• 한국문헌정보학회지
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• 제56권4호
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• pp.29-49
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• 2022

책은 신성과 이성, 우상과 파괴, 찬양과 저주, 오만과 편견, 진위 등이 혼재하는 삶과 기억의 각주이자 지식과 지성의 기호다. 이러한 이유로 역대 제왕과 군주, 성직자, 지배자들은 검열과 금서, 분서와 파괴 등을 통해 책을 학살해 왔다. 고대사, 고고학, 전쟁사, 문화사, 문헌정보학 등에서 많은 연구가 수행되었으나 서양사관이 지배적이고 국수주의적 접근과 논리적 비약도 있다. 본 연구는 많은 미스터리와 쟁점이 혼재하는 이집트 알렉산드리아도서관 파괴, 몽골 제국의 바그다드 도서관 파괴, 그리고 조선총독부 한국사료 20만 분서설을 대상으로 진상을 추적하였다. 그 결과, 알렉산드리아도서관은 로마 제국이 지배할 때 완파되었을 가능성이 높다. 몽골 군대의 바그다드 도서관 학살은 서양의 날조와 극단적 과장이 아니라 역사적 사실이다. 그리고 조선총독부가 35년간 강탈·소각한 한국사료는 '20만권 +α'로 인식해야 한다. 사료 발굴을 통한 비블리오코스트의 배후와 행간을 추적하여 진상을 규명하는 연구는 계속되어야 한다.

• Architectural research
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• 제13권3호
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• pp.11-18
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• 2011

With the rapid development of computer technology and ongoing destruction of traditional buildings, more and more attention is paid to digital methods for the design and preservation of traditional buildings. Unlike 2D methods, Building Information Modeling (BIM) provides an object-oriented and parametric digital representation way for traditional building components. However, one of the main limitations currently is that parametric information cannot be exchanged between BIM software packages. Therefore each kind of software must have their own parametric library which causes extensive works. In this research, the authors developed an open BIM-based library using an XML parametric approach to solve the above problems, represented traditional components according to an XML schema, and parametrically implemented these XML files in a browser which can be accessed by users for their easy component edit and selection. And then based on the XML file of one component, implemented an Add-on in ArchiCAD for users to parametrically edit and directly utilize. Thus based on these XML files, a browser for users' view and selection purpose and an add-on for users' application purpose were developed. Future research will focus on implementing these XML files in other BIM tools like Revit and Digital Project. If the whole library was to be completed based on this XML approach, an open BIM-based library would be established that all kinds of BIM software users could apply this parametric library for easy modeling of traditional houses.

• 한국문헌정보학회지
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• 제26권
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• pp.113-139
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• 1994

Government archives are basic source materials in the historical study. Whereas, researches on the archives of Choson-chongdokbu have been very scant. Those archives contain information about both colonism of Japan and independent movement of Korea are comparatively well preserved at Government Archives and Record Services. Therefore, it is necessary to analyze the characteristic of archives and to evaluate the system of archival management of Choson-chongdokbu. Based on the official gazette and archives of Choson-chongdokbu, this study has revealed the division of archival work, the writing and treatment of official document, compilation and preservation, and the procedure of use and destruction. As a result of the research, the followings have been identified; 1. Archival regulations were prepared by the instructions of Choson­chongdokbu at the early days of its establishment. Inspite of several revisions, its basis was maintained until 1945. 2. Each agency had its own archival department instead of central archives. 3. The archival department of Choson-chongdokbu controlled the archival administration of headquarters and attached agencies. But the secret archives were managed by the secretarial department. 4. The writing and treatment of archives were done by the archival regulation made in 1911. 5. Each agency had set more or less different preservation period. 6. There were three ways of using archives, 1) the in-house reading 2) the loan 3) the transcriptions. The archives passed the preservation period were destroyed in accordance with the related departments.

• 한국문헌정보학회지
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• 제40권3호
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• pp.35-51
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• 2006

재평가와 처분은 1980년대까지만 하더라도 기록유산을 구성하는데 장애가 되는 개념으로 간주되었다. 그러나 기록물 보존에 드는 자원을 효율적으로 이용하고, 소장물의 초점이 잘 잡힌 기록관으로 유지하기 위해서는 과거의 평가 및 수집 결정을 재평가하는 절차가 필요하다는 인식이 최근 들어 아키비스트들의 공감대를 얻기 시작했다. 즉 이제는 기록관의 목적과 환경에 맞추어 기록물의 보존관리의 범위를 한정시키기 위해서는 지속적으로 기록물의 보존가치를 평가하고 처분해야 할 것이다. 본 연구는 보존되고 있는 기록물에 대한 재평가 및 처분에 대한 여러 학자들의 견해를 고찰하여 보존관리 업무에서의 그 역할을 분석하고 재평가와 처분이 보존관리 기능으로 수행될 때 도움이 될 수 있는 재평가의 원칙과세 가지 처분업무 즉 원소유자로의 반환, 다른 기록관으로 이관, 폐기에 대한 업무 프로세스를 제시하였다.

• Parasites, Hosts and Diseases
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• 제42권1호
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• pp.35-40
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• 2004

The nfa 1 gene was cloned from a cDNA library of pathogenic Naegleria fowleri by immunoscreening; it consisted of 360 bp and produced a 13.1 kDa recombinant protein (rNfa1) that showed the pseudopodia-specific localization by immunocytochemistry in the previous study. Based on the idea that the pseudopodia-specific Nfa1 protein mentioned above seems to be involved in the pathogenicity of N. fowleri, we observed the effect of an anti-Nfa1 antibody on the proliferation of N. fowleri trophozoites and the cytotoxicity of N. fowleri trophozoites on the target cells. The proliferation of N. fowleri trophozoites was inhibited after being treated with an anti-Nfa1 polycional antibody in a dose-dependent manner for 48 hrs. By a light microscope, CHO cells co-cultured with N. fowleri trophozoites (group I) for 48 hrs showed severe morphological destruction. On the contrary, CHO cells co-cultured with N. fowleri trophozoites and anti-Nfa1 polyclonal antibody (1:100 dilution) (group II) showed less destruction. In the LDH release assay results, group I showed 50.6% cytotoxicity, and group II showed 39.3%. Consequently, addition of an anti-Nfa1 polyclonal antibody produced a decreasing effect of in vitro cytotoxicity of N. fowleri in a dose-dependent manner.

• Molecules and Cells
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• 제37권8호
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• pp.628-635
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• 2014

2-(Trimethylammonium) ethyl (R)-3-methoxy-3-oxo-2-stearamidopropyl phosphate [(R)-TEMOSPho], a derivative of an organic chemical identified from a natural product library, promotes highly efficient megakaryopoiesis. Here, we show that (R)-TEMOSPho blocks osteoclast maturation from progenitor cells of hematopoietic origin, as well as blocking the resorptive function of mature osteoclasts. The inhibitory effect of (R)-TEMOSPho on osteoclasts was due to a disruption of the actin cytoskeleton, resulting from impaired downstream signaling of c-Fms, a receptor for macrophage-colony stimulating factor linked to c-Cbl, phosphoinositol-3-kinase (PI3K), Vav3, and Rac1. In addition, (R)-TEMOSPho blocked inflammation-induced bone destruction by reducing the numbers of osteoclasts produced in mice. Thus, (R)-TEMOSPho may represent a promising new class of antiresorptive drugs for the treatment of bone loss associated with increased osteoclast maturation and activity.

• 대한한의진단학회지
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• 제22권1호
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• pp.11-18
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• 2018

Objectives The incidence of degenerative diseases is increasing as society ages, and this increased the economic burden on society. Oxidative stress was also under suspicion as one of the causes. Recent studies have found that Curcuma longa Rhizoma had antioxidant, anti-inflammatory, antimutagenic, and anticancer effects. Through this study, we figure out trends in Curcuma longa Rhizoma research and evaluate the therapeutic potential of Curcuma longa Rhizoma for dementia. Methods The search was made using domestic and international internet search sites. "Naver academic," "Google scholar," "Korea institute of oriental medicine (KIOM OASIS)," "Korean traditional knowledge portal (KTKP)," "Library of Congress," "Research information sharing service (RISS)," "National Digital Science Links (NDSL)," and "Pub med" are used to search. The searched for words were "turmeric," "Curcuma longa Rhizoma," "antioxidant," and "nerve regeneration." Results It could be seen that a lot of research done on Curcuma longa recently. In previous studies, the most common research disease was cancer. In previous studies, the most common effects of Curcuma longa was antioxidant and anticancer. Curcumin, Vitamin B1, and various essential oils were the functional components of Curcuma longa Rhizoma. Curcuma longa Rhizoma performs DPPH radical scavenging activity and ABTS radical cation decolorization activity; it inhibits NO and iNOS. Conclusion The destruction of nerve cells due to oxidative stress is a cause of dementia. Curcuma longa Rhizoma have antioxidant effects. Therefore, we believed that it is an effective treatment for dementia. Various studies will be made on Curcuma longa Rhizoma.

• Journal of Microbiology
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• 제41권4호
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• pp.295-299
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• 2003

Adenovirus (Ad) precursor to the terminal protein (pTP) plays an essential roles in the viral DNA replication. Ad pTP serves as a primer for the synthesis of a new DNA strand during the initiation step of replication. In addition, Ad pTP forms organized spherical replication foci on the nuclear matrix (NM) and anchors the viral genome to the NM. Here we identified the interferon inducible gene product 1-8D (Inid) as a pTP binding protein by using a two-hybrid screen of a HeLa cDNA library. Of the clones obtained in this assay, nine were identical to the Inid, a 13-kDa polypeptide that shares homology with genes 1-8U and Leu-13/9-27, most of which have little known functions. The entire open reading frame (ORF) of Inid was cloned into the tetracycline inducible expression vector in order to determine the biological functions related with adenoviral infection. When Inid was introduced to the cells along with adenoviruses, fifty to sixty percent of Ad-infected cells expressing Inid had rounded morphology, which was suggestive of apoptosis. Results from the terminal deoxynucleotidyl transferase (TdT) and DNA fragmentation assays confirmed that Inid induces apoptosis in Ad-infected or in uninfected cells. The Inid binding to pTP may target the cell for apoptotic destruction as a host defense mechanism against the viral infection.

• 대한환경공학회지
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• 제35권10호
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• pp.687-693
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• 2013

다양한 난개발과 해안도로, 방파제 등의 인공 구조물 설치로 인한 해안 침식과 해안선 파괴 등으로 해안사구가 크게 훼손되고 있다. 이에 본 연구에서는 해안사구에서 서식하고 있는 토착식물의 근권으로부터 식물 성장 촉진 능력이 있으면서 동시에 염분에 강한 내성을 가지는 근권세균의 library를 구축하였고, 이들 균주를 대상으로 식물 성장 촉진 능력을 평가하였다. 또한, 내염성 식물을 대상으로 사구 토양에서의 성장률에 근권세균이 미치는 영향을 평가한 후, 훼손된 사구의 복원에 가장 유용한 미생물을 선별하고 분리된 근권세균이 식물 성장에 미치는 영향을 평가하였다. 실험은 선정된 균주와 갯기름나물과 줄무늬갈대를 해안사구에 식재한 후 성장에 미치는 영향을 평가하였다. 그 결과, MH1RS1는 (IAA) production, siderophores, 1-aminocyclopropane-1-carboxylate deaminase (ACC deaminase) 그리고 염분내성을 가지고 있다. 갯기름나물의 경우는 줄기의 길이와 뿌리의 무게는 크게 향상되었다. 특히, 줄기의 생체와 뿌리 무게는 control과 비교했을 때 25% 성장이 향상되었다. 줄무늬 갈대는 Bacillus aerius MH1RS1 에 의해 초장은 18%와 뿌리의 생체 중은 20%로 크게 향상 되었다.

• 한국해양환경ㆍ에너지학회지
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• 제19권2호
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• pp.99-110
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• 2016

해양에서 시추작업 중 라이저가 손상되어 기름유출이 발생하면 경제적인 피해 뿐 아니라 해양환경에 막대한 피해를 가져오게 되므로 사고 발생 시 신속하게 사고에 대처해야 될 뿐만 아니라 초기의 기름 유출량 및 확산 정도를 파악하는 것이 중요하다. 본 연구에서는 소스코드가 공개된 전산유체역학 라이브러리인 OpenFOAM을 이용하여 손상된 라이저로 부터 기름이 유출되는 현상을 해석하였다. 수치방법을 검증하기 위해 제트 유동과 밀도 차에 의한 확산 문제인 Rayleigh-Taylor instability를 해석하였다. 라이저의 손상된 크기, 기름 유출량, 손상된 위치, 해류의 속도를 변화시키며 해석하였다. 해석 결과 기름이 유출 될 경우 수면에 도달 할 때까지 이동한 거리 및 시간을 예측하여 기름 확산에 대비할 수 있는 가이드라인을 제시하였다.