• Korean Journal of Fisheries and Aquatic Sciences
• /
• v.43 no.5
• /
• pp.437-444
• /
• 2010

Extracts of the marine microalgae Nannochloropsis oculata were obtained using 80% methanol (MeOH) and water. The 80% MeOH extract was further fractionated with n-hexane, chloroform, ethyl acetate (EtOAc), n-butanol (n-BuOH), and water to isolate the active fraction. Seven samples were prepared and their angiotensin converting enzyme (ACE), $\alpha$-glucosidase, and cancer cell growth inhibitory activities in vitro were determined. The most profound ACE inhibitory activity was observed in the chloroform fraction, while the others had moderate effects. By contrast, greater $\alpha$-glucosidase inhibitory activity was found in the EtOAc fraction, n-hexane fraction, and water extract of N. oculata. The antiproliferative effects of the extracts and fractions against HL-60, U937, CT-26, and SK-Hep1 cancer cells were also determined. The n-BuOH fraction had the strongest antiproliferative effects on CT-26 cells in a time-dependant manner (P<0.05). These results suggest that the extracts and fractions from N. oculata could be used as a potential functional food or as pharmaceutical ingredients.

• The Journal of the Korea Contents Association
• /
• v.7 no.11
• /
• pp.76-83
• /
• 2007

In the sequentially rotated array antennas, the characteristics of antenna gain, axial ratio and cross polarization have been analyzed with a varying of sequential array constant(number of array element, figure of rotation) respectively. Where the antenna element of array is a probe feeding, LHCP truncated microstrip antenna whose resonant frequency is in 11.85GHz. The simulation results of 23 SRA antennas((M=2, 3, 4, 6, 8), $(1\leqP\leqM)$) has shown as follows. The widest 3dB bandwidth of axial ratio appears at P=2 which is in-dependant of M, the highest antenna gain appears when a sequential array constant has a pair of (2, 1), (3, 2), (4, 1), (6, 3), (8, 1) respectively. Specially, all of the SRA antenna appear very poor characteristics in case of M=P. Therefore the SRA antenna has to be designed as selecting a optimal sequential array constant among a lot of simulation data.

• Journal of Hydrogen and New Energy
• /
• v.9 no.1
• /
• pp.31-37
• /
• 1998

The crystal structures, the lattice parameters and the characteristics of hydrogen storage at 303K has been investigated in the ternary alloys of Ti-Cr-V system. All of these alloys, in the range of this study, have shown a bcc structure. The hydrogen storage capacities and the effective hydrogen storage capacities of the alloys were strongly dependant on the composition ratio of Ti/Cr, showing their maximum values at the Ti/Cr ratio of about 0.75. It was also found that the lattice parameters of the alloys increased linearly with an increase of the Ti/Cr ratio. The differences in affinities to hydrogen and lattice parameters of pure metal states of the three elements have been adopted in oder to explain the Ti/Cr ratio dependance of the lattice parameter and hydrogen storage capacity of the alloys.

• Proceedings of the Korean Institute Of Construction Engineering and Management
• /
• autumn
• /
• pp.143-148
• /
• 2001

Digital documentation is now becoming a must throughout a building process including design, construction, inspection, procurement and even facility management. The Internet is a backbone of such process, and web-based information exchange is the standard among other mainstream technologies. The current information management techniques, however, is heavily dependant on the server-side processing, which naturally results in the overload of the overall system. This paper proposes an XML-based approach in order to resolve such problems. A VE system was developed to demonstrate the efficiency of the XML solution, in term of efficient VE data management and fast decision making. also in this paper suggests 1) introduce XML based DBMS to improve data management efficiency and 2) introduce Mobile Computing to improve data accessibilities on sites.

• Imaging Science in Dentistry
• /
• v.38 no.4
• /
• pp.195-202
• /
• 2008

Purpose : To characterize the effects of 2-deoxy-D-glucose (2-DG) and quercetin (QCT) on gene expression of osteonectin (ON) and osteopontin (OP) in irradiated MC3T3-El cells. Materials and Methods : When MC3T3-El osteoblastic cells had reached 70-80% confluence, cultures were transferred to a differentiating medium supplemented with 5 mM 2-DG or 10 ${\mu}M$ QCT and then irradiated with 2, 4, 6, and 8 Gy. At various times after irradiation, the cells were analyzed for the expression of bone mineralization genes such as ON and OP. Results : The mRNA expression of both ON and OP was increased according to the culture time in the differentiation medium, and the increase of the genes peaked at 14 days after the differentiation induction. In the case of OP, the increase of mRNA expression was maintained to 28 days after the differentiation, while the mRNA level of ON was reduced to the basal level at the same time. Irradiation adding 2-DG showed a significant peak value in the expression pattern of ON at 4 Gy 7 days after irradiation. Irradiation adding QCT increased the mRNA expression of ON and OP in a dose-dependant manner, but irradiation adding 2-DG did not show any differences between the control and experiments 14 days after irradiation. Irradiation adding QCT increased significantly the expression patterns of ON 21 days after irradiation. Conclusion : The results showed that QCT acted as a radiosensitizer in the gene expression of ON and OP during differentiation of the late stage of irradiated MC3T3-E1 osteoblastic cells in vitro. (Korean J Oral Maxillofac Radiol 2008; 38: 195-202)

• The Korea Journal of Herbology
• /
• v.31 no.5
• /
• pp.79-84
• /
• 2016

Objective : Nypa fruticans Wurmb. Fruit (NF) has been used as a conventional medicine to treat inflammatory peridontal diseases in Myanmar and Eastern Asia. However, the anti-inflammatory effect of NF aqueous extract on lipopolysaccharide (LPS)-induced inflammatory responses was not well-investigated. Therefore, this study was aimed to investigate the anti-inflammatory effect of NF on LPS-induced inflammatory responses on RAW 264.7 cells.Methods : To induce inflammation on the macrophage cell line, RAW 264.7 cells were treated with 500 ng/mL of LPS. Water extracts of NF was treated 1 h prior to treatment of LPS. Cell viability was measured by MTT assay. Production of nitrite was measured with Griess assay and pro-inflammatory cytokines such as interleukine (IL)-1β and IL-6, and tumor necrosis factor (TNF)-α was measured by enzyme-linked immunosorbent assay (ELISA) and real-time polymerase chain reaction (PCR). In addition, we examined the inhibitory mechanisms of NF by western blot and immunocytochemistry.Result : Water Extract from NF itself did not have any cytotoxic effect at the concentration of 200 ㎍/ml in RAW 264.7 cells. Treatment of NF inhibited the production of nitrite, and pro-inflammatory cytokines inlcuding IL-1β, IL-6 and TNF-α in a dose dependant. In addition, NF treatment inhibited the LPS-induced activation and translocation of nuclear factor (NF)-κB.Conclusion : In summary, our result suggest that treatment of NF could reduce the LPS-induced inflammatory responses via deactivation of NF-κB. This study could suggest that NF could be a beneficial drug or agent to prevent inflammation.

• Journal of the Korean Ceramic Society
• /
• v.36 no.7
• /
• pp.734-741
• /
• 1999

Al2O3/t-ZrO2 particulate composites were prepared by sintering at 150$0^{\circ}C$ and 1$600^{\circ}C$ for 2h in air and microstructure and mechanical properties of the composites were investigated. Although most ZrO2 particles existed at Al2O3 grain boundaries a few ZrO2 particles within Al2O3 grains. Al2O3 grain growth was depressed due to the pinning effect by ZrO2 particles. During sintering coarsening of intergranular ZrO2 particles occurred as a results of the elimination of ZrO2 intraagglomerate grain boundaries and the coalescence of dragged ZrO2 particles by migrating Al2O3 grain boundries. Changes in mechanical properties of Al2O3 composites were dependant on microstructure of Al2O3 matrix and on size and structure of dispersed ZrO2.

• The Journal of Natural Sciences
• /
• v.8 no.1
• /
• pp.115-121
• /
• 1995

The Conventional database management system is not applicable because of their inadequate performance and difficulty of CAD database that is dependant to hierarchical structure and to repeat accesses of large data. For effective management and easy tool integration of CAD database, hierarchy Interface System(HIS) is designed and GROCO(Graph Representation fOr Complex Objects) Model is presented. Hierarchy Interface System which is composed of two subsystems of a configurator and a converter is designed for the interface between a conventional database management system and CAD tools. GROCO Model is a directed cyclic graph having five node-types for representing semantics and supports efficiently CAD database characters having a hierarchical structure of complex objects.

• Journal of the East Asian Society of Dietary Life
• /
• v.18 no.6
• /
• pp.1081-1088
• /
• 2008

In this study, the antioxidant activities and quality characteristics of noodles amended with spirulina were evaluated. Wheat flour noodles were prepared using three levels of spirulina (0, 0.63, 1.25 and 2.5%). The moisture content of the noodles that contained spirulina was higher before and after cooking. and these increases occurred in a concentration dependant manner. Furthermore the Hunter L (lightness), a (redness) and b (yellowness) values of noodles that contained spirulina were higher before and after cooking. and these values increased as the concentration of spirulina increased. Moreover the textural properties, which included, hardness, cohesiveness, springiness, gumminess, and chewiness, were significantly higher in noodles that contained than in the controls. Additionally, the antioxidant activity of noodles that contained spirulina increased in a concentration dependent manner. Specifically, the: $IC_{50}$ values of the DPPH radical scavenging activity for raw noodle was 726.00 mg/g, whereas that of raw noodles that contained 1.25 and 2.5% spirulina was 449.96 mg/g and 439.44 mg/g, respectively. Finally, a sensory preference test revealed that cooked noodles that contained 1.25% spirulina had the highest color, odor, taste and overall preference scores. Taken together, these findings suggest that up to 1.25% of the wheat flour could be substituted with spirulina to improve the quality of the noodles.

• Journal of Welding and Joining
• /
• v.25 no.5
• /
• pp.58-63
• /
• 2007

The relationship between GMA welding conditions and the bead shape of overlay weld was studied by using ${\Phi}1.6mm$ hypo-eutectic metal-cored wire designed for hardfacing against the severe metal-to-metal wear. As the welding voltage increased, the dilution also increased but the sudden drop of dilution was observed at $30{\sim}33V$. It was considered to be due to the decrease of penetration resulting from the change of transfer mode, from short circuit to spray. It was also found that the behavior of penetration with welding current was dependant on the transfer mode. The short circuit mode exerted the penetration to decrease while the spray mode did it to increase with increase of welding current. The former was considered to be responsible for the remarkable decrease in dilution at low welding voltage region. The change of transfer mode also had an effect on the behavior of bead width with welding current but it did not on the bead spreadability defined as W/H ratio. It was considered that the optimal welding conditions for multi-pass overlay welding could be obtained from the bead spreadability suitable for bead lapping and the dilution as low as possible in the spray transfer mode.