• 정보보호학회논문지
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• 제31권5호
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• pp.875-888
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• 2021

본 논문에서는 경량 블록 암호 PIPO에 대한 인테그랄 구별자(integral distinguisher)을 탐색한 결과를 통해 8-라운드 PIPO-64/128에 대한 키 복구 공격을 수행한다. ICISC 2020에서 제안된 경량 블록 암호 PIPO는 고차 마스킹 구현을 고려한 설계를 통해 부채널 공격에 대한 저항성을 갖는 효율적인 구현이 가능하다. 동시에 차분 분석, 선형 분석 등의 다양한 분석법을 적용하여 PIPO의 안전성을 보였다. 그러나 인테그랄 공격에 대해, 5-라운드 이상의 인테그랄 구별자가 존재하지 않을 것이라고 제안되었을 뿐 인테그랄 공격에 대한 안전성 분석은 현재까지 수행된 바 없다. 본 논문에서는 MILP 기반 Division Property를 통해 PIPO에 대한 인테그랄 구별자를 탐색하는 방법을 제시하고, 기존의 결과와 달리 6-라운드 인테그랄 구별자가 존재함을 보인다. 뿐만 아니라, PIPO의 라운드 함수 구조를 활용하여 입출력에 대한 선형 변환을 고려하는 인테그랄 구별자 탐색 방법을 통해 총 136개의 6-라운드 인테그랄 구별자를 제시한다. 마지막으로, 획득한 6-라운드 인테그랄 구별자 중 4개를 이용하여 2^124.5849의 시간 복잡도와 2⁹³의 메모리 복잡도를 가지는 8-라운드 PIPO-64/128 키 복구 공격을 제안한다.

• 터널과지하공간
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• 제28권6호
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• pp.596-608
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• 2018

도시 기반시설이 노후화됨에 따라 도시 재난 발생 가능성이 증가하고 있다. 특히, 하수관로, 상수도관망, 지하철 등 노후화된 지하 시설물은 도심지 지반함몰을 유발하는 잠재적 원인이 된다. 도심지 지반함몰은 토양 침식 혹은 유실로 인해 생성된 지하 공동이 확장하여 지역적이고 갑작스런 지반 붕괴까지 이르는 현상으로 정의할 수 있다. 이는 석회암과 같은 용해성 암반에서 발생하는 싱크홀과는 구분된다. 지반 거동과 관련된 전통적인 계측 방식은 좁은 측정 범위와 각 센싱 지점에서의 계측값을 제공하기 때문에 불특정 다수 지역에서 발생할 수 있는 지반함몰 감시체계로서 한계가 있다. 따라서, 도시에 발생하는 지하 공동에 의한 지반함몰을 예방하기 위한 감시체계로서는 적절하지 않으며 지반 내 물리적 환경변화를 감시할 수 있는 새로운 상시 영역 감시 기술이 필요하다. 본 연구에서는 비방사 유도 자기장(자기공명) 기반 감시 체계의 기술적 타당성을 실험적으로 검토하였다. 공기, 물, 흙 등 매질과 공진 주파수, 임피던스 그리고 송 수신기 거리 등과 같은 환경변수에 따른 경로 손실 변화를 측정하는 방식으로 이루어졌다. 이론적으로 자기장의 전달 특성은 매질의 밀도와 독립된 것으로 알려졌으나, 실험 결과 매질의 조건에 따라 경로 손실에 의미있는 차이를 보이는 것으로 나타났다. 또한, 매질의 물리적 환경변화에 따라 경로손실보다는 반사계수가 명확한 차이를 보였으며, 입력 반사계수가 출력 반사계수에 비해 보다 판별이 용이한 것으로 나타났다.

• 전기전자학회논문지
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• 제22권4호
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• pp.1006-1011
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• 2018

본 논문은 멀티비트 플라잉 커패시터의 전압제어를 이용한 3-레벨 벅 변환기를 제안한다. 기존의 3-레벨 벅 변환기는 플라잉 커패시터 전압을 제어하지 못하여 동작이 불안정하거나 플라잉 커패시터 전압을 제어하는 회로가 PWM방식에 적용되지 못하는 문제가 있었다. 또한 부하전류에 증가할 때 인덕터 전압에 오차가 발생하였다. 본 논문에서 제안하는 구조는 입력이 4개인 차동증폭기와 공통모드 피드백 회로를 이용하여 PWM모드에서 플라잉 커패시터 전압을 제어할 수 있다. 또한 3비트 플라잉 커패시터 전압 제어회로를 제안하여 부하전류에 따른 3-레벨 벅 변환기의 동작을 최적화할 수 있으며 슈미트 트리거 회로를 이용한 삼각파 생성 회로를 제안하였다. 제안하는 3-레벨 벅 변환기는 $0.18{\mu}m$ CMOS 공정으로 설계되었으며 2.7~3.6V의 공급 전압 범위와 0.7V~2.4V의 출력 전압 범위를 갖는다. 동작 주파수는 2MHz, 부하전류 범위는 30mA~500mA이며 출력 전압 리플은 최대 32.5mV로 측정되었다. 측정 결과 130mA의 부하전류에서 약 85%의 최대 전력변환 효율을 보인다.

• 한국전산구조공학회논문집
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• 제32권4호
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• pp.249-256
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• 2019

이 논문은 재료의 전기 전도도 분포를 재구성하는 전기임피던스 단층이미지 기법(electrical impedance tomography; EIT)을 제시한다. 이 문제는 구조물 표면의 전극에서 측정된 전위와 계산된 전위의 차를 최소화하여 전기 전도도의 공간적 분포를 재구성하는 최적화 문제로 정의된다. 전류 입력 시 전위를 구하는 정해석 문제의 수학적 모델로서 완전전극모델(complete electrode model; CEM)을 사용하였다. 완전전극모델은 전기 포텐셜에 대한 라플라스 방정식과 전류 입력에 따른 경계조건들로 구성되는 경계값 문제이다. 완전전극모델 해의 정확성을 검증하기 위하여 유한요소법을 이용해 구한 원형 구조물의 전위해와 Technology Computer Aided Design(TCAD) 소프트웨어를 사용해 얻은 결과를 비교하였다. 완전전극모델의 지배방정식과 경계조건을 구속조건으로 하는 최적화 문제를 라그랑주 승수법(lagrange multiplier method)을 이용해 비구속 최적화 문제로 전환하고 라그랑지안의 1차 최적화 조건으로부터 전극에서의 전위 차를 최소화하는 최적의 전기전도도 분포를 도출하였다. 원형 균일영역의 전기 전도도 분포를 재구성하는 역해석 예제를 통해 완전전극모델 기반 EIT 프레임워크의 적용성을 검토하였다.

• 한국수자원학회논문집
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• 제53권2호
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• pp.107-119
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• 2020

본 연구는 한반도의 관측 강우자료를 기반으로 하여 과거의 가뭄 특성을 파악함과 동시에 RCP 8.5 기후변화 시나리오를 활용한 장래 발생 가능한 극치 가뭄에 대한 장기전망을 수행하였다. 정량적인 가뭄 분석을 위해 기상학적 가뭄지수인 표준강수지수(Standardized Precipitation Index, SPI)를 적용하였으며 일단위 강우 관측 자료 및 RCP 시나리오를 단일한 장기 시계열 자료로 구축하여 1, 3, 6, 9, 12개월 지속기간의 SPI 입력인자로 활용하였다. 한반도의 지역별 가뭄특성 분석을 위한 대상 강우관측소는 1954년 시점부터 강우 자료를 보유하고 있는 12개 관측 지점을 선정하였으며, 동일 지점의 10개 GCM(General Circulation Model)을 적용하였다. 기후변화에 따른 가뭄 특성 변화 분석을 위해 강우발생일수와 총강수량에 대한 12개 강우관측소별 추세 변동 분석 및 군집화를 수행하였다. 샘플링 기법을 활용한 비정상성 빈도분석을 위해 베이지안 기반의 DE(Differential Evolution)와 MCMC(Markov Chain Monte Carlo)를 결합한 DEMC 기법을 채택하였고, 비정상성 가뭄빈도해석을 통하여 12개 지점별 SDF(Severity-Duration-Frequency) 곡선을 유도하였다. 비정상성을 가정한 장기 수문자료를 보유한 지점들의 SDF 곡선 산정을 통해 미래의 가뭄에 대한 정량적인 전망을 수행하였다. 장기시계열 자료를 보유한 12개 지점의 군집분석을 수행한 결과 Zone 1-2, 2, 3-2에 해당하는 제주를 제외한 전주, 광주, 여순, 목포, 추풍령 등에서 장래에 가뭄발생 위험이 높은 것으로 분석되었다. 장래 발생 가능한 가뭄 위험성을 정량적으로 파악함으로써 미래 가뭄관리 정책에 충분히 활용될 수 있을 것으로 기대된다.

• 생명과학회지
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• 제14권3호
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• pp.484-489
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• 2004

인공관절은 21세기 정형외과 발전의 주요변화들 중의 하나이다. 1997년이래 전 세계적으로 무릎인공관절(Total Knee Arthroplasty: TKA)을 사용하는 사람들이 해마다 약 600,000명씩 증가하고 있는 추세이고 미국에서만 인공관절을 사용하고 있는 사람들이 210,000명에 달하고 있으며 그 시장은 대략 $5 billion을 넘고 있다(7). 무릎인공관절은 일상생활에서 의자에 앉았다 일어날 때 계단을 올라 갈 때 등, 무릎의 근 모멘트가 적당한 활동을 해서 무릎관절 근육에 지레와 같은 작용을 하게 하고, 완전한 무릎으로 정상인의 무릎과 같은 기능을 오랫동안 유지하게 한다. 이러한 목적을 달성하기 위해서는 무릎인공관절 디자인 시 정상적인 무릎 회전축(normal knee's axes of rotation)들의 정확한 위치를 파악하는 것은 중요하다. 인공관절 수술 후 무릎관절의 신전과 굴곡 운동을 하는 동안 하나의 회전축(single-axes)을 가진 하나의 회전 반경(single-radius)을 알아보는 것은 여러 축(multi-axes)으로 움직이게 된다는 다축 회전반경(multi-radius)을 분석하기에 앞서 중요한 연구이다. 따라서 본 연구에 서는 무릎이 신전운동과 굴곡 운동 시 신전과 굴곡 모멘트를 만들어내는 대퇴 사두근(quadriceps muscle)과 무릎 오금근 (hamstring)의 역할을 알아보았고, 또한 모멘트와 대퇴 사두근의 iEMG 형태를 파악하였다. 본 연구를 수행하기 위해 무릎인공관절 수술을 받고 1년과 3년이 지난 정상적인 생활을 하는 피검자(1년2명, 3년2명)를 대상으로 Isometric 테스트를 위한 KIN-COM III을 사용하여 60$^\circ$, 30$^\circ$의 무릎굴곡 측정을 하였고, Isokinetic concentric 테스트를 위해서 무릎굴곡각도의 $10^\circ$-80$^\circ$까지 움직임을 측정하였다 또한 15$^\circ$-75$^\circ$까지의 신전운동(sit-to-stand movement)과 굴곡운동(stand-to-sit movement)을 실시하여 시간의 차이, 내전과 외전의 차이 그리고 iEMG의 차이를 알아보았다. 본 연구의 데이터는 여러 번의 실험을 통하여 가장 일반적인 수치를 사용하였다. 이 때 16-channel BTS TELEMG를 사용하여 대퇴사두근과 무릎오금근의 근육활동모양을 알아보았다. 본 연구결과는 시술 후 3년이 지나면서 TKR (Total Knee Replacement)의 대퇴 사두근 토큐가 약해지는 것으로 나타났고, iEMG 실험에서는 N-TKR (Non-Total Knee Replacement)의 대퇴 사두근이 TKR의 대퇴 사두근 보다 근 수축력이 더 크게 발휘되는 것으로 밝혀졌다. 단축회전반경의 굴곡과 신전의 $10^\circ$-80$^\circ$까지의 각 속도는 굴곡동작이 1.19s, 신전 동작이 1.68s로 나타났다. 굴곡과 신전동작에서 다리의 외전(abduction)의 각도변화는 굴곡 시 5.5$^\circ$, 신전 시 5.2$^\circ$로 나타났고, 내전(adduction)의 각도변화는 굴곡 시 7.2$^\circ$, 신전 시 6.1$^\circ$로 나타났다. 대퇴 사두근의 iEMG변화에서는 15$^\circ$-60$^\circ$까지 vastus medialis (VM), vastus lateralis (VL), rectus femoris (RF) 모두 굴곡동작에서 큰 값으로 나타났고, 61$^\circ$-75$^\circ$사이에서는 신전동작에서 iEMG가 큰 값으로 나타났다. 이와 같은 결과들은 인공관절 수술자들의 다축회전 반경을 분석하기에 앞서 중요한 선행연구가 될 것으로 생각된다.

• 대한핵의학회지
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• 제38권3호
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• pp.233-240
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• 2004

목적: 내 외측 측두엽간질의 감별은 중요하고 F-18-FDG PET이 도움을 주나 성능이 아주 우수하지는 않다. 이 연구에서는 수술과 수술 후 추적 병리소견으로 확진한 내측성 또는 외측성 측두엽간질 환자의 F-18-FDG PET영상을 후향적으로 조사하여 내측 및 외측 측두엽 대사 감소 양상을 추출하고 내측성과 외측성 간질을 감별하기 위한 인공신경회로망을 이용한 감별시스템을 개발하였으며 판독 성능을 핵의학전문가와 비교하였다. 대상 및 방법 : 수술로 확진한 내측성 또는 외측성 측두엽간질 환자 113명(좌 우측 내측성 측두엽간질 각 41, 42명, 좌 우측 외측성 측두엽간질 각 14, 16명)의 뇌 FDG PET을 대상으로 하였다. 모든 PET 영상을 PET 표준지도에 공간정규화하였으며 표준지도에서 추출한 뇌실질 영역의 평균 화소 값이 100이 되도록 계수정규화를 하였다. 표준지도에 미리 정의한34개 영역에서 평균 계수 값을 추출하였으며 마주보는 17개 영역간의 비대칭계수와 내측 및 외측 측두엽간의 비대칭계수를 구하여 신경회로망 시스템의 입력으로 넣었다. 신경회로망 시스템은 세 개의 독립적인 다층 퍼셉트론으로 구성하였다. 첫 번째 퍼셉트론은 간질 원인병소의 편측화(우측 또는 좌측)를 판단하게 하였다. 다른 두개의 퍼셉트론은 우측 또는 좌측 측두엽간질로 나뉘어진 입력 패턴들을 각각 내측성 또는 외측성 측두엽간질로 구분하는 역할을 하게 하였다. 신경회로망 시스템의 감별 성능을 평가하기 위하여 각 환자군에서 무작위로 8명의 PET 영상을 학습군으로 선정하여 신경회로망을 학습시켰으며 나머지 총 81명의 영상으로 신경망 시스템의 진단 정확성을 평가하였다. 이러한 무작위 실험을 50번 시행하여 얻은 신경회로망 시스템의 출력과 진단명과의 일치도를 핵의학 의사의 판독결과와 비교하였다. 핵의학 의사의 판독은 신경회로망과 동일한 조건 하에서 시행되도록 하기 위하여 각 환자가 측두엽간질환자라는 정보이외에는 어떠한 다른 임상정보도 모르는 상태에서 각 환자를 좌측 또는 우측 내측성 측두엽간질이나 좌측 또는 우측 외측성 측두엽간질 중 하나로 감별하도록 하였다. 결과: 내측 또는 외측 측두엽에 대한 최종 국소화가 정확했는지 여부에 관계없이 간질병소가 속한 뇌반구가 좌측인지 우측인지를 맞게 판단하였으면 편측화에 성공한 것으로 보았을 때 신경회로망과 핵의학 전문가가 모두 평균 90% 정도의 높은 편측화 성공률을 보였다. 편측화는 물론 간질병소가 내측에 있는지 외측에 있는지 여부를 정확하게 판단한 국소화 성공률 또한 신경회로망(59%)과 핵의학 전문가(72%)의 진단 성적이 거의 다르지 않았다. 결론: 이 연구에서 개발한 간질병소 국소화를 위한 신경회로망 시스템은 측두엽간질 감별 진단에 도움이 될 것으로 기대된다.

• 대한핵의학회지
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• 제30권1호
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• pp.130-138
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• 1996

전기화상후 조직이나 뼈의 상태를 관찰하고 창상변연절제술, 피부판 이식후 경과 관찰 및 절단술여부와 부위를 정하는 데 골스캔이 지표가 되고 골결손이 있는 환자에서 피부판 이식술 시행후 경과가 호전되었는지 여부를 알기 위해 골스캔검사가 유용하다고 알려져 있다. 본 연구에서는 1991년부터 1995년 11월까지 본원에 내원한 전기화상 환자중 골스캔 및 경과관찰이 가능했던 37명을 대상으로 골스캔의 유용성을 조사하였다. 골스캔 시행시기는 대상환자 37명 모두에서 1주일이 내에 골스캔을 시행하였다. 저압전류에 수상한 환자는 8명, 고압전류에 수상한 환자는 29명이었다. 유입부별 분포를 보면 수부가 27례, 두부가 6예, 견관절부위가 2예, 좌흉벽부위가 1예, 수혜부위가 1예로 나타났다. 사출부별 분포는 저압전류 8명에서는 사출부위를 찾을 수 없었고 고압전류 29명중 족부가 22예, 수부가 3예, 견관절부위가 2예, 좌측 흉부가 1예, 둔부부위가 1예 순으로 나타났다. 유입부의 골스캔 소견은 저압전류에 손상받은 환자8명 모두 봉와직염 소견을 보였고 고압전류에 손상받은 환자 29명줌 15명은 골수염, 10명은 봉와직염, 4명은 골결손 소견으로 나타났다. 사출부의 골스캔 소견은 저압전류 손상 8명을 제외한 고압전류 손상 환자29명 모두 봉와직염 소견을 보였다. 피부이식이나 피부판 이식술 시행후 추적관찰이 가능했던 4명의 환자모두 피부이식이나 피부판 이식술 시행후, 골결손 부위가 좋아지는 것을 관찰할 수 있었다. 심근에 섭취가 증가된 경우가 2예, 간에 섭취가 증가된 경우가 1예, 신장에 섭취가 증가된 경우가 6예였는데, 혈청 칼슘농도, 심전도, 심근 효소, 간기능 검사 및 신기능 검사상에서는 이상이 없는 것으로 나타났다. 결론적으로 골스캔은 전기화상후 손상부위를 평가하는데 도움이 되고 봉와직염과 골수염의 감별진단, 피부이식이나 피부판 이식술후 평가에 도움이 된다. 그러나 인체 내부 장기의 손상평가는 앞으로 많은 연구가 필요할 것으로 생각된다.

• 대한의용생체공학회:의공학회지
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• 제6권2호
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• pp.1-8
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• 1985

The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70$\pm$1.32mmHg/min)compared to CF dialyzers(4.32$\pm$0.55mmHg/min)(p<0.05). However, there was no observable difference in the UFR between the two dialyzers. Neither APD nor UFR showed any significant increase with an increasing number of reuses for up to more than 20reuses. A substantial number of failures observed in APD(larger than 20mmHe/min)on the reused dialyzers(2 out of 40 CP and S out 26 C-DAK) were attributed to the Possible damage on the fibers. The CF 15-11 HFDs which failed APD test did not show changes in the UFR compared to normal dialyzers indicating that APD is a more sensitive test than UFR test to evaluate the integrity of the fibers. 30527 T00401030527 ^x For quantitative measurement of reflected light from a clinical diagnostic strip, a prototype old reflectance photometer was designed. The strip loader and cassette were made to obtain more accurate reflectance parameters. The strip was illuminated at 45˚c through optical fiber and the intensity of reflected light was determined at rectanguLat angle using a photodiode. The kubelka-munk coefficient and reflection optical density were determined ar four different wavelengths(500, 550, 570 and 610nm) for blood glucose strip. For higher concentration than 300mg/41 about glucose, a saturation state of abforbance was observed at 500, 550 and 570nm. The correlation between glucose concentration and parameters was the best at 610nm. 30535 T00401030535 ^x Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100, 300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise. 30536 T00401030536 ^x We investigated the structural geometry of thirty-eight Korean femurs. The purpose of this study is to identify major geometrical differences between Korean femurs 3nd others that we believe belong to Caucasians so that we would be able to get insights into the femoral component design that fits Asians including Koreans. We utilized computerized tomography (CT) images of femurs extracted from cadavers. The CT images were transformed into bitmap data by using a film scanner, and then analyzed by using a commercially available software called Image v.1.0 and a Macintosh IIci computer.The resulting data were compared with already published data. The major results show that the geometry of the Korean femurs is significantly different from that of Caucasians: (1) the anteversion angle and the canal flare index are greater by the amount of approximately 8˚ and 0.5, respectively, (2) the shape of the isthmus cross section is more round, and (3) the distance between the teaser trochanter and the proximal border of the isthmus is shelter by about 15 mm. The results suggested that the femoral component suitable for Asians should be different from the currently-used components designed and manufactured mostly by European or American companies. 30537 T00401030537 ^x It is well known that nonlinear propagation characteristics of the wave in the tissue may give very useful information for the medical diagnoisis. In this paper, a new method to detect nonlinear propagation characteristics of the internal vibration in the tissue for the low frequency mechanical vibration by using bispectral analysis is proposed. In the method, low frequency vibration of f0( = 100Hz) is applied on the surface of the object, and the waveform of the internal vibration x (t) is measured from Doppler frequency modulation of silmultaneously transmitted probing ultrasonic waves. Then, the bispectra of the signal x (t) at the frequencies (f0, f0) and (f0, 2f0) are calculated to estimate the nonlinear propagation characteristics as their magnitude ratio, w here since bispectrum is free from the gaussian additive noise we can get the value with high S/N. Basic experimental system is constructed by using 3.0 MHz probing ultrasonic waves and the several experiments are carried out for some phantoms. Results show the superiority of the proposed method to the conventional method using power spectrum and also its usefulness for the tissue characterization. 30541 T00401030541 ^x This paper describes the implementation of a computerized radial pulse diagnosis by aids of a clinical expert. On this base, we composed of the radial pulse diagnosis system in korean traditional medicine. The system composed of a radial pulse wave detection system and a radial pulse diagnosis system. With a detection system, we detected Inyoung and Cheongu radial pulse wave and processed it. Then, we have got the characteristic parameters of radial pulse wave and also quantified that according to the method of Inyoung-Cheongu Comparison Radial Pulse Diagnosis. We defined the jugement standard of radial pulse diagnosis system and then we confirmed the possibility for realization of automatic radial pulse diagnosis in korean traditional medicine. 30545 T00401030545 ^x Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, immunomagnetic cell separation. To synthesize microspheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio of synthesized microspheres was always smaller than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6~13 times higher than that of the microspheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin).The effect of the kind and the amount of surface functional group was also examined. 30575 T00401030575 ^x A medical image workstation was developed using multimedia technique. The system based on PC-486DX was designed to acquire medical images produced by medical imaging instruments and related audio information, that is, doctors' reporting results. Input information was processed and analyzed, then the results were presented in the form of graph and animation. All the informations of the system were hierarchically related with the image as the apex. Processing and analysis algorithms were implemented so that the diagnostic accuracy could be improved. The diagnosed information can be transferred for patient diagnosis through LAN(local area network). 30592 T00401030592 ^x In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensional optic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the intfrared thermography system composed of the proposed optic system has the temperature resolution of 0.1˚c under the spatial resolution of lmrad, the image matrix size of 256 X 240, and tile imaging time of 4 seconds. 30593 T00401030593 ^x In this paper, MIIS (Medical Image Information System) has been designed and implemented using INGRES RDBMS, which is based on a client/server architecture. The implemented system allows users to register and retrieve patient information, medical images and diagnostic reports. It also provides the function to display these information on workstation windows simultaneously by using the designed menu-driven graphic user interface. The medical image compression/decompression techniques are implemented and integrated into the medical image database system for the efficient data storage and the fast access through the network. 30594 T00401030594 ^x In this paper, computerized BEAM was implemented for the space domain analysis of EEG. Trans-formation from temporal summation to two-dimensional mappings is formed by 4 nearest point inter-polaton method. Methods of representation of BEAM are two. One is dot density method which classify brain electrical potential 9 levels by dot density of gray levels and the other is colour method which classify brain electrical 12 levels by red-green colours. In this BEAM, instantaneous change and average energy distribution over any arbitrary time interval of brain electrical activity could be observed and analyzed easily. In the frequency domain, the distribution of energy spectrum of a special band can easily be distinguished normality and abnormality. 30608 T00401030608 ^x Laboratory information system (LIS) is a key tool to manage laboratory data in clinical pathology. Our department has developed an information system for routine hematology using down-sized computer system. We have used an IBM 486 compatible PC with 16MB main memory, 210 MB hard disk drive, 9 RS-232C port and 24 pin dot printer. The operating system and database management system were SCO UNIX and SCO foxbase, respectively. For program development, we used Xbase language provided by SCO foxbase. The C language was used for interface purpose. To make the system use friendly, pull-down menu was used. The system connected to our hospital information system via application program interface (API), so the information related to patient and request details is automatically transmitted to our computer. Our system interfaced with fwd complete blood count analyzers(Sysmex NE-8000 and Coulter STKS) for unidirectional data tansmission from analyzer to computer. The authors suggests that this system based on down-sized computer could provide a progressive approach to total LIS based on local area network, and the implemented system could serve as a model for other hospital's LIS for routine hematology. 30609 T00401030609 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength. 30618 T00401030618 ^x This paper is a study on the design of adptive filter for QRS complex detection. We propose a simple adaptive algorithm to increase capability of noise cancelation in QRS complex detection with two stage adaptive filter. At the first stage, background noise is removed and at the next stage, only spectrum of QRS complex components is passed. Two adaptive filters can afford to keep track of the changes of both noise and QRS complex. Each adaptive filter consists of prediction error filter and FIR filter The impulse response of FIR filter uses coefficients of prediction error filter. The detection rates for 105 and 108 of MIT/BIH data base were 99.3% and 97.4% respectively. 30619 T00401030619 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased. 30620 T00401030620 ^x We have developed a monoleaflet polymer valve as an inexpensive and viable alternative, especially for short-term use in the ventricular assist device or total artificial heart. The frame and leaflet of the polymer valve were made from polyurethane, To evaluate the hemodynamic performance of the polymer valve a comparative study of flow dynamics past a polymer valve and a St. Jude Medical prosthetic valve under physiological pulsatile flow conditions in vitro was made. Comparisons between the valves were made on the transvalvular pressure drop, regurgitation volume and maximum valve opening area. The polymer valve showed smaller regurgitation volume and transvalvular pressure drop compared to the mechanical valve at higher heart rate. The results showed that the functional characteristics of the polymer valve compared favorably with those of the mechanical valve at higher heart rate. 30621 T00401030621 ^x Explosive evaporative removal process of biological tissue by absorption of a CW laser has been simulated by using gelatin and a multimode Nd:YAG laser. Because the point of maximun temperature of laser-irradiated gelatin exists below the surface due to surface cooling, evaporation at the boiling temperature is made explosively from below the surface. The important parameters of this process are the conduction loss to laser power absorption (defined as the conduction-to-laser power parameter, Nk), the convection heat transfer at the surface to conduction loss (defined as Bi), dimensionless extinction coefficient (defined as Br.), and dimensionless irradiation time (defined as Fo). Dependence of Fo on Nk and Bi has been observed by experiment, and the results have been compared with the numerical results obtained by solving a 2-dimensional conduction equation. Fo and explosion depth (from the surface to the point of maximun temperature) are increased when Nk and Bi are increased.To find out the minimum laser power for explosive evaporative removal process, steady state analysis has been also made. The limit of Nk to induce evaporative removal, which is proportional to the inverse of the laser power, has been obtained. 30622 T00401030622 ^x N1 and N2 gross neural action potentials were measured from the round window of the guinea pig cochlea at the onset of the acoustic stimuli. N1-N2 audiograms were made by means of regulating stimulant intensities in order to produce constant N1-N2 potentials as criteria for different input tone pip frequencies. The lowest threshold was measured with an input tone pip I5 dB SPL in intensity and 12 KHz in frequency when the animal was in normal physiological condition. The procedure of experimental measurements is explained in detail. This experimental approach is very useful for the investigation of the Cochlear function. Both noN1inear and active functions of the Cochlea can be monitored by N1-N2 audiograms. 30623 T00401030623 ^x In electrical impedance tomography(EIT), we use boundary current and voltage measurements toprovide the information about the cross-sectional distribution of electrical impedance or resistivity. One of the major problems in EIT has been the inaccessibility of internal voltage or current data in finding the internal impedance values. We propose a new image reconstruction method using internal current density data measured by NMR. We obtained a two-dimensional current density distribution within a phantom by processing the real and imaginary MR images from a 4.77 NMR machine. We implemented a resistivity mage reconstruction algorithm using the finite element method and sensitivity matrix. We presented computer simulation results of the mage reconstruction algorithm and furture direction of the research. 30624 T00401030624 ^x A new method of digital image analysis technique for discrimination of cancer cell was presented in this paper. The object image was the Thyroid eland cells image that was diagnosed as normal and abnormal (two types of abnormal: follicular neoplastic cell, and papillary neoplastic cell), respectively. By using the proposed region segmentation algorithm, the cells were segmented into nucleus. The 16 feature parameters were used to calculate the features of each nucleus. A9 a consequence of using dominant feature parameters method proposed in this paper, discrimination rate of 91.11% was obtained for Thyroid Gland cells. 30625 T00401030625 ^x An electrical stimulator was designed to induce locomotion for paraplegic patients caused by central nervous system injury. Optimal stimulus parameters, which can minimize muscle fatigue and can achieve effective muscle contraction were determined in slow and fast muscles in Sprague-Dawley rats. Stimulus patterns of our stimulator were designed to simulate electromyographic activity monitored during locomotion of normal subjects. Muscle types of the lower extremity were classified according to their mechanical property of contraction, which are slow muscle (msoleus m.) and fast muscle (medial gastrocneminus m., rectus femoris m., vastus lateralis m.). Optimal parameters of electrical stimulation for slow muscles were 20 Hz, 0.2 ms square pulse. For fast muscle, 40 Hz, 0.3 ms square pulse was optimal to produce repeated contraction. Higher stimulus intensity was required when synergistic muscles were stimulated simultaneously than when they were stimulated individually. Electrical stimulation for each muscle was designed to generate bipedal locomotion, so that individual muscles alternate contraction and relaxation to simulate stance and swing phases. Portable electrical stimulator with 16 channels built in microprocessor was constructed and applied to paraplegic patients due to lumbar cord injury. The electrical stimulator restored partially gait function in paraplegic patients. 30626 T00401030626 ^x Two-Dimensional modelling of the Cochlear biomechanics is presented in this paper. The Laplace partial differential equation which represents the fluid mechanics of the Cochlea has been transformed into two-dimensional electrical transmission line. The procedure of this transformation is explained in detail. The comparison between one and two dimensional models is also presented. This electrical modelling of the basilar membrane (BM) is clearly useful for the next approach to the further. Development of active elements which are essential in the producing of the sharp tuning of the BM. This paper shows that two-dimension model is qualitatively better than one-dimensional model both in amplitude and phase responses of the BM displacement. The present model is only for frequency response. However because the model is electrical, the two-dimensional transmission line model can be extended to time response without any difficult. 30627 T00401030627 ^x A method has been proposed for the fully automatic detection of left ventricular endocardial boundary in 2D short axis echocardiogram using geometric model. The procedure has the following three distinct stages. First, the initial center is estimated by the initial center estimation algorithm which is applied to decimated image. Second, the center estimation algorithm is applied to original image and then best-fit elliptic model estimation is processed. Third, best-fit boundary is detected by the cost function which is based on the best-fit elliptic model. The proposed method shows effective result without manual intervention by a human operator. 30628 T00401030628 ^x The intelligent trajectory control method that controls moving direction and average velocity for a prosthetic arm is proposed by pattern recognition and force estimations using EMG signals. Also, we propose the real time trajectory planning method which generates continuous accelleration paths using 3 stage linear filters to minimize the impact to human body induced by arm motions and to reduce the muscle fatigue. We use combination of MLP and fuzzy filter for pattern recognition to estimate the direction of a muscle and Hogan's method for the force estimation. EMG signals are acquired by using a amputation simulator and 2 dimensional joystick motion. The simulation results of proposed prosthetic arm control system using the EMf signals show that the arm is effectively followed the desired trajectory depended on estimated force and direction of muscle movements. 30638 T00401030638 ^x A new neural network architecture for the recognition of patterns from images is proposed, which is partially based on the results of physiological studies. The proposed network is composed of multi-layers and the nerve cells in each layer are connected by spatial filters which approximate receptive fields in optic nerve fields. In the proposed method, patterns recognition for complicated images is carried out using global features as well as local features such as lines and end-points. A new generating method of matched filers representing global features is proposed in this network. 30659 T00401030659 ^x An implementation scheme of the magnetic nerve stimulator using a switching mode power supply is proposed. By using a switching mode power supply rather than a conventional linear power supply for charging high voltage capacitors, the weight and size of the magnetic nerve stimulator can be considerably reduced. Maximum output voltage of the developed magnetic nerve stimulator using the switching mode power supply is 3, 000 volts and switching time is about 100 msec. Experimental results or human nerve stimulations using the developed stimulator are presented. 30768 T00401030768 ^x In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.SpO2 with Plethysmograph.

• 한국우주과학회:학술대회논문집(한국우주과학회보)
• /
• 한국우주과학회 1993년도 한국우주과학회보 제2권2호
• /
• pp.17-17
• /
• 1993

The wall shear stress in the vicinity of end-to end anastomoses under steady flow conditions was measured using a flush-mounted hot-film anemometer(FMHFA) probe. The experimental measurements were in good agreement with numerical results except in flow with low Reynolds numbers. The wall shear stress increased proximal to the anastomosis in flow from the Penrose tubing (simulating an artery) to the PTFE: graft. In flow from the PTFE graft to the Penrose tubing, low wall shear stress was observed distal to the anastomosis. Abnormal distributions of wall shear stress in the vicinity of the anastomosis, resulting from the compliance mismatch between the graft and the host artery, might be an important factor of ANFH formation and the graft failure. The present study suggests a correlation between regions of the low wall shear stress and the development of anastomotic neointimal fibrous hyperplasia(ANPH) in end-to-end anastomoses. 30523 T00401030523 ^x Air pressure decay(APD) rate and ultrafiltration rate(UFR) tests were performed on new and saline rinsed dialyzers as well as those roused in patients several times. C-DAK 4000 (Cordis Dow) and CF IS-11 (Baxter Travenol) reused dialyzers obtained from the dialysis clinic were used in the present study. The new dialyzers exhibited a relatively flat APD, whereas saline rinsed and reused dialyzers showed considerable amount of decay. C-DAH dialyzers had a larger APD(11.70${\pm}$1.32mmHg/min)compared to CF dialyzers(4.32${\pm}$0.55mmHg/min)(p<0.05). However, there was no observable difference in the UFR between the two dialyzers. Neither APD nor UFR showed any significant increase with an increasing number of reuses for up to more than 20reuses. A substantial number of failures observed in APD(larger than 20mmHe/min)on the reused dialyzers(2 out of 40 CP and S out 26 C-DAK) were attributed to the Possible damage on the fibers. The CF 15-11 HFDs which failed APD test did not show changes in the UFR compared to normal dialyzers indicating that APD is a more sensitive test than UFR test to evaluate the integrity of the fibers. 30527 T00401030527 ^x For quantitative measurement of reflected light from a clinical diagnostic strip, a prototype old reflectance photometer was designed. The strip loader and cassette were made to obtain more accurate reflectance parameters. The strip was illuminated at 45˚c through optical fiber and the intensity of reflected light was determined at rectanguLat angle using a photodiode. The kubelka-munk coefficient and reflection optical density were determined ar four different wavelengths(500,550,570 and 610nm) for blood glucose strip. For higher concentration than 300mg/41 about glucose, a saturation state of abforbance was observed at 500,550 and 570nm. The correlation between glucose concentration and parameters was the best at 610nm. 30535 T00401030535 ^x Radiation-induced fibrosarcoma tumors were grown on the flanks of C3H mice. The mice were divided into two groups. One group was injected with Photofrin II, intravenously (2.5mg/kg body weight). The other group received no Photofrin II. Mice from both groups were irradialed for approximately 15 minutes at 100,300, or 500 mW/cm2 with the argon (488nm/514.5 nm), dye(628nm) and gold vapor (pulsed 628 nm) laser light. A photosensitizer behaved as an added absorber. Under our experimental conditions, the presence of Photolfrin II increased surface temperature by at least 40% and the temperature rise due to 300 mW/cm2 irradiation exceeded values for hyperthermia. Light and temperature distributions with depth were estimated by a computer model. The model demonstrated the influence of wavelength on the thermal process and proved to be a valuable tool to investigate internal temperature rise. 30536 T00401030536 ^x We investigated the structural geometry of thirty-eight Korean femurs. The purpose of this study is to identify major geometrical differences between Korean femurs 3nd others that we believe belong to Caucasians so that we would be able to get insights into the femoral component design that fits Asians including Koreans. We utilized computerized tomography (CT) images of femurs extracted from cadavers. The CT images were transformed into bitmap data by using a film scanner, and then analyzed by using a commercially available software called Image v.1.0 and a Macintosh IIci computer.The resulting data were compared with already published data. The major results show that the geometry of the Korean femurs is significantly different from that of Caucasians: (1) the anteversion angle and the canal flare index are greater by the amount of approximately 8˚ and 0.5, respectively, (2) the shape of the isthmus cross section is more round, and (3) the distance between the teaser trochanter and the proximal border of the isthmus is shelter by about 15 mm. The results suggested that the femoral component suitable for Asians should be different from the currently-used components designed and manufactured mostly by European or American companies. 30537 T00401030537 ^x It is well known that nonlinear propagation characteristics of the wave in the tissue may give very useful information for the medical diagnoisis. In this paper, a new method to detect nonlinear propagation characteristics of the internal vibration in the tissue for the low frequency mechanical vibration by using bispectral analysis is proposed. In the method, low frequency vibration of f0( = 100Hz) is applied on the surface of the object, and the waveform of the internal vibration x (t) is measured from Doppler frequency modulation of silmultaneously transmitted probing ultrasonic waves. Then, the bispectra of the signal x (t) at the frequencies (f0, f0) and (f0, 2f0) are calculated to estimate the nonlinear propagation characteristics as their magnitude ratio, w here since bispectrum is free from the gaussian additive noise we can get the value with high S/N. Basic experimental system is constructed by using 3.0 MHz probing ultrasonic waves and the several experiments are carried out for some phantoms. Results show the superiority of the proposed method to the conventional method using power spectrum and also its usefulness for the tissue characterization. 30541 T00401030541 ^x This paper describes the implementation of a computerized radial pulse diagnosis by aids of a clinical expert. On this base, we composed of the radial pulse diagnosis system in korean traditional medicine. The system composed of a radial pulse wave detection system and a radial pulse diagnosis system. With a detection system, we detected Inyoung and Cheongu radial pulse wave and processed it. Then, we have got the characteristic parameters of radial pulse wave and also quantified that according to the method of Inyoung-Cheongu Comparison Radial Pulse Diagnosis. We defined the jugement standard of radial pulse diagnosis system and then we confirmed the possibility for realization of automatic radial pulse diagnosis in korean traditional medicine. 30545 T00401030545 ^x Microspheres are expected to be applied to biomedical areas such as solid-phase immunoassays, drug delivery systems, immunomagnetic cell separation. To synthesize microspheres for biomedical application, "two stage shot growth method" was developed. The uniformity ratio of synthesized microspheres was always smaller than 1.05. And the surface charge density (or the number of ionizable functional groups) of the microspheres synthesized by "two stage shot growth method" was 6~13 times higher than that of the microspheres synthesized by conventional seeded batch copolymerization. As a previous step for biomedical application, adsorption experiments of bovine albumin on microspheres were carried out under various conditions. The maximum adsorbed amount was obtained in the neighborhood of pH 4.5. Isoelectric point of bovine albumin is pH 5.0, so experimental result shows that it shifted to acid area. The adsorption isotherm was obtained, the plateau region was always reached at 2.Og/L (bulk concentration of bovine albumin).The effect of the kind and the amount of surface functional group was also examined. 30575 T00401030575 ^x A medical image workstation was developed using multimedia technique. The system based on PC-486DX was designed to acquire medical images produced by medical imaging instruments and related audio information, that is, doctors' reporting results. Input information was processed and analyzed, then the results were presented in the form of graph and animation. All the informations of the system were hierarchically related with the image as the apex. Processing and analysis algorithms were implemented so that the diagnostic accuracy could be improved. The diagnosed information can be transferred for patient diagnosis through LAN(local area network). 30592 T00401030592 ^x In the conventional infrared imaging system, complex infrared lens systems are usually used for directing collimated narrow infrared beams into the high speed 2-dimensional optic scanner. In this paper, a simple reflective infrared optic system with a 2-dimensional optic scanner is proposed for the realization of medical infrared thermography system. It has been experimentally proven that the intfrared thermography system composed of the proposed optic system has the temperature resolution of 0.1˚c under the spatial resolution of lmrad, the image matrix size of 256 X 240, and tile imaging time of 4 seconds. 30593 T00401030593 ^x In this paper, MIIS (Medical Image Information System) has been designed and implemented using INGRES RDBMS, which is based on a client/server architecture. The implemented system allows users to register and retrieve patient information, medical images and diagnostic reports. It also provides the function to display these information on workstation windows simultaneously by using the designed menu-driven graphic user interface. The medical image compression/decompression techniques are implemented and integrated into the medical image database system for the efficient data storage and the fast access through the network. 30594 T00401030594 ^x In this paper, computerized BEAM was implemented for the space domain analysis of EEG. Trans-formation from temporal summation to two-dimensional mappings is formed by 4 nearest point inter-polaton method. Methods of representation of BEAM are two. One is dot density method which classify brain electrical potential 9 levels by dot density of gray levels and the other is colour method which classify brain electrical 12 levels by red-green colours. In this BEAM, instantaneous change and average energy distribution over any arbitrary time interval of brain electrical activity could be observed and analyzed easily. In the frequency domain, the distribution of energy spectrum of a special band can easily be distinguished normality and abnormality. 30608 T00401030608 ^x Laboratory information system (LIS) is a key tool to manage laboratory data in clinical pathology. Our department has developed an information system for routine hematology using down-sized computer system. We have used an IBM 486 compatible PC with 16MB main memory, 210 MB hard disk drive, 9 RS-232C port and 24 pin dot printer. The operating system and database management system were SCO UNIX and SCO foxbase, respectively. For program development, we used Xbase language provided by SCO foxbase. The C language was used for interface purpose. To make the system use friendly, pull-down menu was used. The system connected to our hospital information system via application program interface (API), so the information related to patient and request details is automatically transmitted to our computer. Our system interfaced with fwd complete blood count analyzers(Sysmex NE-8000 and Coulter STKS) for unidirectional data tansmission from analyzer to computer. The authors suggests that this system based on down-sized computer could provide a progressive approach to total LIS based on local area network, and the implemented system could serve as a model for other hospital's LIS for routine hematology. 30609 T00401030609 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed a composite that is consisted of calcium phosphate and collagen. To use as the structural matrix of the composite, collagen was purified from human umbilical cord. The obtained collagen was treated by pepsin to remove telopeptides, and finally, the immune-free atelocollagen was produced: The cross linked atelocollagen was highly resistant to the collagenase induced collagenolysis. The cross linked collagen demonstrated an improved tensile strength. 30618 T00401030618 ^x This paper is a study on the design of adptive filter for QRS complex detection. We propose a simple adaptive algorithm to increase capability of noise cancelation in QRS complex detection with two stage adaptive filter. At the first stage, background noise is removed and at the next stage, only spectrum of QRS complex components is passed. Two adaptive filters can afford to keep track of the changes of both noise and QRS complex. Each adaptive filter consists of prediction error filter and FIR filter The impulse response of FIR filter uses coefficients of prediction error filter. The detection rates for 105 and 108 of MIT/BIH data base were 99.3% and 97.4% respectively. 30619 T00401030619 ^x To develop an artificial bone substitute that is gradually degraded and replaced by the regenerated natural bone, the authors designed and produced a composite that is consisted of calcium phosphate and collagen. Human umbilical cord origin pepsin treated type I atelocollagen was used as the structural matrix, by which sintered or non-sintered carbonate apatite was encapsulated to form an inorganic-organic composite. With cross linking atelocollagen by UV ray irradiation, the resistance to both compressive and tensile strength was increased. Collagen degradation by the collagenase induced collagenolysis was also decreased. 30620 T00401030620 ^x We have developed a monoleaflet polymer valve as an inexpensive and viable alternative, especially for short-term use in the ventricular assist device or total artificial heart. The frame and leaflet of the polymer valve were made from polyurethane, To evaluate the hemodynamic performance of the polymer valve a comparative study of flow dynamics past a polymer valve and a St. Jude Medical prosthetic valve under physiological pulsatile flow conditions in vitro was made. Comparisons between the valves were made on the transvalvular pressure drop, regurgitation volume and maximum valve opening area. The polymer valve showed smaller regurgitation volume and transvalvular pressure drop compared to the mechanical valve at higher heart rate. The results showed that the functional characteristics of the polymer valve compared favorably with those of the mechanical valve at higher heart rate. 30621 T00401030621 ^x Explosive evaporative removal process of biological tissue by absorption of a CW laser has been simulated by using gelatin and a multimode Nd:YAG laser. Because the point of maximun temperature of laser-irradiated gelatin exists below the surface due to surface cooling, evaporation at the boiling temperature is made explosively from below the surface. The important parameters of this process are the conduction loss to laser power absorption (defined as the conduction-to-laser power parameter, Nk), the convection heat transfer at the surface to conduction loss (defined as Bi), dimensionless extinction coefficient (defined as Br.), and dimensionless irradiation time (defined as Fo). Dependence of Fo on Nk and Bi has been observed by experiment, and the results have been compared with the numerical results obtained by solving a 2-dimensional conduction equation. Fo and explosion depth (from the surface to the point of maximun temperature) are increased when Nk and Bi are increased.To find out the minimum laser power for explosive evaporative removal process, steady state analysis has been also made. The limit of Nk to induce evaporative removal, which is proportional to the inverse of the laser power, has been obtained. 30622 T00401030622 ^x N1 and N2 gross neural action potentials were measured from the round window of the guinea pig cochlea at the onset of the acoustic stimuli. N1-N2 audiograms were made by means of regulating stimulant intensities in order to produce constant N1-N2 potentials as criteria for different input tone pip frequencies. The lowest threshold was measured with an input tone pip I5 dB SPL in intensity and 12 KHz in frequency when the animal was in normal physiological condition. The procedure of experimental measurements is explained in detail. This experimental approach is very useful for the investigation of the Cochlear function. Both noN1inear and active functions of the Cochlea can be monitored by N1-N2 audiograms. 30623 T00401030623 ^x In electrical impedance tomography(EIT), we use boundary current and voltage measurements toprovide the information about the cross-sectional distribution of electrical impedance or resistivity. One of the major problems in EIT has been the inaccessibility of internal voltage or current data in finding the internal impedance values. We propose a new image reconstruction method using internal current density data measured by NMR. We obtained a two-dimensional current density distribution within a phantom by processing the real and imaginary MR images from a 4.77 NMR machine. We implemented a resistivity mage reconstruction algorithm using the finite element method and sensitivity matrix. We presented computer simulation results of the mage reconstruction algorithm and furture direction of the research. 30624 T00401030624 ^x A new method of digital image analysis technique for discrimination of cancer cell was presented in this paper. The object image was the Thyroid eland cells image that was diagnosed as normal and abnormal (two types of abnormal: follicular neoplastic cell, and papillary neoplastic cell), respectively. By using the proposed region segmentation algorithm, the cells were segmented into nucleus. The 16 feature parameters were used to calculate the features of each nucleus. A9 a consequence of using dominant feature parameters method proposed in this paper, discrimination rate of 91.11% was obtained for Thyroid Gland cells. 30625 T00401030625 ^x An electrical stimulator was designed to induce locomotion for paraplegic patients caused by central nervous system injury. Optimal stimulus parameters, which can minimize muscle fatigue and can achieve effective muscle contraction were determined in slow and fast muscles in Sprague-Dawley rats. Stimulus patterns of our stimulator were designed to simulate electromyographic activity monitored during locomotion of normal subjects. Muscle types of the lower extremity were classified according to their mechanical property of contraction, which are slow muscle (msoleus m.) and fast muscle (medial gastrocneminus m., rectus femoris m., vastus lateralis m.). Optimal parameters of electrical stimulation for slow muscles were 20 Hz, 0.2 ms square pulse. For fast muscle, 40 Hz, 0.3 ms square pulse was optimal to produce repeated contraction. Higher stimulus intensity was required when synergistic muscles were stimulated simultaneously than when they were stimulated individually. Electrical stimulation for each muscle was designed to generate bipedal locomotion, so that individual muscles alternate contraction and relaxation to simulate stance and swing phases. Portable electrical stimulator with 16 channels built in microprocessor was constructed and applied to paraplegic patients due to lumbar cord injury. The electrical stimulator restored partially gait function in paraplegic patients. 30626 T00401030626 ^x Two-Dimensional modelling of the Cochlear biomechanics is presented in this paper. The Laplace partial differential equation which represents the fluid mechanics of the Cochlea has been transformed into two-dimensional electrical transmission line. The procedure of this transformation is explained in detail. The comparison between one and two dimensional models is also presented. This electrical modelling of the basilar membrane (BM) is clearly useful for the next approach to the further. Development of active elements which are essential in the producing of the sharp tuning of the BM. This paper shows that two-dimension model is qualitatively better than one-dimensional model both in amplitude and phase responses of the BM displacement. The present model is only for frequency response. However because the model is electrical, the two-dimensional transmission line model can be extended to time response without any difficult. 30627 T00401030627 ^x A method has been proposed for the fully automatic detection of left ventricular endocardial boundary in 2D short axis echocardiogram using geometric model. The procedure has the following three distinct stages. First, the initial center is estimated by the initial center estimation algorithm which is applied to decimated image. Second, the center estimation algorithm is applied to original image and then best-fit elliptic model estimation is processed. Third, best-fit boundary is detected by the cost function which is based on the best-fit elliptic model. The proposed method shows effective result without manual intervention by a human operator. 30628 T00401030628 ^x The intelligent trajectory control method that controls moving direction and average velocity for a prosthetic arm is proposed by pattern recognition and force estimations using EMG signals. Also, we propose the real time trajectory planning method which generates continuous accelleration paths using 3 stage linear filters to minimize the impact to human body induced by arm motions and to reduce the muscle fatigue. We use combination of MLP and fuzzy filter for pattern recognition to estimate the direction of a muscle and Hogan's method for the force estimation. EMG signals are acquired by using a amputation simulator and 2 dimensional joystick motion. The simulation results of proposed prosthetic arm control system using the EMf signals show that the arm is effectively followed the desired trajectory depended on estimated force and direction of muscle movements. 30638 T00401030638 ^x A new neural network architecture for the recognition of patterns from images is proposed, which is partially based on the results of physiological studies. The proposed network is composed of multi-layers and the nerve cells in each layer are connected by spatial filters which approximate receptive fields in optic nerve fields. In the proposed method, patterns recognition for complicated images is carried out using global features as well as local features such as lines and end-points. A new generating method of matched filers representing global features is proposed in this network. 30659 T00401030659 ^x An implementation scheme of the magnetic nerve stimulator using a switching mode power supply is proposed. By using a switching mode power supply rather than a conventional linear power supply for charging high voltage capacitors, the weight and size of the magnetic nerve stimulator can be considerably reduced. Maximum output voltage of the developed magnetic nerve stimulator using the switching mode power supply is 3,000 volts and switching time is about 100 msec. Experimental results or human nerve stimulations using the developed stimulator are presented. 30768 T00401030768 ^x In this paper, we describe the design methodology and specifications of the developed module-based bedside monitors for patient monitoring. The bedside monitor consists of a main unit and module cases with various parameter modules. The main unit includes a 12.1" TFT color LCD, a main CPU board, and peripherals such as a module controller, Ethernet LAN card, video card, rotate/push button controller, etc. The main unit can connect at maximum three module cases each of which can accommodate up to 7 parameter modules. They include the modules for electrocardiograph, respiration, invasive blood pressure, noninvasive blood pressure, temperature, and SpO2 with Plethysmograph.