other is an unknown gene. RanBP2 is a nucleoporin with SUMO E3 ligase activity that functions in both nucleocytoplasmic transport and mitosis and its role as a novel tumor suppressor has been recently proposed. Thus, these results may suggest the clue elucidating the toxic mechanism of TCDD through RanBP2.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.31 no.6
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• pp.331-337
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• 2018

This paper presents dynamic algorithm of the MLS(moving least squares) difference method using first order differential Approximation. The governing equations are only discretized by the first order MLS derivative approximation. The system equation consists of an assembly of the approximate function, so the shape of system equation is similar to FEM(finite element method). The CDM(central difference method) is used for time integration of dynamic equilibrium equation. The natural frequency analyses of the MLS difference method and FEM are performed, and two analysis results are compared. Also, the accuracy of the proposed numerical method is verified by displaying the dynamic analysis results together with the results by the existing second order differential approximation. In the process of assembling the first order MLS derivative approximation, the oscillation error was suppressed and the stress distribution was interpreted as relatively uniform.

• Journal of Digital Convergence
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• v.17 no.9
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• pp.451-469
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• 2019

The purpose of this study is to find developing way of community welfare aimed community-initiative by analyzing differential perception of citizen-initiative between social workers and community members. For this purpose, this study did a difference analysis on self-rating result of importance and difficulty in 59 statements about the citizen-initiative. Participants were 10 social workers in charge of community center over 2 years and 10 community members joined in community group over 2 years. The results are as follows. Differential perception between social workers and community members appeared both importance and difficulty. Especially, differential perception in difficulty was bigger. The statements that social workers as well as community members answered high level of difficulty were related with securing budget and external financial support. As the analysis of categorized statements, the differential perception in 'Goal and responsibility' and 'Democratic system' in procedural aspects were statistically significant. Based on these results, this study presented practical suggestions to make consensus about citizen-initiative in community organization.

• Journal of the Korea Institute of Information Security & Cryptology
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• v.20 no.6
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• pp.3-13
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• 2010

Differential Fault Analysis (DFA) is widely known for one of the most efficient method analyzing block cipher. In this paper, we propose a new type of DFA on DES (Data Encryption Standard). DFA on DES was first introduced by Biham and Shamir, then Rivain recently introduced DFA on DES middle rounds (9-12 round). However previous attacks on DES can only be applied to the encryption process. Meanwhile, we first propose the DFA on DES key-schedule. In this paper, we proposed a more efficient DFA on DES key schedule with random fault. The proposed DFA method retrieves the key using a more practical fault model and requires fewer faults than the previous DFA on DES.

• Proceedings of the KSME Conference
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• 2000.04b
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• pp.199-204
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• 2000

A low temperature differential model stirling engine is manufactured, and its operation characteristics are measured and analyzed by SIMPLE analysis model, in which heat transfer processes are simply considered. The heat transfer coefficients between working fluid and heat sources in the analysis are estimated by comparing the P-V diagrams by experiment and by analysis. This result may be very useful for further design and manufacture of model Stilting engines as well as real engines because it provides a comparatively correct predictions of the operation conditions and power output. It will be also conveniently used as an educational material for mechanical engineering students because it can be a nice example of optimal design process to decide the phase angle and compression ratio of engine design with a simple but realistic simulation.

• ETRI Journal
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• v.34 no.6
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• pp.800-806
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• 2012

Transmission performances of direct detection-based 100-Gb/s modulation formats are investigated and compared for metro area optical networks. The effects of optical signal-to-noise ratio sensitivity, chromatic dispersion, cross-channel nonlinearity, and transmission distance on the performance of differential 8-ary phase-shift keying (D8PSK), differential phase-shift keying plus three-level amplitude-shift keying (DPSK+3ASK), and dual-carrier differential quaternary phase-shift keying (DC-DQPSK) are evaluated. The performance of coherent dual-polarization quadrature phase-shift keying (DP-QPSK) with block phase estimation and coherent DP-QPSK with digital differential detection are also presented for reference. According to our analysis, all three direct detection modulation formats could transmit a 100-Gb/s signal over several hundred kilometers of a single-mode fiber link. The results also show that DC-DQPSK outperforms D8PSK and DPSK+3ASK, and the performance of DC-DQPSK is comparable to that of coherent DP-QPSK with digital differential detection. The maximum transmission distance of DC-DQPSK is over 1,000 km, which is enough distance for metro applications.

• Journal of Institute of Control, Robotics and Systems
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• v.7 no.1
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• pp.1205-1210
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• 2001

This paper describes a methodology using neural network to compensate the nonlinear error of deriving speed for electric differential system included in electric vehicle. An electric differential system which drives each of the left and right wheels of the electric vehicle independently. The electric vehicle driven by induction motor has the nonlinear speed error which depends on a steering angle and speed command. When a vehicle drives along a curved road lane, the speed unblance of inner and outer wheels makes vehicles vibration and speed reduction. To compensate for the speed error, we collected the speed data of the inner wheel and outer wheel in various speed and the steering angle data by using an manufactured electric vehicle and the real system. According to the analysis of the acquisited data, we designed the differential speed control system based on a speed error compensator using neural network.