• Asian Pacific Journal of Cancer Prevention
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• v.14 no.4
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• pp.2269-2272
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• 2013

Matrix metalloproteinases (MMPs) degrade various components of the extracellular matrix and functional polymorphisms in encoding genes may contribute to genetic susceptibility to many cancers. Up to now, associations between MMP-7 (-181A>G) and digestive system cancer risk have remained inconclusive. To better understand the role of the MMP-7 (-181A>G) genotype in digestive cancer development, we conducted this comprehensive meta-analysis encompassing 3,518 cases and 4,596 controls. Overall, the MMP-7 (-181A>G) polymorphism was associated with higher digestive system cancer risk on homozygote comparison (GG vs. AA, OR=1.21, 95% CI = 1.12-1.60) and in a dominant model (GG/GA vs. AA, OR=1.16, 95% CI =1.03-1.46). On subgroup analysis, this polymorphism was significantly linked to higher risks for gastric cancer (GG vs. AA, OR=1.22, 95% CI = 1.02-1.46; GA vs. AA, OR=1.82, 95% CI =1.16-2.87; GG/GA vs. AA, OR=1.13, 95% CI =1.01-1.27; GG vs. GA/AA, OR= 1.25, 95% CI = 1.06-2.39. We also observed increased susceptibility to colorectal cancer and esophageal SCC in both homozygote (OR = 1.13, 95% CI = 1.06-1.26) and heterozygote comparisons (OR = 1.45, 95% CI = 1.11-1.91). In the stratified analysis by controls, significant effects were only observed in population-based studies (GA vs. AA, OR=1.16, 95% CI=1.08-1.50; GA/AA vs. GG, OR=1.10, 95% CI=1.01-1.72). According to the source of ethnicity, a significantly increased risk was found among Asian populations in the homozygote model (GG vs. AA, OR=1.40, 95% CI=1.12-1.69), heterozygote model (GA vs. AA, OR=1.26, 95% CI=1.02-1.51), and dominant model (GG/GA vs. AA, OR=1.18, 95% CI=1.08-1.55). Our findings suggest that the MMP-7 (-181A>G) polymorphism may be a risk factor for digestive system cancer, especially among Asian populations.

• Journal of the Society of Disaster Information
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• v.8 no.1
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• pp.1-9
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• 2012

Informatization of society through the computer and the Internet, because large amounts of information production and exchange and new way of communicating is born. Passive way past the one-sided information flows actively interact to evolve in a manner of information producers and information consumers distinction and personal relationships that enhance the online Social Networking Service (SNS) has developed into the social structure of. Thus, the spread of information work closely with the social network structure spark social conflict may act as a factor, and systems and the environment, personal and cultural adaptation of speed to keep up with the rapid development of science and technology as the inability conflict and confusion should lead to even. This paper the characteristics of the information society, with a look at the evolution of social risk factors as the wavelength of information about this look at the role of private security sought to evaluate. Information Society in time and space by shrinking the area of human life that has brought the convenience and simplicity, whereas the non-performance due to the nature of anonymous raises many social side-effects are. This made the preparation of national regulatory measures, but for the protection of personal protection devices in the private sector has not yet been discussed. Way of life and property of the purchaser to protect an individual's private security will have to charge it.

• Journal of the Korean GEO-environmental Society
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• v.14 no.8
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• pp.11-21
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• 2013

In-situ test to find the change of $Fe^{2+}$ and $Mn^{2+}$ concentrations and ion contents in groundwater was conducted during two pumping tests at the riverbank filtration site, where is the riverine area of the Nakdong River in Changnyeong-Gun. Groundwater was sampled at one pumping well and 10 monitoring wells during a 5 steps drawdown pumping test with the rates from $500m^3/day$ to $900m^3/day$ and a constant pumping test with $800m^3/day$. The change in ion concentration of groundwater was more remarkable during a step drawdown pumping test than a constant pumping test. Especially, the decrease in $Fe^{2+}$ and $Mn^{2+}$ concentrations was distinct in a step drawdown pumping test and it happens predominantly along the direction that the radius of pumping influence was small due to a good aquifer connectivity to a pumping position. The precipitation and the oxidation of iron and manganese were caused by an air inflow and a disturbance in groundwater flow due to an abrupt change in pumping rate. The pumping rate and spatial distribution of an aquifer around a pumping well need to be considered as an important factor for the development of in-situ iron and manganese treatment technology.

• Journal of Korean Society of Coastal and Ocean Engineers
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• v.25 no.5
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• pp.317-326
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• 2013

Probabilistic design methods can consider uncertainties of design variables and are widely used in the design of vertical breakwaters. The probabilistic design methods include a partial safety factor method, reliabilitybased design method, and performance-based design method. Especially the performance-based design method calculates the accumulated sliding distance during the lifetime of the breakwater or during a design storm. Recently a time-dependent performance-based design method has been developed based on the first-passage probability of individual sliding distance during a design storm. However, because the allowable criteria in the first-passage probability method are not established, the stability of structures cannot be quantitatively evaluated. In this study, the allowable first-passage probabilities for two limit states are proposed by calculating the first-passage probabilities for the cross-sections designed with various water depths and characteristics of extreme wave height distributions. The allowable first-passage probabilities are proposed as 5% and 1%, respectively, for the repairable limit state (allowable individual sliding distance of 0.03 m) and ultimate limit state (allowable individual sliding distance of 0.1 m). The proposed criteria are applied to the evaluation of the effect of wave-height increase due to climate change on the stability of the breakwater.

• International Commerce and Information Review
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• v.15 no.3
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• pp.431-451
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• 2013

The aim of this study is to thoroughly review prior literature related to electronic bill of lading and investigate the current state of electronification of operational processes of both major international and domestic shipping lines. In addition, this study examines the meaning of Electronic Bill of Lading; the perception on Electronic Bill of Lading; and the impediment to Electronic Bill of Lading in the perspective of shipping lines. As a result, following obstacles deter further development of e-B/L: negative attitude on the utilization of e-B/L; the matter of trust on the utilization of e-B/L; and technical issues in relation to the use of e-B/L.

• Journal of Korean Society of Archives and Records Management
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• v.4 no.2
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• pp.76-90
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• 2004

There had been substantial demand for record management system with which to efficiently control the information circulation processes, involving accumulation of recorded materials, classification of information resources, and users access to them. It converged to a collaboration of Australian federation, and Sydney Records Centre and finally induced Australian Standard Records Management, commonly known as AS 4390. AS 4390 served later as a model for International Standard of Record Management. This paper introduces the current undertaking of Recordkeeping system development in Australia, which stems from the line of AS 4390 by analysing exhibited research approaches. The analysis includes the definition, regime of Recordkeeping system, design and implementing of guidelines of Recordkeeping System and information on metadata projects. It also highlights the necessity for standardization, as is the prime factor in promoting inter-linking of Tabularium on New Southwales State, CRS(Commonwealth Record Series), database system of Canberra National Archives and Australian Government Locator Service. From year 2005, as dictates, any record management system, serving public agency will be required to adapt Professional Archives Management System, which, by far, will enhance the inter-compatibility. In its application, the government need Thesaurus to eliminate possible redundancy in use of terminology and to promote correct usage of words.

• Journal of The Korean Association For Science Education
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• v.34 no.2
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• pp.123-134
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• 2014

This study aims to develop and validate an instrument to measure students' attitude toward convergence. To do so, we have defined five constructs (i.e. knowledge about convergence, personal relevance, social relevance, interest and self-efficacy) of 'attitude toward convergence' based on literature review, developed items, and collected data from 233 11th grade science track students. The validity of these items have been evaluated by Messick's framework (1995) (i.e. content, substantive, structural aspects of validity), experts' review, Rasch analysis, and confirmatory factor analysis using structural equation modeling. Our results have confirmed the five constructs and 23 selected items have met the benchmark of item validity. Moreover, the theoretical model illustrating that the high level of attitude toward convergence increases the level of science motivation has also been supported by the data. The items developed in this study will be used to measure students' attitude toward convergence and to estimate the effect of learning program for convergence science.

• Applied Chemistry for Engineering
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• v.21 no.6
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• pp.593-602
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• 2010

Chitosan as a natural polymer has superior physicochemical properties such as biocompatibility, biodegradability and nontoxicity, but application of chitosan for therapy of cancer and gene related-disease has been limited by poor solubility in aqueous solution. Therefore, low molecular weight water-soluble chitosan (LMWSC) with high reactivity and strong positive charge can be applied as a delivery system having function to carry in the specific tissue the bioactive material like poor solubility drug, or therapeutic gene and developed as a therapeutic system having good therapeutic efficiency. The most important factor for therapy of various diseases is to reveal the antigen or receptor expressed in specific lesion tissue and the antibody and ligand which can bind with antigen is to introduce at the biomaterials for enhancement the therapeutic efficiency. The studies for cationic synthetic polymer as drug or gene delivery have been actively performed, but it has many problems such as toxicity in the body, therapeutic efficiency. From this point of view, this article demonstrated the introduction of functional groups to target the specific tissue and therapeutic strategy using the modification of LMWSC with free-amine group. The development of these delivery system will provide a positive vision for cancer therapy.

• International Journal of Highway Engineering
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• v.13 no.3
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• pp.147-156
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• 2011

Since the urbanization process has been taking place, negative outcomes such as environmental pollution and traffic congestion have produced as well. Reflecting the phenomenon, our study assumed that physical structure of urban form were implicit in relation to both economic performance and cost. It can be interpreted that as the urban space has been growing bigger, economic performances such as regional product output, economy of scale and the effect of agglomeration economies are increased. On the contrary, the negative effects such as environmental pollution and traffic congestion were incurred as economic loss and expenses. It means that even though economic performance can help increase regional product output, we should consider the loss on economic expenses which are paid for social problems such as environmental pollution and traffic congestion, which are caused by urbanization. Therefore, this study aims to statistically validate the relationship between traffic congestion as the most representative economy costs and physical characteristics of urban in a large city such as Seoul and to suggest its implications. As a result of model development for empirical analysis, GRDP(0.604), the population(0.582), employment GINI coefficients(0.296), population GINI coefficients(0.254) in order led to congestion cost. We can come to the conclusion that in case of scale factor such as the population, if the population tends to concentrate, urban becomes more crowded and that if GINI coefficients (the population, employment) which are variable on inequality according to region have the disparity with surrounding areas, congestion cost is caused a lot on account of movement related with employment. In addition, this phenomenon was caused if both the population and employment were geographically biased on one side.

• Journal of Korea Water Resources Association
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• v.45 no.2
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• pp.179-189
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• 2012

To simulate the transport of pollutant, a numeric model for the advection-diffusion equation with the decay term is developed. This is finite-difference model using the implicit method (with the weight factor ${\alpha}$) and Gauss-Seidel SOR(successive over-relaxation). This model is compared to the analytical solutions (of simpler dimensional or boundary conditions), and in the condition of Peclet number < 5~20, the result shows stable condition, and Crank-Nicolson method (${\alpha}$=0.5) shows the more accurate results than fully-implicit method (${\alpha}$=1). The mass of advection, diffusion and decay is calculated and the error of mass balance is less than 3%. This model can evaluate the 3-D concentrations of the advection-diffusion and decay problems, but this model uses only the finite-difference method with the fixd grid system, so it can be effectively used in the problems with small Peclet numbers like the pollutant transport in groundwater.