• Journal of the Korean Association of Geographic Information Studies
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• v.15 no.2
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• pp.23-34
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• 2012

As the quality of life grows, the role of cultural facilities in urban areas is becoming more important. However, due to various reasons, the location of these facilities shows the geographical imbalance between urban regions. Even though provision of road network can improve this kind of urban problem, in many countries, the provision of urban infrastructure plays a role which is magnifies the cultural gap between regions and socio-economic classes. The findings of this study are as follows. First of all, the inequality of accessibility to cultural facilities is shown over the period. Cross-sectional data shows that the higher the income of a region, the higher the accessibility index(AI) of the zone to cultural facilities at any time. Next, the provision of road network contributes the improvement of AI of high income region. Finally the provision of new facilities has a tendency that these kind of facilities are located to make AI of high income zone better. It means that the decision making by city government intensifies the geographical inequality. This result would be very useful in the decision making process for determining the number and the location of cultural facilities and other similar urban infrastructure as well. Also it will be helpful for the selection of optimal location which considered not only physical distances but also social equalities.

• Journal of Korean society of Dental Hygiene
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• v.10 no.1
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• pp.157-172
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• 2010

Objectives : This study is to grasp the efficacy, locus of control, oral disease management beliefs, etc and to make a close inquiry the relevance between theses key figures and oral health promotion practice for a teacher and oral care about children and to provide the basic materials of oral health education for the teachers of infant nursery. Methods : This study was made from July to September in 2009 to nursery teacher by having the self-report questionnaire for teachers of infant nursery who are performing nursry school tearcher. Total 187 questionnaire were distributed and among these, 167 questionnaire excluding 20 questionnaire of incomplete responses were statistically analyzed with SPSS12.0. Results : The efficacy is highly in a married person(p=0.001) according to the teacher's age(P=0.006), perceived good oral status(p=0.001) according to the oral conditions and has the significant difference. The internal locus of control is highly in a married person(p=0.006) according to the teacher's age(P=0.037) and the marital status and has the significant difference statistically. The external locus of control is the highest(p=0.038) in the age of 40 among teacher's age and has the significant difference statistically. The oral disease management beliefs is the highest in the age of 20 ~ 29(p=0.001), highly in married(p=0.003) and has the significant difference according to the marital status and perceived good oral status(p=0.045) according to the oral conditions. There has no significant difference in the efficacy, the internal locus of control, the external Lotus of Control, oral disease management beliefs following by the infant oral care after taking medicines and oral care of infants after tooth brushing. Conclusions : Therefore, the oral health promotion activities should be induced by educating the nursery teacher and it needs to spread out the oral care education with the development to operate practically. It is considered in need of the infant oral care which is not burden on to the nursery teacher but helpful to the infant by connecting the subjects of dental hygiene and oral health education training.

• Journal of Life Science
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• v.25 no.8
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• pp.947-952
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• 2015

Prostate apoptosis response-4 (Par-4) was originally identified in androgen-independent prostate cancer cells undergoing apoptosis. Par-4 is ubiquitously expressed in normal cells and tissues, but it is downregulated in several types of cancers. Par-4 is a 38 kDa tumor suppressor protein encoded by the PARW gene. Par-4 promotes apoptosis in a variety of cancerous cells, but not in normal cells. In this review, we focused on the structure, expression and function of Par-4 in apoptotic signaling pathway. Functional domains of Par-4 include two nuclear localization sequences (NLS), a leucine zipper (LZ) domain, a nuclear export sequence (NES) and selective for apoptosis in cancer cell (SAC) domain. Many studies have underlined the importance of Par-4 in preventing cancer development. The activity of Par-4 is differently regulated by localization of intracellular and extracellular Par-4. Intracellular Par-4 inhibits Akt- and NF-κB-mediated cell survival pathways and downregulates Bcl-2 expression. Extracellular Par-4 activates the extrinsic apoptotic pathway by binding to cell surface receptor GRP78, a stress response protein that is in the endoplasmic reticulum (ER). Endogenous Par-4 sensitizes cancer cells to various apoptotic stimuli, while exogenous Par-4 enhances SAC domain-dependent apoptosis in cancer cells, but not normal cells. Therefore, Par-4 is an attractive target for cancer therapy.

• Journal of the Korean association of regional geographers
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• v.21 no.3
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• pp.489-502
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• 2015

Sometimes called the Silicon Fen, the Cambridge cluster is well known as the most innovative hi-tech cluster in the world. This paper attempts to explore the evolutionary dynamics of the Cambridge cluster, drawing upon the triple-helix approach. To understand the evolutionary dynamics of the Cambridge cluster, it is important to examine the role and impact of the University of Cambridge, which is conceived as one of the best higher educational institutions in the world. The Cambridge cluster has been evolved on the basis of a strong university-industry relationship. University spin-outs have a long tradition in Cambridge with the history of more than a century, and they have played a critical role in making the cluster more innovative. Business networks and social capital molded for a long time in the region become a foundation for active local spin-out activities. However, since 2000 the central government started steadily to require British universities to be an entrepreneurial university, with the purpose of the reduction of university subsidies. As a result of this, spin-out activities in the Cambridge cluster show a sharp decline, which is a factor of threatening the dynamic evolution of the cluster.

• Journal of Chest Surgery
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• v.47 no.4
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• pp.378-383
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• 2014

Background: Brother of the regulator of imprinted sites (BORIS) is a putative new oncogene that is classified as a cancer germline gene; however, its role in the development of cancer is unclear. This study investigated the expression of BORIS in lung cancer and its clinical implications. Methods: The expression of BORIS messenger ribonucleic acid (mRNA) in the sputum of 100 patients with lung cancer (50 with squamous cell carcinoma, 36 with adenocarcinoma, and 14 with small-cell carcinoma) was evaluated by reverse transcription polymerase chain reaction. Results: The overall expression rate of BORIS in patients with lung cancer was 36.0%: 19 of 50 squamous cell carcinomas (38.0%), 13 of 36 adenocarcinomas (36.1%), and 4 of 14 (28.6%) small-cell carcinomas. There was no significant difference in the BORIS expression according to age, gender, or histologic type. However, the mRNA expression of BORIS was significantly related to the pathologic cancer stage (p=0.004) and lymph node metastasis (p=0.001). The expression of the melanoma antigen gene family A1-6 was not associated with the expression of BORIS. Conclusion: Our results suggest that the expression of BORIS might be a negative prognostic factor in lung cancers and implicate BORIS as a molecular target for immunotherapy.

• Journal of Navigation and Port Research
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• v.38 no.4
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• pp.399-407
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• 2014

Due to the increase of container terminals, as the volume of terminals become distributed, the competition of preserving existing volume and inviting new volume are becoming fierce, and various ways for processing terminal volume and inviting volume are being sought. Container terminal efforts to maximize efficiency in order to improve the volume handling capability and productivity by both expansion of the latest equipment and development of the latest terminal system. There are a variety of factors that influence the improvement of productivity at container terminals. Among them, in the case of yard transfer equipment, if it were to convert from the method of a Yard Tractor(YT) being fixed allocated to a certain Gantry Cranes(GC) to a Pooling System that processes in a method that properly distributes and allocates a Yard Tractor(YT) to multiple Gantry Cranes(GC), the terminal productivity and the fusibility of YT may be increased. The KPI which is an indicator for the productivity at container terminals is GC productivity and since GC productivity cannot exceed the speed of physical GC operations, a Pooling System is applied to increase productivity which its meaning and effect is massive. Here in the Report, we produce the Pooling Algorithm system to improve the efficiency of the transported equipments in container terminal which is actually applying for this method and have compared Non pooling system with Pooling system in the fields. By introducing a transfer equipment pooling system and enhancing the productivity compared to other terminals, it may become an essential factor for increasing the continuous service quality and profitability in terms of terminal business.

• Journal of Korean Society of Transportation
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• v.34 no.1
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• pp.43-54
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• 2016

Although there are continuous demands for activating BSSs(Bicycle Sharing Systems) due to the convenience and positive health effects, it is difficult to make a decision to support the existing systems and build more systems because of the deficit resulting from the operation of BSSs. Consequently, this study estimated the economic effects(WTP; Willingness to Pay) of BSS and analyzed the impact factors of WTP to support the above decision making in Daejeon. For this, we conducted a survey and collected 668 samples from the users and non-users of TASHU that is the BSS operated in Daejeon. Also, we used CVM(Contingent Valuation Method) for the estimation of WTP. The results show that the number of bicycle uses is a determinant factor having a positive relationship with WTP and car ownership and age are also determinant factors having a negative relationship with WTP. On the other hand, income and sex have no significant statistical relationship with WTP. Also, the economic benefit of TASHU was estimated as much as 49.9 billion KRW to 63.6 billion KRW. Considering the operation cost of 2.5 billion KRW, it is quite big benefit. Based on the results, it needs to support TASHU from a user perspective for the efficient operation of the system.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.28 no.1
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• pp.85-92
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• 2015

This article presents the dynamic instability response of sigmoid functionally graded material plates on elastic foundation using the higher-order shear deformation theory. The higher-order shear deformation theory has ability to capture the quadratic variation of shear strain and consequently shear stress through the plate thickness. The governing equations are then written in the form of Mathieu-Hill equations and then Bolotin's method is employed to determine the instability regions. The boundaries of the instability regions are represented in the dynamic load and excitation frequency plane. The results of dynamic instability analysis of sigmoid functionally graded material plate are presented using the Navier's procedure to illustrate the effect of elastic foundation parameter on dynamic response. The relations between Winkler and Pasternak elastic foundation parameter are discussed by numerical results. Also, the effects of static load factor, power-law index and side-to-thickness ratio on dynamic instability analysis are investigated and discussed. In order to validate the present solutions, the reference solutions are used and discussed. The theoretical development as well as numerical solutions presented herein should serve as reference for the dynamic instability study of S-FGM plates.

• Journal of the Korean Society of Marine Environment & Safety
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• v.19 no.2
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• pp.171-178
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• 2013

This paper presents the Part 1 of the Questionnaire Survey on Marine Safety and VTS in the Philippine Coastal Waters. This part deals with respondents profiles; experiences onboard and ashore; familiar areas; and their subjective perception of marine risks- by factors and by areas. The subjects are chosen from different regions nationwide with connection and/or with maritime background. There are 202 responses returned and these are put into a database for analysis made through Excel programs and statistics references. The result of the nationwide responses show that 97 % of respondents have shipboard experiences onboard of different ships' types and sizes; and 88 % are directly involved in the navigation of ships. Risk Perception levels - by factors and by familiar areas - show a higher risk degree in the 3rd level ('Sometimes Increases Risks') and 4th level ('Often Increases Risk') in each respondents' response indices. The study finds that the most risky factor is the "Violation of Rules and Regulations" which has a high risk at 5th level (Very Often Increases Risk), and for the over-all familiar areas, the Manila Bay area (NCR region) garners the most risky perception, also, at the 5th level. It is, therefore, recommended by this paper to conduct a comprehensive review of the rules and regulations viable in each locality; strengthening the maritime traffic systems, structures and educating the stake-holders specifically in Manila Bay area and other busy waterways of the country. The ultimate goal of this paper is to gather information, analyze these data and develop a set of tools and techniques to be utilized as a guide in the improvement and development of maritime traffic safety in the country.

• Korean Journal of Microbiology
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• v.49 no.2
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• pp.105-111
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• 2013

The Erm family of adenine-$N^6$ methyltransferases (MTases) is responsible for the development of resistance to macrolide-lincosamide-streptogramin B antibiotics through the methylation of 23S ribosomal RNA. Recently, it has been proposed that well conserved amino acids in ErnC' located in concave cleft between N-terminal 'catalytic' domain and C-terminal 'RNA-binding' domain interacts with substrate RNA. We carried out the site-directed mutagenesis and studied the function of the ErmSF R237 mutant in vitro and in vivo. R237 amino acid residue is located in the concave cleft between two domains. Furthermore this residue is very highly conserved in almost all the Erm family. Purified mutant protein exhibited only 51% enzyme activity compared to wild-type. Escherichia coli with R237A mutant protein compared to the wild-type protein expressing E. coli did not show any difference in its MIC (minimal inhibitory concentration) suggesting that even with lowered enzyme activity, mutant protein was able to efficiently methylate 23S rRNA to confer the resistance on E. coli expressing this protein. But this observation strongly suggests that R237 of ErmSF probably interacts with substrate RNA affecting enzyme activity significantly.