• 대한한의학원전학회지
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• 제35권4호
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• pp.77-96
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• 2022

Objectives : This paper examines the medical treatise and treatment methods of Zhang Jiebin on the depressive pattern, for clinical application today. Methods : The Zazhengmo/Yuzheng chapter of the Jingyue Quanshu, related texts and annotations of the Huangdineijing, and related contents among the medical texts of the JinYuan masters were analyzed. Developmental process of the medical theories were compared and examined. Results : Zhang focused on the mechanism in which emotion affects Qi leading to a disease state, and categorized Yu[鬱, depressed state] into three: anger depression, contemplative depression and comprehensive depression. The concept of the Five Depressive Patterns and its treatment from the Huangdineijing·Suwen which was considered as excess pattern was expanded to include deficiency pattern based on comparison with annotations of Wangbing, Hwashou, and Wang Andao. Treatment methods centered on purging was also expanded to include tonifying to restore the damaged Jing Qi. The depressive patterns anger depression, contemplative depression and comprehensive depression were subdivided according to excess and deficiency, for which formulas such as Shenxiangsan, Shoupijian, Guipitang were suggested. As the depressive pattern is caused by emotions and thus the Heart, the Yiqingbianqi method that directly deals with emotions was suggested. Zhang adopted Zhu Zhenheng's opinion which expands the category of Yu, and in the perspective of excess/deficiency, it is most similar to that of Li Dongyuan. Conclusions : Before Zhang, the depressive pattern was discussed in terms of it being excess pattern. However, Zhang's discussion on depressive pattern based on anger depression, contemplative depression and comprehensive depression focuses on emotional stagnation while suggesting the possibility of deficient stagnation, expanding previous understanding. In terms of treatment, tonifying methods for deficiency pattern was added, while consideration of emotion itself became necessary in treatment.

• 성인간호학회지
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• 제20권5호
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• pp.756-764
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• 2008

Purpose: The purpose of this study was to examine the effects of aromatherapy on dysmenorrhea, menstrual pain, anxiety, and depression in female college students. Methods: A two-group cross-over design was used. The sample included a total of 20 female students who were enrolled in a 3 year nursing program. The treatments(aroma essential oil inhalation and the placebo inhalation) were given using a necklace. The data were analyzed by $x^2$-test, paired t-test, and Mann-Whitney test using SPSS/WIN 12.0 program. Results: The level of dysmenorrhea after the aroma treatment was not significantly different from the dysmenorrhea levels at pre-test and after the post-placebo treatment. The menstrual pain, anxiety and depression significantly improved after the aroma treatment. However, the levels of pain, anxiety, and depression after the aroma treatment were not significantly different from those after the placebo treatment. Conclusion: Aroma inhalation may be a effective in managing menstrual pain, anxiety, and depression. In order to further clarify the effect of aroma treatment on discomfort during menstruation, replication studies are necessary. Future studies need to examine the effects of different types of essential oils, administrating methods, and the lasting time of aroma treatment effect.

• 생물정신의학
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• 제23권1호
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• pp.1-11
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• 2016

Development of various antidepressants such as monoamine oxidase inhibitors, tricyclic antidepressants, selective serotonin reuptake inhibitors, serotonin norepinephrine reuptake inhibitors, and noradrenergic and specific serotonergic antidepressant has led to a tremendous progression of pharmaceutical treatment for depression, but still there are some limitations of current antidepressants, such as treatment-resistant depression and delayed onset of antidepressants. The pathogenesis of depression is unclear because depression is a heterogeneous disease state, and the mechanisms of antidepressants remain uncertain as well. Nevertheless, in an attempt to develop novel antidepressants, some trials have been conducted based on the potential biological mechanism discovered in the numerous research results. This review will provide information about the potential novel antidepressants and the current states of clinical studies using them. In particular, some potential novel antidepressants anti-inflammatory agents, antioxidants, anticholinergics, modulators of Hypothalamic Pituitary Adrenal Axis, glutamate, and opioid systems, as well as some neuropeptides such as susbstance P, neuropeptide Y, and galanin will be discussed.

• 대한통합의학회지
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• 제11권1호
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• pp.53-62
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• 2023

Purpose : This study evaluated the effects of transcranial direct current stimulation and a virtual reality program on the depression, hand functions, cognitive function, and activities of daily living of patients with mild cognitive impairment by dividing 20 patients with mild cognitive impairment and depression. The 20 patients were divided into a treatment group (transcranial direct current stimulation + a virtual reality program) and a control group (placebo transcranial direct current stimulation + a placebo virtual reality program). Methods : This study allocated ten subjects to the treatment group and ten subjects to the control group. The treatment was given five times per week for six weeks (30 sessions), and each session was 30 minutes. This study screened depression by using SGDS-K, a short geriatric depression scale, to examine depression before and after treatment intervention. This study also used the box and block test, NCSE, and FIM to evaluate hand functions, cognitive function, and activities of daily living, respectively. Results : The results showed that depression significantly decreased, hand functions significantly increased, cognitive function significantly improved, and activities of daily living significantly increased after intervention in the treatment and control groups. The magnitude of changes in depression, hand functions, cognitive function, and activities of daily living was significantly different between the two groups after intervention (p>.05). Conclusion : The results showed that the application of transcranial direct current stimulation and a virtual reality program could improve cognitive function, hand functions, and activities of daily living by decreasing depression. Therefore, it can be concluded that the simultaneous application of transcranial direct current stimulation and a virtual reality program is an intervention method, which can be applied for decreasing depression, enhancing hand functions, improving cognitive function, and increasing activities of daily living in patients with mild cognitive impairment.

• Journal of Nutrition and Health
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• 제35권1호
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• pp.45-52
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• 2002

This study was to investigate 1) the correlation of serum Ca, with depression and anxiety ; and 2) the effect of Ca intake on those symptoms. The subjects were three females and two males who were 53-66 years old with the severe subjective symptoms of depression and anxiety. They have taken more than twice Ca of RDA(recommended dietary allowances for Koreans) daily for 6 months(dietary treatment). The prestudy Ca intake of the subjects was low: 60% of RDA for Koreans. Their serum Ca concentration was also low: 6.67 $\pm$ 0.15mg/d1 before the dietary treatment. They expressed severs depression and anxiety, with high self scores in a psychological test. Their serum Ca concentration increased to 8.32 $\pm$ 0.17mg/dl after six months of dietary treatment, while the symptoms of depression and anxiety decreased significantly after two months and nearly disappeared after six months. This result seemed to be an effect of the dietary high Ca intake. Serum Ca and the psychological states of depression and anxiety correlated negatively, and the coefficients of determination were high in the results of linear regression analysis of depression and anxiety by serum Ca. Therefore the serum Ca concentration could be a good marker to predict depression or anxiety relatively well. The continuous high Ca intake could decrease the probability of developing depression or anxiety and mitigate their symptoms because serum Ca concentration increased, while the state of depression and anxiety decreased with the increased Ca intake.

• 생물정신의학
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• 제14권1호
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• pp.5-13
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• 2007

Objectives : Depression disturbs the individual life from the loss of productivity to suicide. Furthermore the whole society is also influenced by depression in social and economic areas. Many scientific treatment methods are known to be effective in depression. But in reality more than half of patients with depression prefer self help treatment rather than medically based treatment. For the patients with mild depression and primary physicians, it is reasonable to provide the evidence based self care including self help or alternative treatment. This study is supported by the Korean Health 21 R&D Project for the Depression Center to establish the Korean treatment guideline for depression. Methods : The members of Depression Center including the authors attended the workshops where the methods of evidence based medicine such as literature search, quality evaluation of the articles, making the level of evidence were educated. The professional librarians helped the authors for get the searched articles. Among the total of 354 abstracts of systemic review and 300 abstracts of random controlled trials, 3 systemic reviews and 2 random controlled trials were the main structure of evaluation. Result : Among the 37 self care methods known to be effective for depression, 11 kinds of methods were worth of evaluation. The first step for the self care of mild depression is to use St. John's wort, exercise, bibliotherapy, and light therapy in depression during winter season. Acupuncture, negative ion therapy, massage, relaxation technique are known to be efective with evidence. Music therapy, hypnotherapy, and aromatherapy are known to be effective but until now the evidences is insufficient and further evaluations are needed. Conclusion : Among 11 listed self-care methods, several methods need more evidence especially in Korean situation. Exercise is the most recommendable evidence based self care method in Korea nowadays. St. John's wort is effective with evidence, but it is not the OTC drug in Korea, so it is not recommendable now. For the bibliotherapy, there is no book such as "Feeling Good" in Korea. Only the introductory book about depression is available. Publishing the self help book based upon cognitive behavioral approach or psychodynamic approach is needed. Light therapy is practiced in a few clinics, but not self-help style. Exposure to the sunlight is recommended in the level of commen sense. These self care methods are for the mild patient. Moderate to severe patients with depression should seek the professional treatment.

• 생물정신의학
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• 제13권1호
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• pp.3-10
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• 2006

Depression is the leading cause of disease-related disability among women. Postpartal depression (PPD) can produce substantial clinical, economic, and psychosocial impairment, not only for the women experiencing it but also for the women's children and family. Therefore, a comprehensive understanding the accurate detection and appropriate treatment of depression is mandatory in women of childbearing age. This review focused on the current knowledge of PPD.

• 동의신경정신과학회지
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• 제25권3호
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• pp.263-270
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• 2014

Objectives: This study aimed to examine the effects of multidimensional five senses treatment on patients with depression or anxiety. Methods: This study examined the effects of multidimensional five senses treatment for patients with depression or anxiety who visited the neuropsychiatric clinic of Korean medicine. STAI-X1,X2, BDI, BAI, PAS were used to determine whether the mood (depression or anxiety) of patients was improved. Results: Our results showed that multidimensional five senses treatment improved the depressive symptoms or anxiety symptoms. In addition, after the multidimensional five senses treatment, PAS score in patients with panic disorder was improved. Conclusions: The multidimensional five senses treatment was effective for the improvement of patients with depression or anxiety.

• 정신신체의학
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• 제11권1호
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• pp.52-59
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• 2003

연구목적: 여성 요실금 환자들의 불안과 우울의 정도를 알아보고 체외자기장신경치료 전후로 불안과 우울의 정도를 비교하고자 하였다. 연구방법: 산부인과 외래 여성 요실금 환자 55명을 대상으로 자가보고형 설문지를 이용하여 환자들을 호전군과 비호전군으로 나누어 체외자기장신경치료 전후로 불안과 우울의 정도를 측정하였다. 측정도구로는 Beck Depression Inventory(BDI), Beck Anxiety Inventory(BAI), Spielberger State-Trait Anxiety Inventory (STAI)를 사용하였고 통계분석은 SPSS를 사용하여 치료전후의 불안과 우울의 정도를 T-test를 하여 비교하였다. 결과 및 결론: 여성 요실금 환자들은 높은 수준의 불안과 우울을 보였다. 불안과 우울의 정도는 체외자기장신경치료 후 요실금의 호전과 관계없이 감소하였다. 체외자기장신경치료를 포함하여 요실금의 치료는 치료의 성공유무와 상관없이 치료한다는 그 자체로 요실금 환자들의 불안과 우울에 도움을 주는 것 같다.

• Korean Journal of Acupuncture
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• 제33권1호
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• pp.33-36
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• 2016

Objectives : The objective of this clinical case report is to describe an acupuncture treatment for dizziness after acoustic neuroma surgery. Methods : The patient was treated with acupuncture treatment for 4 months, 3 times per week. Duration for every treatment were 30 min by manual acupuncture with De Qi, which was designed to treat the dizziness and accompanied symptoms. Side-lying test was also used to evaluate dizziness and Hamilton Rating Scale for Depression(HDRS) to evaluate depression. We evaluated the clinical result of the treatment by observing the patients symptoms. Results : After acupuncture treatments for 4 months, patient's Side-lying test reduced to 10 second, and Hamilton Rating Scale for Depression reduced 4 points. Conclusions : The clinical case treatment report may suggest that the acupuncture treatment can be a meaningful option for the intractable dizziness after acoustic neuroma surgery, and also able to reduced depression scale.