• Korean Chemical Engineering Research
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• v.57 no.3
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• pp.305-312
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• 2019

The discovery of nitric oxide (NO) as a major signaling molecule in a number of pathophysiological processes - vasodilation, immune response, platelet aggregation, wound repair, and cancer biology - has led to the development of various exogeneous NO delivery systems. However, the development of ideal delivery system for human body application is still left as a challenge due to its high reactivity and short half-life in physiological condition. In this article, an overview of several nano-structures as potential NO delivery system will be presented, along with their recent research results and biomedical applications. Nano-size delivery system has immense advantages compared to others due to its high surface-to-volume ratio and capability for surface modification; thus, it has been proven to be effective in delivering nitric oxide with enhanced performance. Through this novel nano-structure delivery system, we are expecting to achieve sustained release of nitric oxide within adequate range of concentration, which ensures desired drug effects at the target site. Among different nano-structures, in particular, nanoparticle, microemulsion and nanofilm will be reviewed and compared to each other in respect of nitric oxide release profile. The proposed nano-structures for exogeneous NO delivery have a biological significance in that it can be further utilized in diverse biomedical fields as a highly promising therapeutic method.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.23 no.59
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• pp.105-118
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• 2000

The rise in population and the increase of urbanization and industrial growth has resulted in an ever-increasing volume of municipal solid waste that must be regularly collected, transported, and ultimately disposed of. Therefore, over the last decade the public, commercial and legislative awareness of environmental issues has been increased dramatically on earth particularly some industrial countries which has a shortage of landfill capacity. A quality, cost and delivery lead-time are usually considered as the competitive factors for each industry. However, the concepts of environmental issue are emerging common terms and concerns more seriously. More attention than ever is being focused on the recycling and source reduction techniques to reduce the total volume of waste. Unfortunately, however, a shortage of landfill capacity and increasing disposal cost requests a fundamental solution about the environmental issue. That is the remanufacturing which allow manufacturers to minimize waste, production cost and to turn end-of-life product into a profitable product. The objectives of this research were to growth the remanufacturing system by suggesting issues and implementation methods for the remanufacturing. In order to accomplish these objectives, we introduced backgrounds of appearance and benefits of the remanufacturing.

• Special Issue of the Society of Naval Architects of Korea
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• 2008.09a
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• pp.33-37
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• 2008

The evidence of the Cargo tank volume is very important between Buyer and Seller for agreement each other for LNG Ship. CTS(Custody Transfer System) Radar type level gauging sensor to be measured for cargo volume. The data of Trim & List sensor to be compensated for measuring data which is original data of the CTS sensor. The latest days, the Buyer would have posed a problem both the location and the accuracy of trim/list sensor specially neared final stage of the ship's delivery. So, we would like to report the introducing to the trim/list sensor and the confirmation of actual location for the trim/list sensor.

• Journal of the Korean Society of Manufacturing Process Engineers
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• v.19 no.10
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• pp.8-15
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• 2020

The diffusion cell method is the main technique employed for the in vitro diffusion test of transdermal drug delivery preparations. Most existing transdermal diffusion devices use a water bath heating structure and direct current motor magnetic stirrer. However, these devices are confronted with problems, such as large volume, incompatible vertical and horizontal diffusion cells, few diffusion cell sets, and poor reliability. To overcome these deficiencies, the system adopts a dry heating method and uses a rotating magnetic field generated by the electromagnetic stirrer to drive the magnetic stirrer. Accordingly, the resulting device is characterized by a simple structure and small volume, convenient operation, compatible vertical and horizontal diffusion cells, and numerous diffusion cell sets. The reliability and practicability of the system is verified by the in vitro percutaneous permeability test of the bisoprolol patch.

• Journal of Environmental Science International
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• v.21 no.8
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• pp.965-975
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• 2012

Loading of NPS pollutant was valued through simulation by using BASINS/HSPF model which can simulate runoff volume in rainfall by time. For the verification of the model, it was analyzed the scatter diagram of the simulation value and measure value of water quality and runoff volume in Dongcheon estuary. Using the built model, a study on the time-variant characteristics of runoff and water quality was simulated by being classified into four cases. The result showed the simulation value was nearly same as that of the measured runoff. In the result of fit level test for measured value and simulated value, correlation of runoff volume was computed high by average 0.86 and in the water quality items, fit level of simulation and measurements was high by BOD 0.82, T-N 0.85 and T-P 0.79.

• Journal of Korean Academy of Nursing
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• v.44 no.2
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• pp.149-158
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• 2014

Purpose: This study was conducted to compare effects of open and closed suctioning methods on lung dynamics (dynamic compliance, tidal volume, and airway resistance) and hypoxemia (oxygen saturation and heart rate) in mechanically ventilated patients. Methods: This study was a cross-over repeated design. Participants were 21 adult patients being treated with endotracheal intubation using a pressure-controlled ventilator below Fraction of Inspired Oxygen ($FiO_2$) 60% and PEEP $8cmH_2O$. Data were collected at baseline and 1, 2, 3, 4, 5, and 10 minutes after suctioning. Data were analyzed using two-factor ANOVA with repeated measures on time and suctioning type. Results: Effects of the interaction between suction type and time were significant for oxygen saturation and heart rate but not significant for dynamic compliance, tidal volume, or airway resistance. Prior to performance of suctioning, tidal volume and oxygen saturation were significantly lower, but airway pressure and heart rate were significantly higher using the closed suctioning method as compared with the open suctioning method. Conclusion: For patients on ventilator therapy below $FiO_2$ 60% and PEEP $8cmH_2O$, open suctioning performed after delivery of 100% $FiO_2$ using a mechanical ventilator may not have as much negative impact on lung dynamics and hypoxemia as closed suctioning.

• International Journal of Fluid Machinery and Systems
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• v.7 no.3
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• pp.110-124
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• 2014

Surge phenomena in the zone of reduced speeds in a system of a nine-stage axial flow compressor coupled with ducts were studied analytically by use of a surge transient simulation code. Main results are as follows. (1) Expansion of apparently stable, non-surge working area of the pressure vs. flow field beyond the initial stage-stall line was predicted by the code in the lower speed region. The area proved analytically to be caused by significantly mismatched stage-working conditions, particularly with the front stages deep in the rotating stall branch of the characteristics, as was already known in situ and in steady-state calculations also. (2) Surge frequencies were found to increase for decreasing compressor speeds as far as the particular compressor system was concerned. (3) The tendency was found to be explained by a newly introduced volume-modified reduced surge frequency. It suggests that the surge frequency is related intimately with the process of emptying and filling of air into the delivery volume. (4) The upstream range of movement of the fluid mass having once passed through the compressor in surge was found to reduce toward the lower speeds, which could have caused additionally the increase in surge frequency. (5) The concept of the volume-modified reduced surge frequency was able to explain, though qualitatively at present, the behaviors of the area-pressure ratio parameter for the stall stagnation boundary proposed earlier by the author.

• Journal of Pharmaceutical Investigation
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• v.29 no.4
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• pp.315-321
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• 1999

Poly (lactide-co-glycolide) (PLGA) microspheres containing ovalbumin (OVA) as a model protein drug were prepared by double emulsification method, and various conditions such as mixing rate, volume of outer phase and isopropyl alcohol concentration in outer phase during secondary emulsification were observed to control the size of microspheres. In addition, entrapment efficiency of OVA and protein denaturation were also evaluated. As the rate of stirring was increased, the size of particles was decreased. But excessive stirring increased the particle size of microspheres. In a preparation condition of small volume of outer phase, the particle size was decreased but the entrapment efficiency was increased. Adding isopropyl alcohol to outer phase decreased the size of particles, but increased the entrapment efficiency. Microparticles should have smaller size than $10\;{\mu}m$ to be uptaked by Peyer's patch in small intestine. High speed of mixing and relatively small volume of outer phase are needed to reduce the size. In addition, appropriate amount of isopropyl alcohol in outer phase also plays an important role in size reduction of PLGA microspheres.

• Progress in Medical Physics
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• v.28 no.4
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• pp.164-170
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• 2017

One of the methods to consider the effect of respiratory motion of a tumor target in radiotherapy is to establish a treatment plan with the internal target volume (ITV) created based on an accurate analysis of the target motion displacement. When this method is applied to intensity modulated radiotherapy (IMRT), it is expected to yield a different treatment dose distribution under the motion condition according to the IMRT method. In this study, we prepared ITV-based IMRT plans with conventional IMRT using fixed gantry angle beams, RapidArc using volumetric modulated arc therapy, and tomotherapy using helical therapy. Then, the variation in dose distribution caused by the target motion was analyzed by the dose measurement in the actual motion condition. A delivery quality assurance plan was prepared for the established IMRT plan and the dose distribution in the actual motion condition was measured and analyzed using a two-dimensional diode detector placed on a moving phantom capable of simulating breathing movements. The dose measurement was performed considering only a uniform target shape and motion in the superior-inferior (SI) direction. In this condition, it was confirmed that the error of the dose distribution due to the target motion is minimum in tomotherapy. This is thought to be due to the characteristic of tomotherapy that treats the target sequentially by dividing it into several slices. When the target shape is uniform and the main target motion direction is SI, it is considered that tomotherapy for the ITV-based IMRT method has a characteristic which can reduce the dose difference compared with the plan dose under the target motion condition.

• Journal of Pharmaceutical Investigation
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• v.36 no.6
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• pp.363-369
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• 2006

Granisetron is a selective 5-HT3 receptor antagonist that is used therapeutically for the prevention of vomiting and nausea associated with emetogenic cancer chemotherapy. Although this drug is commercially available for intravenous and oral dosage, there is a need for intranasal delivery formulations in specific patient populations in which the use of these dosage forms may be unfeasible and/or inconvenient. A rapid and specific high-performance liquid chromatography method with mass spectrometric detection(LC-MS) was developed and validated for the analysis of granisetron in plasma after nasal administration in rats. This method has been validated for concentrations ranging from 5 to 1000 ng/ml with simple treatment. This technique has high level reproducibility, accuracy, and sensitivity. The method described was found to be suitable for the analysis of all samples collected during preclinical pharmacokinetic investigations of granisetron in rats after nasal administration. This study was aimed to investigate the feasibility of nasal delivery of granisetron for the elimination of vomiting. The effects of osmolarity, dosage volume at the same dose and applied dose on the nasal absorption of granisetron in rats were observed. No significant difference in the effect of osmolarity and dosage volume at the same dose was observed. As the applied dose of granisetron in nasal formulation increased, the absorption increased linearly. Based on these results it appears that only the applied dose(drug mass) determines the nasal absorption of granisetron. The bioavailability of granisetron on nasal administration of 4 mg/kg appeared to be comparable to that of intravenous administration of the same dose. These results suggest that granisetron can be efficiently delivered nasally and the development of nasal formulation will be feasible.