Applied Microscopy

Korean Society of Microscopy (한국현미경학회)
권호 표지
DOI QR코드

DOI QR Code

Morphological Study on the Correlation of Prenatal and Postnatal Development between Mouse Parotid Salivary Gland and Tooth

  • Jeong, Soon-Jeong (Department of Dental Hygiene, College of Health Science, Youngsan University) ;
  • Jeong, Moon-Jin (Department of Oral Histology and Developmental Biology, School of Dentistry, Chosun University)
  • Received : 2017.10.17
  • Accepted : 2017.12.04
  • Published : 2017.12.30
Download PDF
⟨ Previous Next ⟩

Abstract

The purpose of this study was to characterize the prenatal and postnatal development of the mouse parotid salivary gland and tooth, and to investigate the relationship between the developmental timing of the two organs. Development of parotid salivary gland begins on embryonic day 15 (E15), which is the prebud stage; E17 is the initial bud stage; E21 to postnatal day 3 (PN3) is the pseudoglandular stage; PN5 to PN10 is the canalicular stage; and PN21 is the terminal bud stage. At E15, the developing maxillary molar tissue is at the bud stage; at E17, it is at the cap stage; at E21, it is at the early bell stage; PN3 to PN5 comprises the advanced bell stage; at PN10, it is at the crown stage; at PN21, it is at the functional stage. Therefore, unlike the other major salivary glands, the development of mouse parotid salivary gland is completed through a process of prenatal and postnatal morphogenesis and becomes functional at about the same time as the developing tooth. The developmental completion times of the parotid salivary gland and tooth are closely related to the weaning time of animal.

Keywords

References

  1. Amano O (2011) The salivary gland: anatomy for surgeons and researchers. Jap. J. Oral Maxillofac. Surg. 57, 384-393. https://doi.org/10.5794/jjoms.57.384
  2. Amano O, Mizobe K, Bando Y, and Sakiyama K (2012) Anatomy and histology of rodent and human major salivary glands-Overview of the Japan salivary gland society-sponsored workshop. Acta Histochem. Cytochem. 45, 241-250. https://doi.org/10.1267/ahc.12013
  3. Antonio N (2008) Salivary glands. In: Ten Cate's Oral Histology, Development, Streucture and Function, 7th ed. ed. Antonio N, pp. 290-318, (Elsevier, St. Louis).
  4. Ball W D (1974) Development of the rat salivary glands. III. Mesenchymal specificity in the morphogenesis of the embryonic submaxillary and sublingual glands of the rat. J. Exp. Zool. 188, 277-288. https://doi.org/10.1002/jez.1401880304
  5. Chi J G (1996) Prenatal development of human major salivary glands. Histological and immunohistochemical characteristics with reference to dault and neoplastic salivary glands. J. Korean Med. Sci. 11, 203-216. https://doi.org/10.3346/jkms.1996.11.3.203
  6. Cutler L S and Gremski W (1991) Epithelial-mesenchymal interactions in the development of salivary glands. Crit. Rev. Oral Med. 2, 1-12. https://doi.org/10.1177/10454411910020010101
  7. Denny PC, Ball WD, and Redman RS (1997) Salivary glands: a paradigm for diversity of gland development. Crit. Rev. Oral Biol. Med. 8, 51-75. https://doi.org/10.1177/10454411970080010301
  8. Hardman P, Landels E, Woolfe A, and Spooner B (1994) TGF-beta inhibits growth and branching morphogenesis in embryonic mouse submandibular and sublingual glands in vitro. Dev. Growth Diff. 36, 567-577. https://doi.org/10.1111/j.1440-169X.1994.00567.x
  9. Jaskoll T, Chen H, Denny P, Denny P, and Melnick M (1998) Mouse submandibular gland mucin: embryo-specific mRNA and protein species. Mech. Dev. 74, 179-183. https://doi.org/10.1016/S0925-4773(98)00062-8
  10. Jaskoll T and Melnick M (1999) Submandibular gland morphogenesis: stage-specific expression of TGF-alpha, EGF, TGF-beta, TNF and IL-6 signal transduction in normal mice and the phenotypic effects of TGF-beta2, TGF-beta3, and EGF-R null mutaions. Anat. Rec. 256, 252-268. https://doi.org/10.1002/(SICI)1097-0185(19991101)256:3<252::AID-AR5>3.0.CO;2-6
  11. Larsen M, Yamada K M, and Musselmann K (2010) Systems analysis of salivary gland development and disease. Rev. Syst. Biol. Med. 2, 670-682.
  12. Lawson K A (1972) The role of mesenchyme in the morphogenesis and functional differentiation of rat salivary epithelium. J. Embryol. Exp. Morphol. 27, 497-513.
  13. Leith N J, Nelson J W, Mellas R E, McCall A D, and Baker O J (2014) Threedimensional cultures of mouse submandibular and parotid glands: a comparative study. J. Tissue Eng. Regen. Med. doi: 10.1002/term.1952.
  14. Lui F and Wang S (2014) Moleculra cues for development and regeneration of salivary glands. Histol. Histopathol. 29, 305-312.
  15. Kallenbach E (1970) Fine structure of rat incisor enamel organ during late pigmentation and regression stages. J. Ultrastruct. Res. 30, 38-63. https://doi.org/10.1016/S0022-5320(70)90063-8
  16. Kashimata M and Gresik E (1997) Epidermal growth factor system is a physiological regulator of development of the mouse fetal submandibular gland and regulates expression of the ${\alpha}6$-integrin subunit. Develop. Dyn. 208, 149-161. https://doi.org/10.1002/(SICI)1097-0177(199702)208:2<149::AID-AJA2>3.0.CO;2-I
  17. Kashimata M, Sayeed S, Ka A, Onetti-Muda A, Sakagami H, Faraggiana T, and Gresik E W (2000a) The ERK-1/2 signaling pathway is involved in the stimulation of branching morphogenesis of fetal mouse submandibular glands by EGF. Dev. Biol. 220, 183-196. https://doi.org/10.1006/dbio.2000.9639
  18. Kashimata M W, Sakagami H W, and Gresik E W (2000b) Intracellular signaling cascades activated by the EGF receptor and/or intgrins, with potential relevance for branching morphogenesis of the fetal mouse submandibular gland. Eur. J. Morphol. 38, 269-275. https://doi.org/10.1076/ejom.38.4.0269
  19. Maas R and Bei M (1997) The genetic control of early tooth development. Crit. Rev. Oral Biol. Med. 8, 4-39. https://doi.org/10.1177/10454411970080010101
  20. Melnick M, Chen H, Zhou Y M, and Jaskoll T (2001) Embryonic mouse submandibular salivary gland morphogenesis and the TNF/TNF-R1 signal transduction pathway. Anat. Rec. 262, 318-320. https://doi.org/10.1002/1097-0185(20010301)262:3<318::AID-AR1023>3.0.CO;2-3
  21. Melnick M and Jaskoll T (2000) Mouse submandibular gland morphogenesis: a paradigm for embryonic signal processing. Crit. Rev. Oral Biol. 11, 199-215. https://doi.org/10.1177/10454411000110020401
  22. Ogawa M, Oshima M, Imamura A, Sekine Y, Ishida K, Yamashita K, Nakajima K, Hirayama M, Tachikawa T, and Tsuji T (2013) Functional salivary gland regeneration by transplantation of a bioengineered organ germ. Nat. Commun. doi: 10.1038/ncomms3498.
  23. Okumura K, Shinohara M, and Endo F (2012) Capability of tissue stem cells to organize into salivary rudiments. Stem Cells Int. doi: 10.1155/2012/502136.
  24. Poulsen K, Jakobsen B K, Mikkelsen B M, Harmark Kim, Nielsen J T, and Hjorth J P (1986) Coordination of murine parotid secretory protein and salivary amylase expression. EMBO. J. 5, 1891-1896.
  25. Redman R S (1988) Development of the salivary glands. In: The Salivary System, ed. Sreebny L M, pp. 1-20, (CRC Press, Boca Raton, FL).
  26. Redman R S and Sreebny L M (1970) The prenatal phase of the morphosis of the rat parotid gland. Anat. Rec. 168, 127-138. https://doi.org/10.1002/ar.1091680201
  27. Rego M J, Silva Filho A F, Sobral A P, and Beltrao E I (2016) Glycomic profile of the human parotid gland between 18th and 26th week of fetal development. J. Oral Sci. 58, 353-360. https://doi.org/10.2334/josnusd.15-0299
  28. Riberiro T T, Sottovia A D, Cestari T M, and Taga R (2006) Morphometric study of the postnatal growth of the parotid gland of the mouse. Braz. Oral Res. 20, 13-20. https://doi.org/10.1590/S1806-83242006000100004
  29. Rodrigo S L, Nanci A, Kurtz I, Wright J T, and Paine M L (2010) Regulation of pH During amelogenesis. Calcif. Tissue Int. 86, 91-103. https://doi.org/10.1007/s00223-009-9326-7
  30. Saracco C G and Crabill E V (1993) Anatomy of the human salivary glands. In: Biology of the Salivary Glands, ed. Dobrosielski-Vergona K, pp. 1-14, (CRC Press, Boca Raton, FL).
  31. Theslef I and Sharpe P (1997) Signaling networks regulating dental development. Mech. Dev. 67, 111-123. https://doi.org/10.1016/S0925-4773(97)00115-9
  32. Tucker A S (2007) Salivary gland development. Semin. Cell Cev. Biol. 18, 237-244. https://doi.org/10.1016/j.semcdb.2007.01.006
  33. Varner V D and Nelson C M (2014) Cellular and physical mechanisms of branching morphogenesis. Development 141, 2750-2756. https://doi.org/10.1242/dev.104794
  34. Williams P L, Warwick R, Dyson M, and Bannister L H (1989) Gray's Anatomy. 37th ed. pp. 1290-1298, (Churchill Livingstone, Edinburgh).
  35. Zhou J, Wang H, Tang G, Wang X, Sun Y, Song T, Zhang C, and Wang S (2010) Histological and ultrastructural characterization of developing miniature pig salivary glands. Anat. Rec. 293, 1227-1239. https://doi.org/10.1002/ar.21153