• Biomolecules & Therapeutics
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• v.21 no.2
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• pp.173-179
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• 2013

Objective of present study was to prepare and characterize self-nanoemulsifying drug delivery system (SNEDDS) of lutein and to evaluate its effect on bioavailability of warfarin. The SNEDDS was prepared using an oil, a surfactant, and co-surfactants with optimal composition based on pseudo-ternary phase diagram. Effect of the SNEDDS on the bioavailability of warfarin was performed using Sprague Dawley rats. Lutein was successfully formulated as SNEDDS for immediate self-emulsification and dissolution by using combination of Peceol as oil, Labrasol as surfactant, and Transcutol-HP or Lutrol-E400 as co-surfactant. Almost complete dissolution was achieved after 15 min while lutein was not detectable from the lutein powder or intra-capsule content of a commercial formulation. SNEDDS formulation of lutein affected bioavailability of warfarin, showing about 10% increase in $C_{max}$ and AUC of the drug in rats while lutein as non-SNEDDS did not alter these parameters. Although exact mechanism is not yet elucidated, it appears that surfactant and co-surfactant used for SNEDDS formulation caused disturbance in the anatomy of small intestinal microvilli, leading to permeability change of the mucosal membrane. Based on this finding, it is suggested that drugs with narrow therapeutic range such as warfarin be administered with caution to avoid undesirable drug interaction due to large amount of surfactants contained in SNEDDS.

• Journal of Institute of Control, Robotics and Systems
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• v.12 no.4
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• pp.389-394
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• 2006

Inaccurate localization exposes a robot to many dangerous conditions. It could make a robot be moved to wrong direction or damaged by collision with surrounding obstacles. There are numerous approaches to self-localization, and there are different modalities as well (vision, laser range finders, ultrasonic sonars). Since sensor information is generally uncertain and contains noise, there are many researches to reduce the noise. But, the correctness is limited because most researches are based on statistical approach. The goal of our research is to measure more exact robot location by matching between built VRML 3D model and real vision image. To determine the position of mobile robot, landmark-localization technique has been applied. Landmarks are any detectable structure in the physical environment. Some use vertical lines, others use specially designed markers, In this paper, specially designed markers are used as landmarks. Given known focal length and a single image of three landmarks it is possible to compute the angular separation between the lines of sight of the landmarks. The image-processing and neural network pattern matching techniques are employed to recognize landmarks placed in a robot working environment. After self-localization, the 2D scene of the vision is overlaid with the VRML scene.

• Journal of Sensor Science and Technology
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• v.22 no.3
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• pp.191-196
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• 2013

A particulate matter sensor fabricated by MEMS process is proposed. It is developed to accommodate Euro6 on-board diagnostics regulation for diesel automobile. In the regulation, emission of diesel particulate matter is restricted to 9 mg/km. Particulate matter sensor is designed to use induced charges by charged particulate matter. To increase sensitivity of the sensor, groove is formed on sensor surface because wider surface area generates more induced charges. Sensitivity of the sensor is measured 10.6 mV/(mg/km) and the sensor shows good linearity up to 15.7 mg/km. Also its minimum detectable range is about 0.25 mg/km. It is suitable to detect failure of a diesel particulate filter which should filter particulate matter more than 9 mg/km. For removing accumulated particulate matter on the sensor which can disturb normal operation, platinum heater is designed on the backside of the sensor. The developed sensor can sense very low amount of particulate matter from exhaust gas in real-time with good linearity.

• Proceedings of the KIEE Conference
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• 1987.07b
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• pp.1163-1165
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• 1987

A novel temperature difference-to-frequency converter using two resistance temperature detectors (RTDs) has been developed. The resistance difference of two RTDs is converted into its equivalent inductance to form the resonant circuit of the Colpitts oscillator. The conversion sensitivity of $16\;Hz/^{\circ}C$ and the residual nonlinearity less than 2.15% over the temperature difference range from $35^{\circ}C$ to $155^{\circ}C$ are obtained by the prototype converter. The frequency drift of oscillator itself is ${\pm}0.5\;Hz$. Thus, the minimum detectable temperature difference is estimated to be ${\pm}0.013^{\circ}C$. The proposed converter, except for two RTDs, can be fabricated in monolithic IC form.

• Korean Journal of Veterinary Service
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• v.23 no.1
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• pp.77-91
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• 2000

This study was conducted to investigate the antibiotic resistance and plasmid profiles of 58 salmonella spp isolated from mesenteric lymphnodes of slaughter pigs in Kyoungbuk province during the period from September 1997 to June 1998. The results obtained are as follow that all isolates were susceptible to amikacin, gentamicin, ciprofloxacin and enrofloxacin, and the majority of isolates were highly susceptible to norfloxacin, colistin, nalidixic acid and apramycin while they were moderately susceptible to kanamycin, cephalothin, chloramphenicol, ampicillin, trimethoprim and penicillin. The majority of isolates were over 90% resistant rates to lincomycin, sulfadimethoxine, vancomycin, methicillin and erythromycin. The plasmid profiles of 58 salmonella spp are developed 1 to 4 fractions, 0.9 to 29.5 Kb molecular range sizes and U strains (45.5%) were showed plasmid profiles by agarose gel electrophoresis. 5 derby harbored 29.5 Kb and 7 Kb, and S schwarzengrund had 14 Kb and 0.9 Kb harboring sizes. Four of 10 S agona and 2 of 4 S typhimurium were harbored 3.1 Kb and n.5 Kb, respectively. Thirty-five untypable strains are developed variable size fractions its showed small size plasmid profile less than 6 Kb and 22 (62.8%) of them had no detectable plasmids.

• Journal of the Korean Institute of Telematics and Electronics
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• v.25 no.11
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• pp.1282-1285
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• 1988

A novel temperature difference-to-frequency converter using two resistance temperature detectors (RTD) has been developed. The resistance difference of two RTD is converted into its equivalent inductance to form the resonant circuit of the Colpitts oscillator. The conversion sensitivity of 16 Hz/$^{\circ}C$ and the residual nonlinearity less than 2.15% over the temperature difference range from 35$^{\circ}C$ to 155$^{\circ}C$ are obtained by the prototype converter. The frequency drift of oscillator itself is $\pm$ 0.5Hz. Thus, the minimum detectable temperature difference is estimated to be $\pm$ 0.013$^{\circ}C$. The proposed coverter, except for two RTD, can be fabricated in monolithic IC form.

• Progress in Medical Physics
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• v.4 no.1
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• pp.41-53
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• 1993

The electron spin resonanec of sigle crystals of L-alanine have been observed at T=300K, 100K and analyzed for different orieantations of the crystal in the magnetic field and at microwave frequency X-band. The stable free radical profuced by the irradiation is proved to be of the form CH$_3$CHR, where R is a group which has no nuclei with detectable coupling A notable dependence on temperature of the absorption was observed in the range from 1100K to 2l0K. It was concluded that the reorietation of the methy group of the radical H$_3$CCHR is quenched at low temperature.

• The Journal of Korean Physical Therapy
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• v.29 no.3
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• pp.145-151
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• 2017

Purpose: The purpose of this study was to investigate the validity and reliability of the measurement of shoulder joint motions using an inertial measurement unit (IMU). Methods: For this study, 33 participants (32 females and 1 male) were recruited. The subjects were passively positioned with the shoulder placed at specific angles using a goniometer (shoulder flexion $0^{\circ}-170^{\circ}$, abduction $0^{\circ}-170^{\circ}$, external rotation $0^{\circ}-90^{\circ}$, and internal rotation $0^{\circ}-60^{\circ}$ angles). Kinematic data on the shoulder joints were simultaneously obtained using IMU three-dimensional (3D) angular measurement (MyoMotion) and photographic measurement. Test-retest reliability and concurrent validity were examined. Results: The MyoMotion system provided good to very good relative reliability with small standard error of measurement (SEM) and minimal detectable change (MDC) values from all three planes. It also presented acceptable validity, except for some of shoulder flexion, shoulder external rotation, and shoulder abduction. There was a trend for the shoulder joint measurements to be underestimated using the IMU 3D angular measurement system compared to the goniometer and photo methods in all planes. Conclusion: The IMU 3D angular measurement provided a reliable measurement and presented acceptable validity. However, it showed relatively low accuracy in some shoulder positions. Therefore, using the MyoMotion measurement system to assess shoulder joint angles would be recommended only with careful consideration and supervision in all situations.

• Journal of architectural history
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• v.21 no.1
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• pp.65-81
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• 2012

This is a study concerning about the definition of the concept of industrial heritage being mentioned often lately, and considering the term's origin and changing process aiming at clarifying and improving its undertone and understanding. Especially, it's a basic study to make people understand fundamentally what industrial heritage means and differences in Korea in where any innovative affair such as industrial revolution has never occurred. Looking into the origin and changing process of the industrial archaeology & industrial heritage terms, their concepts appear ambiguously defined due to their generational, phenomenal and terminological reason. but it's detectable that their subjects and timing range have been extended. Korea, China and Japan, the Asian nations also have gone through mainly phenomenal and terminological mess in accepting the terms. Korean industrial heritage can define from the definition of industrial heritage in Nyzni Tagil charter. It, however, have to redefine about period of industrialization. This study suggest the 4 steps of modern industrialization in Korea and insist that we have to conserve industrial heritages not only in colonial period but also in 1960-80 industrialization in korea.

• Proceedings of the KIEE Conference
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• 2006.04a
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• pp.318-320
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• 2006

Inaccurate localization exposes a robot to many dangerous conditions. It could make a robot be moved to wrong direction or damaged by collision with surrounding obstacles. There are numerous approaches to self-localization, and there are different modalities as well (vision, laser range finders, ultrasonic sonars). Since sensor information is generally uncertain and contains noise, there are many researches to reduce the noise. But, the correctness is limited because most researches are based on statistical approach. The goal of our research is to measure more exact robot location by matching between built VRML 3D model and real vision image. To determine the position of mobile robot, landmark-localitzation technique has been applied. Landmarks are any detectable structure in the physical environment. Some use vertical lines, others use specially designed markers, In this paper, specially designed markers are used as landmarks. Given known focal length and a single image of three landmarks it is possible to compute the angular separation between the lines of sight of the landmarks. The image-processing and neural network pattern matching techniques are employed to recognize landmarks placed in a robot working environment. After self-localization, the 2D scene of the vision is overlaid with the VRML scene.