• Communications for Statistical Applications and Methods
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• v.27 no.1
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• pp.15-35
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• 2020

In research on behavioral studies, significant attention has been paid to the stage-sequential process for multiple latent class variables. We now explore the stage-sequential process of multiple latent class variables using the multivariate latent class profile analysis (MLCPA). A latent profile variable, representing the stage-sequential process in MLCPA, is formed by a set of repeatedly measured categorical response variables. This paper proposes the extended MLCPA in order to explain an association between the latent profile variable and the latent group variable as a form of a two-dimensional contingency table. We applied the extended MLCPA to the National Longitudinal Survey on Youth 1997 (NLSY97) data to investigate the association between of developmental progression of depression and substance use behaviors among adolescents who experienced Authoritarian parental styles in their youth.

• BMB Reports
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• v.35 no.1
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• pp.94-105
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• 2002

Apoptotic cell death is a fundamental and highly regulated biological process in which a cell is instructed to actively participate in its own demise. This process of cellular suicide is activated by developmental and environmental cues and normally plays an essential role in eliminating superfluous, damaged, and senescent cells of many tissue types. In recent years, a number of experimental studies have provided evidence of widespread neuronal and glial apoptosis following injury to the central nervous system (CNS). These studies indicate that injury-induced apoptosis can be detected from hours to days following injury and may contribute to neurological dysfunction. Given these findings, understanding the biochemical signaling events controlling apoptosis is a first step towards developing therapeutic agents that target this cell death process. This review will focus on molecular cell death pathways that are responsible for generating the apoptotic phenotype. It will also summarize what is currently known about the apoptotic signals that are activated in the injured CNS, and what potential strategies might be pursued to reduce this cell death process as a means to promote functional recovery.

• International Journal of Oral Biology
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• v.32 no.1
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• pp.35-43
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• 2007

Tooth loss in elderly is mainly caused by alveolar bone loss via severe periodontitis. Although the severity of periodontitis is known to be affected by age, the aging process or the genetic changes during the aging of periodontal tissue cells are not well characterized. In this study, we investigated the effect of in vitro aging on the change of gene expression pattern in periodontal fibroblasts. Gingival fibroblasts (GF) and periodontal ligament fibroblasts (PDL) were obtained from two young patients and replicative senescence was induced by sequential subcultivation. When more than 90% cells were positively stained with senescence-associated ${\beta},-galactosidase$, those cells were regarded as aged cells. In aged GF and PDL, the level of phosphorylated retinoblastoma (RB) and $p16^{INK4A}$ protein was significantly decreased and increased, respectively. However, the protein level of p53 and p21, well known senescence-inducing genes, did not increase in aged GF and PDL. Although $p27^{Kip1}$ and $p15^{INK4B}$, another cyclin-dependent kinase inhibitors, were reported to be involved in replicative senescence of human cells, they were decreased in aged GF and PDL. Because senescent cells showed flattened and enlarged cell shape and are known to have increased focal adhesion, we examined the protein level of several integrins. Aged GF and PDL showed increased protein level of integrin ${\alpha}2$, ${\alpha}v$, and ${\beta}1$. When the gene expression profiles of actively proliferating young cells and aged cells were compared by cDNA microarray of 3,063 genes and were confirmed by reverse transcription-polymerase chain reaction, 7 genes and 15 genes were significantly and commonly increased and decreased, respectively, in aged GF and PDL. Among them, included are the genes that were known to be involved in the regulation of cell cycle, gene transcription, or integrin signaling. The change of gene expression pattern in GF and PDL was minimally similar to that of oral keratinocyte. These results suggest that $p16^{INK4A}/RB$ might be involved in replicative senescence of periodontal fibroblasts and the change of gene expression profile during aging process is cell type specific.

• Proceedings of the KSAR Conference
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• 2003.06a
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• pp.56-56
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• 2003

Beta-catenin is very important in early development including involvement in cell adhesion, cell signaling, and developmental fate specification. Cell-cell interaction is an important process during mammalian embryonic development. In preimplantation embryos, embryonic compaction is the process of increased cellular flattening and adhesion of junctional complexes and results in a polarized distribution. Beta-catenin is associated with embryonic compaction in mammals. Here, we examined the relationship between beta-catenin expression and compaction in porcine embryos derived from in vitro fertilization. First of all, we investigated beta-catenin expression in each embryonic developmental stage and also focused on expression pattern according to full, partial and non-compaction at morula stage. We used the immunocyto-chemical method in this research. To confirm compaction affects on the embryonic development, we compared between compaction and developmental rates to the blastocyst. The result showed that compaction and non-compaction rates were 14.6% and 63.8% at 4 days after IVF, respectively The developmental rates to the blastocyst and their total cell number were 50.9% vs 36.4% and 41.4$\pm$11.5 vs 26.8$\pm$12.7 in compaction and non-compaction groups. Although no difference was detected in the ratio of ICM to total cells between two groups, total cell number of the blastocysts in compaction group was superior to that of the blastocysts in non-compaction group (P<0.05). Expression of beta-catenin appeared in the boundary of membrane surface between blastomeres in 2- and 4-cell stage, and observed irregular pattern from 8-cell to blastocyst stage. We also investigated beta-catenin expression pattern according to the degree of compaction in the 3 groups; full, partial (>50%) and non-compaction. The expression signal in fully compacted embryos was stronger than those of partial and non-compacted embryos. Especially, beta-catenin expression appeared various patterns in morula stage suggesting the aberrant distribution of beta-catenin is affected by compaction patterns. Our results suggest that abnormal beta-catenin expression was affected by embryo quality and further development in porcine embryos in vitro.

• 재활복지
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• v.22 no.2
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• pp.53-82
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• 2018

The purpose of this study was to understand the experience of persons with developmental disabilities participating in the Personalized Support Services. For case study, we conducted in-depth interviews with the persons with developmental disabilities and with the active supporters for them who were using the community welfare centers for the disabled. Through this, we have come up with three core categories: 'coming out into the community', 'experimenting with various choices in life', and 'living a subjective life'. This suggests the followings; First, it can be seen that persons with developmental disabilities who have limited communication and self-determination should be allowed to participate in the service through the participation process, and active support for the parties is needed in the process. Second, it is necessary to plan and support for them, centering on the parties, away from institution-centered services. Third, sufficient budget support should be provided for the self-determination, selection and control of the parties. Fourth, we should be able to enjoy everyday life by participating together in the local community, and change the perception of local residents to participate in the community. Fifth, continuous support is needed rather than temporary support. Finally it will be needed for us to listen to the voices of both parties and to represent their rights with all our efforts.

• KIEAE Journal
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• v.13 no.4
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• pp.87-94
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• 2013

This Study, as a Eco-Friendly Design Process of Office for sustainable design, aims to develop a sustainable design process by letting the designers easily approach the concept of Eco-Friendly Design Process and applying this to Eco-Friendly Design Process when the designers perform design. Through a review on simulation, a research was made on the seriousness of environmental problems and control that was caused by design, Environmentally friendly design, sustainability, and sustainable design's background and definition were studied. In order to develop a Eco-Friendly Design Process, an existing review from Building Energy Simulation that proposed about energy environmentally friendly design element and sustainable design element's semantic similarities were restructured as sustainable design element comparative analysis. Restructured sustainable design elements and the relationship between sustainable design elements and the relationship of each product developmental process levels were analyzed. Finally, through clustering, sustainable design guideline were developed. This Eco-Friendly Design Process is expected to be applied to as one of the methods in solving the global environmental issues in design practice.

• Culinary science and hospitality research
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• v.16 no.2
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• pp.155-169
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• 2010

Only specialized coffee stores which have a competitive power will survive in the future and what matters is that how well they satisfy customers. A variety of costumers regard their individuality as important and prefer the store which meets their value. Therefore, managers should have a marketing strategy which comes up to customers' expectations with a clarified concept. In this respect, this study focuses on the structure of a specialized Japanese coffee store system which is similar to that of Korea and its changing process. The purpose of this paper is to present an ideal strategy for a specialized Korean coffee store system after investigating Japanese various kinds of coffee, their developmental process, and the Japanese coffee market trend. According to this results, Korean studies on coffee are just focusing on the quality of services. Therefore, it is necessary to study the scale of stores, the classification between domestic coffee stores and those of foreign enterprises, and the comparative analysis of both individual coffee stores and franchised coffee stores.

• Journal of Forest and Environmental Science
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• v.23 no.1
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• pp.35-49
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• 2007

This study analyzed on the developmental process of forest policy direction in Korea and present status of forest desolation in North Korea of the pre and post division of the Korean peninsular with historical point of view and indicates future tasks to take. Forests in Korea were destroyed in the early of 1900s while Korean peninsular was under Japanese colonial rule. In 1945, Korea was divided into two parts, which developed its own forest policy under the different political system. South Korea was at Korean war in 1950 and accomplished the greening movement from 1970s to 1980s. After 1990s, the country has aimed to sustainable forest management. North Korea has focused on forestation until 1960. However, the result has been doubtful with North Korean economic depression, and these days North Korea faces forest desolation due to failures of forest management. Therefore, necessary is that recovery measures for forest desolation in North Korea, cooperation and interchange between North and South Korea and plans of forest management in case of unification.

• Journal of the Korea Computer Industry Society
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• v.2 no.10
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• pp.1285-1290
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• 2001

These days, good-quality multimedia educational data are exceedingly needed for ICT(Information and Communication Technology)-based instruction in elementary and secondary schools. In order to produce high quality multimedia educational data, it is important to design a series of development process and conduct a coherent examination. This paper presents a process of developing multimedia educational data and provides systematic assessment standards with respect to each step in which an evaluation is required. The step-by-step assessment standards may serve as a guideline in managing and monitoring the entire developmental process of multimedia educational data.

• Journal of the Korean Society for Library and Information Science
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• v.34 no.4
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• pp.27-47
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• 2000

The main project of the village mini-library movement is to establish and guide mini-libraries in the rural villages in Korea since 1961 in order to promote reading campaign. The purpose of this study is to examine into early developmental process of Korean mini-library movement from the formative period to 1967. Therefore, this study analyzes the principles of this movement, the policies for rearing mini-libraries, financial accommodation and the performance of this movement in 1960's. The study, in final, reviews the overall figure of the early process of this movement in Korea.