• Journal of the Korea Safety Management & Science
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• v.12 no.3
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• pp.37-52
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• 2010

This study is aimed at proposing the national policy for medical device control system in Korea as deeply analysed the present status of the system. On 1979, Korean government had started to inspect 24 kinds of the medical devices such as X-ray diagnostic equipments, medical sterilizer and etc. mostly imported from advanced countries which USA, Germany and Japan for the first time according to the Pharmaceutical Affairs Law. However medical devices were becoming consideration as an important partner of diagnosis, curing and alleviation of diseases by medical doctors and also much important keeping the health at home. Furthermore medical devices industry can be designated as a national growth engine industry. So it is necessary not only to harmonize to international standards but also the harmonization of the system including pre-market application and post-market surveillance, is strongly needed by the Korea Food and Drugs Administration(KFDA).

• Journal of The Korean Astronomical Society
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• v.36 no.3
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• pp.105-110
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• 2003

Recent observations of galaxy clusters in radio and X-ray indicate that cosmic rays and magnetic fields may be energetically important in the intracluster medium. According to the estimates based on theses observational studies, the combined pressure of these two components of the intracluster medium may range between $10\%{\~}100\%$ of gas pressure, although their total energy is probably time dependent. Hence, these non-thermal components may have influenced the formation and evolution of cosmic structures, and may provide unique and vital diagnostic information through various radiations emitted via their interactions with surrounding matter and cosmic background photons. We suggest that shock waves associated with cosmic structures, along with individual sources such as active galactic nuclei and radio galaxies, supply the cosmic rays and magnetic fields to the intracluster medium and to surrounding large scale structures. In order to study 1) the properties of cosmic shock waves emerging during the large scale structure formation of the universe, and 2) the dynamical influence of cosmic rays, which were ejected by AGN-like sources into the intracluster medium, on structure formation, we have performed two sets of N-body /hydrodynamic simulations of cosmic structure formation. In this contribution, we report the preliminary results of these simulations.

• The Bulletin of The Korean Astronomical Society
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• v.37 no.2
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• pp.70.1-70.1
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• 2012

We investigate 53 late-type galaxies in Virgo to get better understanding galaxy evolution driven by environmental effects in the cluster. The goal is to study how galaxies are strongly affected gravitationally by their surroundings and/or how interstellar medium (ISM) of galaxies changes through the interaction with intracluster medium (ICM). To quantify these, a variety of diagnostic methods have been introduced. Our diagnostics have two different perspectives. First, we have carefully examined the morphological and kinematical properties of individual galaxies using high resolution HI images and compared with multi-wavelength data. Based on the visual inspection, we have identified signatures of the interactions with other galaxies or the ICM. Second, we have quantified influence of local environments of individual galaxies using X-ray data and optical catalog of the cluster. By combining all the diagnostics, we have identified the environmental effect(s) at work on individual galaxies. We also probe the environmental processes as a function of the cluster centric distance. Various gravitational interactions are found throughout the cluster, while the ICM-ISM interaction is mainly dominant near the cluster center. However, we find some evidence that galaxies start losing their gas already in the low density outskirts of the cluster.

• Journal of Oral Medicine and Pain
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• v.25 no.2
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• pp.241-245
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• 2000

In this case report, I discussed the diagnosis and treatment of two pregnant women with temporomandibular disorders(TMD) who visited the Department of Oral Medicine, PNUH. Also, I reviewed some investigations of diagnosis and treatment of TMD in pregnant women. The obtained results were as follows; 1. No single X-ray diagnostic procedure for TMD results in radiation dose that threatens the well-being of the developing embryo and fetus. 2. Most non-steroidal anti-inflammatory drugs(NSAIDs) have commonly used because these drugs are considered to be nonteratogenic, but these agents are not recommended for routine use after 3rd trimester. 3. Electro-acupuncture stimulation therapy(EAST) is contraindicated for 1st trimester, and ultrasonic deep heat therapy, microwave deep heat therapy, low level laser therapy, myo-monitor are not contraindicated for pregnant women but clinician must consider some risk of adverse fetal effects. 4. The occlusal stabilization splint may be used for pregnant women, if it is fabricated indirectly. 5. Surgical treatment is contraindicated for pregnant women.

• Proceedings of the ESK Conference
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• 1996.10a
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• pp.21-25
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• 1996

The Electomyographic (EMG) signals of flexor-extensor muscle pairs were investigated to identify the neural excitation pattern of low-back pain (LBP) patients during a repetitive bending motion. New parameters and EMG normalization technique were developed to quantitatively represent the difference of temporal EMG patterns between ten healthy subjects and ten LBP patients. Flexor-extensor muscle pairs such as rectus abdominis(RA)-erector spinae (ES at LS), external oblique(EO)-internal oblique(IO), rectus femois (quadriceps: QUD)-biceps femoris(hamstrings:HAM), and tibialis anterior(TA)-gastrocnemius(GAS) pairs of muscles were selected in this study. Results indicated that the temporal EMG pattern such as the peak timing difference of QUD-HAM muscle pair and the duration of coexcitation of ES-RA muscle pair showed a statistically isgnificant difference between healthy subjects and LBP patients. These results indicated that the new technique and parameters could be used as a diagnostic tool especially for LBP patients with soft tissue injuries that are rarely dentified by traditional imaging techniques such as X-ray, CT scan or MRI. Improtantly, the new EMG technique did not require the maximal volutary contraction(MVC) measure for normalization that helped patients minimize the pain experience during and after the session. Further study needs to be made to validate and refine this method for clinical application.

• Journal of Veterinary Clinics
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• v.40 no.2
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• pp.164-174
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• 2023

Canine splenic tumors (STs) are commonly diagnosed during imaging examinations, such as in X-ray and ultrasonography examinations, suggesting their higher prevalence, especially in older dogs. Despite this high prevalence, there are no effective treatment options for STs because of the difficulties in determining therapeutic targets. However, recently, the importance of microRNAs (miRNAs) has evolved owing to their ambivalent characteristics. Biomarkers and novel therapies using miRNAs have been well-studied in human cancer research compared to canine research, except for mammary gland tumors. Therefore, this study aimed to comparatively analyze miRNA expression profiles according to malignancy and biopsy sites to identify novel therapeutic and diagnostic targets. Tissue samples were collected directly from splenic tumor masses and immersed in RNAlater solution for further analysis. To investigate differentially expressed genes (DEGs) between tumor and normal tissues, we used RNA-seq and miRNA microarray analysis. Then, functional analysis based on DEGs was conducted to sort tumor-related DEGs. We found that cfa-miR-150 was upregulated in benign tumors, whereas cfa-miR-134 was upregulated in malignant tumors. Despite limited information on canine miRNAs, we identified two potential biomarkers for the differential diagnosis of STs.

• Imaging Science in Dentistry
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• v.53 no.3
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• pp.257-263
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• 2023

Fibrodysplasia ossificans progressiva is a rare hereditary disorder characterized by progressive heterotopic ossification in muscle and connective tissue, with few reported cases affecting the head and neck region. Although plain radiographic findings and computed tomography features have been well documented, limited reports exist on magnetic resonance findings. This report presents 2 cases of fibrodysplasia ossificans progressiva, one with limited mouth opening due to heterotopic ossification of the lateral pterygoid muscle and the other with restricted neck movement due to heterotopic ossification of the platysma muscle. Clinical findings of restricted mouth opening or limited neck movement, along with radiological findings of associated heterotopic ossification, should prompt consideration of fibrodysplasia ossificans progressiva in the differential diagnosis. Dentists should be particularly vigilant with patients diagnosed with fibrodysplasia ossificans progressiva to avoid exposure to diagnostic biopsy and invasive dental procedures.

• Applied Microscopy
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• v.50
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• pp.25.1-25.11
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• 2020

Scanning acoustic microscopy (SAM) or Acoustic Micro Imaging (AMI) is a powerful, non-destructive technique that can detect hidden defects in elastic and biological samples as well as non-transparent hard materials. By monitoring the internal features of a sample in three-dimensional integration, this technique can efficiently find physical defects such as cracks, voids, and delamination with high sensitivity. In recent years, advanced techniques such as ultrasound impedance microscopy, ultrasound speed microscopy, and scanning acoustic gigahertz microscopy have been developed for applications in industries and in the medical field to provide additional information on the internal stress, viscoelastic, and anisotropic, or nonlinear properties. X-ray, magnetic resonance, and infrared techniques are the other competitive and widely used methods. However, they have their own advantages and limitations owing to their inherent properties such as different light sources and sensors. This paper provides an overview of the principle of SAM and presents a few results to demonstrate the applications of modern acoustic imaging technology. A variety of inspection modes, such as vertical, horizontal, and diagonal cross-sections have been presented by employing the focus pathway and image reconstruction algorithm. Images have been reconstructed from the reflected echoes resulting from the change in the acoustic impedance at the interface of the material layers or defects. The results described in this paper indicate that the novel acoustic technology can expand the scope of SAM as a versatile diagnostic tool requiring less time and having a high efficiency.

• Physical Therapy Rehabilitation Science
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• v.12 no.1
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• pp.19-25
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• 2023

Objective: Patients with scoliosis complain of various symptoms such as muscle imbalance, dysfunction, back pain, abnormal posture and gait abnormality. The most basic treatment for scoliosis is to observe the progress based on conservative treatment. Therefore, in this case report, the effect of cytoskeletal manual therapy (CMT), a soft tissue mobilization technique, on pain intensity, muscle thickness, and pressure pain threshold (PPT) in a patient with scoliosis was investigated. Design: A case report Methods: A 25-year-old male diagnosed with scoliosis visited the Neuromusculoskeletal Science Laboratory with chronic back pain. In the laboratory, scoliosis was confirmed through the X-ray image used for his diagnosis, and it was confirmed again through Adam's forward bending test. Pain, pressure pain threshold and muscle thickness were measured to compare the immediate effects of CMT applied in the laboratory for 40 minutes. Treatments were visited two weeks after the first visit and outcome measures were assessed after a total of two visits. Results: After receiving CMT up to the second session, the pain intensity decreased by 4 points and the screening angle decreased by 15 degrees. Muscle thickness decreased in all but 10 mm on the dominant side of the thoracic spine. All of the PPTs increased, and the greatest increase was 3.1 lb on the dominant side of the thoracic spine. Conclusions: CMT showed positive improvement in pain during trunk flexion, spinal curvature, muscle imbalance, and pressure pain, which is considered as an ancillary treatment option for scoliosis management.

• Imaging Science in Dentistry
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• v.53 no.2
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• pp.161-168
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• 2023

Nasopalatine duct cysts (NPDCs), the most common non-odontogenic cysts of maxilla, are often incidental findings on diagnostic imaging. When symptomatic, they usually present as a painless swelling with possible fistula. Conventional radiography shows a round-to-ovoid or heart-shaped radiolucency between the roots of central maxillary incisors. While the radiographic features of NPDCs in X-ray-based modalities have been well described, their magnetic resonance imaging (MRI) features have rarely been reported. Developments in dental MRI in recent years and the introduction of various dental MRI protocols now allow a wide range of applications in dental medicine. MRI is becoming an important tool for the detection and diagnosis of incidental or non-incidental dentomaxillofacial cysts. This report presented and discussed the characteristics of 2 NPDC cases visualized on MRI using both conventional and newly implemented specific dental MRI protocols with a novel 15-channel mandibular coil, demonstrating the use of these protocols for radiation-free maxillofacial diagnoses.