• 대한한방내과학회지
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• 제33권4호
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• pp.609-614
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• 2012

Drug-induced liver injury (DILI) is a common cause of acute hepatitis. Regarding the risk of DILI from herbal preparations, there are controversial issues such as exaggerated reports straying far from the truth and lack of discrimination between herbal drugs and folk remedies or food supplements. This study reported one case of a patient with DILI caused by Smilacis Chinae Radix and cured in an Oriental hospital. Smilacis Chinae Radix has been used as an anti-inflammatory, anti-microbial, detoxification and anticancer compound, as a folk remedy. This report would provide helpful information for management of DILI by folk remedies or herbal drugs.

• 한방비만학회지
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• 제14권2호
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• pp.80-85
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• 2014

Coffee enema was started by American doctor Max Gerson for cancer patients in 1920s. Coffee enema is known to remove waste material and toxins in the colon, and increase the enzymatic activity in the liver. In alternative medicine, It is to be used for fecal stasis removal, detoxification, obesity, pain control etc. In recently, The Society of Korean Medicine for Obesity Research make strenuous efforts to spread a new treatment about obesity. And Obesity is already known as one of the main causes of adult diseases. If we use the Korean medical treatment, and at the same time use coffee enema, maybe we will have a good or better clinical result about obesity and metabolic syndrome. In conclusion, we introduce a method that can be easily coffee enema. Thus, we hope that the reference to the teaching of patients.

• 전기화학회지
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• 제3권2호
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• pp.81-84
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• 2000

This article deals with various photochemical processes occurring at $TiO_2$ surface and its applications in practical living conditions. In the first part, we present an overview of $TiO_2$ photocatalysis under weak W illumination with a special emphasis on bactericidal and detoxification properties of $TiO_2$ films. The second part deals with the photoinduced super hydrophilic TiCt surftce which has a wide commercial applications. In the last part, we present our recent work on boehmite-based super hydrophobic surfaces containing small amount of $TiO_2$ to obtain self-cleaning effect.

• 대한본초학회지
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• 제20권4호
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• pp.11-16
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• 2005

Objectives : This study was designed to propose the effective herb-processing method of Ginkgo Folium in the Oriental medicine. Methods : The books, papers and patents were used to examine the recent usage of Ginkgo Folium. Results : The toxic ingredients of Ginkgo Folium should be removed. Accordingly, a detoxification process using a nonpolar solvent and a vinegar-roasting process in sequence are desirable to assure its safety. The previously developed standard extract (e.g. EGb 761) could be used as a powdered Oriental medicine as well. Conclusions : Ginkgo Folium could not be used widely to treat the diseases in ancient Oriental medicine, because the toxic ingredients could not be removed by any method until recent year. However, Ginkgo Folium might be used as a herbal medicine that invigorates the blood without any difficulty using herb-processing methods suggested in this paper.

• 한국동물번식학회:학술대회논문집
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• 한국동물번식학회 2004년도 춘계학술발표대회
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• pp.186-186
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• 2004

In this study, we generated 40 somatic cell cloned (scNT) piglets. Of these, three displayed congestion in both liver and lung, and died within the first week of life. Two-dimensional gel electrophoresis experiments revealed changes in the responses of several detoxification-related proteins to stress and inflammation. As a result, congestive livers and lungs displayed extensive hepatopneumonic apoptosis.(omitted)

• Toxicological Research
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• 제29권3호
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• pp.165-172
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• 2013

Acetaminophen (APAP) known as paracetamol is the main ingredient in Tylenol, which has analgesic and anti-pyretic properties. Inappropriate use of APAP causes major morbidity and mortality secondary to hepatic failure. Overdose of APAP depletes the hepatic glutathione (GSH) rapidly, and the metabolic intermediate leads to hepatocellular death. This article reviews the mechanisms of hepatotoxicity and provides an overview of current research studies. Pharmacokinetics including metabolism (activation and detoxification), subsequent transport (efflux)-facilitating excretion, and some other aspects related to toxicity are discussed. Nuclear factor erythroid 2-related factor 2 (Nrf2)-regulated gene battery plays a critical role in the multiple steps associated with the mitigation of APAP toxicity. The role of Nrf2 as a protective target is described, and potential natural products inhibiting APAP toxicity are outlined. This review provides an update on the mechanism of APAP toxicity and highlights the beneficial role of Nrf2 and specific natural products in hepatoprotection.

• Radiation Oncology Journal
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• 제33권2호
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• pp.66-74
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• 2015

Trace elements play crucial role in the maintenance of genome stability in the cells. Many endogenous defense enzymes are containing trace elements such as superoxide dismutase and metalloproteins. These enzymes are contributing in the detoxification of reactive oxidative species (ROS) induced by ionizing radiation in the cells. Zinc, copper, manganese, and selenium are main trace elements that have protective roles against radiation-induced DNA damages. Trace elements in the free salt forms have protective effect against cell toxicity induced by oxidative stress, metal-complex are more active in the attenuation of ROS particularly through superoxide dismutase mimetic activity. Manganese-complexes in protection of normal cell against radiation without any protective effect on cancer cells are more interesting compounds in this topic. The aim of this paper to review the role of trace elements in protection cells against genotoxicity and side effects induced by ionizing radiation.

• Journal of Microbiology
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• 제44권1호
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• pp.121-125
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• 2006

Mycothiol is a low molecular weight thiol compound produced by a number of actinomycetes, and has been suggested to serve both anti-oxidative and detoxifying roles. To investigate the metabolism and the role of mycothiol in Streptomyces coelicolor, the biosynthetic genes (mshA, B, C, and D) were predicted based on sequence homology with the mycobacterial genes and confirmed experimentally. Disruption of the mshA, C, and D genes by PCR targeting mutagenesis resulted in no synthesis of mycothiol, whereas the mshB mutation reduced its level to about $10\%$ of the wild type. The results indicate that the mshA, C, and D genes encode non-redundant biosynthetic enzymes, whereas the enzymatic activity of MshB (acetylase) is shared by at least one other gene product, most likely the mca gene product (amidase).

• 미생물과산업
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• 제16권3호
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• pp.56-62
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• 1990

일반적으로 산업폐수및 생활하수의 생물학적 처리에 관계하는 미생물의 종류는 약1,000-2,000종에 이르는 것으로 추정된다. 이와 같은 미생물의 범위는 매우 넓어서 세균, 균류는 물론이고, 조류, 원생동물, 후생동물까지 포함한다. 19세기 이전에 미생물을 이용한 폐하수 처리는 생활하수와 같이 쉽게 분해하는 물질로만 구성되어 있기 때문에 간단한 처리 공정으로도 충분히 운영되었으나, 산업혁명 이후 새로운 화학물질이 합성되어 폐하수로 배출되므로 처리효율을 달성하는데 더욱 어렵게 되므로 미생물을 전공한 전문인력의 역할이 가일층 높아지게 되었다. 특히 1970년대 이후에는 생물공학 기법을 이용하여 독성 유해물질을 무해화(Detoxification) 하고, 광물화(Mineralization)할 수 있는 미생물 균류를 연구 개발하여 폐수나 폐기물을 처리하는데 활용코자하는 노력이 활발히 진행되고 있으며 일부는 큰 결실을 맺은 것도 있지만 아직도 연구가 진행 중인 분야가 더 많은 편이다. 그러므로 본 고에서는 지금까지 연구 보고된 결과와 앞으로 미생물을 전공한 우리들이 나아갈 방향을 제시코자 한다.

• 대한임상독성학회지
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• 제1권1호
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• pp.40-42
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• 2003

Korean people use a lot of herbal agents for medical purposes, such as curing diseases, improving health state, but some of the herbal agents have toxic side effects. In terms of toxicology, herbal agents classified into 3 categories generally nontoxic, potentially toxic and toxic. But, there are few studies about the mechanisms and clinical features of intoxication of herbal agents. So detoxification or initial treatment of these agents is very difficult to clinicians in hospital. Authors experienced an uncommon case of intoxication after Arisaematis Rhizoma Ingestion. We report this case with review of Arisaematis Rhizoma.