• 한국산림과학회지
• /
• 제98권2호
• /
• pp.170-177
• /
• 2009

There are remarkable differences in growth and morphological characters of roots between mountain and field cultivated Panax ginseng. Growth of root in mountain cultivated ginseng was much slower than that of field cultivated ginseng. However, the factor affecting the retarded growth in mountain ginseng was not known. Soil analysis revealed that phosphorus (P) content of mountain soil was exceptionally low at least ten-fold lower compared to that of field soil. Thus, we suggest that low availability of P in mountain soil may be one of the limiting factors for growth of ginseng in mountain soil environment. We had monitored the growth of ginseng plants after one and three years of phosphate fertilizer application. Three kinds of phosphate fertilizers: fused magnesium phosphate, fused superphosphate, and single superphosphate were applied to mountain soil. Application of phosphate fertilizers increased the fresh-, dry weight, and diameter of ginseng roots and resulted in increased P accumulation in roots. These results demonstrate that slow growth of ginseng in mountain soil environment might be attributed to the low P content in mountain soil. Thus, analysis of P amount in mountain soil will be a good indicator for the selection of suitable site the ginseng cultivation in forest.

• Asian Pacific Journal of Cancer Prevention
• /
• 제15권8호
• /
• pp.3817-3823
• /
• 2014

Background: The MDM2 oncogene, a negative regulator of p53, has a functional polymorphism in the promoter region (SNP309) that is associated with multiple kinds of cancers including non-melanoma skin cancer. SNP309 has been shown to associate with accelerated tumor formation by increasing the affinity of the transcriptional activator Sp1. It remains unknown whether there are other factors involved in the regulation of MDM2 transcription through a trans-regulatory mechanism. Methods: In this study, SNP309 was verified to be associated with overexpression of MDM2 in tumor cells. Bioinformatics predicts that the T to G substitution at SNP309 generates a stronger E2F1 binding site, which was confirmed by ChIP and luciferase assays. Results: E2F1 knockdown downregulates the expression of MDM2, which confirms that E2F1 is a functional upstream regulator. Furthermore, tumor cells with the GG genotype exhibited a higher proliferation rate than TT, correlating with cyclin D1 expression. E2F1 depletion significantly inhibits the proliferation capacity and downregulates cyclin D1 expression, especially in GG genotype skin fibroblasts. Notably, E2F1 siRNA effects could be rescued by cyclin D1 overexpression. Conclusion: Taken together, a novel modulator E2F1 was identified as regulating MDM2 expression dependent on SNP309 and further mediates cyclin D1 expression and tumor cell proliferation. E2F1 might act as an important factor for SNP309 serving as a rate-limiting event in carcinogenesis.

• 한국산학기술학회논문지
• /
• 제18권10호
• /
• pp.669-674
• /
• 2017

화석 연료의 고갈 및 환경오염의 증가로 인하여 전기 에너지를 사용하는 전기 자동차가 차세대 교통수단으로 주목받고 있으며 전 세계적으로 인기를 끌고 있다. 전기 자동차의 보급률 및 관심이 높아짐에 따라 V2G (Vehicle to Grid) 및 IT 기술을 이용한 충전 인프라에 대한 연구가 활발히 진행되고 있다. 특히, 전기 자동차의 안정적인 충전 및 부하 관리를 위하여 그리드 네트워크와의 통신은 가장 중요한 요소이다. 그러나 기존의 중앙 집중형 인프라 구조의 경우 제어 메시지 요청이 증가할 경우 느린 응답속도로 인하여 충전 인프라가 효율적으로 작동하지 못하는 문제점들이 존재한다. 본 논문에서는 분산형 클라우드 컴퓨팅 기술을 무선 기지국에 적용하여 충전 인프라에 혼잡을 줄이고 지연시간을 줄이기 위해 MEC (Mobile Edge Computing)를 활용한 새로운 전기자동차 충전 인프라 구조를 제안한다. 성능 평가를 통해 본 논문에서 제안한 저 지연시간을 가지는 충전 인프라가 기존에 존재하는 충전 인프라보다 효율적으로 전력 피크 상황에 대처함을 확인하였다.

• 센서학회지
• /
• 제18권2호
• /
• pp.110-115
• /
• 2009

Polystyrene (PS) microspheres were used to good advantage as a template material to prepare macroporous $TiO_2$ thin films. This is enabled to run the thermal decomposition of the PS without the collapsing of the 3-D macroporous framework during the calcination step. $TiO_2$ thin films were deposited onto the colloidal templated substrates at room temperature by RF sputtering, and then samples were thermally treated at $450^{\circ}C$ for 40.min in air to remove the organic colloidal template and induce crystallization of the $TiO_2$ film. The macroporous $TiO_2$ thin film exhibited a quasi-ordered partially hexagonal close-packed structure. Burst holes, estimated to be formed during PS thermal decomposition, are seen as the hemisphere walls. the inner as well as the outer surfaces of the hollow hemispheres formed by the method of thermal decomposition can be easily accessed by the diffusing gas species. As a consequence, the active surface area interacting with the gas species is expected to be enlarged about by a factor of fourth as large as compared to that of a planar films. Also the thickness at neighboring hemisphere could be controlled a few nm thickness. If the acceptor density becomes as large that depletion width reaches those thickness, the device is in the pinch off-situation and a strong resistance change should be observed.

• 동의생리병리학회지
• /
• 제18권1호
• /
• pp.93-100
• /
• 2004

This study was carried out for analyzing pathological and epidemiological factors of osteoporosis and doing pilot test using trial compounds of tuna bone and oriental herbs based on the factors. Osteoporosis is originated from osteoblast, osteoclast, organic and inorganic factors etc. Therefore the pathology of osteoporosis is not simple because the cytokine, growth factors and hormones of the components are various a lot. Taking a view of epidemiological factors of type I osteoporosis, ageㆍmenarcheㆍcholesterolㆍBMI etc. have definite relation to them. So we can approach to aging or consumptive disease in oriental medicine, specifically differential diagnosis of blood depletion with deficiency of qi, deficiency of kidney, deficiency of yin, bony weakness etc. And it should be considered together with rules for maintaining good health or habit concomitantly. Therefore IL1ㆍ6 or TNF αㆍβ are generally used as molecular biological index for osteoblast and osteoclast because the most important index is bone mineral density and strength, but the factors like collagen and noncollagen protein must be accounted as biomarkers. Trial compounds generally showed favorable effects on accompanying subjective symptoms of osteoporosis in the pilot test for menopausal woman. But if she didn't have specific symptoms of osteoporosis there wasn't any specific change. And osteocalcin was increased in case of being under standard level, but wasn't changed in case of normal level. Therefore these trial compounds can be used as a funcdonal diet for type I osteoporotic patients or preventive measures.

• 한방재활의학과학회지
• /
• 제30권1호
• /
• pp.1-12
• /
• 2020

Objectives Depletion of ovarian function after menopause in women induces estrogen deficiency leading to increased fat and decreased muscle mass. In this study, we examined the effect of herbal medicines by measuring hormone expression in muscle tissue of estrogen-deficient rats induced by ovariectomy. Methods Ovariectomy was performed to induce estrogen deficiency, and mice were given herbal prescription (HP) for 6 weeks. Estrogen-deficient rats were divided into two groups: one group (HPH) which were orally administered HP 200 mg/kg and the other group (HPL) administered HP 40 mg/kg. Weight changes in both groups were measured using polymerase chain reaction (PCR). After extraction of the femoral muscles in mice, the expression of the leptin, lipoprotein lipase (LPL), diacyl glycerol acyltransferase (DGAT)1, peroxisome proliferator-activated receptor-γ coactivator (PGC)-1α, NADH dehydrogenase (NDH), farnesyl diphosphate farnesyltransferase (FDFT)1, lanosterol synthase (LSS), phosphatidylethanolamine N-methyltransferase (PEMT), and peroxiredoxin (Prdx6) were measured using PCR. Results HP increased the expression of leptin, LPL, DGAT1, PGC-1α, NDH, FDFT1, LSS, PEMT, and Prdx6. HP affects body fat metabolism and is effective in improving menopausal obesity and obesity complications caused by estrogen deficiency. However, HP does not affect the expression of tumor necrosis factor-α and 3-hydroxy-3-methylglutaryl-CoA reductase, and thus will not be effective in obesity-related metabolic diseases. Conclusions HP is thought to inhibit weight gain by regulating hormone expression related to glucose metabolism and lipid metabolism in muscle tissue of estrogen-deficient rats.

• 설비공학논문집
• /
• 제7권3호
• /
• pp.435-449
• /
• 1995

In this paper, pressure drop through a capillary tube is modeled to determine the length of a capillary tube for a given set of conditions. HCFC-22 and its alternatives, HFC-134a, R407B, and R410A are used as working fluids. The conditions on which the model is tested are as follows : condensing temperature; 40.0, 45.0, 50.0, $55.0^{\circ}C$, degree of subcooling;0.0, 2.5, $5.0^{\circ}C$, capillary tube exit condition;choked flow, capillary tube diameter;1.2~2.4mm, mass flow rate;5.0~50.0g/sec. The results justify the use of Stoecker's model which yields the results very close to the values in ASHRAE handbook. While McAdams' method yields much better results than Duckler's in calculating the viscosity of the fluid in 2-phase, the friction factor suggested by Stoecker seems to be the best for capillary tubes of large diameter used in residential air conditioners. For each refrigerant, 372 data with various variables are calculated by the model. The results show that capillary tube length varies very uniformly with changes in condensing temperature and degree of subcooling. Based on this fact, regression analysis is performed to determine the dependence of mass flow rate on the length and diameter of a capillary tube, condensing temperature, and degree of subcooling. Thus determined correlation yields a mean deviation of 2.36% for 1,488 data, showing an excellent agreement.

• The Korean Journal of Physiology
• /
• 제11권1호
• /
• pp.37-44
• /
• 1977

In the previous study of the release, excretion, and plasma concentration of aldosterone in normal Koreans, the author found that urinary aldosterone excretion and aldosterone secretion rate of the Korean who usually take high amount of salt are significantly lower, in compared to Americans, although the plasma concentration is only tended to be low. The control of plasma aldosterone level depends on the secretion rate and the metabolic clearance of the hormone. In this experiments, the metabolic clearance rate of aldosterone was determined in normotensive korean and the effects of adrenal stimulations on the rates were also studied in the same subjects. The metabolic clearance rate of the normal Korean was not significantly different from those of the American, and shown a little increase in response to sodium restriction. These results indicate that the decrease in secretion rate rather than the increase in metabolic clearance Tate is the major factor maintaining lower plasma aldosterone level. After furosemide diuresis, on the contrary, the removal of aldosterone showed significant the decrease despite slight increase of secretion rate. This suggest that the reduction in metabolic clearance rate of the hormone during volume depletion found to be major cause of high plasma concentration. Additional potassium supply produced detectable decrease of metabolic clearance rate, but the changes were smaller than that of secretion rate, which suggested that the higher secretion rate could account for elevated plasma concentration of aldosterone rather than metabolic clearance. Above results also support author's previous evidences that the normal Korean who already adapted to a high sodium diet have ability to produce adequate aldosterone activity without producing detectable changes on the metabolic clearance rate under the condition of sodium restriction with approp riate potassium intake.

• 천문학회보
• /
• 제41권1호
• /
• pp.73.1-73.1
• /
• 2016

We present preliminary results of the submillimeter continuum observations of 14 Planck Galactic Cold Clumps (PGCCs), located in the ${\lambda}$ Orionis Complex. This region is the nearest large HII region, which is an ideal site for a study of the stellar feedback to its surroundings. We observed 14 PGCCs with JCMT/SCUBA-2 and used J=1-0 transitions of CO isotopologues from the PMO mapping observation. Several sub-clumps toward three PGCCs were detected at $850{\mu}m$. In order to examine whether these clumps can be candidates for pre-stellar cores, we compared each clump mass calculated from the $850{\mu}m$ continuum map to its Virial mass and Jeans mass calculated from the $^{12}CO$ and $C^{18}O$ (1-0) spectra, respectively. All clumps have masses smaller than their Virial and Jeans masses, indicating that none of them are gravitational bound and thus in the pre-stellar core stage. Also, the CO depletion factor, which has been derived from the dust continuum and the $C^{18}O$(1-0) line and can be an indicator of core evolution, toward the clumps is in the range of 1 to 5, suggesting that they are not very evolved dense pre-stellar cores. In addition, within individual PGCCs, we found clear gradients of velocity (${\sim}1km\;s^{-1}\;pc^{-1}$) and temperature (${\sim}10K\;pc^{-1}$) in the $^{13}CO$ (1-0) first moment map and the $^{12}CO$(1-0) excitation temperature map, respectively. This can be attributed to the compression and external heating by the HII region, which may prevent clumps from forming gravitationally bound structures and eventually disperse clumps. These results could be a hint about the negative effect of stellar feedback on core formation.

• 농업과학연구
• /
• 제47권3호
• /
• pp.485-496
• /
• 2020

Recent changes in the disaster environment have greatly increased the possibility of internal erosion in deteriorated reservoirs; thus, countermeasure methods are required to enhance the drainage performance of embankments. Sand filters have been mainly used to prevent internal erosion; however, due to the sand depletion and environmental problems, new alternative materials are required to replace the sand in the filter zone. In this study, crushed stone was used instead of sand as a material that could satisfy permeability, material supply, demanding conditions, and economic efficiency. Although crushed stone has excellent drainage performance, it has a clogging phenomenon due to its high permeability. Accordingly, the materials need to be separated with a geotextile wrapping method. Additionally, the 3D numerical analysis and a large model experiment were conducted to evaluate the seepage characteristics and in-site application of the crushed stone filter. As a result, the crushed stone filter showed an excellent dispersion effect by reducing the pore water pressure by about 9.5 times that of the sand filter. In addition, it was shown that the safety factor for piping increased significantly by reducing internal erosion. When comparing the economics and supply and demand conditions of the material, crushed stone was evaluated as an effective method to reduce the internal erosion of embankments at deteriorated reservoirs.