• 대한의생명과학회지
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• 제10권3호
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• pp.285-291
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• 2004

To determine the magnetic resonance (MR) imaging findings and natural history of cerebral fat embolism in a cat model, and to correlate the MR imaging and histologic fmdings. Intemel carotid artery of 11 cats was injected with 0.1 ml of triolein. T2-weighted, T1-weighted and Gd-enhanced T1-weighted images were obtained serially for 2 hours, 1 days, 4 days, 1 week, 2 weeks and 3 weeks after embolization. Any abnormal signal intensity was evaluated. After MR imaging at 3 weeks, brain tissue was obtained for light microscopic (LM) examination using hematoxylin-eosin (HE) and Luxol fast blue staining, and for electron microscopic examination. The LM examination with HE staining revealed normal histological findings in the greater part of an embolized lesion. Cystic change was observed in the gray matter of 8 cats, while in the gray and white matter of 3 cats. At LM examination, Luxol fast blue, staining demonstrated demyelination around the cystic change occurring in the white matter, and EM examination of the embolized cortex revealed sporadic intracapillary fat vacuoles (n=11) and disruption of the blood-brain barrier (n=4). Most lesions were normal, however, and perivascular interstitial edema and cellular swelling were mild compared with the control side. The greater part of an embolized lesion showed reversible findings at MR and histological examination. Irreversible focal necrosis was, however, observed in gray and white matter at weeks 3.

• 한국방사선학회논문지
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• 제5권6호
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• pp.377-381
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• 2011

이 연구의 목적은 일반방사선촬영에서 입사표면선량에 대하여 나노도트선량계의 측정값과 Non Dosimeter Dosimetry-Method(NDD-M)의 계산값과 비교 평가하는 데 있다. 입사표면선량들의 측정과 계산은 두부(AP), 복부(AP), 골반(AP), 흉추(AP)와 요추(AP)에 대하여 수행하였다. 결과로서, 계산값에 대한 측정값의 상대비들은 각 부위에 대하여 1.5-2.1을 얻었다. 재현성은 변동계수로서 0.035를 얻었다.

• 대한방사선기술학회지:방사선기술과학
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• 제43권4호
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• pp.289-295
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• 2020

This study investigated the feasibility of establishing a college of medicine in the western region of Chungnam to fill the gap in the medical doctor in charge of essential medical care in the region. Currently, the level of medical services in Chungnam is low compared to provinces across the country and in particular, 7 cities and towns, which account for 760,000 people, one-third of Chungnam's population, are located in the western regions of Chungnam. Because of this, in the event of an emergency patients, it is necessary to travel to Cheonan, Daejeon, Seoul, etc. where the regional emergency medical center is located for more than 1 hour and 30 minutes. In the case of critically ill and emergency patients transfer, it is a situation that misses the golden time and causes valuable loss of life. In order to improve the medical environment in the western region of Chungnam and improve the lives of residents in vulnerable areas of medical services, it is believed that establishing a college of medicine in the western region of Chungnam is essential.

• 대한의용생체공학회:의공학회지
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• 제19권6호
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• pp.563-570
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• 1998

The purpose of this study was to investigate the effects of scintillator and collimator parameters that tradeoff between system sensitivity and spatial resolution. The parameters simulated using Monte Carlo program were scintillator thickness, colimator hole shape, septal thickness, and hole length. The results show that the sensitivity increases exponentially upto about 1 cm of scintillator thickness as the thickness increases. However the sensitivity is almost constant when the scintiallator is thicker than about 1 cm. The simulation of collimator hole shape shows that the hexagonal hole gives the best spatial resolution for the same system sensitivity. The system statical resolution is improved, as both collimator septal thickness and hole length increase, however that system sensitivity is rapidly decreased. In conclusion, The optimization of scintillator and collimator parameters using monte carlo simulation may be useful to develop a high-resolution miniature gamma probe.

• 생약학회지
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• 제36권3호통권142호
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• pp.159-163
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• 2005

We screened the anti-oxidative effect on V79-4 hamster lung fibroblast cells induced by hydrogen peroxide with fifteen herbal extracts. Uncariae rhynchophylla JACKS and Rheum coreanum NAKAI were found to show DPPH radical scavenge activity (25 and 29% compared to control). Rheum coreanum NAKAI and Siegesbeckia orientalis L. were shown to scavenge intracellular reactive oxygen species (57 and 55% compared to control) which is measured by dichlorodihydrofluorescin diacetate method (DCHF-DA). Rheum coreanum NAKAI which showed the most strong intracellular reactive oxygen species scavenging activity had low DPPH radical scavenging activity compared to Uncariae rhynchophylla JACKS.

• 대한방사선기술학회지:방사선기술과학
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• 제47권3호
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• pp.213-218
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• 2024

The myocardial nuclear medicine examination is widely performed to diagnose myocardium disease using various radionuclides. Although image quality according to radionuclides has improved, the radiation exposure for target organ as well as peripheral organs should be considered. Here, the aim of this study was to evaluate absorbed dose (Gy) for peripheral organs in myocardial nuclear medicine scan from myocardium according to various scan environments based on Monte Carlo simulation. The simulation environment was modeled 5 cases, which were considered by radionuclides, number of injections, and radiodosage. In addition, the each radionuclide simulation such as distribution fraction was considered by recommended standard protocol, and the mesh computational female phantom, which is provided by International Commission on Radiological Protection (ICRP) 145, was used using the particle and heavy ion transport code system (PHITS) version 3.33. Based on the results, the closer to the myocardium, the higher the absorbed dose values. In addition, application for dual injection for radionuclides leaded to high absorbed dose compared with single injection for radionuclide. Consequently, there is difference for absorbed dose according to radionuclides, number of injections, and radiodosage. To detect the accurate diseased area, acquisition for improved image quality is crucial process by injecting radionuclides, however, we need to consider absorbed dose both target and peripheral inner organs from radionuclides in terms radiation protection for patient.

• 한국임상수의학회지
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• 제39권4호
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• pp.197-197
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• 2022

• 한국방사선학회논문지
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• 제10권5호
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• pp.351-358
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• 2016

부산지역 의료종사자를 대상으로 병원감염관리 인식을 분석한 본 연구의 결론은, 먼저, 개인위생, 장비위생, 청소 및 환경 관리의 인지도와 수행도는 학력이 낮을수록 척도가 높았다. 또한 개인손씻기의 경우 인지도는 1차, 2차, 기타의료기관의 종사자들이, 수행도는 의료인 집단이 높은 수치를 나타냈으며, 유의수준 .001에서 통계적인 차이를 나타냈다. 병원 내 위생관리 역시 의료인이 높은 인지도와 수행도를 나타냈으며, 통계적인 차이를 보였다. 전체적으로 인지도에 비해 수행도가 낮아 감염관리에 대한 개인의 적극적인 수행과 이를 위한 현실성 있는 개선방안의 마련이 필요할 것으로 사료된다.

• 대한방사선기술학회지:방사선기술과학
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• 제40권1호
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• pp.79-85
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• 2017

본 연구는 양전자 컴퓨터단층촬영(Positron Emission Computed Tomography; PET-CT) 유방암 영상에서 질환관심영역(Region of Interest; ROI)의 대조도 대 잡음비(Contrast to Noise Ratio; CNR)와 신호 대 잡음비(Signal to Noise Ratio; SNR)를 재구성 기법별로 측정 평가하여 통계적 분석을 하고자 하였다. 연구대상은 서울소재 대학병원에서 유방 양전자 컴퓨터단층촬영(Breast PET-CT)을 검사한 환자 100명이다. 측정방법은 ImageJ 프로그램을 사용하여 표본의 인구사회학적 특성, 영상 재구성 기법별 유방암의 SNR과 CNR의 평균값, 95% 신뢰구간 값, SNR과 CNR의 평균차이 값 등을 분석하였다. SPSS Statistics21 통계프로그램으로 ANOVA 분석을 하였으며 p<0.05에서 유의한 것으로 판단하였다. 영상 재구성 기법별 분석결과는 CNR과 SNR 모두 TrueX_TOF, Iterative, Iterative-TOF, FBP-TOF 순으로 높은 값을 나타냈다(p<0.05). CNR과 SNR수치로 영상 재구성 기법의 특징을 조합하여 PET/CT 검사의 정확성과 편의성을 제공할 것이라 사료된다.

• Biomolecules & Therapeutics
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• 제13권4호
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• pp.220-226
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• 2005

The present study was performed to evaluate combination effect of 7$\beta$-hydroxycholesterol (7$\beta$-OHC) and $\gamma$-radiation in NCI-H460 human lung cancer cells. 7$\beta$-OHC in combination with $\gamma$-irradiation has an enhanced effect in decreasing clonogenic survival and increasing cellular DNA damage. Pretreatment of cells with 7$\beta$-OHC enhanced radiation-induced apoptosis. Apoptosis of the cells by combined treatment of 7$\beta$-OHC and $\gamma$-irradiation was associated with reactive oxygen species generation and loss of mitochondrial membrane potential, resulting in the activation of caspase 9 and caspase 3. The combined treatment also resulted in an increased G1 cell cycle distribution. These results indicate that 7$\beta$-OHC shows the additive effect of radiation sensitivity in human lung carcinoma cells in vitro.