• 대한소아치과학회지
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• 제50권4호
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• pp.421-433
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• 2023

This study was to examine the developmental dental abnormalities in childhood cancer survivors. Risk factors were assessed for 125 children with radiographic data through a retrospective analysis of medical records and panoramic images. 68.0% of childhood cancer survivors exhibited at least one dental abnormality. The types of abnormalities varied depending on the age at cancer diagnosis and treatment intensity, ranging from microdontia (43.2%), to abnormal root development (39.2%) and tooth agenesis (33.6%). Logistic regression analysis demonstrated that a young age at diagnosis (under 3 years), the use of heavy metal agents, a history of hematopoietic stem cell transplantation (HSCT), and combination treatment of chemotherapy, radiation therapy, and HSCT were associated with a significantly higher risk for overall dental abnormalities. The increased risk ratios were 6.00, 3.06, 3.22, and 7.87, respectively (p < 0.05). The results of this study will predict dental abnormality in permanent dentition according to the diagnosis age and treatment method of childhood cancer.

• 대한소아치과학회지
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• 제11권1호
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• pp.255-259
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• 1984

Ectodermal dysplasia is a rare hereditary abnormality of which the outstanding characteristics are hypodontia, hypohidrosis and hypotricosis. Patient afflicted with this malformation shows a typical face resembling that of congenital-syphilis. Dental abnormality (delayed eruption, oligodontia) becomes apparent in this child and causes the parents to bring him to the dentist. Prosthetic appliances are usually indicated and he must be adjusted or be remade as the child matures.

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제35권1호
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• pp.21-25
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• 2009

Objective: The purpose of this study is to determine the prevalence of sinus disease and abnormalities in patients scheduled for dental implant in maxillary posterior area using cone beam CT. Patients and Method: One hundred five maxillary sinuses in eighty-seven patients who underwent cone beam CT for dental implant in maxillary posterior area were included. Any patients who had previous history of sinus operations were not included. The sinus abnormalities were classified as follows ; normal (membrane thickness <2 mm), mucosal thickening (membrane thickness ${\geq}$ 2 mm and < 6 mm), partial opacification (membrane thickness > 6 mm but not full), full opacification and mucous retention cyst. The relationship between the remaining bone height, sinus symptoms and maxillary sinus abnormality was statistically surveyed. Results: Of 105 maxillary sinuses in 87 patients, 80 (76%) maxillary sinuses showed abnormalities ; 4 of 4 symptomatic patients and 76 of 101 asymptomatic patients. Mucosal thickening was the most common sinus abnormality. Only 3 (4%) of 80 maxillary sinus abnormalities were caused by the odontogenic origin. The prevalence of maxillary sinus abnormalities was higher in the symptomatic group than asymptomatic one (p<0.05). Conclusion: Maxillary sinus abnormalities were very common in the patients who were planning implantation in maxillary posterior areas. This result supports that thorough evaluation for maxillary sinus is recommended when implant treatment is planned for those areas.

• 대한치과의사협회지
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• 제54권9호
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• pp.704-711
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• 2016

Radiologic images in dentistry are essential to perform the diagnosis, treatment, and tracking process of prognosis, thus the ability of accurate evaluation in the diagnostic images is requested for dental clinician. Radiologic interpretation means recognition of a normality and an abnormality and to report the possible diagnosis and differential diagnosis list. Therefore, dental clinicians should be familiar with the basic principle of interpretation of intraoral and extraoral radiographic images primarily used in dental clinics. Recently, dental cone beam CT is widely used for diagnositc process, thus understanding the three dimensional images is requested. The objective of this manuscript is to help the dental clinicians to interpret accurately the diagnostic images by introducing the basic principles of the step by step analytic process in the appearance of a lesion.

• Maxillofacial Plastic and Reconstructive Surgery
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• 제42권
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• pp.30.1-30.7
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• 2020

Background: Dental studies of precocious puberty have focused on examination of jaw and dentition growth. The aim of the study was to analyze the relationship between precocious puberty and maxillary dental developmental abnormalities (DDAs). Methods: This retrospective study was conducted on the Korean patients in whom dental panoramic and hand-wrist radiographs had been taken before they were 15 years of age. The maxillary DDAs were assessed as mesiodens, congenital missing teeth, peg-shape lateral incisors, or impacted teeth. The chronological ages of the control group members were within the normal range of the hand-wrist bone age. Others with a peak luteinizing hormone of ≥ 5 and < 5 IU/L were allocated to central precocious puberty (CPP) and peripheral precocious puberty (PPP), respectively. Results: Of the enrolled 270 patients, 195, 52, and 23 were allocated to the control, CPP, and PPP groups, respectively. The maxillary DDAs were significantly more prevalent in the CPP group than in the other groups. Among those with maxillary DDA, the mesiodens predominated. Age- and sex-adjusted multivariate analysis revealed maxillary DDA (odds ratio, 3.36; 95% CI, 1.60-7.05) and especially mesiodens (odds ratio, 5.52; CI, 2.29-13.28) to be significantly associated with CPP. Conclusions: Maxillary DDAs were significantly more prevalent in the CPP group than in the PPP or control groups. Among the many types of maxillary DDAs, mesiodens was significantly associated with CPP and may be considered a predictor of the development of CPP.

• 치위생과학회지
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• 제11권4호
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• pp.299-303
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• 2011

The purpose of this case report was to present an example of an esthetic and functional rehabilitation of anterior teeth with tetracycline discoloration and minor morphological abnormality of a 39-year old female. A chairside computer-aided design/computer-aided manufacturing (CAD/CAM) system with CEREC AC was applied for the prosthetic procedure and all ceramic crowns made with lithum disilicate (IPS e.max CAD) restored the esthetic and functional features of sixteen anterior teeth successfully.

• 대한치과의사협회지
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• 제15권6호
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• pp.437-443
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• 1977

Author came to the following conclusion and made the following report as a result of corticotomy that treated in department of orthodontics and oral surgery, Tokyo Dental College. 1. In the respect of oral surgery, corticotomy is able to operate under local anesthesia. This operation is very simple and there is little clinical discomfort after operation. 2. In the respect of orthodontics, tooth movement is 2-3 times rapid than common orthodontic treatment in adult and clinical problem such as pain, root resorption are slight. Especially, tooth movement by differential force, rapid expansion in adult and unilateral expansion which was difficult, came to possible. 3. Corticotomy shorten the treatment time in preoperative orthodontic treatment of developmental abnormality of jaw, application to cleft lip & palate, orthodontic treatment before prosthetics. It's application is so wide that bring on much profits.

• 대한구순구개열학회지
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• 제7권1호
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• pp.35-46
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• 2004

The frequency of abnormality at birth is average 1-1.5%, and of these, cleft lip & palate is known to be the most frequent congenital abnormality, Cleft is considered to be due to multi-factorial heredity correlated with genetic and environmental factors, Cleft patients require the collaborative treatment with several medical departments, Clinics for Maxillo-Oral Disorders of Tohoku University Dental Hospital performs the total managements related to such as occlusion and language for the patients with congenital maxilla-facial abnormality, This study examined the patients with cleft lip and/or palate who came to the Clinics for Maxilla-Oral Disorders of Tohoku University Dental Hospital for the past 17 years from Jan. 1987 to Dec, 2002, and had the results as follows, 1. Annual mean number of patients The annual mean number of the patients for 17 years from Jan, 1987 to Dec, 2002 was 91 patients, ranging from 63 minimum to 116 maximum, 2, Gender and types of cleft There were 747(51%) males and 709(49%) females, with a male to female ratio 1,05:1. CLP was the most frequent cleft type as shown in 616 patients, and other patients manifested different complaints such as CL, CP, SMCP and MC in order. 3. The laterality in cleft type The lip cleft was frequently expressed orderly on left, right and both sides of CL patients while orderly being shown on left, both and right sides of CLP patients. Accordingly, lip cleft was most commonly found on the left side. 4. Address at first visit Of 1,456 subjects, 850(58.4%) patients were residing in Miyagi Prefecture, where this hospital is located. 5. Age at first visit 615(42.2%) patients came to the hospital at their age younger than 1 year old, comprising 282(19.4%) patients age younger than 2 months old and 333(22.9%) patients age between 2 month old and 1 year old. 6. Mother's age at birth For the mother's age at birth, 526(39.9%) patients were at the age of 25 to 30 years old, and 17(1.3%) patients were over 40 years old. 7. Birth weight 34.3%(443 patients) had a birth weight of 2500-3000gm and 56.0%(724 patients) had a 3000-4000gm. It was also found that 7.9%(102 patients) had a birth weight of less than 2500gm. 8. Familial expression The frequency of familial expression was 6.5%(94 patients).

• Journal of the Korean Association of Oral and Maxillofacial Surgeons
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• 제37권6호
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• pp.550-555
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• 2011

Chromosomal loss of heterozygosity (LOH) is a common mechanism for the inactivation of tumor suppressor genes in human epithelial cancers. LOH patterns can be generated through allelotyping using polymorphic microsatellite markers; however, owing to the limited number of available microsatellite markers and the requirement for large amounts of DNA, only a modest number of microsatellite markers can be screened. Hybridization to single nucleotide polymorphism (SNP) arrays using Affymetarix GeneChip Mapping 10 K 2.0 Array is an efficient method to detect genome-wide cancer LOH. We determined the presence of LOH in oral SCCs using these arrays. DNA was extracted from tissue samples obtained from 10 patients with tongue SCCs who presented at the Hospital of Tokyo Dental College. We examined the presence of LOH in 3 of the 10 patients using these arrays. At the locus that had LOH, we examined the presence of LOH using microsatellite markers. LOH analysis using Affymetarix GeneChip Mapping 10K Array showed LOH in all patients at the 1q31.1. The LOH regions were detected and demarcated by the copy number 1 with the series of three SNP probes. LOH analysis of 1q31.1 using microsatellite markers (D1S1189, D1S2151, D1S2595) showed LOH in all 10 patients (100). Our data may suggest that a putative tumor suppressor gene is located at the 1q31.1 region. Inactivation of such a gene may play a role in tongue tumorigenesis.

• 대한소아치과학회지
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• 제49권3호
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• pp.241-252
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• 2022

이 연구는 안장의 형태와 지연된 치령의 연관성을 알아보고자 수행되었다. 16세 미만 389명의 치령을 Demirjian 방법으로 평가하였고, 치령에서 연대 연령을 뺀 Age discrepancy (AD)를 계산하였다. 측방두부계측 방사선 사진 상 안장 형태에 따라 8가지로 분류하고 Sella turcica bridging (STB) 정도를 수치화하기 위해 Interclinoid distance를 안장의 길이로 나눈 Bridging ratio를 기준으로 4가지로 분류하였다. Kruskal Wallis 검정과 Mann Whitney 검정을 이용하여 8군과 4군에서 각각 AD의 유의성을 확인하였다. 일부 안장 형태 이상 군에서 정상보다 낮은 AD를 보였고 정상 안장 형태군과의 AD의 차이는 4 - 5개월에서 1년 3개월로 다양했다. STB 정도가 심해질수록, AD는 감소하였다. 정상 STB군과 경미한 STB군의 AD 차이는 7개월이고, 중등도 이상의 STB군에서는 1세 이상 치령이 지연되었다. 성별에 따른 안장 형태와 STB 정도는 유의한 차이가 없었다. 이 연구를 통해 일부 안장 형태 이상과 STB가 지연된 치령과 연관성이 있음을 확인하였다. 안장의 형태는 지연된 치령을 예측하는 보조적 수단으로 사용될 수 있다.