• Asian Pacific Journal of Cancer Prevention
• /
• v.15 no.13
• /
• pp.5111-5116
• /
• 2014

Computed Tomography Colonography (CTC) is a medical imaging technology used in identifying polyps and colon cancer masses in the large intestine. The technique has evolved a great deal since its invention and has become a routine diagnostic procedure in Western countries due to its non invasiveness and ease of use. The objective of our study was to explore the possibility of CTC application in Indian hospitals. This paper gives an overview of the procedure and its commercial viability. The explanation begins with the domain aspects from gastroenterologist perspective, the new way of thinking in polyp classification, the technical components of CTC procedure, and how engineering solutions have helped clinicians in solving the complexities involved in colon diagnosis. The colon cancer statistics in India and the results of single institution study we carried out with retrospective data is explained. By considering the increasing number of patients developing colon malignancies, the practicality of CTC in Indian hospitals is discussed. This paper does not reveal any technical aspects (algorithms) of engineering solutions implemented in CTC.

• Clinical and Experimental Pediatrics
• /
• v.53 no.3
• /
• pp.273-285
• /
• 2010

Completion of the human genome project has allowed a deeper understanding of molecular pathophysiology and has provided invaluable genomic information for the diagnosis of genetic disorders. Advent of new technologies has lead to an explosion in genetic testing. However, this overwhelming stream of genetic information often misleads physicians and patients into a misguided faith in the power of genetic testing. Moreover, genetic testing raises a number of ethical, legal, and social issues. Diagnostic genetic tests can be divided into three primary but overlapping categories: cytogenetic studies (including routine karyotyping, high-resolution karyotyping, and fluorescent in situ hybridization studies), biochemical tests, and DNA-based diagnostic tests. DNA-based testing has grown rapidly over the past decade and includes preandpostnatal testing for the diagnosis of genetic diseases, testing for carriers of genetic diseases, genetic testing for susceptibility to common non-genetic diseases, and screening for common genetic diseases in a particular population. Theoretically, once a gene's structure, function, and association with a disease are well established, the clinical application of genetic testing should be feasible. However, for routine applications in a clinical setting, such tests must satisfy a number of criteria. These criteria include an acceptable degree of clinical and analytical validity, support of a quality assurance program, possibility of modifying the course of the diagnosed disease with treatment, inclusion of pre-and postnatal genetic counseling, and determination of whether the proposed test satisfies cost-benefit criteria and should replace or complement traditional tests. In the near future, the application of genetic testing to common diseases is expected to expand and will likely be extended to include individual pharmacogenetic assessments.

• Journal of Sasang Constitutional Medicine
• /
• v.33 no.2
• /
• pp.15-23
• /
• 2021

Objectives The purpose of this study was to evaluate the possibility of Korea Sasang Constitutional Diagnostic Questionnaire(KS-15) when was applied to the Vietnamese. Methods The subjects of this study were Vietnamese participants who visited National Hospital of Traditional Medicine in Hanoi in 2012-2013 among the data established at the Korean Medicine Data Center. Among them, 188 people were used to assess the reliability, and 116 people were used to assess the validity. The reliability test was conducted through test-retest analysis, and the validity test was conducted through cross analysis comparing to diagnosis by Sasang Constitutional experts. Results & Conclusions Three items of total 14 items, except for BMI, showed 0.4 or below in Kappa, 3 items were ranged in 0.4-0.6 and 8 items showed 0.6 or over, using 188 people. The concordance rate between the results of KS-15 and diagnosis of experts was 66.4% in 116 people (85.4% in Taeeumin, 47.4% in Soeumin, and 64.9% in Soyangin). The KS-15 could be usable for supporting to diagnose the Sasang constitution of the Vietnamese.

• Journal of Multimedia Information System
• /
• v.8 no.4
• /
• pp.233-242
• /
• 2021

Various anatomical MRI imaging biomarkers for Alzheimer's Disease (AD) identification have been recognized so far. Cortical and subcortical volume, hippocampal, amygdala volume, and genetics patterns have been utilized successfully to diagnose AD patients from healthy. These fundamental sMRI bio-measures have been utilized frequently and independently. The entire possibility of anatomical MRI imaging measures for AD diagnosis might thus still to analyze fully. Thus, in this paper, we merge different structural MRI imaging biomarkers to intensify diagnostic classification and analysis of Alzheimer's. For 54 clinically pronounce Alzheimer's patients, 58 cognitively healthy controls, and 99 Mild Cognitive Impairment (MCI); we calculated 1. Cortical and subcortical features, 2. The hippocampal subfield, amygdala nuclei volume using Freesurfer (6.0.0) and 3. Genetics (APoE ε4) biomarkers were obtained from the ADNI database. These three measures were first applied separately and then combined to predict the AD. After feature combination, we utilize the sequential feature selection [SFS (wrapper)] method to select the top-ranked features vectors and feed them into the Multi-Kernel SVM for classification. This diagnostic classification algorithm yields 94.33% of accuracy, 95.40% of sensitivity, 96.50% of specificity with 94.30% of AUC for AD/HC; for AD/MCI propose method obtained 85.58% of accuracy, 95.73% of sensitivity, and 87.30% of specificity along with 91.48% of AUC. Similarly, for HC/MCI, we obtained 89.77% of accuracy, 96.15% of sensitivity, and 87.35% of specificity with 92.55% of AUC. We also presented the performance comparison of the proposed method with KNN classifiers.

• Journal of Korean Society of Rural Planning
• /
• v.27 no.4
• /
• pp.109-122
• /
• 2021

The purpose of this study is to develop a application procedure and survey method for the empirical diagnostic indices system. In order to know the survey method, which has 65 investigation items for 52 indicators, this study not only presented so that the each survey items could be surveyed in at least 1 to 3 steps, but also presented the 4 survey method for each investigation items: preliminary survey, administrative survey, field survey, and interview survey. As a result of applying to 15 sample villages, the period of surveying a village of 100 households was 1.4 days, and it was confirmed that the survey was generally efficient in a short time. As a result of applying the survey system to the sample village, the developed survey system showed the possibility of investigating even the details of rural villages. Therefore, it was judged that it could be used as a basic procedure for a rural village unit survey.

• Current Optics and Photonics
• /
• v.7 no.3
• /
• pp.283-296
• /
• 2023

An intraoral spectral domain optical coherence tomography (SD-OCT) system has been developed, using a custom-built hand-held scanner and spectrometer. The hand-held OCT probe, based on a microelectromechanical systems scanner and a self-built miniaturized drive circuit, had a field of view sufficient for dental diagnosis. The spectrometer using a fabricated f-theta lens provided the image depth required for dental diagnosis. The axial and transverse resolutions of the OCT system in air were 7.5 ㎛ and 12 ㎛ respectively. The hand-held probe could scan an area of 10 × 10 mm², and the spectrometer could image along a depth of 2.5 mm. To verify the utility of the developed OCT system, OCT images of tooth hard and soft tissues were acquired, and a user-interface program for diagnosis was developed. Early caries and microcracks that were difficult to diagnose with existing methods could be found, and the state of restoration could be observed. Measuring the depth of the gingival sulcus, distinguishing subgingival calculus, and detecting an implant under the gingiva suggested the possibility of the SD-OCT system as a diagnostic for dental soft tissues. Through the presented OCT images, the capability of the developed SD-OCT system for dental diagnosis was demonstrated.

• Journal of the Semiconductor & Display Technology
• /
• v.22 no.4
• /
• pp.53-58
• /
• 2023

The storage capacity of 3D-NAND flash memory has been enhanced by the multi-layer dielectrics. The deposition process has become more challenging due to the tight process margin and the demand for accurate process control. To reduce product costs and ensure successful processes, process diagnosis techniques incorporating artificial intelligence (AI) have been adopted in semiconductor manufacturing. Recently there is a growing interest in process diagnosis, and numerous studies have been conducted in this field. For higher model accuracy, various process and sensor data are required, such as optical emission spectroscopy (OES), quadrupole mass spectrometer (QMS), and equipment control state. Among them, OES is usually used for plasma diagnostic. However, OES data can be distorted by viewport contamination, leading to misunderstandings in plasma diagnosis. This issue is particularly emphasized in multi-dielectric deposition processes, such as oxide and nitride (ON) stack. Thus, it is crucial to understand the potential misunderstandings related to OES data distortion due to viewport contamination. This paper explores the potential for misunderstanding OES data due to data distortion in the ON stack process. It suggests the possibility of excessively evaluating process drift through comparisons with a QMS. This understanding can be utilized to develop diagnostic models and identify the effects of viewport contamination in ON stack processes.

• Journal of Yeungnam Medical Science
• /
• v.40 no.4
• /
• pp.321-327
• /
• 2023

Recently, the International Working Group on the Diabetic Foot and the Infectious Diseases Society of America divided diabetic foot disease into diabetic foot infection (DFI) and diabetic foot osteomyelitis (DFO). DFI is usually diagnosed clinically, while numerous methods exist to diagnose DFO. In this narrative review, the authors aim to summarize the updated data on the diagnosis of DFO. An extensive literature search using "diabetic foot [MeSH]" and "osteomyelitis [MeSH]" or "diagnosis" was performed using PubMed and Google Scholar in July 2023. The possibility of DFO is based on inflammatory clinical signs, including the probe-to-bone (PTB) test. Elevated inflammatory biochemical markers, especially erythrocyte sedimentation rate, are beneficial. Distinguishing abnormal findings of plain radiographs is also a first-line approach. Moreover, sophisticated modalities, including magnetic resonance imaging and nuclear medicine imaging, are helpful if doubt remains after a first-line diagnosis. Transcutaneous bone biopsy, which does not pass through the wound, is necessary to avoid contaminating the sample. This review focuses on the current diagnostic techniques for DFOs with an emphasis on the updates. To obtain the correct therapeutic results, selecting a proper option is necessary. Based on these numerous diagnosis modalities and indications, the proper choice of diagnostic tool can have favorable treatment outcomes.

• Journal of the Korean Society of Radiology
• /
• v.13 no.2
• /
• pp.283-290
• /
• 2019

The purpose of this study is to suggest a quantitative supplementary index for patients with suspected Raynaud phenomenon. The subjects were 99 patients with suspected Raynaud phenomenon, 48 patients with low likelihood, 16 patients with middle range and 35 patients with high range. The test was instilled in ice water at $15.2{\pm}0.8^{\circ}C$ for 10 minutes of both hands and then venous injected of 99m-Tc 370 Mbq(10 mCi). After 5, 10 and 20 minutes, temperature changes of both fingers were measured. As a result, the temperature of the fingers was $32.6{\pm}4.9^{\circ}C$ in patients with a low diagnostic probability of Raynaud syndromes and $22.7{\pm}6.0^{\circ}C$ for those with a high diagnostic probability(p<0.05). In conclusion, we could confirm the difference of Raynaud phenomenon and finger temperature, and confirmed the possibility of secondary diagnosis as a quantitative index of Raynaud's diagnosis.

• Journal of the Korean Society of Safety
• /
• v.33 no.2
• /
• pp.21-27
• /
• 2018

The expansion and stable operation of electric power facilities are important factors with development of industrial facilities in modern society. In high-voltage equipment such as GIS, the insulation characteristics may be deterioated by environment-friendly gas adaption and miniaturization. There is also the possibility of accidents due to insulation breakdown due to the deterioration of power facilities. Therefore, it is necessary to extend the diagnosis system to continuously monitor the danger signals of these power equipment and to prevent accidents. Most of the internal defects in the GIS system are conductive particles, floating electrode defects, protrusion defects, and the like. In this case, a partial discharge phenomenon is accompanied. These partial discharge signals occur irregularly and various noise signals are included in the field, so it is difficult to evaluate the reliability in the development of the diagnostic system. In this paper, a study was made on equipment capable of generating a partial discharge simulated signal that can be adjusted in size and frequency to be applied to a diagnostic device by electromagnetic wave detection method. The PD simulated pulse generator consists of a user interface module, a high-voltage charging module, a pulse forming circuit, a voltage sensor and an embedded controller. In order to simulate the partial discharge phenomenon similar to the actual GIS, a discharge cell was designed and fabricated. The application of the prototype pulse generator to the commercialized PD diagnosis module confirmed that it can be used to evaluate the performance of the diagnostic device. It can be used for the development of GIS diagnosis system and performance verification for reliability evaluation.