• 대한예방의학회:학술대회논문집
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• 대한예방의학회 2002년도 제54차 추계 학술대회 연제집
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• pp.548-548
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• 2002

• 수면정신생리
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• 제8권1호
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• pp.11-17
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• 2001

In 2000, the number of people aged 65 and over increased to 3.37 million, accounting for 7.1% of the total population of South Korea. The elderly population will increase up to 19.3% in 2030. Sleep disordered breathing (SDB) seems to increase with age. More than 50-60% of old people complain of SDB-related signs and symptoms including awakening headache, excessive daytime sleepiness, fatigue, cognitive dysfunction, memory loss, personality changes, and depression. The influence of a mild degree of SDB upon the elderly is unclear, but moderate to severe SDB is well known to be associated with many diseases including hypertension, arrhythmia, myocardial infarction, stroke, dementia, and sudden death. Therefore, physicians should pay attention to elderly patients who complain of SDB related symptoms and signs that may not be normal signs of aging. Physicians need to become more sensitive to treat SDB in the elderly.

• 생물정신의학
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• 제17권4호
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• pp.194-202
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• 2010

Alzheimer's disease(AD) is the most common neurodegenerative disorder and constitutes about two thirds of dementia. Despite a lot of effort to find drugs for AD worldwide, an efficient medicine that can cure AD has not come yet, which is due to the complicated pathogenic pathways and progressively degenerative properties of AD. In its early clinical phase, it is important to find the subtle alterations in synapses responsible for memory because symptoms of AD patients characteristically start with pure impairment of memory. Attempts to find the target synaptic proteins and their pathogenic pathways will be the most powerful alternative strategy for developing AD medicine. Here we review recent progress in deciphering the role of target synaptic proteins related to AD in hippocampal glutamatergic synapses.

• 동의신경정신과학회지
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• 제15권1호
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• pp.211-217
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• 2004

간경변이 없이 자발성 비신단락으로 인해 발생한 만성후천성간뇌퇴행으로 진단된 1례를 경험하였기에 문헌고찰과 함께 보고하였다. 본 증례는 만성후천성간뇌퇴행의 임상양상인 인지기능 저하, 의식변화, 기면, 구음장애, 진전, 보행장애 등의 증상을 가지면서도, 간질환이 없이 자발성 문맥-체순환 단락에 의한 것이란 점과, 피질하 혈관성 치매가 동반되었다는 점에서 그 진단에 주목할 만하다. 대개 만성후천성간뇌퇴행이 일반적인 간성 혼수 치료에 잘 반응하지 않는다고 알려져 있으나, 한약 치료를 통해 의식변화, 진전, 보행장애 등의 증상에 좋은 반응을 관찰할 수 있었다.

• Korean Journal of Radiology
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• 제21권12호
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• pp.1345-1354
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• 2020

Objective: To evaluate radiomics analysis in studies on mild cognitive impairment (MCI) and Alzheimer's disease (AD) using a radiomics quality score (RQS) system to establish a roadmap for further improvement in clinical use. Materials and Methods: PubMed MEDLINE and EMBASE were searched using the terms 'cognitive impairment' or 'Alzheimer' or 'dementia' and 'radiomic' or 'texture' or 'radiogenomic' for articles published until March 2020. From 258 articles, 26 relevant original research articles were selected. Two neuroradiologists assessed the quality of the methodology according to the RQS. Adherence rates for the following six key domains were evaluated: image protocol and reproducibility, feature reduction and validation, biologic/clinical utility, performance index, high level of evidence, and open science. Results: The hippocampus was the most frequently analyzed (46.2%) anatomical structure. Of the 26 studies, 16 (61.5%) used an open source database (14 from Alzheimer's Disease Neuroimaging Initiative and 2 from Open Access Series of Imaging Studies). The mean RQS was 3.6 out of 36 (9.9%), and the basic adherence rate was 27.6%. Only one study (3.8%) performed external validation. The adherence rate was relatively high for reporting the imaging protocol (96.2%), multiple segmentation (76.9%), discrimination statistics (69.2%), and open science and data (65.4%) but low for conducting test-retest analysis (7.7%) and biologic correlation (3.8%). None of the studies stated potential clinical utility, conducted a phantom study, performed cut-off analysis or calibration statistics, was a prospective study, or conducted cost-effectiveness analysis, resulting in a low level of evidence. Conclusion: The quality of radiomics reporting in MCI and AD studies is suboptimal. Validation is necessary using external dataset, and improvements need to be made to feature reproducibility, feature selection, clinical utility, model performance index, and pursuits of a higher level of evidence.

• 대한통합의학회지
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• 제8권1호
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• pp.219-228
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• 2020

Purpose : This study highlights the importance of occupational therapy at adult day care centers by examining the current state of this therapy at these centers. Methods : Data on 1,527 adult day care centers in South Korea were retrieved from a long-term care insurance site for the elderly and were statistically processed. Results : Of these centers, 1,331 (87.2 %) were cognitive activity-oriented, 37 (2.4 %) were exclusively for dementia treatment, and 159 were nonspecialized centers (10.4 %). A second finding was that 294 (19.3 %) of the centers operated occupational therapy programs. Third, only 40 occupational therapists (2.6 %) were working at one of these 1,527 care centers nationwide. Fourth, the occupational therapy programs comprised 4.91 ± 3.93 cognitive enhancement programs per center, 2.58 ± 2.26 training assistance programs per center, and other programs 2.56 ± 2.58 per center. Fifth, a regional comparison of the operation of occupational therapy programs at these centers showed a statistically significant difference in the number of programs between Seoul and other regions. Conclusion : Although most adult day care centers currently deliver cognitive enhancement programs, they show a low employment rate of occupational therapists. Therefore, additional research involving workers at adult day care centers is required to investigate perceptions and the necessity of occupational therapy.

• 한국노년학
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• 제28권4호
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• pp.1279-1295
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• 2008

본 연구는 치매노인들을 대상으로 집단미술치료 프로그램을 실시하여 인지기능의 하위영역과 자아존중감에 미치는 효과를 알아보고자 하였다. 연구대상은 서울시 ${\bigcirc}{\bigcirc}$노인종합노인복지관 내의 케어센터에 의뢰된 노인들 중 MMSE-K 총점이 19점 이하인 경증치매 여자노인 4명이었다. 연구기간은 2008년 1월15일부터 2008년 4월30일까지 1회기 60분씩 주 1회, 총 15회기를 실시하였고, 연구도구로는 MMSE-K(한국형 간이정신상태검사)와 Rosenberg의 Self-Esteem Scale(자아존중감 척도)을 사전, 사후에 실시하였다. 자료 분석은 사전 사후 검사한 결과의 단순 평균값 비교를 위한 기술통계와 Wilcoxon 비모수 통계를 이용하여 검증하였다. 본 연구결과를 통해 다음과 같은 결론을 얻었다. 첫째, 집단미술치료가 치매노인들의 인지기능에 효과가 있는 것으로 나타났다. 간이정신상태검사의 사전 사후 점수에 대하여 평균 16.75에서 19.75로 향상되었으며, Wilcoxon 비모수 통계를 이용한 검증결과 p값이 .046으로 통계적으로 유의하게 나타났으며, 하위영역별로 지남력, 기명력, 집중 및 계산, 언어기능, 이해 및 판단은 사전, 사후 검증에서 평균점수는 향상되었지만, 통계적 유의도는 없었으며, 기억회상은 사전 사후 검증에서 평균 0.70이 향상되었고, Wilcoxon 비모수 통계를 이용한 검증결과 p값이 .043으로 통계적으로 유의하게 나타났다. 둘째, 집단미술치료가 치매노인들의 자아존중감에 효과가 있는 것으로 나타났다. Self-Esteem Scale 사전 사후 검증에서 평균 20.75에서 24.25로 향상되었으며, 통계결과 p값이 .048로 통계적으로 유의하여 프로그램의 효과성이 입증되었다.

• 대한지역사회작업치료학회지
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• 제10권3호
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• pp.37-52
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• 2020

목적 : 본 연구는 보건소에 근무하는 작업치료사를 대상으로 지역사회 작업치료사의 업무 특성 및 실태를 파악하여, 2020년 현재 지역사회 작업치료사에 관한 기초자료로서 활용하고자 시행하였다. 연구방법 : 전국 보건소에 근무하는 작업치료사를 대상으로 이메일을 통해 설문지를 배포하여 응답을 수렴하였다. 수집된 응답지 77부를 기술통계 및 상관관계 분석을 적용하였다. 결과 : 설문응답자는 여자(77.9%), 20-30대(96.1%)가 많았고, 주로 치매 관련 팀(72.7%)에서 근무하였으며 방문, 건강, 재활 관련 다양한 팀에 소속되어 있었다. 보건소 경력은 1-2년(67.5%), 계약형태는 시간선택제 공무원(61%)이 가장 많았고, 업무 강도는 보통-매우 높음(94.8%)이, 만족도는 보통-매우 만족(85.7%)이라는 응답이 가장 많았다. 업무 고충은 예산 행정 업무(26.7%), 업무 외 고충은 계약에 따른 불평등(27.2%)이 가장 높았다. 주로 참여하는 업무는 치매 쉼터, 방문 작업치료, 그룹 작업치료이었으며, 난이도는 예산 행정, 치매 쉼터, 방문 작업치료가 높았다. 주요 치료 목표는 인지능력 향상, 가족 지지가 많았고, 빈도는 인지능력 향상, 가족 지지, 평가가 높았다. 보건소 작업치료 대상은 치매, 일반 노인, 성인 뇌병변 순이었으며, 일반인, 정신과 질환, 아동 관련 대상도 포함되어있었다. 주로 평가를 진행하는 직군은 간호사(35.7%), 작업치료사(33.7%)였으며, MMSE-DS, SGDS, SMCQ를 많이 사용하는 것으로 조사되었다. 결론 : 본 연구를 통해 지역사회 작업치료사의 업무 특성 및 실태를 확인하였다. 치매 관련 사업 등 일부분에 집중되어 있는 작업치료 업무를 넘어선 전문적인 분야 개발 및 참여가 필요하며, 추후 커뮤니티 케어로 확장되고 있는 지역사회 재활의 흐름에 발맞춘 지역사회 작업치료사의 전문적인 역할 정립을 위한 자료로 활용되기를 바란다.

• 대한의생명과학회지
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• 제25권1호
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• pp.7-14
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• 2019

Alzheimer's disease (AD) is highly prevalent in dementia, with no specifically effective treatment having yet been discovered. Amyloid plaques are one of the key hallmarks of AD. Transgenic mouse models exhibiting Alzheimer's disease-like pathology have been widely used to study the pathophysiology of Alzheimer's disease. In this study, we showed an age-dependent correlation between cognitive function, pathological findings, and [F-18] Florbetaben (FBB) PET images. Nineteen transgenic mice (12 with AD, 7 with controls) were used for this study. We observed an increase in ${\beta}$-Amyloid deposition ($A{\beta}$) in brain tissue and [F-18] FBB amyloid PET imaging in the AD group. The [F-18] FBB data showed a mildly negative trend with cognitive function. Pathological findings were negatively correlated with cognitive functions. These finding suggests that amyloid beta deposition can be well-monitored with [F-18] FBB PET and a decline in cognitive function is related to the increase in amyloid plaque burden.

• 인간식물환경학회지
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• 제22권2호
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• pp.119-126
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• 2019

This study was conducted to examine effects of community gardening on job stress and job satisfaction experienced by public officials in general administration working in a 24-hour shift. The subjects were public officials at the Center for Missing Children in the Department of Women and Adolescents at the National Police Agency. The center receives initial reports of disappearance of missing children, the elderly with dementia, and people with intellectual disabilities, sends out the report to each police station, and clears the report after the missing individual is found. Twelve public officials working at the center in a double shift (full day off after a night shift, four-day interval) were grouped into four teams and total 11 of them participated in the experiment. They engaged in autonomous community gardening activities such as sowing seeds, cultivating plants, harvesting, or cooking in the workplace for five weeks from August 19 to September 22, 2018. The findings were as follows. After five weeks of autonomous gardening activities, job stress of the subjects decreased significantly. Their mean scores of job satisfaction and organizational commitment under organizational effectiveness showed a significant increase after the activities. Finally, there were significant differences in their self-esteem after participating in the gardening activities in the workplace. These results suggest that gardening activities in the workplace can help to manage job stress and quality of work life for shift workers.