• Title/Summary/Keyword: Developmental study

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Developmental and reproductive toxicity assessment in rats with KGC-HJ3, Korean Red Ginseng with Angelica gigas and Deer antlers

  • Lee, Jinsoo;Jeong, Ji-Seong;Cho, Kyung-Jin;Moon, Kyeong-Nang;Kim, Sang Yun;Han, Byungcheol;Kim, Yong-Soon;Jeong, Eun Ju;Chung, Moon-Koo;Yu, Wook-Joon
    • Journal of Ginseng Research
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    • v.43 no.2
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    • pp.242-251
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    • 2019
  • Background: Korean Red Ginseng has been widely used in traditional oriental medicine for a prolonged period, and its pharmacological effects have been extensively investigated. In addition, Angelica gigas and deer antlers were also used as a tonic medicine with Korean Red Ginseng as the oriental herbal therapy. Methods: This study was conducted to evaluate the potential toxicological effect of KGC-HJ3, Korean Red Ginseng with angelica gigas and deer antlers, on reproductive and developmental functions including fertility, early embryonic development, maternal function, and embryo-fetal development. KGC-HJ3 was administered by oral gavage to Sprague-Dawley rats (22 animals per sex per group) at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on fertility and early embryonic development. In addition, KGC-HJ3 was also administered by oral gavage to mating-proven Sprague-Dawley rats (22 females per group) during the major organogenesis period at dose levels of 0 mg/kg (control), 500 mg/kg, 1000 mg/kg, and 2000 mg/kg to evaluate the potential toxicological effect on maternal function and embryo-fetal development. Results and conclusion: No test item-related changes in parameters for fertility, early embryonic development, maternal function, and embryo-fetal development were observed during the study period. On the basis of these results, it was concluded that KGC-HJ3 did not have toxicological potential on developmental and reproductive functions. Therefore, no observed adverse effect levels of KGC-HJ3 for fertility, early embryonic development, maternal function, and embryo-fetal development is considered to be at least 2000 mg/kg/day.

Clinical Profiles of Relationships in the Play Expression of Children by Developmental, Behavioral, and Emotional Disorders (발달·행동·정서장애 아동이 놀이표현에서 보이는 관계 요소의 임상적 프로파일)

  • Hwang, Mi Young;Kim, Yeong Hee
    • Korean Journal of Child Studies
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    • v.29 no.5
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    • pp.197-214
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    • 2008
  • The purpose of this study was to investigate clinical characteristics and the attribution of children having play therapy by developmental, behavioral, and emotional disorders. Subjects of this study were 118 3- to 9-year-old children randomly selected from children who were receiving or who already finished play therapy at one of the child and family counseling centers in Cheong-Ju City. Results showed that children with developmental disorders had lower levels of relationship during play, and their relationships were more disorganized or separated than children with emotional or with behavioral disorders. This study has significance by providing psychological information on play characteristics of children by type of disorder.

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Self-consciousness Improvement Effect of Nonstructured Developmental Art Therapy on a Developmental Disordered Child -A Study on the Single Case- (비구조적 발달 미술치료를 통한 발달장애아의 자아의식 향상 효과 -단일사례를 중심으로-)

  • Kang, Young-Ja;Kang, Soung-A
    • Korean Journal of Human Ecology
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    • v.11 no.4
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    • pp.321-334
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    • 2002
  • This study is a non-structured developmental art-therapy case study having done 134 times of total treatments for a 12 years old girl, having extremely poor verbal communication ability and sociality comparing to her ability in perception and motion. I presumed the cause of this gap between perceptibility and the communication ability was a problem related to self-consciousness. To cure the problem, I provided treatment programs designed to use material which can create a stable and reliable environment and can give body experiences such as painting and play-dough. As the treatment programs progressed, I found she had changed gradually to lead the game by herself and to express her favorite colors and shapes. Also she became to be able to express her experience as a simple word and to response short answers for questions.

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A Study on the Leisure Activities and Their Constraints of Housewives (주부의 여가활동과 여가제약요인에 관한 연구)

  • 홍성희
    • Journal of the Korean Home Economics Association
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    • v.29 no.3
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    • pp.153-174
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    • 1991
  • The purpose of this study is to examine the leisure activities of housewives, to identify the factors that influence leisure activities, and to explore the factors contribute to their life satisfaction. So, this study analyses the effects of econo-demographic and socio-cultural variables and of leisure constraint factors on the leisure activities of housewives. And it deals with how these variables and the leisure activities influence life satisfaction of housewives. For these puoposes, 508 housewives residing in Seoul & Daegu were selected for interviews. For data analysis such statistical methods as ANOVA, t-test, Pearson's correlation, adn Multiple Regression Analysis can be summarised. The main findings of the research are as follows: 1. Leisure acivities are classified in Self-developmental, Home-oriented, Time-consuming, Social and Children-concerned types by the technique of factor analysis. The average particiation level was high in Time-consuming type, but low in Self-developmental type. 2. The participation level of leisure activities shows significant differences by selected variables: The Self-developmental type shows significant differences by housewife's education level, income, husband's occupation, role orientation, home management type and leisure constraints. And Children-concerned type was differed to number of family nember, number of children, age of housewife and age of housewife and age of the youngst child. 3. The preference level of leisure activities differ by housewife's education level, income, husband's occupation, home management type and leisure constraints in the Self-developmental and the Social type. And the preference level of Home-oriented leisure activities was high in the middle class of income and husband's occupation. 4. The preference and participation level of leisure activities show differences. And the variables affecting the differences were housewife's age, education level, home management type, role orientation, leisure constraint factors in the Self-developmental type, and were demographic variables such as number of family member, housewife's age in the Home-oriented type. 5. The variables which affected the level of life satisfaction independently were leisure space, income, the participation level of the Self-developmental and the Social type and the preference level of the Self-developmental type.

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The Child Rearing and Inner Growth Experiences of Mothers of Children with Developmental Disabilities: A Photovoice Study (발달장애 자녀를 둔 어머니의 양육과 성장 경험에 관한 포토보이스 연구)

  • Kim, Kyung-Hee;Kim, Miok;Jung, Min Ah
    • Korean Journal of Family Social Work
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    • no.54
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    • pp.263-296
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    • 2016
  • This study aimed to understand the child rearing burden of mothers of youth with developmental disabilities and mothers' inner growth through their rearing experiences. The researchers conducted focus group interviews using the 'photovoice' method and individual interviews with a mothers' group of an orchestra whose members are youth with developmental disabilities. The data were qualitatively analyzed applying systematic content analysis. The results revealed that the lives of mothers of children with developmental disabilities were framed as 'keeping walking, even it's invisible', and their experiences were summed up by the phrase 'coming together and growing with their children.' Although the mothers of children with developmental disabilities experienced distress and difficulties, they also experienced joy and growth while parenting their children. Their children's participation in the orchestra were associated with changes in the mothers' perceptions of their children as well as their self-perceptions as caregivers, and the relationships with the support systems. Based on these findings, the implications of this study for social welfare practice were discussed.

Discrimination Experience and Employment of People with Developmental Disabilities: Moderating Effect of Family Employment Support (발달장애인의 차별경험이 취업에 미치는 영향: 가족취업지지의 조절효과)

  • Ham, Hyun-Jin
    • Journal of Digital Convergence
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    • v.20 no.5
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    • pp.703-712
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    • 2022
  • The purpose of this study is to present practical implications for employment of people with developmental disabilities by analyzing the moderating effect of family employment support in the relationship between discrimination experience and employment of people with developmental disabilities. The subjects of the study were 394 people with developmental disabilities who participated in the 2nd wave 4th survey of the 2019 Employment Panel Survey for the Disabled, and a hierarchical binary logistic regression analysis was conducted to verify the hypothesis. As a result of the study, it was found that the experience of discrimination among people with developmental disabilities negative effects employment, and family employment support has a significant moderating effect, strengthening the negative effect of discrimination on employment. Therefore, the importance of improving the working environment reflecting the needs of families with developmental disabilities, the necessity of employment support policies, and strengthening trust with the state and local communities were discussed.

The Effects of a Healing Garden Program based on Vocational Adaptation on Career Attitude for College Students with Developmental Disabilities

  • Kim, Soo Yeon
    • Journal of People, Plants, and Environment
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    • v.23 no.1
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    • pp.77-85
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    • 2020
  • The purpose of this study was to examine the effects of a healing garden program based on internal factors of vocational adaptation on career attitude for college students with developmental disabilities. First, healing garden program was defined by a group of experts related to education for developmental disabilities in the industry and academia through the focus group interview. Second, the healing garden program for college students with developmental disabilities was carried out for 15 weeks. Third, this study examined the effects of healing garden program based on internal factors of vocational adaptation on career attitude for college students with developmental disabilities. The participants of this study were 55 college students with developmental disabilities in N University, with 25 students placed in the experimental group and the other 30 in the control group. As a result of examination, the difference between before and after the program, it was found that factors of career attitude were improved significantly after the program in the experimental group, with Factor 1 (determination) increased from 2.08 to 3.39, Factor 2 (finality) from 2.28 to 3.19, Factor 3 (confidence) from 2.20 to 3.69, Factor 4 (preparation) from 2.12 to 3.79, and Factor 5 (independence) from 1.88 to 3.63. But the control group did not show a significant improvement after 15 weeks of the program except Factor 3 (confidence) and Factor 5 (independence). It was found that the healing garden program based on internal factors of vocational adaptation had effects on career attitude for college students with developmental disabilities. Finally, the program will contribute to vocational rehabilitation for college students with disabilities. The findings further suggest that healing gardening programs that facilitate career attitudes must be continuously developed and applied in order to establish effective transition from school to the world of vocational adaptation.

A study of the Effect of Sensory Processing on Sleep Disturbance for Life care of Preschool Children with Developmental Disabilities (학령전기 발달장애 아동의 라이프 케어를 위한 감각처리가 수면장애에 미치는 영향에 관한 연구)

  • Kim, Hee-Young
    • Journal of Korea Entertainment Industry Association
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    • v.13 no.3
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    • pp.203-211
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    • 2019
  • The purpose of this study was to investigate the relations between sensory processing and sleep disturbances and to investigate the effect of sensory processing on sleep disorder in preschool children with developmental disorder. This study was conducted for 110 children with developmental disorder in developmental clinic and rehabilitation hospital in Gwang Ju from June to August, 2017. The final 109 data were analyzed. Sensory processing and Sleep disturbances were measured using the Shortened sensory profile(SSP) and Korean-the Children's Sleep Habits Questionnaire(K-CSHQ). Statistical analysis was performed using descriptive analysis, Pearson correlation analysis, and multiple regression analysis were performed. Children with developmental disorder had problems with sensory processing and sleep habits. Sensory processing was related to sleep habit and most important factors of sensory processing influencing sleep was taste/olfactory sensitivity, auditory filtering. Conclusion: In order to help children with developmental disorder with sleep problem, it is necessary to consider the sensory processing especially taste/olfactory sensitivity, auditory filtering.

Assessment of Developmental Toxicants using Human Embryonic Stem Cells

  • Hong, Eui-Ju;Jeung, Eui-Bae
    • Toxicological Research
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    • v.29 no.4
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    • pp.221-227
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    • 2013
  • Embryonic stem (ES) cells have potential for use in evaluation of developmental toxicity because they are generated in large numbers and differentiate into three germ layers following formation of embryoid bodies (EBs). In earlier study, embryonic stem cell test (EST) was established for assessment of the embryotoxic potential of compounds. Using EBs indicating the onset of differentiation of mouse ES cells, many toxicologists have refined the developmental toxicity of a variety of compounds. However, due to some limitation of the EST method resulting from species-specific differences between humans and mouse, it is an incomplete approach. In this regard, we examined the effects of several developmental toxic chemicals on formation of EBs using human ES cells. Although human ES cells are fastidious in culture and differentiation, we concluded that the relevancy of our experimental method is more accurate than that of EST using mouse ES cells. These types of studies could extend our understanding of how human ES cells could be used for monitoring developmental toxicity and its relevance in relation to its differentiation progress. In addition, this concept will be used as a model system for screening for developmental toxicity of various chemicals. This article might update new information about the usage of embryonic stem cells in the context of their possible ability in the toxicological fields.

Effects of Hormones, Oviduct Epithelial Cells, Cumulus Cells during the In Vitro Culture in Medium on In Vitro Developmental Rates of Bisected Bovine Embryos (소 분할배와 호르몬, 난관상피세포, 난구세포와의 공배양이 체외발생율에 미치는 영향에 관한 연구)

  • 김상근;남윤이;이명헌;이만휘
    • Korean Journal of Animal Reproduction
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    • v.21 no.3
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    • pp.281-285
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    • 1997
  • The study was conducted to investigate on in vitro developmental rates of bisected bovine embryos co-culture in 10% FCS+TCM-199 media containing hormones, oviductal epithelial cells and cumulus cells 0 to 7 days after bisection. In vitro developmental rates was defined as development rates on in vitro culture or FDA-test. The results are summarized as follows : 1. In vitro developmental rates of bisected bovine embryos co-cultured in 10% FCS+TCM-199 media containing PMSG+hCG, PMSG+$\beta$-estradiol, hCG+$\beta$-estradiol, PMSG, hCG 0 to 3 days and 4 to 7 days were 16.7~30.0% and 11.1~25.0%, respectively. In vitro developmental rates of bisected embryos co-cultured in 10% FCS+TCM-199 media containing hormones significantly higher than that of non co-culture. 2. In vitro developmental rates of bisected bovine embryos co-cultured 10% FCS+TCM-199 media containing oviductal epithelial cells 0 to 3 days and 4 to 7 days were 25.0% and 22.2%, respectively.

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