• Journal of Ginseng Research
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• 제30권2호
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• pp.70-77
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• 2006

Ginseng has an anti-cancer effect in several cancer models. As a mechanism study of ginsenoside-induced growth inhibition in cancer cells, we measured change of membrane potential in prostate cancer and glioma cells by ginsenosides, active constituents of ginseng. Membrane potential was estimated by measuring fluorescence change of DiBAC-Ioaded cells. Among 11 ginsenosides tested, ginsenosides $Rb_2$, $Rg_3$, and $Rh_2$ increased significantly and robustly the membrane potential in a concentration-dependent manner in prostate cancer and glioma cells. Ginsenosides Rc, Ro, and $Rb_1$ slightly increased membrane potential. The ginsenoside-induced membrane potential increase was not affected by treatment with pertussis toxin or U73122. The ginsenoside-induced membrane potential increase was not diminished in $Na^+$-free or $HCO_3^-$-free media. Furthermore, the ginsenoside-induced increase of membrane potential was not changed by EIPA (5-(N-ethyl-N-isopropyl)-amiloride), SITS (4-acetoamido-4'-isothiocyanostilbene-2,2'-disulfonic acid), and omeprazole. In summary, ginsenosides $Rb_2$, $Rg_3$, and $Rh_2$ increased membrane potential in prostate cancer and glioma cells in a GPCR-independent and $Na^+$ independent manner.

• Biomolecules & Therapeutics
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• 제14권2호
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• pp.110-113
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• 2006

We tested effect of sarcotride A, a bioactive cyclitol derivative from a marine sponge, on membrane potential in C6 glioma cells. Membrane potential was estimated by measuring fluorescence change of DiBAC-loaded glioma cells. Sarcotride A increased membrane potential in a concentration-dependent manner. We tested effects of pertussis toxin, U73122, EIPA, and $Na^+-free$ media on sarcotride A-induced increase of membrane potential to investigate involvement of G proteins, phospholipase C, $Na^+/H^+$ exchanger, and $Na^+$ channels. However, we were not able to observe any significant effect of those pharmacological inhibitors, excluding the involvement of the molecules as candidate targets or signaling molecules of sarcotride A-induced increase of membrane potential. Further investigation is necessary to elucidate action mechanism of sarcotride A.

• 한국지리정보학회지
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• 제11권4호
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• pp.112-121
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• 2008

본 연구에서는 부산광역시 기장군 개발제한구역 해제지내 집단취락지를 대상으로 순수개발지표 및 향후 개발여건들을 고려한 표준화 점수 도출로 우선순위를 결정하여 집단취락의 개발 잠재력을 도출하고자 하였다. 본 연구는 부산광역시 GIS Data를 사용하여 객관적이고 과학적인 분석을 위해 자연적, 물리적, 개발적, 접근성 측면의 4개 부문에서 개별지표를 선정하여 분석하였다. 분석 결과 해안변에 입지한 대규모 취락들은 개별지표 값들이 높은 지역으로 개발 잠재력이 높은 것으로 평가되었으며, 국도 14호선 서측의 내륙에 입지한 소규모 취락들은 개별지표 값들이 낮게 나타나 개발 잠재력이 낮은 것으로 평가되었다.

• The Journal of Asian Finance, Economics and Business
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• 제4권2호
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• pp.37-44
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• 2017

This research is devoted to the development of methods general and standard methodological approaches and approbation those for the evaluation of economic potential and level of concentration of the regions of Kazakhstan. This paper presents the results of development of the authors on the selection and justification of the methodological approaches for quantitative evaluation of the economic potential (the degree of territorial differentiation of the profile) and concentration of regions. In this study, we used scientific methods: method of analysis the main trends of economic development, and method of evaluation of concentration of the region. Based on the analysis of foreign techniques developed and tested methodical approaches to the assessment of the economic potential (index and coefficient methods). Proposed methodological approaches to the assessment profile of the territory and developed a system of indicators, which includes an aggregated index of spatial concentration, which accurately reflects the concentration of production in the region. This study shows the results of the analysis of the potential regional disparities and trends of economic development of Kazakhstan. By using, the proposed methodology shows the possibility of their use; we calculated the indicators of integrated assessment of the economic potential and indicators of spatial concentration.

• The Journal of Asian Finance, Economics and Business
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• 제7권5호
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• pp.103-110
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• 2020

This study analyzes the strategy of determining economic development planning on SME improvement in Indonesia. A qualitative approach was conducted through interview questionnaires with twenty respondents, including sixteen Regional Apparatus Work Unit, Fisheries and Marine Office lecturers, subdistrict heads, and development observers. The method used is Analytical Hierarchy Process (AHP). AHP prioritizes criteria and sub-criteria to increase economic growth, reduce poverty, and increase community participation, while indicating the sub-criteria to optimize resource potential, strengthen micro-economy, develop tourism potential, utilize fishery potential and cultivation, and improve institutional performance. The AHP weighting results based on competitiveness and regional development of Bantaeng Regency is the priority in policy-making for a solution. The research shows that the government strategy, based on the perception of the stakeholders, is: optimizing resources strategy with priority to maximize the resource-carrying capacity that includes agriculture and farm, tourism development potential strategy, self-reliance of community groups and coaching and management. Strategies to strengthen micro economy include: industrial control, SMEs, community cooperatives and infrastructure improvements, strategies to improve institutional performance work capacity and work ethic, and strategies to utilize fisheries and cultivation potential technological development, provision of processed industries of fishery products, and improvement of the quality of the environment.

• 한국응용곤충학회지
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• 제23권4호
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• pp.242-246
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• 1984

감자 괴경에 타박상을 입혔거나 세균현탁액을 주입했을 때 낮은 water potential(-6.46 bar) 보다 높은 water potential (-6.06 bar)에서 더 쉽게 부패를 초래하였으며, 높은 water potential을 가진 괴경과 낮은 water potential을 가진 괴경 사이에 있어서의 부패의 진전에는 큰 차이를 발견할 수 있었으며, 현탁액의 농도의 종류에 따른 괴경의 연부병의 이병정도는 높은 water potential에서 높았으며, 세균 현탁액 농도의 $ED_{50}$은 높은 water potential에서 $10^{8.5}\;cells/ml$이며 낮은 water potential에 서는 $100^{9.8}\;cells/ml$이었으며, 높은 water potential과 낮은 water potential $ED_{50}$에서는 작은 차이를 인정할 수 있었다. 이 시험에서 감자는 상처나 타박상이 나지 않도록 다루어야 하며 수확후 충분히 건조하여야 오랜 운반과 저장중에 연부병 발생을 크게 줄일 수 있다는 것을 나타낸다.

• 영재교육연구
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• 제5권2호
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• pp.91-119
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• 1995

The purpose of this study was to research the brain development program of childrens. Information gained from this study may be useful to school teachers who seek educational psychologist who are willing to guide students with potential minds. This study aimed to answer the research question as follows; What educational brain development program and strategegies did the children thinking as having influenced their potential minds. What educational brain development program and strategegies did the teachers thinking as having influenced their potential minds. To investigate the elementary students in kang seo gu bang hwa dong were selected. And the writing mind maps were examined for reports of mind maps. Some of the more salient findings are presented: Most of the elementary school 30 students came from very well mind maps where mind potential mind toward thinking. this study of the elementary school teacher came form well mind maps where mind potential mind toward thinking. The mind maps seemed to have been influenced positively in children brain development. Educational condition and events such as recommendation from mind maps had more effect on thinking than learning experiences had.

• International Journal of Computer Science & Network Security
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• 제22권1호
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• pp.340-346
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• 2022

The article examines the formation of the scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants. Based on the study of different scientific views on the nature and properties of potential-forming space through the study of approaches to understanding the concept of "space" clarified the complexity and multifaceted nature of the phenomenon and found that its characteristics are relevant to the industrial development model. It is revealed that the leading modern trends related to the spread of globalization and regionalization, rapid development of information and communication technologies, diffusion of innovations accompany the transition from industrial to post-industrial development and its development, which leads to new development: changes production, nature and relations between business entities, etc. It is proved that under such conditions, the region as a key element of the economic system, acquires a leading role in achieving sustainable and balanced development. These processes significantly affect the potential-forming space of the regional economy under the influence of intellectual and innovative determinants, leading to the need for its transformation and change in accordance with modern realities, which is reflected in thorough research on the formation of scientific paradigm based on the formation of its theoretical foundations and methodological basis. This study reveals the essence, role, functions, structure, process of formation of the scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants. It is proved that the formation of the modern scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants occurs in the context of building a post-industrial model of development, accompanied by consideration of the region as a spatial object territories from the physical plane to the spatial environment in which the development of human capital, innovation and self-development of the region. Taking into account the above, the article outlines the prerequisites and factors of formation of the scientific paradigm of transformation of the potential-forming space of the regional economy under the influence of intellectual and innovative determinants.

• Agribusiness and Information Management
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• 제2권1호
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• pp.105-116
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• 2010

In this knowledge based society, the debate on ICT has permanently shifted from 'why' ICT for development, to 'how' comprehensive and holistic ICT policies can unleash human potential and enhance people's capabilities to improve their lives. Recognizing this untapped potential and development strategies incorporating ICT are being increasingly promoted and launched across the developing countries. While the potential advantages of ICT for development are enormous in developed countries, national policies of developing countries are yet to adequately reflect truly comprehensive and integrated strategies for harnessing and exploiting this potential. This paper presents an analysis of National ICT policy of Bangladesh. Through the examination of ICT policy, in particular in the field of agriculture and rural development and analysis of applied policies and strategies implemented in these area, this paper identifies challenges and opportunities which provides lessons for policy-makers and practitioners involved in the field. This analysis reveals that the policy is inadequate to impact positively on the agriculture and rural development of Bangladesh. The policy places little emphasis on the integration and infusion of ICT in the country's agriculture and rural development. Policy implications and suggestions are offered to ensure maximum use of ICT potentials in the country's agriculture and rural development.

• International Journal of Computer Science & Network Security
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• 제21권8호
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• pp.97-104
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• 2021

The key challenges and problematic aspects of the formation of intellectually and innovation-oriented strategies of regional entities at the present stage of their development are considered. The main tasks that arise in the process of strategizing the potential-forming development of regional economic systems in the context of digitalization are identified. The list of key organizational and economic directions of strategic character of providing intellectual and innovative development of regional economic systems is formed, which includes clustering of centers of high-tech development of regions, creation of creative hubs, development of knowledge infrastructure and improvement of interregional cooperation; a brief description of each of the presented strategic organizational and economic directions is given. Based on the analysis, the key strategic guidelines for the development of regional economic entities in the context of digitalization under the influence of potential-forming determinants, which form the content basis for further processes of strategizing qualitative aspects of development of specific regional entities.