• Development and Reproduction
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• v.14 no.1
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• pp.27-34
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• 2010

A fertilized oocyte can get the competence for implantation through cleavage and stage-specific gene expression. These are under the control of autonomous and exogenous regulators including physiological culture condition. Endogenous and exogenous growth factors are considered as critical regulators of cleaving embryos during travel the oviduct and uterus. In this study, an effort was made to evaluate comprehensively the quality of embryos for implantation, grown in media enriched with EGF and PAF. The study evaluated developmental rates on given time, blastulation and hatching rates, and adhesion rates. Developmental rates of blastocyst to the hatching stage were significantly high in PAF treated group compared to the control in a dose-dependent manner but not in EGF group. Implantation rates were significantly high both PAF and EGF in a dose-dependent manner. H7, a PKC inhibitor, blocked the process of hatching of the blastocysts but combined treatment of EGF and PAF enhanced the hatching and implantation of blastocsyts. Based on these results it is suggested that EGF and PAF support acquirement of implantation competence at blastocyst stage through a PKC pathway.

• Clinical and Experimental Pediatrics
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• v.49 no.10
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• pp.1019-1025
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• 2006

Motor delay, when present, is usually the first concern brought by the parents of children with developmental delay. Cerebral palsy that is the most common motor delay, is a nonspecific, descriptive term pertaining to disordered motor function that is evident in early infancy and is characterized by changes in muscle tone, muscle weakness, involuntary movements, ataxia, or a combination of these abnormalities. A wide range of causative disorders and risk factors have been identified for cerebral palsy, and broadly classified into 5 groups; perinatal brain injury, brain injury related to prematurity, developmental abnormalities, prenatal risk factors, and postnatal brain injury. Delay in attaining developmental milestones is the most distinctive presenting complaint in children with cerebral palsy. A detailed history and thorough physical and neurologic examinations are crucial in the diagnostic process. The clinician should be cautious about diagnostic pronouncement unless the findings are unequivocal. Several serial examinations and history review are necessary. All children with cerebral palsy should undergo a neuroimaging study, preferably MRI, because an abnormality is documented on head MRI(89%) and CT(77%). The high incidence rates for mental retardation, epilepsy, ophthalmologic defects, speech and language disorders and hearing impairment make it imperative that all children with cerebral palsy be screened for mental retardation, ophthalmologic and hearing impairments, and speech and language disorders; nutrition, growth, and swallowing also should be closely monitored.

• Journal of The Korean Association For Science Education
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• v.23 no.4
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• pp.386-400
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• 2003

This paper presents an analysis of the Developmental Approaches in Science, Health and Technology (DASH) program, a K-6 curriculum developed by the Curriculum Research & Development Group (CRDG) at the University of Hawaii employing the curriculum analysis framework created by Posner. Using this framework the analyst found that the DASH design is based on the research on learning, teaching, and assessment now driving efforts to reform science education at the elementary level. DASH embraces the constructivist idea that learning is a personal and social process and the recapitulation model that new concepts are built out of theories previously learned. DASH provides an understandable, exciting, and memorable experience in the operations of science, health, and technology, and develops their capacity to use the skills and knowledge of science, health, and technology both in and outside school. A number of studies of DASH have examined its functionality, effectiveness of pedagogy and what students learn. The innovative nature of DASH necessitated a multidimensional assessment that included both quantitative and qualitative research techniques. Ongoing development of the DASH program in the research setting of a university laboratory school permits ever deeper connections with emerging curriculum theory and curriculum practice, and allows new linkages as ideas are tested in research classrooms.

• Applied Microscopy
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• v.47 no.4
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• pp.242-250
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• 2017

The purpose of this study was to characterize the prenatal and postnatal development of the mouse parotid salivary gland and tooth, and to investigate the relationship between the developmental timing of the two organs. Development of parotid salivary gland begins on embryonic day 15 (E15), which is the prebud stage; E17 is the initial bud stage; E21 to postnatal day 3 (PN3) is the pseudoglandular stage; PN5 to PN10 is the canalicular stage; and PN21 is the terminal bud stage. At E15, the developing maxillary molar tissue is at the bud stage; at E17, it is at the cap stage; at E21, it is at the early bell stage; PN3 to PN5 comprises the advanced bell stage; at PN10, it is at the crown stage; at PN21, it is at the functional stage. Therefore, unlike the other major salivary glands, the development of mouse parotid salivary gland is completed through a process of prenatal and postnatal morphogenesis and becomes functional at about the same time as the developing tooth. The developmental completion times of the parotid salivary gland and tooth are closely related to the weaning time of animal.

• Journal of Sport and Applied Science
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• v.5 no.2
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• pp.47-53
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• 2021

Purpose: The purpose of this study is to generate industrial insights for developing sports movie industry. Related studies are scare. Research design, data, and methodology: The study employed case study and selected typical case samples who seem informative about sport movie industry. The authors interviewed six experts who are experienced in sport movie and related academic sector. Interviews were audio-taped and the text were decoded by multiple reading. Through this process, the study categorized significant meanings and produced results. Interviewees reviewed again the final findings to confirm validity, which calls member check. Results: It was suggested that developmental factors of sports movie were the realization of realistic sports scenes by using technologies. Second, participants told that contents of sport movie need to reflect real stories and it should tell the stories. Regarding constraints of sport movies, movie producers feel difficulty to make scenes in that sports are inherently quickly performed. Another constraints are that production cost is expensive but audiences are barely attended. Conclusions: For promoting economic outcomes and developing sport movie industry, government needs to financially support related markets to support sport movie producers assisting them to concentrate their movie works. Future directions for related-studies were discussed.

• Journal of Animal Science and Technology
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• v.63 no.2
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• pp.281-294
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• 2021

Although somatic cell nuclear transfer (SCNT) is frequently employed to produce cloned animals in laboratories, this technique is expensive and inefficient. Therefore, the handmade cloning (HMC) technique has been suggested to simplify and advance the cloning process, however, HMC wastes many oocytes and leads to mitochondrial heteroplasmy. To solve these problems, we propose a modified handmade cloning (mHMC) technique that uses simple laboratory equipment, i.e., a Pasteur pipette and an alcohol lamp, applying it to porcine embryo cloning. To validate the application of mHMC to pig cloning, embryos produced through SCNT and mHMC are compared using multiple methods, such as enucleation efficiency, oxidative stress, embryo developmental competence, and gene expression. The results show no significant differences between techniques except in the enucleation efficiency. The 8-cell and 16-cell embryo developmental competence and Oct4 expression levels exhibit significant differences. However, the blastocyst rate is not significantly different between mHMC and SCNT. This study verifies that cloned embryos derived from the two techniques exhibit similar generation and developmental competence. Thus, we suggest that mHMC could replace SCNT for simpler and cheaper porcine cloning.

• The Journal of the Korea Contents Association
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• v.12 no.12
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• pp.126-134
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• 2012

The researchers of this study closely looked into the methods for cognitive-scientific approach to problems of marine design at a time when the overall values of marine cultures are acknowledged in full scale. To that end, the researchers analyzed the problems and problem-solving process for the initial approach to marine design. At the same time, the researchers made the matrix of the design-developmental directions by cognitive scientific approach. After selecting the subjects, the researchers collected verbal protocol and behavior protocol which were shown in the process of a designer's thinking. This was for the sake of protocol analysis which is the representative research technique of cognitive science. Based on the collected data, the researchers empirically analyzed the behavior patterns shown in the marine design process so as to develop the design behavior-graph pattern of designers in an objective and systematic way. The behavior graph was helpful for looking into the initial developmental directions of design and for predicting cognitive structure of designers. The researchers hope that this study will become a fundamental material for predicting cognitive directions of designer for planning and designing the marine design.

• Clinical and Experimental Reproductive Medicine
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• v.32 no.4
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• pp.337-346
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• 2005

Objective: The oligosaccharide moieties of glycoproteins and proteoglycans have a vital function in blastocyst differentiation. Concanavalin (ConA), a lectin, is known to bind on the preimplantation embryos, especially on blastocyst. In this study, we investigated whether ConA can modulate the trophoblast development and about the regulating mediator. Also, we investigated whether expansion is enough for hatching procession of the mouse blastocyst. Method: Embryos were collected at 72 h post hCG injection and chemicals were treated after 24 h (96 hr post hCG injection). ConA or calcium ionophore A23187 were exposed to blastocyst and than analysis the developmental process for 48 hr. Intracellular free-$Ca^{2+}$ concentration in trophectoderm was measured with confocal laser microscope after exposing to ConA or calcium ionophore A23187. ConA-pretreated blastocyst exposed to the calcium ionophore A23187 and then analyzed the developmental process. Otherwise ouabain was treated to the blastocyst to block the $Na^+/K^+$-ATPase activity. Results: In contrast to the control blastocyst, the ConA-exposed blastocysts developed beyond the expansion stage with significantly high rate (90.4%) at 12 h post administration. ConA induced an increase the intracellular $Ca^{2+}$ concentration in trophectoderm. Calcium ionophore A23187 also stimulated expansion of blastocyst. Most of the control blastocysts developed to the hatching stage at 144 h post hCG injection. However, strongly 65% of the ConA-exposed embryos were arrested at expanded stage at same time point. The developmental progression rates to hatching stage of both ConA- and calcium ionophore A23187-expose blastocysts were significantly lower than that of the control. However ConA-pretreated embryos developed to the hatching stage like control embryos. Ouabain showed a tendency to delayed the progress to expansion stage but did not inhibit the development to the hatching stage. Conclusion: ConA-mediated expansion is the result of the increase of intracellular free-calcium in blastocyst stage embryo. It is suspected that expansion of the blasocyst is a essential indirect factor in hatching and the calcium may triggering the cellular mechanisms for the both expansion and hatching progression.

• The Korean Journal of Emergency Medical Services
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• v.5 no.1
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• pp.7-14
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• 2001

The purposes of this study which was conducted by inquiring into some curricula for Emergency Medical Dispatchers(EMDs) are to introduce a curriculum into Korea and develop a textbook for training of the EMDs in Korea. The conclusions from this study were summarized as follows; (1) There are some professional demands in our Emergency Medical Dispatch field therefore, now it is necessary to set up an education system for the EMDs in Korea and give them a suitable name to this change. (2) Some historical turning points which are condensed from the developmental process in the USA. including "Medical Self Help" with no formal dispatch protocols, Medical Priority Dispatch System, Practice Standard, Dispatch Protocols will serve as a good reference for establishing and education system for the EMDs. (3) To effectively train the EMDs in Korea, we needed to be introduced to Emergency Medical Dispatch : National Standard of Curriculum from the U.S. Department of Transportation & the National Highway Traffic Safety Administration which is made up Basic Emergency Medical Concepts, Information Gatherin & Dispatch, Introduction to the Emergency Medical Dispatch Protocol Reference System(EMDPRS) & 32 Chief Complaint Types. (4) The introduced curriculum closely related to the medical director, the direct indirect medical control, the scope of practice in the USA, should be revised for the Emergency Medical Service System of Korea. But to reduce the developmental process & time, it is necessary to postpone the consideration on these factors until publishing a new textbook. (5) This study which gives the cornerstone about some developmental methods on textbook for EMDs will be helpful to build up an education system for EMDs such as Curriculum, EMD Certification, National Academy of Emergency Medical Dispatch to fit the Emergency Medical Service System of Korea in the future.

• Health Policy and Management
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• v.12 no.4
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• pp.34-55
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• 2002

In this study, the impact of organizational culture on the quality of social work services in hospitals were empirically analysed. A mailed questionnaire survey was conducted between February 19 and April 10, 2001. A sample of total 70 hospitals, including general hospitals with one social worker at least and single-department hospital with two social workers or more, were identified nationwide through the registry of Korean Association of Medical Social Workers and Korean Association of Hospitals. According to coping strategy and reacting pattern with the environmental changes, four types of organizational culture in each hospital, classified as group culture, developmental culture, hierarchial culture, and rational culture, were adopted for the independent variables. Three dimensional aspects of quality of social work service - structure, process, and outcome were selected as dependent variables in this study. Also the quality of social work service was distributed into provider-perceiving quality and consumer-perceiving quality The major findings were as following in summary; First, most social workers reported that the characteristic of culture in their hospitals are group culture the first, hierarchial culture the second, developmental culture the third, and rational culture finally in order of comparing the level of quality perceived between social worker's recognition. Second, service provider and consumer, The provider-perceiving quality showed less score than that of consumer, especially the lowest was the score of quality of outcome perceived by provider. Third, according to the types of organizational culture, there were significantly different levels of quality in total social work services, structure dimension and process dimension. The quality of outcome dimension did not show significant differences among the type of organizational culture. Finally, the most influential variables to the quality of social work service ice proved departmental form of social work unit, leader of social work unit, and developmental culture of hospital To assure quality services, accordingly, social work unit in hospital is required to be organized as a single unit, that means to be an independent department of which qualified social worker is supposed to control the unit. It is strongly recommended to develop leadership for the leaders of social work unit.