• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.3 no.1
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• pp.117-128
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• 1992

For many years, a number of critical issues have been raised in relation to classification criteria. prevalence and clinical features as well as the concept of childhood depression itself. In order to achieve a better understanding of the childhood depression, empirical data on the prevalence and clinical features of depression in childhood and adolescence were reviewed and discussed from the developmental perspective. The developmental perspective proposes that maladaptive behaviors are products of the coping process to normal developmental tasks and it is necessary to make out the normative and adaptive developmental process in order to understand maladaptive behaviors. Age associated changes in depression symptomatology were discussed in relation to cognitive and socio-emotional development and directions for future research in childhood depression were suggested.

• Korean Journal of Child Studies
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• v.36 no.5
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• pp.115-134
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• 2015

The main purpose of this study is to explore the relationship between latent classes of childhood maltreatment and depression anxiety and aggression from childhood to adolescence. 1,785 participants in a sample form Seoul Panel Study of Children were used in this study. Using latent class analysis, three classes of child maltreatment were identified: 'low maltreatment'(89.2%), 'physical+emotional abuse+neglect'(1.9%), 'physical+emotional abuse'(8.9%). Three developmental trajectories of depression anxiety were classified: 'low depression anxiety'(72.3%), 'moderate depression anxiety'(23.3%), 'high depression anxiety'(4.4%). Two developmental trajectories of aggression were revealed: 'low aggression'(89.3%), 'high aggression'(10.7%). As estimated by latent transition probability, the multiple maltreatment classes were more likely to have higher levels of depression anxiety or aggression than the no maltreatment class. There appeared to be distinct profiles of maltreatment among adolescents that had differential associations to measures of internal and external problems. The implications for both practice and policy implications are also discussed.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.28 no.3
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• pp.183-189
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• 2017

Objectives: The study aimed to identify the characteristics of attention-deficit hyperactivity disorder (ADHD) that was not diagnosed in childhood or adolescence, but only in adulthood. Methods: The characteristics of patients diagnosed with ADHD in adulthood were compared with those of patients diagnosed in childhood were assessed via a retrospective review of the medical records at one university hospital from 2005 to 2013. If the age at which they were confirmed as having ADHD was less than 19 years old, they were grouped as childhood-diagnosed group (CD); if they were 19 years old or more, they were grouped as adulthood-diagnosed group (AD). Results: The CD and AD included 50 (46.3%) and 58 (53.7%) patients, respectively. Inattention was the most common symptom in both groups. Behavioral and emotional problems were the second most frequent symptoms in the CD and AD, respectively. The intelligent quotient was significantly higher in the AD than in the CD. The most common comorbidity was depression in the CD and personality disorder in the AD. The most common reason for visiting the hospital was referral by acquaintances in the CD and media coverage in the AD. Conclusion: Clinicians should put ADHD on the index of suspicion when they examine adults with various psychiatric symptoms, because the diagnosis of ADHD might have been missed in childhood and the symptoms of ADHD might have changed as they grew up.

• The Journal of Pediatrics of Korean Medicine
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• v.15 no.2
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• pp.141-165
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• 2001

Attention-deficit/hyperactivity disorder(ADHD) is one of the most common childhood-onset psychlatric disorders. It is distinguished by symptoms of inattention, hyperactivity, and impulsivity. ADHD may be accompanied by learning disabilities, depression, anxiety, conduct disorder, and oppositional defiant disorder. The etiology of ADHD is unknown, and the disorder may have several different causes. Individual with ADHD present in childhood and may continue to show symptoms as they enter adolescence and adult life. Public interest in ADHD has increased along with debate in the media concerning the diagnostic process and treatment strategies. The purpose of this study is oriental medical approach to ADHD. This study was progressed for oriental diagnosis and treatment for ADHD. In oriental medicine, the reason of ADHD was deficiency of the kidney, hyperactivity of the liver(腎虛肝亢), deficiency of the heart and the spleen(心脾不足), heart disturbed by phlegm and heat(痰熱擾心). The method of medical treatment was nourishing the kidney and checking exuberance of yang(滋腎潛陽), relieving mental stress and promoting wisdom(寧神益智), nourishing the heart and strengthening the spleen(養心健脾), tranquilzation(安神定志). removing heat-phlegm(淸熱化痰), inducing resuscitation and tranquilzation(開窮安神). The prescription was commonly used as Liuwei Dihuang Wan jiajian(六味地黃丸加減), Guipi Tang he Ganmai Dazao Tang jiajian(歸脾湯合甘麥大棗湯加減), Huanglian Wendan Tang jiawei(溫黃連溫膽湯加味). It should help primary care providers in their assessment of a common child health problem.

• Journal of the Korean Society of School Health
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• v.13 no.2
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• pp.261-270
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• 2000

Background: Adolescence is the transitional period between childhood and adulthood. We have to pay attention to their psycho-social problems as well as their physical symptoms. In this context, we need to investigate the adolescent depression tendency and its related factors. Method : From May to June in 1008, we chose one elementary school, one middle school and one high school in Seoul and surveyed for all students who were above the 4th grade of elementary school and their parents. We analyzed the data for 3,685 students. Result: From the 6th grade of elementary school to the 1st grade of high school, the girls' DSRS(Depression self-rating scale) score was significantly higher than the boys'. The DSRS score was increased from the 2nd grade of high school for boys and from the 1st grade of high school for girls. The Pearson correlation coefficient between age and DSRS score was 0.16(p<0.01) and that between APGAR and DSRS score was -0.45(p<0.01). The median number of psychosomatic symptoms of the past month was 6, and when students complained for more psychosomatic symptoms, the DSRS scores were higher. Those who drank or smoked ranked significantly higher in DSRS score; and, those who exercised regularly, had leisure activity, and had a faithful person for counselling ranked significantly lower in DSRS score. Conclusion : Adolescents who complained of many psychosomatic symptoms needed to be screened for depression. A primary physician have to intervene about health related behavior such as family function, smoking, exercise and relieving stress.

• Korean Journal of Social Welfare Studies
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• v.41 no.4
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• pp.225-246
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• 2010

The family environment children are exposed to growing up greatly influences their future potential and achievements. Previous findings show that changes in family structure during childhood, particularly those resulting from divorce or death, cause lasting negative consequence that affect the child physically, psychologically, economically, and socially. Unfortunately, single-parent households are becoming increasingly common in Korea, nearly doubling to more than a million cases in the last two decades. Existing domestic and international studies of this area tend to focus on the short-term effects of growing up in a single-parent household. In addition, these studies group their samples in ways that result in findings that may be too broad or are not necessarily an accurate representation of the subjects. This study attempts to address some of these shortcomings by focusing on the long-term effects of how changes in family structure early in children's lives affect achievement during their transition to adulthood. In addition, it takes into account the development cycle the child is in at the time of family restructuring, and what kind of long-term effects result from that. In this analysis, we find that there are several cases of statistically significantly differences in domain achievement depending on the developmental stage the child was in when the parental divorce or death occurred. The findings indicate that changes in family structure during the infant/toddler period influence health condition and depression, while changes in family structure during middle-childhood and adolescence do not. Meanwhile, changes in family structure during any point in the developmental stages have negative effects on educational attainment, with the severity of these negative effects depending on when the family changes occur. The negative effect on educational attainment is most prominent when a change in family structure occurs during the infant/toddler period, followed by adolescence, then middle-childhood.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.1
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• pp.113-125
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• 2023

It has been reported that stressful events in early life influence behavior in adulthood and are associated with different psychiatric disorders, such as major depression, post-traumatic stress disorder, bipolar disorder, and anxiety disorder. Maternal separation (MS) is a representative animal model for reproducing childhood stress. It is used as an animal model for depression, and has well-known effects, such as increasing anxiety behavior and causing abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. This study investigated the effect of MS on anxiety or aggression-like behavior and the number of GABAergic neurons in the hippocampus. Mice were separated from their dams for four hours per day for 19 d from postnatal day two. Elevated plus maze (EPM) test, resident-intruder (RI) test, and counted glutamic acid decarboxylase 67 (GAD67) or parvalbumin (PV) positive cells in the hippocampus were executed using immunohistochemistry. The maternal segregation group exhibited increased anxiety and aggression in the EPM test and the RI test. GAD67-positive neurons were increased in the hippocampal regions we observed: dentate gyrus (DG), CA3, CA1, subiculum, presubiculum, and parasubiculum. PV-positive neurons were increased in the DG, CA3, presubiculum, and parasubiculum. Consistent with behavioral changes, corticosterone was increased in the MS group, suggesting that the behavioral changes induced by MS were expressed through the effect on the HPA axis. Altogether, MS alters anxiety and aggression levels, possibly through alteration of cytoarchitecture and output of the ventral hippocampus that induces the dysfunction of the HPA axis.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.20 no.5
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• pp.145-154
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• 2019

As the interest in the positive quality of life is increasing throughout the world, the number of people who are suffering from negative sentiments, such as depression, anxiety, or stress, is increasing, as well. Especially, the adolescence period is the period of transition from childhood to adulthood and accompanies significant changes in terms of the body and mind alike. The purpose of this study is to examine the negative sentiment of the juveniles, caused by the stress they experience in their social and personal domains and the distress tolerance that can protect the inner feelings of them at the same time, to understand how they are related to the subjective well-being of the juveniles. For this study, the researcher employed the data from 362 high school students from the high schools located in Seoul and Gyeonggi area, which were analyzed using the statistics suites SPSS 22.0 and AMOS 22.0. According to the findings of this study, first, the depression and anxiety of the adolescent population showed a significant relationship for each variable with regard to the distress tolerance and the subjective well-being. Especially, the negative correlation with the subjective well-being was highly significant. Second, the depression and anxiety of the juveniles turned out to influence the distress tolerance and subjective well-being of them in a negative manner. In both distress tolerance and subjective well-being, the influence of anxiety was higher than that of depression. Third, in the relationship between depression, anxiety, and subjective well-being, the distress tolerance turned out to have a mediating effect. Such results of this study provided the basic data for suggesting the strategies to promote the perceived psychological well-being and help the juveniles who are under stress.

• Archives of Craniofacial Surgery
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• v.12 no.2
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• pp.102-106
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• 2011

Purpose: It is accepted universally that correction of the cleft lip nasal deformity requires multiple stages of surgery. Following primary lip repair in infancy or early childhood, secondary surgery to improve the deformity of the lip and nose is frequently necessary. A suitable surgical procedure to correct the accompanying deformity, such as cleft palate and alveolus, must be carried out at an appropriate age. In developing countries, it is common for patients with cleft lip nasal deformity to present severe secondary deformities in adolescence, because of poor follow-up and inappropriate surgery. Methods: The first patient was a 12 year old Mongolian boy. He presented prominent lip scar, short lip, wide columella, asymmetric nostril, palatal fistula, cleft alveolus, and velopharyngeal incompetence. He underwent cheilorhinoplasty, transpositional flap, alveoloplasty by iliac bone graft, and sphincter pharyngoplasty. On follow-up, a bilateral maxillary hypoplasia and a class III malocclusion developed. He underwent LeFort I osteotomy and maxillary advancement at the age of 16 years. The second patient was an 18 year old Eastern Russian girl. She presented with a deviated nose, right alar base depression, short lip, protrusion on vermilion, large palatal fistula, and severe VPI due to short palate. She underwent the combined procedure of cheilorhinoplasty, corrective rhinoplasty, tongue flap for palatal fistula, and superiorly based pharyngeal flap. And the tongue flap was detached at postoperative 3 weeks. Results: The overall results have been extremely pleasing and satisfactory to patients. There were no postoperative complications. Conclusion: We discovered the one stage operation for radical correction was sufficient procedure to provide excellent clinical outcomes in patients with severe cleft lip nose deformity.

• Journal of the Korean Academy of Child and Adolescent Psychiatry
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• v.14 no.1
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• pp.12-25
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• 2003

Objectives：As increasing number of new antidepressants have been being introduced in clinical practice, pharmacological understanding has been broadened. These changes mandate new information and theories to be incorporated into the treatment process of children with depressive disorders. In light of newly coming knowledge, this review intended to recapitulate the characteristics of new antidepressants and to consider the pivotal issues to develope guidelines for the treatment of depression in childhood and adolescence. Methods：Searching the Pub-Med online database for the articles with the key words of 'new', 'antidepressants' and 'children' ninety-seven headings of review articles were obtained. The author selected the articles of pertinent subjects in terms of either treatment guideline or psychopharmacology of new antidepressants. When required, articles about the clinical effectiveness of individual antidepressants were separatedly searched. In addition, the safety information of new antidepressants was acquired by browsing the official sites of the United States Food and Drugs Administration and Department of Health and Human Services. Results：1) For the clinical course, treatment phase, and treatment outcome, the reviews or treatment guidelines adopted the information from adult treatment guidelines. 2) Systematic and critical reviews unambiguously concluded that selective serotonin reuptake inhibitors(SSRIs) excelled tricyclic antidepressants( TCAs) for both efficacy and side effect profiles, and were recommend for the first-line choice for the treatment of children with depressive disorders. 3) New antidepressants generally lacked treatment experiences and randomized controlled clinical trials. 4) SSRIs and other new antidepressants, when used together, might result in pharmacokinetic and/or pharmacodynamic drug-to-drug interaction. 5) The difference of the clinical effectiveness of antidepressants between children and adults should be addressed from developmental aspects, which required further evidence. Conclusion：Treatment guidelines for the pharmacological treatment of childhood and adolescence depression could be constructed on the basis of clinical trial findings and practical experiences. Treatment guidelines are to best serve as the frame of reference for a clinician to make reasonable decisions for a particular therapeutic situation. In order to fulfill this role, guidelines should be updated as soon as new research data become available.