• Journal of Microbiology and Biotechnology
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• v.16 no.5
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• pp.651-660
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• 2006

Natural products are a rich source of biologically active small molecules and a fertile area for lead discovery of new drugs [10, 52]. For instance, 5% of the 1,031 new chemical entities approved as drugs by the US Food and Drug Administration (FDA) were natural products between 1981 and 2002, and another 23% were natural product-derived molecules [53]. These molecules have evolved through millions of years of natural selection to interact with biomolecules in the cells or organisms and offer unrivaled chemical and structural diversity [14, 37]. Nonetheless, a large percentage of nature remains unexplored, in particular, in the marine and microbial environments. Therefore, natural products are still major valuable sources of innovative therapeutic agents for human diseases. However, even when a natural product is found to exhibit biological activity, the cellular target and mode of action of the compound are mostly mysterious. This is also true of many natural products that are currently under clinical trials or have already been approved as clinical drugs [11]. The lack of information on a definitive cellular target for a biologically active natural product prevents the rational design and development of more potent therapeutics. Therefore, there is a great need for new techniques to expedite the rapid identification and validation of cellular targets for biologically active natural products. Chemical genomics is a new integrated research engine toward functional studies of genome and drug discovery [40, 69]. The identification and validation of cellular receptors of biologically active small molecules is one of the key goals of the discipline. This eventually facilitates subsequent rational drug design, and provides valuable information on the receptors in cellular processes. Indeed, several biologically crucial proteins have already been identified as targets for natural products using chemical genomics approach (Table 1). Herein, the representative case studies of chemical genomics using natural products derived from microbes, marine sources, and plants will be introduced.

• Plant Journal
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• v.13 no.4
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• pp.41-47
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• 2017

This paper is a study on validation model that can verify the arrangement of equipment constituting offshore plant using system engineering approach in offshore plant tender stage. In order to design offshore plant topside maintenance equipment, topside layout verification should be preceded. However, there are many errors in the bidding stage due to the FEED results that are not perfect, the verification can not be performed sufficiently due to the limitation of the bidding period and others reasons. Therefore, we propose a validation model that can effectively verify the equipment layout within a limited condition by simplifying the main process in the system engineering process, which is a multidisciplinary approach, and confirmed through the Functional Deployment Model. Also, we verified the validation model for topside equipment deployment through case studies.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2008.11a
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• pp.547-548
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• 2008

• Proceedings of the Korean Society of Precision Engineering Conference
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• 2010.05a
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• pp.1087-1088
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• 2010

• Journal of the Korean Society for Precision Engineering
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• v.23 no.9 s.186
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• pp.39-46
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• 2006

• Communications of the Korean Institute of Information Scientists and Engineers
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• v.30 no.9
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• pp.37-45
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• 2012

• Proceedings of the KIEE Conference
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• 1996.11a
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• pp.71-74
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• 1996

The concept of uniformity in control implementation is exploded for improving efficiency of design procedure. A controller area operating system which includes real time kernel and control specific shell are developed. Three examples are discussed for the validation of tile system.

• Journal of Ocean Engineering and Technology
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• v.34 no.4
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• pp.263-271
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• 2020

In this study, we performed a three-dimensional (3D) topology optimization of a fixed offshore structure to enhance its structural stiffness. The proposed topology optimization is based on the solid isotropic material with penalization (SIMP) method, where a volume constraint is applied to utilize an equivalent amount of material as that used for the rule-based scantling design. To investigate the effects of the main legs of the fixed offshore structure on its structural stiffness, the leg region is selectively considered in the design domain of the topology optimization problem. The obtained optimal designs and the rule-based scantling design of the structure are manufactured by 3D metal printing technology to experimentally validate the topology optimization. The behaviors under compressive loading of the obtained optimal designs are compared with those of the rule-based scantling design using a universal testing machine (UTM). Based on the structural experiments, we concluded that by employing the topology optimization method, the structural stiffness of the structure was enhanced compared to that of the rule-based scantling design for an equal amount of the fabrication material. Furthermore, by effectively combining the topology optimization and rule-based scantling methods, we succeeded in enhancing the structural stiffness and improving the breaking load of the fixed offshore structure.

• Journal of the Korean Statistical Society
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• v.22 no.2
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• pp.361-368
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• 1993

In recent years, kernel type estimates are abundant. In this paper, we propose a bandwidth selection method for kernel regression of fixed design based on bootstrap procedure. Mathematical properties of proposed bootstrap-based bandwidth selection method are discussed. Performance of the proposed method for small sample case is compared with that of cross-validation method via a simulation study.

• ETRI Journal
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• v.11 no.4
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• pp.22-36
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• 1989

In this paper, a design and implementation of an efficient protocol verification system named LOVE has been described. The LOVE has been developed specifically for LOTOS. It performs not only protocol syntax validation (PSV) but also protocol functional verification(PFV). The PSV is a test to check if a protocol is free from protocol syntax errors such as deadlocks and livelocks. The PFV confirms whether or not a protocol achieves its functional objectives. For the PSV, the reachability analysis is employed, and the observational equivalence test is used for the PFV. For protocol verification using the LOVE, a schematic protocol verification methodology has been outlined.