• Title/Summary/Keyword: Development factor

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Cell Differentiation Might Predict the Recurrence in Surgically Resected Non-Small Cell Lung Carcinoma (비소세포폐암 수술 후 세포분화도가 재발에 영향을 미친다)

  • Kang, Hyung-Koo;Cho, Sung-Gun;Lee, Hye-Min;Park, Sung-Woon;Lee, Byung-Ook;Lee, Jae-Hee;Kim, Bo-Min;Park, In-Won
    • Tuberculosis and Respiratory Diseases
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    • v.68 no.1
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    • pp.10-15
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    • 2010
  • Background: Lung cancer is the most common cause of cancer mortality in Korea. The TNM stage at presentation in patients with non-small cell lung cancer (NSCLC) has the greatest impact on prognosis. Patients who undergo a complete resection for NSCLC are likely to develop recurrent and/or metastatic disease. There are several factors influencing the development of recurrence. We explored risk factors of recurrence in patients with stages I and II NSCLC, who had undergone curative resection. Methods: We reviewed patients who had complete surgical resection as definitive treatment for stage I or II. Patients followed up for more than 36 months. We evaluated several factors which might have relationship with recurrence, such as patient's demographic factors, TNM staging, pathologic finding, tumor markers and surgical technique. Results: A total of 75 patients were enrolled for analysis, of whom 58 were men and 17 were women with mean age of 61 (range, 37 to 76) years. The average size of tumors was 3.9 cm (0.7 to 10 cm). There were 64 patients with stage I NSCLC and 11 with stage II NSCLC. Among 64 patients with stage I NSCLC, 35 patients showed recurrences whereas 8 patients have recurred in stage II NSCLC. Grade of differentiation of tumor was closely related to the recurrence. Seventy-five percent of patients who had poor tumor differentiation experienced a recurrence. In contrast, 3 patients of twelve had recurrences, who revealed differentiation in their tissue (p<0.05). Conclusion: Tumor differentiation could be a predictive factor for tumor recurrence in patients who have undergone curative resection for stage I or II NSCLC.

Effect of Therapeutic Gymnastic Ball Exercise in Patients With Chronic Low Back Pain (만성 요통환자의 치료를 위한 치료용 볼 운동의 효과)

  • Lee, Eun-Young;Bang, Yoo-Soon;Ko, Ja-Kyung
    • Physical Therapy Korea
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    • v.10 no.3
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    • pp.109-126
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    • 2003
  • This study was designed 10 investigate the effects of therapeutic gymnastic ball exercise on pain, flexibility, lumbar disability level and daily activity levels in male patients of the armed forces medical hospital who complain of chronic low back pain. Twenty-three males were placed in the experimental group and twenty-nine males were placed in the control group. All of the subjects were chosen on the basis of availability among in-patients who were diagnosed with low back pain. The control patients were matched to the experimental group and they were selected considering gender, pain duration and age. Gymnastic ball exercise therapy was developed by the author with the assistance of a rehabilitation specialist. Gymnastic ball exercise therapy includes muscle relaxation, flexibility, muscle strength and posture development exercises. The gymnastic ball exercise therapy was carried out by the experimental group three times a week for eight weeks. Before and after the experiments, the intensity of pain, the lumbar joint mobility (flexibility), the lumbar disability levels, and the daily activity levels of the subjects were measured, respectively. The intensity of pain and the lumbar disability levels were measured by the Visual Analogue Scale, the level of flexibility by a measurement ruler, and the level of disability by the Oswestry Low Back Pain Disability Scale. Data were analysed using a t-test, a paired t-test and an unpaired t-test. The results were as follows: 1. The intensity of pain in the lumbar spine in the experimental group was significantly decreased compared with that of the control group during the 4th week and 8th week. 2. The flexibility of the lumbar spine in the experimental group was significantly increased compared with that of the control group during the 4th week and 8 week. 3. The level of pain caused by anterior, posterior, left lateral and right lateral bending and by rotation in experimental group was significantly decreased compared with that of the control group. 4. The Oswestry Disability score of the experimental group was significantly increased compared with that of control group. These findings indicate that gymnastic ball exercise therapy could be effective in decreasing pain and lumbar disability, and increasing the daily activity levels and lumbar flexibility in patients with chronic low back pain. The study also suggests that gymnastic ball exercise therapy could be an essential factor for effective nursing intervention for patients suffering from chronic low back pain.

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Ecological Risk Assessment of Pharmaceuticals in the Surface Water Near a Pharmaceutical Manufacturing Complex in Korea (제약단지 인접 지역 지표수의 잔류 의약물질 생태위해성평가)

  • Park, Suhyun;Kang, Habyeong;Shin, Hyesoo;Ryoo, Ilhan;Choi, Kyungho;Kho, Younglim;Park, Kyunghwa;Kim, Kyungtae;Ji, Kyunghee
    • Journal of Environmental Health Sciences
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    • v.46 no.1
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    • pp.45-64
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    • 2020
  • Objectives: Limited information is available on the presence and associated ecological risks of pharmaceutical residues in aquatic environments near pharmaceutical manufacturing areas in Korea. In this study, we investigated the current state of pharmaceutical contamination and its associated ecological risks in streams near a pharmaceutical manufacturing complex. Methods: Seven pharmaceuticals (acetaminophen, clarithromycin, diclofenac, diphenhydramine, ibuprofen, mefenamic acid and roxithromycin) were measured in water samples collected from the streams near a pharmaceutical manufacturing complex. A predicted no-effect concentration (PNEC) was derived using either the assessment factor method or species sensitivity distribution method. In addition, a hazard quotient for each pharmaceutical was calculated by dividing its measured environmental concentration by its PNEC. Results: Samples collected downstream from the wastewater treatment plant (WWTP) had higher concentrations of pharmaceuticals than those collected from the reference site (upstream). Moreover, pharmaceutical concentrations were greater in ambient water than in the final effluent from the WWTP, which suggested that non-point sources were contributing to the contamination of the ambient water environment. Some of the target pharmaceuticals exhibited a hazard quotient >1, indicating that their potential ecological effects on the aquatic environment near the pharmaceutical industrial area should not be ignored. Conclusion: This study demonstrated that the pharmaceutical manufacturing area was contaminated with residual drugs, and that there was a possible non-point source near the WWTP effluent discharge area. The results of this study will aid in the development of management plans for pharmaceuticals, particularly in hotspots such as pharmaceutical industrial sites and their vicinities.

A Study(VI) on the Development of Charts and Equations Predicting Bearing Capacity for Prebored PHC Piles Socketed into Weathered Rock through Sandy Soil Layers - Axial Compressive Bearing Capacity Prediction Table Solution or Chart Solution - (사질토를 지나 풍화암에 소켓된 매입 PHC말뚝에서 지반의 허용압축지지력 산정도표 및 산정공식 개발에 관한 연구(VI) - 지반의 허용압축지지력 산정용 표해 또는 도해 -)

  • Nam, Moon S.;Kwon, Oh-Kyun;Park, Mincheol;Lee, Chang Uk;Choi, Yongkyu
    • Journal of the Korean Geotechnical Society
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    • v.35 no.11
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    • pp.75-95
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    • 2019
  • The numerical analysis on PHC piles socketed into weathered rocks through sandy soil layers was conducted to propose the table solution or the chart solution to obtain the mobilization capacity. The mobilization capacity was determined at the settlement of 5% pile diameter and applied a safety factor of 3.0. In order to utilize the excellent compressive strength of the PHC pile effectively, it is recommended that the allowable bearing capacity of ground would be designed to be more than the long-term allowable compressive pile load. A procedure for determining an allowable pile capacity for PHC piles socketed into weathered rocks through sandy soil layers is given by the sum of the allowable skin friction of the sandy soil layer and the weathered rock layer and the allowable end bearing capacity of the weathered rock layer. The design efficiency of the PHC pile is about 85% at the reasonable design stage in the verification of the newly proposed method. Thus, long-term allowable compressive load (Pall) level of PHC piles can be utilized in the optimal design stage.

A Study on the Status of Physical Exercise of Community People in City Area (도시지역주민의 운동실태와 관련요인)

  • 한중호;남철현
    • Korean Journal of Health Education and Promotion
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    • v.8 no.1
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    • pp.68-86
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    • 1991
  • This study was carried out to investigate consciousness level of physical exercise and analyze factors affection to the practice of exercise. The main purpose of the study was to give basic and necessary data in developing of program regarding to the physical exercise of the people and social athletics. This study was conducted by trained surveyers, for dweller in three cities(Seoul, Taegu and Ulsan) during January 4. 1990 to January 24. 1990. The results of this study can be summarized as follows 1. The subject of criticism an investigation for general charactristic be conducted in Seoul, Taegu and Ulsan city area an objective 417 person, 432 person and 366 person was among those comparatively little more by male was higher rate than female. Those in classification was adopted by age group 20 years old adult 41.3% of most higher rate, age group evaluation, were 24.9% and other group were 18.4% comprehensively appearanced by adult group has most many value rate. 2. An objective of investigation survey was made to personnel were comparative an educated level significantly higher such as college graduated 48.8% this rate of value has most higher, High school graduated ; 30.1% and middle School gratuated were 11.7%. In addition the native comes from large city, Farming and fishing villages an rural area rate were shown as 29.6%, 28.4% and 19.9% each other. There by classification of occupational job was shown by students has 27.4% are most higher significantly, also there sales and service field job appearanced 15.1% and expert technical job is 9.0% Although nonreligion person rate were 37.3%, buddist, Christianity, Roman Catholicism all them each other shown 33.6%, 16.7% and 12.4%. An evaluation in economic situation value rate was appearanced by middle class level 61.7% and higher and low level are 14.4% and 23.9% with each other and married were 59.2%. 3. The people resident in cities area has pratice of health development by exercise person were 43.5% and value of rate for male has exercise practice is 52.5%, was significantly higher than female has by age group 10 years old and age group 50 years old is 52.6% and 47.3% was comparative higher rate also age group 30 is 35.1% of low factor was indicated. Although evaluated an economic situation rate was higher level get more taken the practice of health develop exercise(higher level 60.0% and low level is 32.9%). Although by higher level of educated were more taken pratice of their proper physical exercise(college graduated rate ; 52.2% of most higher and high school graduted ; 39.7% and then middle school graduated is 19.1%) unmarried taken exercise rate ; 48.4% is significantly higher than married person rate ; 40.8%. Although objective of native area of exercise rate of Urban area cities ; 52.5% are significantly higher farming and fishing native person rate ; 40.4% shown is most low.

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Civilization conflict factors of the spread of Terrorism - Focusing on Islam and Christianity - (테러 확산의 문명 갈등적 요인 : 기독교와 이슬람을 중심으로)

  • Gong, Bae Wan
    • Convergence Security Journal
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    • v.13 no.5
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    • pp.107-116
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    • 2013
  • Occur in various parts of the world and the new aspects of the regional conflict is spreading. Nation and civilization, one based on religious ideology, hegemonic tendencies areas of conflict are factors that appear. It has the characteristic that inheritance and conflict between civilizations is spreading. Christian and Islamic books, especially the confrontation and conflict is surfaced in the international political aspects, and a threat to the security of the human race is approaching. To assert the superiority of Western Christianity emerging countries, the salvation of mankind and world peace mission with the historical non-democracy, human rights, women's rights, underdevelopment, nuclear issues, and the spirit of Christian civilization, considered to be linked and reverse, Democracy Launching and human rights issues are forcing Western development model. Islam believes in absolute monotheism that God Lord only determined by the 'slave' and having the determination to serve the religious, political, social and cultural nature ingrained, and closely adjacent to each other geographically, to focus on in quency characteristics higher than the other civilizations are appearing. To assert the doctrine of non-violent Islam 'Koran' and 'knife' became known as the violent images appear in the armed conflict between the culture method. Today the world is facing a clash of civilizations is derived from the religious conflicts and confrontation and friction between the nations appear. In particular, the deep religious roots of Christianity and Islam, the Arab-Israeli conflict, including the right to live in strife confrontation between Christianity and Islam was spread. By a factor of civilization and the spread of terrorism occurred historically proven came here from all over the earth that is being generated is true. Civilization are the symbol of the nation and the species identity.

A Study of the Price Determinants for Public Residential Land Investment - From the Perspective of Land and Market Factors - (택지지구 공동주택용지의 투자가격 결정요인에 관한 연구 - 토지특성 및 시장요인 관점에서 -)

  • Choi, Kiheon;Lee, Sangyoub
    • Korean Journal of Construction Engineering and Management
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    • v.17 no.3
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    • pp.108-115
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    • 2016
  • The price determinant for land investment depends on the internal information process and subjective decision making by management in general. Accordingly, the systematic frame to determine the feasibility of investment price to the public residential land for multi-housing development by private sector has not been proposed. The purpose of this study is to explore the frame to determine the investment price for public residential land from the perspectives of land attribute and apartment market factor. Multiple regression has been implemented to confirm the eligibility of proposed model. Research findings indicate that the land area, floor area ratio, coverage ratio, location have been identified as the total land cost determinant, and for the determinants for floor area land cost, the ratio of apartment, sale price, rent price, etc, have been identified. This research intends to provide the basis for land providers to predict the land value as a raw material in market and present the indicators for land buyers to review the price adequacy for the investment.

Effect of Perceived Relational Supports on Entrepreneurial Motivation of Korean and Chinese University Students: Focused on mediating role of self-efficacy (지각된 관계적 지원이 한·중 대학생의 기업가적 동기에 미치는 영향: 자기효능감의 매개효과를 중심으로)

  • Yang, Jun Hwan
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.10 no.3
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    • pp.1-13
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    • 2015
  • Strong ties such as family members, relatives and close friends have been widely acknowledged as a vital factor when a potential entrepreneur attempts to initiate entrepreneurial activity. Recent theoretical arguments focus that family social capital, a form of social capital, that is embedded in family relationships can contribute to venture creation as well as to the development of competitive advantage for established firms. Meantime, there have been arguments that the most dominant single entrepreneurial ethnic group in the world is the Chinese people, while the People's Republic of China is widely recognized as fast growing economic power that is driven by entrepreneurial ventures in a large scale. This study tests the effect of perceived relational supports typically being provided by family members, close relatives and friends on forming self-efficacy and entrepreneurial motivation of university students by using samples collected from 4 Korean Universities(Wonkwang, Baekseok, Soongsil and Dankook university) and Guangzhou University in China. The mediating of self-efficacy was also tested to gain better understanding of the role of the variable. The results of the study suggest that 1) both self-efficacy and entrepreneurial motivation are influenced positively by the perceived relational supports, 2) self-efficacy of university students affects their entrepreneurial motivation positively, 3) self-efficacy is appeared to be mediated partially for China in between perceived relational supports and entrepreneurial motivation, but the same variable is exhibited a full mediation in the same path of the research model for Korea, which was a distinction between the students of two countries in this study. Discussion and practical implication on the results are provided.

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An Exploratory Study of Key Success Factors in Public R&D Institutions' Business Supporting Service -Focused on Ceramic Hidden Champion Project- (국가연구개발기관 기술사업화 종합지원사업 성공요인에 관한 탐색적 연구 -세라믹히든챔피언사업을 중심으로-)

  • Kwon, Kyung-Sup;Kim, Byeong-Jin;Ha, Kyu-Soo
    • Asia-Pacific Journal of Business Venturing and Entrepreneurship
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    • v.7 no.1
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    • pp.225-232
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    • 2012
  • The purpose of this study is to explore the necessity of technology commercialization aiding service from government-supported R&D institutions and find key success factors for market performance improvement of business ventures and SMEs. For this aim, we researched relevant theories and KICET(Korea Institute of Ceramic Engineering and Technology)'s "Ceramic Hidden Champion Supporting Project. As government-supported R&D institutions, KICET is not only providing its original main service which is technology advising and development, but also providing a full range of technology commercialization aiding service for business ventures including diagnosis, strategy planning, capital procurement, overseas marketing activity. Qualitative analysis based on relevant theories and meta-analysis framework suggest that such expansion of services is desirable for government-supported R&D institutions to increase market performance of business ventures and SMEs. To lead this business to success, we should develop effective management system and incentive system for external supporting companies and client companies. Also, coordination between team member's activities and budget procurement issue should be solved for further performance creation.

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A Study on the Traffic Accident Characteristics Analysis in Expressway Longitudinal Tunnel using a Logit Model (로짓모형을 이용한 고속도로 장대터널 교통사고 특성분석에 관한 연구)

  • Seo, Im-Ki;Park, Je-Jin;AhnNam, Byung-Ho;Lee, Jun-Young
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.32 no.6D
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    • pp.549-556
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    • 2012
  • Longitudinal tunnels are defined as tunnels with length of over 1km. Because of Korea's topographical conditions and as safety measures for linear design, many tunnels are inevitably being constructed in Korea. The number of longitudinal tunnels constructed on expressways amounted to 104 as of the end of 2010 with a total length of 192km. Given the increasing demand for tunnels and the increasing length of tunnels, a safety evaluation of longitudinal tunnels needs to be conducted. As such, this study selected design elements, transportation environment and delineation system as elements to check and tried to determine factors influencing road crashes. For this, tunnels have been classified based on history of crashes; ones with crashes and ones without crashes and statistically meaningful explanatory variables were selected. By using these variables, a logit model was development in order to better grasp the factors that directly and strongly influence crashes. The result, related to crashes as well as the analysis were utility tunnel interior materials of driving lane and passing lane, which are related to driver's visibility, lateral width widening to consolidate space in a tunnel, and annual average daily traffic (AADT) per lane. These results may be used in the future as analysis indicators when drawing up plans to prevent crashes in longitudinal tunnels.