• The Transactions of the Korean Institute of Electrical Engineers C
• /
• v.52 no.1
• /
• pp.42-46
• /
• 2003

Arresters are deteriorated by overvoltages or impulse currents, and the resistive leakage current of arresters increases as the deterioration of the arrester progresses, showing an increase in the 3$^{rd}$ harmonic component of the leakage current. In this reason, arrester diagnostic techniques based on the 3$^{rd}$ harmonic leakage current as a reference parameter of deterioration are widely used. The technique, however, includes an error due to the harmonics of power system voltage. Therefore, the influence of the harmonics on arrester diagnostics should be considered. In this paper, we designed a PSpice ZnO arrester model to simulate the influence of the voltage harmonics described above. A pure sinusoidal voltage and its the 3r harmonic voltage were applied to the model, and the leakage current components were analyzed. From the simulation results, it is confirmed that the peak value of resistive leakage current depends not only on the phase of the 3$^{rd}$ harmonic voltage but also on the magnitude of it. Consequently, the errors caused 1)y the harmonic voltage could be minimized by correcting the magnitude of leakage current upon analyzing the harmonics.cs.

• Mass Spectrometry Letters
• /
• v.15 no.2
• /
• pp.69 -78
• /
• 2024

The advancement of high-throughput omics technologies and systems biology is essential for understanding complex biological mechanisms and diseases. The integration of proteomics and metabolomics provides comprehensive insights into cellular functions and disease pathology, driven by developments in mass spectrometry (MS) technologies, including electrospray ionization (ESI). These advancements are crucial for interpreting biological systems effectively. However, integrating these technologies poses challenges. Compared to genomic, proteomics and metabolomics have limitations in throughput, and data integration. This review examines developments in MS equipped electrospray ionization (ESI), and their importance in the effective interpretation of biological mechanisms. The review also discusses developments in sample preparation, such as Simultaneous Metabolite, Protein, Lipid Extraction (SIMPLEX), analytical techniques, and data analysis, highlighting the application of these technologies in the study of cancer or Huntington's disease, underscoring the potential for personalized medicine and diagnostic accuracy. Efforts by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) and integrative data analysis methods such as O2PLS and OnPLS extract statistical similarities between metabolomic and proteomic data. System modeling techniques that mathematically explain and predict system responses are also covered. This practical application also shows significant improvements in cancer research, diagnostic accuracy and therapeutic targeting for diseases like pancreatic ductal adenocarcinoma, non-small cell lung cancer, and Huntington's disease. These approaches enable researchers to develop standardized protocols, and interoperable software and databases, expanding multi-omics research application in clinical practice.

• Journal of Yeungnam Medical Science
• /
• v.4 no.1
• /
• pp.1-15
• /
• 1987

Magnetic Resonance (M.R.) is rapidly emerging technique that provides high quality images and potentially provides much more diagnostic information than do conventional imaging modalities. M.R.I. is conceptually quite different from currently used imaging methods. The complex nature of M.R.I. allows a great deal of flexibility in image product ion and available information, and key points are as follows. 1. M.R.I. offers a non-invasive technique with which to gene rate in vivo human images without ionizing radiation and with no known adverse biological effects. 2. Imaging mechanism of M.R.I. is quite different from conventional imaging modality and for more accurate diagnostic application, It is necessary for physician to understand imaging mechanism of M.R.I. 3. M.R. makes available basic chemical parameters that may provide to be useful for diagnostic medical imaging and more specific pathophysiologic information which are not available by alternate techniques. 4. M.R. can be produced by number of different methods. This flexibility allows the imaging technique to be applicated for particular clinical purpose. Multiplanar and three dimensional imaging may extend the imaging process beyond the single section available with current CT. 5. Future directions include efforts to; a. Further development of hard ware b. More fasternning scan time c. Respiratory and cardiac gated imaging d. Imaging of additional nuclei except hydrogen e. Further development of contrast media f. M.R. in vivo spectroscopy g. Real time M.R. imaging.

• Proceedings of the KSME Conference
• /
• 2007.05b
• /
• pp.2781-2784
• /
• 2007

Early detection of a disease is important to tackle treatment issues in a better manner. Several diagnostic techniques are in use, these days; for such purpose and tremendous research is going on to develop newer and newer methods. However, more work is required to be done to develop cheap and reliable early detection techniques. Micro-fluidic chips are also playing key role to deliver new devices for better health care. The present study focuses on a review of recent developments in the interrogation of different techniques and present state-of-the-art of microfluidic sensor for better, quick, easy, rapid, early, inexpensive and portable POCT (Point of Care testing device) device for a particular study, in this case, bone disease called osteoporosis. Some simulations of the microchip are also made to enable feasibility of the development of a blood-chip-based system. The proposed device will assist in early detection of diseases in an effective and successful manner.

• Proceedings of the KOSOMBE Conference
• /
• v.1994 no.05
• /
• pp.9-15
• /
• 1994

In last few decades, medical imaging techniques have been developed startling progress. Especially in MRI (Magnetic Resonance Imaging), many imaging techniques such as chemical shift imaging, flow imaging, diffusion and perfusion imaging, fast imaging, susceptibility imaging and functional imaging have been studied and many of them were well known as useful diagnostic instruments. In this paper, recently developing techniques, i.e., NMR microscopy, fringe field imaging and functional imaging will be presented.

• The Korean Journal of Nuclear Medicine
• /
• v.34 no.3
• /
• pp.159-168
• /
• 2000

In the 1980s, techniques to image the human subjects in a three-dimensional direction were developed. Two major techniques are SPECT (Single Photon Emission Computed Tomography) and PET (Positron Emission Tomography) which allow the detector to detect a single photon or annihilation photons emitted from the subjects injected with radiopharmaceuticals. Since the latter two techniques can measure the density of receptors, enzymes and transporters in living human, it may be very important project to develop selective methods of labeling with radionuclides and to develop new radiopharmaceuticals. There has been a considerable interest in developing new compounds which specifically bind to dopamine and serotonin receptor and transporters, and it will be thus very useful to label those compounds with radionuclides in order to gain a better understanding in biochemical and pharmacological interactions in living human. This review mentions the characteristics of radioligands for the imaging of dopamine and serotonin receptors and transporters. Although significant progress has been achieved in the development of new PET and SPECT ligands for in vivo imaging of those receptors and transporters, there are continuous needs of new diagnostic radioligands.

• Journal of Genetic Medicine
• /
• v.20 no.1
• /
• pp.1-5
• /
• 2023

Until now, rare disease studies have mainly been carried out by detecting simple variants such as single nucleotide substitutions and short insertions and deletions in protein-coding regions of disease-associated gene panels using diagnostic next-generation sequencing in association with patient phenotypes. However, several recent studies reported that the detection rate hardly exceeds 50% even when whole-exome sequencing is applied. Therefore, the necessity of introducing whole-genome sequencing is emerging to discover more diverse genomic variants and examine their association with rare diseases. When no diagnosis is provided by whole-genome sequencing, additional omics techniques such as RNA-seq also can be considered to further interrogate causal variants. This paper will introduce a description of these multi-omics techniques and their applications in rare disease studies.

• Proceedings of the KIEE Conference
• /
• 1996.07b
• /
• pp.853-855
• /
• 1996

This paper describes the dissipation factor measuring techniques of insulating oil on the operating transformer by using digital signal processing. After applying voltage to the electrodes which is installed In a transformer, acquiring source voltage and current of electrodes and using cross-correlation techniques. we can check the dissipation factor of insulating oil. To Improve measuring accuracy and the speed of process, we use hardware such as TMS320C31 DSP board and analog filter and software such as cross-correlation techniques, rectangular window, and digital filtering techniques. We simulated the measuring accuracy and the degree of the noise effect of this new measuring techniques by using computer simulation, and compared the simplified measuring devices with schering bridge on degraded insulating oil. The result showed that this measuring technique can be used as diagnostic method on the pole transformers.

• Proceedings of the KIEE Conference
• /
• 1996.11a
• /
• pp.462-463
• /
• 1996

This study describes the dissipation factor measuring techniques of insulating oil on the operating, transformer by using digital signal processing. After applying voltage to the sensor which is installed in a transformer, acquiring source voltage and current of sensor and using cross-correlation techniques, we can check the dissipation factor of insulating oil. To improve measuring accuracy and the speed of process, we use hardware such as TMS320C31 DSP board and analog filter and software such as fast cross-correlation techniques, rectangular window, and digital filtering techniques. We simulated the measuring accuracy and the degree of the noise effect of this new measuring techniques by computer simulation, and compared the simplified measuring devices with Schering Bridge on degraded insulating oil. The result showed that this measuring technique can be used as diagnostic method on the pole transformers.

• Proceedings of the KIEE Conference
• /
• 1996.11a
• /
• pp.270-272
• /
• 1996

This paper describes the dissipation factor measuring techniques of insulating oil on operating pole transformer by using digital signal processor. After applying voltage to the electrodes which is installed in a transformer, acquiring source voltage and current of electrodes and using cross-correlation techniques, we can check the dissipation factor of insulating oil. To improve measuring accuracy and the speed of process, we use hardware such as TMS320C31 DSP board and software such as cross-correlation techniques and rectangular window techniques. We simulated the measuring accuracy and the degree of the noise effect of this new measuring techniques by using computer simulation, and compared the simplified measuring devices with schering bridge on degraded insulating oil. The result showed that this measuring technique can be used as diagnostic method on the pole transformers.