• 한국기록관리학회지
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• 제21권1호
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• pp.163-187
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• 2021

한국의 기록관리는 행정적 발전을 이룬 데 반하여, 민간기업은 물론이고 기록관리가 정착되고 있는 공공기관에서도 경영진은 물론 직원들의 기록관리에 대한 인식이 상당히 부족하다. 이는 기록관리 영역이 기관의 경영 전략의 하나로 포함되어야 할 필요성을 보여주고 있다. 반면 지식경영은 경영의 한 축으로 오랜 시간 연구되어 왔다. 이에 이 연구에서는 ISO 15490-1:2016의 기록관리 프로세스와 지식경영 프로세스를 비교 분석하였다. 또한, ISO 30301에서 제시한 기록경영 구성 요소와 ISO 30401에서 제시한 지식경영의 구성 요소를 비교 분석하여서 기록경영이 지식경영과 같이 경영의 한 축이 될 수 있는지 확인하였다. 마지막으로 프로세스들과 경영 요소들의 비교 분석 내용을 토대로 기록관리와 지식경영의 통합모델을 제시하였고 통합모델 실행방안을 경영의 관점, 정보 거버넌스 관점으로 제시하였다.

• 한국산학기술학회논문지
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• 제22권2호
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• pp.134-138
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• 2021

스마트폰 등에서 사용되는 고성능 디스플레이에는 다양한 종류의 정밀한 플라스틱 박막 필름(Plastic Thin Film)이 사용되고 있다. 롤투롤(Roll-To-Roll) 공정으로 제조되는 플라스틱 박막 필름은 생산 공정 중에 실시간으로 필름의 두께가 계측되고, 정확하게 관리되어야 한다. 필름 제조 과정에서 필름에 장력이 작용하면서 주름이 발생되고, 이러한 주름 발생은 필름의 두께 방향과 두께 측정기의 광축이 서로 경사지게 한다. 결국 두께 측정기는 필름의 수직 두께가 아닌 경사진 두께를 측정하게 됨으로써 실제 두께보다 더 큰 값으로 측정하게 된다. 본 연구에서는, 플라스틱 필름의 경사로 인하여 발생하게 되는 두께 측정기에서의 계측값 오차를 보정하기 위하여, 필름의 경사 각도를 계측하는 연구가 진행되었다. 플라스틱 필름에 슬릿 빔 레이저를 조사하고, 필름에서 반사되는 슬릿 빔 레이저가 PSD(Position Sensitive Device)에 맺히는 광학 시스템을 구성하였으며, 실험을 통하여 필름의 경사 각도와 PSD 출력값의 관계를 1차 방정식 형태로 구하였다. 이를 이용하여 필름의 경사 각도를 측정하는 장치가 구축되었으며, 250KHz의 속도로 경사 각도의 측정이 가능하였다.

• 디지털융복합연구
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• 제19권1호
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• pp.45-49
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• 2021

최근 환경오염과 동물실험에 관한 관심이 대두되면서 소비의 큰 축을 형성하며 새로운 트렌드로 부상하고 있는 비건 뷰티에 관해 알아보고 뷰티산업과의 연관성을 조사하기 위해 비건 뷰티에 관한 인식, 특성 및 실태와 보완점을 중심으로 설문을 통해 조사 분석한 결과 비건 뷰티에 관한 인식은 전체의 31.3%로 매우 낮았으나 특성은 단점(3.04)보다 장점(3.08)이 높게 나타났고 실태는 향후 구매의사가 81.7%로 높게 나타났으며 전망 또한 87.3%로 매우 높게 나타났다. 따라서 아직은 비건 뷰티가 대중화.보편화 되지 않았으나 보완점으로 요구된 가격절충, 제품의 보편화 및 다양성, 성능개선 등을 개선한 비건 뷰티는 미래뷰티산업 발전에 긍정적 전망을 제시하리라 사료된다.

• Molecules and Cells
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• 제44권3호
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• pp.168-178
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• 2021

The retinal pigment epithelium (RPE) forms a monolayer sheet separating the retina and choroid in vertebrate eyes. The polarized nature of RPE is maintained by distributing membrane proteins differentially along apico-basal axis. We found the distributions of these proteins differ in embryonic, post-natal, and mature mouse RPE, suggesting developmental regulation of protein trafficking. Thus, we deleted tumor susceptibility gene 101 (Tsg101), a key component of endosomal sorting complexes required for transport (ESCRT), in embryonic and mature RPE to determine whether ESCRT-mediated endocytic protein trafficking correlated with the establishment and maintenance of RPE polarity. Loss of Tsg101 severely disturbed the polarity of RPE, which forms irregular aggregates exhibiting non-polarized distribution of cell adhesion proteins and activation of epidermal growth factor receptor signaling. These findings suggest that ESCRT-mediated protein trafficking is essential for the development and maintenance of RPE cell polarity.

• Steel and Composite Structures
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• 제42권2호
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• pp.173-190
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• 2022

With the development of spatial structures, the joints are becoming more and more complex to connect tubular members of spatial structures. In this study, an approach is proposed to establish high-efficiency finite element model of multiplanar KTX-joint with the weld geometries accurately simulated. Ultimate bearing capacity the KTX-joint is determined by the criterion of deformation limit and failure mechanism of chord wall buckling is studied. Size effect of fillet weld on the joint ultimate bearing capacity is preliminarily investigated. Based on the validated finite element model, a parametric study is performed to investigate the effects of geometric and loading parameters of KT-plane brace members on ultimate bearing capacity of the KTX-joint. The effect mechanism is revealed and several design suggestions are proposed. Several simple reinforcement methods are adopted to constrain the chord wall buckling. It is concluded that the finite element model established by proposed approach is capable of simulating static behaviors of multiplanar KTX-joint; chord wall buckling with large indentation is the typical failure mode of multiplanar KTX-joint, which also increases chord wall displacements in the axis directions of brace members in orthogonal plane; ultimate bearing capacity of the KTX-joint increases approximately linearly with the increase of fillet weld size within the allowed range; the effect mechanism of geometric and loading parameters are revealed by the assumption of restraint region and interaction between adjacent KT-plane brace members; relatively large diameter ratio, small overlapping ratio and small included angle are suggested for the KTX-joint to achieve larger ultimate bearing capacity; the adopted simple reinforcement methods can effectively constrain the chord wall buckling with the design of KTX-joint converted into design of uniplanar KT-joint.

• Animal Bioscience
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• 제35권5호
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• pp.698-710
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• 2022

Objective: The objective of this study was to investigate the effects of different degrees of maternal dietary energy restriction on lipid deposition in embryonic tissues during the medium laying period (37 to 39 weeks) in Arbor Acres (AA) broiler breeders. Methods: A single factor design was adopted, and 400 AA broiler breeders (20 weeks of age) with a similar weight were randomly allocated into four groups. The birds in the control group were fed a corn-soybean meal based diet, and those in trial groups were fed diets with 80%, 70%, and 50% energy levels of the basal diet. Incubated eggs from the medium laying period were collected. Samples of developing embryos at various stages were prepared for composition analysis. Results: The embryo weight in the 80% energy group was higher than those of the other groups on embryonic day (E) 13, but at 21 E, they were significantly decreased with decreasing energy intake of the broiler breeders (p<0.05). Additionally, the levels of crude fat in tissues in the restriction groups were significantly decreased (p<0.05). The long axis and area of adipocytes in breast muscle, thigh muscle and the liver were significantly decreased (p<0.05) at 21 E in the 80%, 70%, and 50% energy groups. Conclusion: The effects of the 80% maternal dietary energy restriction energy affects egg production performance, egg quality, and nutrient deposition in egg weights, which then directly impacts on the developmental process of embryos, especially on fat utilization and deposition.

• Journal of Forest and Environmental Science
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• 제38권4호
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• pp.239-248
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• 2022

Forestry crane work in a forest harvester or forwarder is regarded as one of most hard work requiring a very high level of operation skill. The operator must handle two or more multi-axes joysticks simultaneously to control the multiple manipulators for maneuvering the crane-tip to its intended location. This study has been carried out to develop a crane-tip controller which can intuitively maneuver the crane-tip, resulting in improving the productivity by decreasing the technical difficulty of control as well as reducing the workload. The crane-tip controller consists of a single 2-axis joystick and a control algorithm run on microcontroller. Lab-scale forestry crane was constructed using electric cylinders. The crane-tip control algorithm has the crane-tip follow the waypoints generated on the given path considering the dead band region using LBO (Lateral Boundary Offset). A speed control gain to change the speed of relevant cylinders relatively is applied as well. By the P (Proportional) control within the control interval of 20 msec, the average error of crane-tip control on the predefined straight path turned out to be 14.5 mm in all directions. When the joystick is used the waypoints are generated in real time by the direction signal from the joystick. In this case, the average error of path control was 12.4 mm for straight up, straight forward and straight down movements successively at a certain constant speed setting. In the slant movement of crane-tip by controlling two axes of joystick simultaneously, the movement of crane-tip was controlled in the average error of 15.9 mm when the crane-tip is moved up and down while moving toward forward direction. It concluded that the crane-tip control was possible using the control algorithm developed in this study.

• Ocean and Polar Research
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• 제44권3호
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• pp.249-260
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• 2022

This mini review examines the habitat connectivity and effectiveness of Korean Marine Protected Areas (MPAs) in the Yellow Sea Large Marine Ecosystem (YSLME) region. We first reemphasize that the Korean region of the YSLME is a single ecosystem (ecoregion) given the biophysical distribution patterns. The MPAs within the YSLME contribute about 50% to the total MPAs in Korea, accounting for about 10% of the territorial sea waters of Korea and 20% of the waters of YSLME on the Korean side. By area, national parks account for nearly 45% of the MPAs, followed by the wetland protected areas at 25%, with other types of MPA comprising the remaining 30%. Large MPA (> 100 km²) is the dominant type of MPA, accounting for 90% of the total area. We find that MPAs in the region are connected physically and perhaps also genetically. However, the level of protection was found to be low, and a no-take zone is rarely implemented. In addition, interrupted freshwater discharge caused by river-mouth dams poses a major hindrance to the physical connectivity of the MPAs. Restoration of the river-mouth dams and strengthened regulation on MPAs, with further expansion of MPAs in line with the current development of post-2020 global biodiversity frameworks, should be priorities for better management of marine resources. The newly revised law incorporating the concept of "Marine Ecosystem Axis Management" would reinforce the processes, and their effectiveness together with overall management of MPAs in Korea should be evaluated by designing appropriate measurement tools.

• Journal of Gastric Cancer
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• 제22권4호
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• pp.319-338
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• 2022

Purpose: Gastric cancer (GC) has high morbidity and mortality, the cure rate of surgical treatment and drug chemotherapy is not ideal. Therefore, development of new treatment strategies is necessary. We aimed to identify the mechanism underlying Sp1 regulation of GC progression. Methods and Methods: The levels of Sp1, β-catenin, SET domain bifurcated 1 (SETDB1), and 15-hydroxyprostaglandin dehydrogenase (HPGD) were detected by quantitative reverse transcription polymerase chain reaction and western blot analysis. The targets of SETDB1 were predicted by AnimalTFDB, and dual-luciferase reporter assay was used for confirming the combination of Sp1, β-catenin, and SETDB1. HGC27 or AGS cells (1×10⁶ cells/mouse) were injected into mice via the caudal vein for GC model establishment. The level of Ki67 was detected using immunohistochemistry, and hematoxylin and eosin staining was performed for evaluating tumor metastasis in mice with GC. Results: HPGD was inhibited, while the protein levels of Sp1, β-catenin, and SETDB1 were up-regulated in GC tissues and cell lines. HPGD overexpression or SETDB1 silencing inhibited the proliferation, invasion, and migration of GC cells, and Sp1 regulated the proliferation, invasion, and migration of GC cells in a β-catenin-dependent manner. Furthermore, HPGD served as a target of SETDB1, and it was negatively regulated by SETDB1; additionally, Sp1 and β-catenin bound to the SETDB1 promoter and negatively regulated HPGD expression. We proved that Sp1 regulated GC progression via the SETDB1/HPGD axis. Conclusions: Our findings revealed that Sp1 transcriptionally inhibited HPGD via SETDB1 in a β-catenin-dependent manner and promoted the proliferation and metastasis of GC cells.

• BMB Reports
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• 제56권3호
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• pp.184-189
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• 2023

Ovarian cancer (OC) is the most common gynecological malignancy worldwide, and chemoresistance occurs in most patients, resulting in treatment failure. A better understanding of the molecular processes underlying drug resistance is crucial for development of efficient therapies to improve OC patient outcomes. Circular RNAs (circRNAs) and ferroptosis play crucial roles in tumorigenesis and resistance to chemotherapy. However, little is known about the role(s) of circRNAs in regulating ferroptosis in OC. To gain insights into cisplatin resistance in OC, we studied the ferroptosis-associated circRNA circSnx12. We evaluated circSnx12 expression in OC cell lines and tissues that were susceptible or resistant to cisplatin using quantitative real-time PCR. We also conducted in vitro and in vivo assays examining the function and mechanism of lnc-LBCSs. Knockdown of circSnx12 rendered cisplatin-resistant OC cells more sensitive to cisplatin in vitro and in vivo by activating ferroptosis, which was at least partially abolished by downregulation of miR-194-5p. Molecular mechanics studies indicate that circSnx12 can be a molecular sponge of miR-194-5p, which targets SLC7A11. According to our findings, circSnx12 ameliorates cisplatin resistance by blocking ferroptosis via a miR-194-5p/SLC7A11 pathway. CircARNT2 may thus serve as an effective therapeutic target for overcoming cisplatin resistance in OC.