• 한국항해항만학회지
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• 제37권3호
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• pp.321-327
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• 2013

As the market of express delivery services expands rapidly, delivery service companies are exposed to severe competition. As a result of the surplus of delivery companies, they are struggling with remaining competitive at a reasonable price with appropriate level of customer satisfaction. To cope with competition pressures, a strategic alliance is suggested as an effective solution to the challenges faced by small and medium enterprises (SMEs) in express delivery services. Therefore, this study suggests a combined optimization and simulation approach to the reconfiguration of an express delivery service network for strategic alliance with respect to strategy partnership of closing/keeping service centers among companies involved and adjustments of their cutoff times. An illustrative numerical example is presented to demonstrate the practicality and efficiency of the approach.

• Journal of mucopolysaccharidosis and rare diseases
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• 제1권1호
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• pp.5-14
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• 2015

This paper addresses the state of arts of microneedles for the transdermal drug delivery applications. Microneedles can be classified based on materials and shapes. For the materials, microneedles could be made of ceramics, metals and polymers. The shape of the microneedles can be classified into solid and hollow microneedles. Methods of transdermal drug delivery based on microneedle patch are discussed, and various fabrication methods of microneedle patches are introduced.

• Journal of Pharmaceutical Investigation
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• 제35권5호
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• pp.343-348
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• 2005

Recently, siRNA has been emerging as new therapeutic agents for various diseases such as cancers and infectious diseases. However, the evaluation for delivery systems for siRNA has not been fully done. In this study, we designed and delivered siRNA of oncogenic E6 and E7 proteins to several cell lines and tested the delivery efficiencies of various cationic nonviral delivery vectors. Of cationic delivery systems tested in this study, lipid-based Lipofectamine revealed higher delivery efficiency of siRNA to cervical cancer cell line, SiHa, compared to other delivery systems. Notably, the polyethylenimine, which showed the comparable delivery efficiencies in plasmid DNA, did not show significant delivery of siRNA in cervical cancer cells. These results indicate that the mechanisms involved in siRNA delivery might be different from those in plasmid DNA delivery, and that cationic lipid-based delivery vehicles deliver siRNA with higher efficiency to intracellular target sites.

• 한국프랜차이즈경영연구
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• 제15권2호
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• pp.39-56
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• 2024

Purpose: Delivery food continues to grow. In the past, restaurant companies directly hired delivery workers to deliver food, but now, restaurant companies use delivery service platform companies to carry out delivery work rather than directly hiring delivery workers. Therefore, this study seeks to determine the impact of delivery food benefits in the restaurant industry on brand image, trust, and word-of-mouth intention. Research design, data, and methodology: To test the hypotheses of this study, 400 questionnaires were distributed and 340 were collected. Among these, 321 questionnaires, excluding 19 questionnaires that were answered insincerely, were used in the final analysis. Result. First, delivery food benefits were found to have a significant impact on brand image and trust. Second, brand image was found to have a significant effect on trust and word-of-mouth intention. Third, trust was found to have a significant effect on word-of-mouth intention. Conclusions: First, existing research focused on studying the attributes of delivery food in the restaurant industry, but this study studied the benefits that consumers can obtain through purchase among these attributes. Second, delivery food restaurants need to design promotions and advertisements in a way that displays coupons, points, or mileage. Third, quick delivery of orders can be a competitive advantage for delivery food restaurants.

• International Journal of Advanced Culture Technology
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• 제11권2호
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• pp.284-290
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• 2023

This study was a phenomenological study to examine the meaning and structure of the difficulty of delivery. Participants in this study conducted deep interviews with seven female 20 to 24. The interview data was conducted through the process of analysis and interpretation using the Giorgi method. As a result of study, 12 themes were derived and 4 categories. As a result of the analysis, young women's thoughts on observing delivery consisted of 'fear', 'powerlessness', 'disgust', and 'inevitable fate'. Based on the above meaning, the structure of young women's thoughts on delivery was found to be a point of view that it is regrettable that delivery compensates for all difficulties and pain with the joy of birth. Accordingly, it is proposed to develop and apply a program that can actually alleviate the anxiety, fear, and physical discomfort experienced by women in childbearing age through childbirth.

• 국제학술발표논문집
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• The 3th International Conference on Construction Engineering and Project Management
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• pp.1440-1445
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• 2009

Clients demands have been changed by construction circumstances such as high-technology, megaprojects, and the complexity of construction. Advanced foreign nations have already introduced and applied new project delivery systems (i.e, CM, DB, etc.) to deal with the change of such that. Korea has also promoted variation of the delivery systems for the progressive measure to the rapid changeable situation. Even though government has made his efforts as stated above, some clients have uniformly used those to public construction projects. That is because there are not selection criteria of project delivery system for clients. Therefore, this study presented the selection criteria of project delivery system based on project types in the public large construction projects. In addition, the study has verified the viability of the presented models through consultation with professionals and experts.

• Clinical and Experimental Reproductive Medicine
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• 제51권1호
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• pp.63-68
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• 2024

Objective: This study was conducted to investigate the impact of previous delivery mode on pregnancy outcomes in patients with secondary infertility after frozen-thawed embryo transfer. Methods: This prospective observational study included 140 patients experiencing secondary infertility. Of these, 70 patients had a previous cesarean delivery (CD), while the remaining 70 patients had a previous normal vaginal delivery (NVD). The primary outcome was the implantation rate. The secondary outcomes included rates of clinical pregnancy, chemical pregnancy, miscarriage, and ectopic pregnancy. Results: The comparison of all fertility outcomes between the two groups revealed no statistically significant differences. The implantation rate was 40.4% in the CD group and 41.7% in the NVD group (p=0.842). The clinical pregnancy rate was 50% in the CD group and 49.3% in the NVD group (p=0.932), while the chemical pregnancy rate was 14.6% in the CD group and 19% in the NVD group (p=0.591). The miscarriage rates in the CD and NVD groups were 20% and 17.6%, respectively (p=0.803). One case of tubal ectopic pregnancy occurred in the NVD group (1.4%). Conclusion: The mode of prior delivery did not significantly impact pregnancy outcomes following frozen-thawed embryo transfer.

• 산업경영시스템학회지
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• 제35권2호
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• pp.189-195
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• 2012

Parcel delivery services are a bit different from general vehicle routing problems since the services require a deliver's walking time to give the parcel to the customer. This time takes more than 1/4 of total delivery time, but it is ignored for the convenience of algorithm design in general. The walking time is too big to be ignored if we need to estimate necessary delivery time precisely as much as possible, or to design a heuristic with varying vehicle moving speeds in metropolitan area. For these reasons, the walking times are surveyed and analyzed to use on the design of VRP heuristic for parcel delivery services in this research.

• Macromolecular Research
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• 제15권2호
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• pp.100-108
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• 2007

Gene therapy has become a promising strategy for the treatment of genetically based diseases, such as cancer, which are currently considered incurable. A major obstacle in the field of cancer gene therapy is the development of a safe and efficient delivery system for therapeutic gene transfer. Non-viral vectors have attracted great interest, as they are simple to prepare, stable, easy to modify and relatively safe compared to viral vectors. In this review, an insight into the strategies developed for polyethylenimine (PEI)-based non-viral vectors has been provide, including improvement of the polyplex properties by incorporating hydrophilic spacer, poly(ethylene glycol) (PEG). Moreover, this review will summarize the strategies for the tumor targeting. Specifically, a targeted polymeric gene delivery system, PEI-g-PEG-RGD, will be introduced as an efficient gene delivery vector for tumor therapy, including its functional analysis both in vitro and in vivo.

• 공업화학
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• 제2권2호
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• pp.87-96
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• 1991

지난 20년 동안에 약물방출조절시스템에 관한 연구가 활발히 진행되고 었다. 본고에서는 약물방출조절시스템을 약물방출메카니즘에 의해서 구분하고 이를 통한 약물방출거동에 대해서 논하였다. 또한 현재 약물방출조절시스템의 현황에 대해서 투여경로를 중심으로 구분하여 소개하였다.