• Development and Reproduction
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• v.22 no.4
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• pp.331-339
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• 2018

NUCB2/nesfatin-1 is first known to be expressed in the hypothalamus while controlling appetite and energy metabolism. However, recent studies have shown that NUCB2/nesfatin-1 was expressed in the various organs as well as the hypothalamus. Our previous reports also demonstrated that NUCB2/nesfatin-1 was expressed in the ovary, testis, pituitary gland, lung, kidney, and stomach of fetal and adult mice. However, the role of NUCB2/nesfatin-1 in mouse fetus remains unknown. Thus, the aim of this study was to investigate whether NUCB2/nestatin-1 is expressed in mouse fetus at the developmental stage in which organogenesis begins. To do this, we performed in situ hybridization (ISH) and immunohistochemistry (IHC) staining to examine the distribution of NUCB2 mRNA and nesfatin-1 protein in the mouse fetal organs during early developmental stages, especially at embryonic day (E) 10.5. As a result of ISH, NUCB2 mRNA positive signals were more frequent in the liver, but there were relatively few positive signals in heart. On the other hand, no positive signals were detected in other organs. These ISH results were validated by IHC staining and qRT-PCR analysis. Expression of nesfatin-1 protein detected by IHC staining was similar to that of NUCB2 mRNA detected by ISH in the liver and heart. In addition, the levels of NUCB2 mRNA expression analyzed by qRT-PCR were significantly increased in the liver and heart compared to other organs of the mouse fetus at E13.5, whereas its level was extensively decreased in the liver, but increased in the lung, stomach, and kidney of the mouse fetus at E17.5. These results suggest that NUCB2/nesfatin-1 may play an important role in liver and heart development and physiological functions in the developmental process of mouse fetus. Further studies are needed on the function of NUCB2/nesfatin-1, which is highly expressed in the various organs, including liver and heart during mouse development.

• Korean Journal of School Psychology
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• v.8 no.3
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• pp.263-285
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• 2011

The present study was designed to evaluate the effects of staff training in PBS on the behaviors of staff and children with developmental disabilities in an inpatient unit. The perceived significance of children's problem behavior and staff's caring stress significantly decreased with the intervention. A satisfaction survey reported staff's high satisfaction with the process and results of staff training. This study suggests that PBS is a socially valid and positive intervention with problem behavior of children with developmental disabilities. The implications and limitations of this study, with directions for future research, are also discussed.

• Journal of the Economic Geographical Society of Korea
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• v.10 no.1
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• pp.1-18
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• 2007

This study examines the development direction of Ulsan automobile cluster and suggests strategic interventions, based on the possibility of system transformation in the open economic system. The spatial characteristics of global, national and local production and R&D networks were analyzed to investigate the conditions of Ulsan automobile cluster. And the agglomeration process of automobile industry and the capabilities accumulated in Ulsan were analyzed and alternative developmental path and policy suggestions were proposed.

• Journal of Environmental Impact Assessment
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• v.10 no.1
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• pp.49-57
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• 2001

With reducing coal mining industry the number of coal mine sites between 1988 and 1998 was dropped from 347 to 12. Since the abandoned coal mine sites have been kept without any cares, they have raised various environmental and safety problems. Then, Korean government initiated a special law in 1995 for enhancing economic conditions and solving environmental problems with promoting developmental projects in the abandoned mining sites. As a result, casino business in Chungsun area has been opened to publics, and other large-scale developments such as ski slopes and resorts are planned. In addition, Boryung area in Chungchung province also will launch a large-scale project building golf courses. Based on this developmental trend, it is expected that lots of large-scale developments in other places will be taken place. In general, the large-scale developments have caused various environmental problems, and, thus, environmental aspects should be considered in a decision-making process. This paper examine the status of the abandoned mine sites in Korea and U.S. and suggests the alternatives of its utilization.

• The Journal of Korean Physical Therapy
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• v.1 no.1
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• pp.47-61
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• 1989

This paper presents the event approach to motor skill acquisition as a theoretical treatment of the learning and relearning of motor skill. 1) The use of norm-referenced developmental assesment tools and standardized qualitative assessment tool is an important component of infant movement evaluation. 2) The kinesthetic modality relaying movement and position imformation to the central nervous system is important for the detection and corretion of movement error. 3) The event approach treats the actor and the environment as inseparable in the acquisition of skills. 4) Motoy learning focuses almost entirely on how the skill is learned, contRolled and reTained. 5) Developmental assessment have needed an assessment of motor development. 6) A significant difference was found between articulation disorders children and motor coordination problem. 7) verbal ability is not essential for the learning of motor skills. 8) The Control of motor skills is a cognitive ability.

• Development and Reproduction
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• v.22 no.3
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• pp.205-212
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• 2018

This study is to observe the developmental process of the larval skeleton according to the growth of the trident goby, Tridentiger obscurus belonging to the larvae and juveniles and use it as the basic data of the taxonomic study. 8 days after hatching, the parasphenoid was ossified with an average total length of 3.62 mm, and basioccipital began to ossify. Caudal vertebrae and neural spine ossified in vertebra. 17 days after hatching, the average total length of the long hairs was 4.32 mm, pterotic and epiotic were ossified, and interhyal and subopercle were ossified. 52 days after hatching, the average total length of the juvenile was 18.2 mm, and lateral ethmoid, hypohyal ossified, vertebrae were parapophysis, and epural bone was osseous to the bone.

• Journal of Korean Physical Therapy Science
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• v.8 no.2
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• pp.953-960
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• 2001

This study is approached the early intervention of children with disability in the aspect of family. The family of didabled children are identified as special individual with responsibilities and roles beyond those of other family. Physical Therapy need of the disabled child should be sought in the context of the family and socio-cultural environment. The process of early developmental facilitation is defined as a approach of the family. As family is the most influential factor in the child developmental facilitation, treatment and education. The family tend to seek complete information about disabilities, desire accurate, straight foreward about their child.

• BMB Reports
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• v.48 no.11
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• pp.599-608
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• 2015

Regeneration, a process of reconstitution of the entire tissue, occurs throughout life in the olfactory epithelium (OE). Regeneration of OE consists of several stages: proliferation of progenitors, cell fate determination between neuronal and non-neuronal lineages, their differentiation and maturation. How the differentiated cell types that comprise the OE are regenerated, is one of the central questions in olfactory developmental neurobiology. The past decade has witnessed considerable progress regarding the regulation of transcription factors (TFs) involved in the remarkable regenerative potential of OE. Here, we review current state of knowledge of the transcriptional regulatory networks that are powerful modulators of the acquisition and maintenance of developmental stages during regeneration in the OE. Advance in our understanding of regeneration will not only shed light on the basic principles of adult plasticity of cell identity, but may also lead to new approaches for using stem cells and reprogramming after injury or degenerative neurological diseases.

• Journal of Plant Biotechnology
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• v.1 no.1
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• pp.56-60
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• 1999

Sexual reproduction is an essential process in the propagation of flowering plants. Recent advances in plant cell biology and biotechnology have brought new and powerful methodologies to investigate and manipulate the reproductive processes of angiosperms including agronomically important crop plants. Successful cryopreservation of maize, rye and triticale pollen and young embryos of microspore-and zygote-origine contributes to long term preservation of important plant germ-lines in gene banks. Discovering morphogenetic characteristics of the different developmental pathways taking place in wheat and maize androgenesis in vitro helps to influence the procedure to produce genetically and phenotipically stable homozygous doubled haploid plants for breeding purposes. Detailed ultrastructural and cell-biological studies on the developmental sequences of male and female gametophyte development in wheat, experimental protocols developed to isolate and micromanipulate egg cell protoplasts, make it possible to use plant gametes and the sexual route itself to produce genetically improved organisms. Plant gametes can become useful tools for crop improvement in the near future. Recent achievements by our laboratory in this field are reviewed in the present paper

• Journal of Institute of Control, Robotics and Systems
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• v.13 no.2
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• pp.108-113
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• 2007

The robot introduced in this paper is the Fire-Extinguishing Rescue Robot for indoor work which is considered to be a part of the Operation for Future Developmental Power. It is briefly introduced about the background of how we began this project, our goals, where we are today and what we would like to achieve from now on. Main contents include introduction to the equipments for Fire-Extinguishing Rescue robots that have been developed in advanced countries and the compositional concept of the developmental process, the GUI schematic, searching methods for fire inside a house, mechanical schematic and the present conditions of how the core technologies are developing through.