• Journal of Oriental Neuropsychiatry
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• v.30 no.2
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• pp.71-88
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• 2019

Objectives: The present study aims to review the antidepressant effect of herbal medicines reported in Korean local journals. Methods: We searched in electronic databases (Koreantk, KISS, OASIS, NDSL) for studies, published in Korean national journals, that assessed herbal medicine effect of depression model. The search term was 'depression' in the abstract or whole text. Depression model, herbal material, experimental results, mechanisms were extracted. Results: We included 43 articles in which 38 studies were in vitro experiments, and the rest 5 were in vivo experiments. The most common experiment subject model was a rat and the most widely used method to induce depression was Despair behavior test. 21 studies used simple herbal medicines, and 22 studies used complex herbal medication. Glycyrrhizae Radix was the most commonly used herbal material to improve depression model. The most common mechanisms of herbal medicine with antidepressant effect were inhibition of Monoamine activation mechanism and depression related neurohormone secretion. Conclusions: Herbal medicines may be a promising resource for treating depression.

• Toxicological Research
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• v.26 no.4
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• pp.315-320
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• 2010

It has been clinically reported that toluene causes mental depression in humans. However, the detrimental effects of toluene exposure on brain function and the relation between features of mental depression and toluene exposure are poorly understood. This study evaluated depression-like behaviors in adult C57BL/6 mice after administration of toluene, and elucidated the effects of classical antidepressants on the depression-like behaviors. For the estimation of depression-like behaviors, tail suspension test (TST) and forcedswim test (FST) were performed 1, 4 and 16 days after toluene (0~1000 mg/kg bw) treatment. In addition, classical antidepressants such as fluoxetine (FLX, 20 mg/kg bw) and imipramine (IMI, 40 mg/kg bw) were administered 12 h and 1 h before the tests. In the TST and FST, toluene-treated mice exhibited a longer duration of immobility than vehicle-treated mice 1 and 4 days after toluene treatment. The depression-like behaviors were significantly reversed by FLX and IMI. The weight of the adrenal gland and the size of adrenocortical cells were significantly higher in toluene-treated mice compared to vehicle-treated controls. It is suggested that acute toluene exposure of adult mice is sufficiently detrimental to induce depression. In addition, this study has established a mouse model for a depressive state induced by toluene treatment.

• Journal of Practical Engineering Education
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• v.15 no.3
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• pp.761-770
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• 2023

This study was conducted to identify factors affecting depression in the elderly using three-year Community Health Survey data from 2020, when COVID-19 was declared an epidemic. Differences in depression according to general characteristics, health behavior, subjective health level, and medical use among 220,921 elderly were analyzed using complex samples t-test and ANOVA, and multiple regression analysis was performed to identify factors affecting depression it was carried out. As a result of the study, the level of depression among elderly women was found to be high, with an average of 1.21±0.01 for elderly men and 1.74±0.02 for elderly women, and there was a difference in generation type, with depression being higher in the first generation for elderly men and the third generation for elderly women. Variables that had a great influence on depression were the experience of depression and perceived stress.

• Journal of agricultural medicine and community health
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• v.35 no.2
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• pp.124-133
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• 2010

Objectives: This study is to offer basic data to understand the relationships between mental health, level of depression, and internet addiction of high school students in farming communities for developing a mental health management program for adolescents. Methods: The survey was carried out on a convenience sample of 299 high school students in farming communities during May of 2008. Data analysis procedure included $X^2$-test, t-test, Pearson correlation among Adolescent Mental Health & Problem-behavior Screening Questionnaire (AMPQ), Children's Depression Inventory (CDI), and Scales of Internet addiction (K-scales). Results: First, the level of mental health according to the AMPQ for subjects from this study showed problematic behavior was lower when compared to other researches. There were statistically significant differences according to the school type for externalization problems and overall problematic behavior. Based on gender, it was even more problematic for male students in regards to externalization problems. Secondly, the level of depression was relatively low : 5.1% for potential risk and 0.3% for high risk. Thirdly, a total of 96.9% were considered normal for Internet addition levels. 1.7% for potential risk, 1.4% for high risk; however, there was no statistically significant difference between each variable. Fourthly, there was a strong relationship between subjects AMPQ, level of depression and Internet addiction. As depression worsens, Internet addiction also becomes stronger. Conclusion: There is a need for awareness of the mental health of adolescents and precautionary measures, the development of a program for early treatment, adequate management, and decisions on the direction of treatment.

• Research in Community and Public Health Nursing
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• v.28 no.3
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• pp.271-279
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• 2017

Purpose: Non-Suicidal Self-Injury (NSSI), a highly prevalent behavior in adolescents, refers to the direct destruction of one's body tissue without suicidal intent. To date, the prevalence of adolescent self-injury in South Korea and its associated factors remain unknown. This study aims to determine the prevalence of self-injury in Korean adolescents as well as its associated factors. Methods: We assessed 717 middle school students by means of an anonymous self-report survey. Information about demographic characteristics, lifestyle, anxiety and depression, self-esteem, and parenting behavior was obtained. Data were analyzed using $x^2$ test, t-test and multiple logistic regression. Results: NSSI was reported by 8.8% of respondents. Univariate analyses showed associations of exposure to alcohol use, anxiety, depression, self-esteem, and parenting methods with self-injury. In multiple analyses, alcohol use, anxiety, and parental abuse were associated with lifetime self-injury. Conclusion: The rate of NSSI in the South Korea was found to be lower than those of other countries. As our study suggests that alcohol use, anxiety, and parental abuse are associated with lifetime self-injury, health care providers at school should take these factors into account when developing prevention and intervention programs for adolescents.

• Korean Journal of Acupuncture
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• v.38 no.3
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• pp.162-174
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• 2021

Objectives : We aimed to identify the antidepressant effect of liver tonification acupuncture treatment (ACU (LT); KI10, LR8, LU8, LR4) and four gate acupuncture treatment (ACU (FG); LI4, LR3) and its brain neural activity in the normal and chronic restraint stress (CRS)-induced mouse model. Methods : Firstly, normal mice were given ACU (LT) or ACU (FG) and the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Secondly, CRS was administered to mice for 4 weeks, then ACU (LT) or ACU (FG) was performed for 2 weeks. The depression-like behavior was evaluated using open field test (OFT) before and after acupuncture treatment. Then, the c-Fos expressions in each brain region were analyzed to examine brain neural activity. Results : In normal mice, ACU (FG) regulated brain neural activities in the hypothalamus, hippocampus, and periaqueductal gray. ACU (LT) changed more brain regions in the prefrontal cortex, insular cortex, striatum, and hippocampus, including those altered by ACU (FG). In CRS-induced model, ACU (LT) alleviated depression-like behavior more than ACU (FG). Also, brain neural activities in the motor cortex area 2 (M2), agranular ventral part and piriform of insular cortex (AIV and Pir), and cornu ammonis (CA) 1 and CA3 of hippocampus were changed by ACU (LT), and those of AIV and CA3 were also changed by ACU (FG). As in normal mice, ACU (LT) resulted in changes in more brain regions, including those altered by ACU (FG) in CRS model. M2, Pir, and CA1 were only changed by ACU (LT) in depression model, suggesting that these brain regions reflect the specific effect of ACU (LT). Conclusions : ACU (LT) relieved depression-like behavior more than ACU (FG), and this acupuncture effect was associated with modulation of brain neural activities in the motor cortex, insular cortex, and hippocampus.

• Journal of muscle and joint health
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• v.29 no.3
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• pp.165-175
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• 2022

Purpose: This study was conducted to identify differences in health behavior, health-related quality of life, and depression between adult men and women during the COVID-19 pandemic. Methods: Data were obtained from 1,927 men and 2,314 women aged 19 to 64 who participated in the 7th Korea National Health and Nutrition Survey in 2020. Data were analyzed using complex sample x² test, complex sample general linear model, and complex sample logistic regression. Results: During the pandemic, men drank more alcohol (OR=2.34, 95% CI: 1.89~2.91) and smoked more (OR=7.89, 95% CI: 6.16~10.09) than women. In addition, men were 2.45 times more exposed to second-hand smoke at the workplace (95% CI: 1.78~3.37) and 1.4 times more exposed in public places (95% CI: 1.12~1.77). The rate of muscle exercise was higher among men than women (OR=2.09, 95% CI: 1.76~2.49). No difference in health-related quality of life was observed between men and women (t=0.17, p=.78), but women had higher depression scores (t=-3.14, p=.002). Conclusion: Customized sex-specific interventions should be developed during the COVID-19 pandemic. This kind of infectious disease disaster requires plans designed to reduce alcohol intake and smoking among men and interventions aimed at increasing muscle exercise among women. Strategies should also be formulated to reduce depression among women.

• The Korean Journal of Physiology and Pharmacology
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• v.27 no.1
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• pp.113-125
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• 2023

It has been reported that stressful events in early life influence behavior in adulthood and are associated with different psychiatric disorders, such as major depression, post-traumatic stress disorder, bipolar disorder, and anxiety disorder. Maternal separation (MS) is a representative animal model for reproducing childhood stress. It is used as an animal model for depression, and has well-known effects, such as increasing anxiety behavior and causing abnormalities in the hypothalamic-pituitary-adrenal (HPA) axis. This study investigated the effect of MS on anxiety or aggression-like behavior and the number of GABAergic neurons in the hippocampus. Mice were separated from their dams for four hours per day for 19 d from postnatal day two. Elevated plus maze (EPM) test, resident-intruder (RI) test, and counted glutamic acid decarboxylase 67 (GAD67) or parvalbumin (PV) positive cells in the hippocampus were executed using immunohistochemistry. The maternal segregation group exhibited increased anxiety and aggression in the EPM test and the RI test. GAD67-positive neurons were increased in the hippocampal regions we observed: dentate gyrus (DG), CA3, CA1, subiculum, presubiculum, and parasubiculum. PV-positive neurons were increased in the DG, CA3, presubiculum, and parasubiculum. Consistent with behavioral changes, corticosterone was increased in the MS group, suggesting that the behavioral changes induced by MS were expressed through the effect on the HPA axis. Altogether, MS alters anxiety and aggression levels, possibly through alteration of cytoarchitecture and output of the ventral hippocampus that induces the dysfunction of the HPA axis.

• Journal of Korea Society of Industrial Information Systems
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• v.24 no.6
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• pp.107-118
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• 2019

The purpose of this study is to analyze the effect of "emotional leadership" on innovative behavior and psychological depression through mediation of job engagement and self-efficacy. In order to accomplish this objective, hypotheses were set up and we distributed questionnaires to bankers and analyzed the final 294 copies. For the hypothesis test, the SPSS Process Macro was used for regression analysis and double mediation. As a result, emotional leadership positively affects self-efficacy, and self-efficacy positively affects job engagement and innovation behavior. Also, job engagement has a negative effect on psychological depression. As a result of verifying the dual mediation effect, both self-efficacy and job engagement showed a full mediating effect.

• Journal of the Korean Dietetic Association
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• v.25 no.2
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• pp.142-155
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• 2019

The aim of this study was to construct and test a structural equation model for the risk factors of metabolic syndrome in Korean adults. The structural equation model hypothesizes that eating alone and feeling depressed is a risk factor for metabolic syndrome. The data of this study were obtained from the Sixth Korea National Health and Nutrition Examination Survey which was cross-sectional data from the representative national survey. A total of 4,013 subjects replied to the survey item of lifestyle and completed the physical examinations among adults aged 19 years or older in South Korea was in 2015. The structural model in this study was composed of four latent variables: eating alone, depression, negative health behavior, and metabolic syndrome. Two variables, the rate of eating alone and depression, were exogenous variables. Negative health behavior was both a mediating variable and endogenous variable, and metabolic syndrome was the final endogenous variable. The data were analyzed using the Maximum Likelihood method and bootstrapping. The structural model was appropriate for the data based on the model fit indices. The results of this study can be summarized as follows: Eating alone is a direct risk factor of metabolic syndrome in Korean women. Depression can mediate metabolic syndrome through negative health behaviors. Negative health behavior had a direct impact on metabolic syndrome in both men and women. This study may be a guideline for interventions and strategies to reduce the incidence of metabolic syndrome in Korean adults.