• Journal of Pharmaceutical Investigation
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• v.26 no.4
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• pp.245-256
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• 1996

Solid lipid nanoparticles (SLN) have been developed as a new drug delivery system. Although many particulate drug carriers, such as microsphere, liposome, niosome, emulsion, etc. have been introduced, they have some disadvantage; low efficiency of incorporation and stability, lack of reproducibility, and so on. Meanwhile, SLN as a new drug delivery system is known to entrap rugs with a high efficiency and a good reproducibility. Moreover, small size SLN can circulate in blood for a prolonged time. Although many preparation methods were introduced, microfluidization method is recommended to be the most useful. This study was attempted to prepare and evaluate ketoprofen-incorporated SLNs (keto-SLN), which were prepared by two methods, ultrasonication and microfluidization. Keto-SLN was evaluated by measurement of particle size and zeta potential, efficacy of entrapment, sedimentation volume, in virto release pattern. The mean particle size was about $0.1\;{\mu}m$, and the size was dependent on the type and the amount of emulsifier. Zeta potential was negative, $-9{\sim}-13mV$ and entrapment efficacy was very high and stability was good for at least 60 days in the respect of particle size and sedimentation volume ratio. Analgesic effect was also determined as well as pharmacokinetic parameters. The former was comparable to that of that of ketoprofen loaded suspension (keto-sus) and the latter revealed that consistent with the delayed release of keto-SLN. $T_{max}$ was longer than keto-sus. Therefore, keto-SLN was favourable dosage forms in the field of drug delivery system such as anti-cancer, analgesics and anti-inflammatory agents.

• Journal of Distribution Science
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• v.10 no.5
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• pp.45-55
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• 2012

In Korea, the parcel delivery service was launched officially in 1992, and the market has grown to 13.2 billion units, or 3.5 trillion won, as of 2011. The service companies accept small packages under 30 kg and deliver them on the next day in most domestic areas. This service plays an important role in business and personal activities. The parcel service companies have themselves designed the tariff for the delivery service based on two criteria: weight and the sum of three side lengths. Further, the tariff is graded in steps of three or four rate structures based on size (small, medium, large, and extra-small). However, the basic freight rate is generally decided according to the cargo's weight or measurement size, and an extra rate is added according to some factors (handling, stowability, liability, and so on). The parcel service tariff adopted by the companies is illogically designed, and this study was carried out to assess the need for redesigning the tariff structure. The cargo volume cannot be logically reflected by three side lengths. For example, two parcels measuring 160 cm based on three side lengths may have different volumes, one measuring 0.152 cbm (53.33 cm × 53.33 cm × 53.34 cm) and the other 0.05 cbm (100 cm × 50 cm × 10 cm). A small package of less than120 cm (sum of three side lengths) may have a volume of as much as 0.064 cbm (40 cm × 40 cm × 40 cm). Sample comparison showed that 17% of medium-size parcels (based on the sum of three side lengths) are small-volume packages, 24% of large-size parcels are small- or medium-volume packages, and 40% of extra-big-size parcels are big- or under-size packages. Therefore, if parcel service companies rate their services for volume cargo based on the three side lengths standard, users may have to pay higher than normal rates, particularly because a large percentage of parcels are volume cargo. According to this study, the average weight per 1 cbm is less than 300 kg. Therefore, users face an increasing risk of paying higher than logical freight charges. Generally, transportation companies are called "public interest enterprises," and parcel service companies operate as postal services. Public interest enterprises must provide the delivery service to all customers without discrimination at a reasonable service level and logical service charges. Therefore, parcels service tariffs must be designed and adopted logically. In this study, freight theories and prior research findings were used to consider the importance of freight rates, and distortion of parcel service rates based on the three side lengths system was verified through regression analysis of a parcel sample and sample comparison. In conclusion, volume sizes based on three side lengths have a higher correlation to the rate level than does the sum of three side lengths. Further, compared to the sum of three side lengths, volume size has a higher correlation to cargo weight, which is the most basic factor determining transportation cost. Therefore, the existing parcel service tariff should be changed to weight- and volume-based rates, and the tariff must be graded in steps of 8 to 10 higher rate structures for a logical freight schedule based on service cost.

• Journal of Digital Convergence
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• v.19 no.5
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• pp.135-144
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• 2021

In Korea, the parcel delivery service is showing a high growth rate every year thanks to the activation of e-commerce, but the courier unit price continues to drop. Due to the low cost of parcel delivery, there is a need for improvement to normalize courier rates due to deterioration in profitability for couriers, deterioration in service for consumers, and overwork and accidents for workers. In this study, a rational rate system model and a systematic approach were presented. The study method modeled the chargeable weight by reflecting the voulumatirc weight and revenue ton by the volume and weight of the cargo, and presented a new parcel freight charge model based on the cost of delivery. In addition, a rate-determining support system was developed that can be easily, conveniently and reasonably determined on-site. In the demonstration, the rate difference was determined by relying on weight rather than volume, and 63.5% for personal courier and 40% for B2C courier were found to be inadequate. This study could be used as an alternative to solving side effects and problems at the delivery site, in the urgent need for research on ways to improve delivery prices.

• Journal of radiological science and technology
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• v.43 no.2
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• pp.105-114
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• 2020

This study aimed to assess of beam-matching accuracy for an 8 MV beam between the same model linear accelerators(Linac) commissioned over two years. Two models were got the customer acceptance procedure(CAP) criteria. For commissioning data for beam-matched linacs, the percentage depth doses(PDDs), beam profiles, output factors, multi-leaf collimator(MLC) leaf transmission factors, and the dosimetric leaf gap(DLG) were compared. In addition, the accuracy of beam matching was verified at phantom and patient levels. At phantom level, the point doses specified in TG-53 and TG-119 were compared to evaluate the accuracy of beam modelling. At patient level, the dose volume histogram(DVH) parameters and the delivery accuracy are evaluated on volumetric modulated arc therapy(VMAT) plan for 40 patients that included 20 lung and 20 brain cases. Ionization depth curve and dose profiles obtained in CAP showed a good level for beam matching between both Linacs. The variations in commissioning beam data, such as PDDs, beam profiles, output factors, TF, and DLG were all less than 1%. For the treatment plans of brain tumor and lung cancer, the average and maximum differences in evaluated DVH parameters for the planning target volume(PTV) and the organs at risk(OARs) were within 0.30% and 1.30%. Furthermore, all gamma passing rates for both beam-matched Linacs were higher than 98% for the 2%/2 mm criteria and 99% for the 2%/3 mm criteria. The overall variations in the beam data, as well as tests at phantom and patient levels remains all within the tolerance (1% difference) of clinical acceptability between beam-matched Linacs. Thus, we found an excellent dosimetric agreement to 8 MV beam characteristics for the same model Linacs.

• Journal of the Korean Society of Safety
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• v.38 no.2
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• pp.52-59
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• 2023

Due to the routine nature of social distancing in accordance with the COVID-19 pandemic, the logistics industry is under rapid development, given that offline demand is focused on online platforms. The number of warehouse workplaces and workers are steadily increasing per annum, and the industrial accident rate of transportation, warehouse, and telecommunication industries to which warehouse employees belong is higher than the total industrial accident rate in Korea. In previous studies, warehouse workers reported exposure to health hazards such as musculoskeletal disorders due to the handling of heavy objects and improper working postures. Accordingly, in this study, a survey was conducted to investigate symptoms of musculoskeletal disorders with focus on parcel delivery workers nationwide. The questionnaire included a musculoskeletal disorder symptom survey table to identify information such as worker occupational history, work type, and signs or symptoms of musculoskeletal disorders. Survey response data from 453 people were obtained to determine the influence of delivery business characteristics on occupational musculoskeletal disorders, and the influencing factors were analyzed. Based on the results, in the analysis of pain with respect to body part, the duration, degree, and frequency of pain were highest in the leg part, and as a result, the average value for the leg part exhibited a significant difference from those of other body parts. In addition, 52.32% of workers exhibited symptoms of musculoskeletal disorders, and a high number of patients with musculoskeletal disorders was observed in the work group with less than three years of service and with ages ranging from 30-39. The results of this study can serve as basic data for the derivation of a management plan that meets the characteristics of musculoskeletal disorders that impact logistics workers overburdened with work due to the rapid increase in parcel delivery volume in accordance with an increase in online consumption.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2021.10a
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• pp.323-325
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• 2021

The size of the delivery market in Korea is growing year by year. In recent years, the growth rate has skyrocketed due to the aftermath of the coronavirus. Looking at the domestic delivery market's volume trend in 2020, about 3.4 billion boxes increased by 21% compared to about 2.8 billion boxes last year. In addition, sales amounted to 7.5 trillion won, an increase of about 19% compared to 6.3 trillion won a year earlier. As the delivery market grows, the proportion of courier damage relief is also occurring at a considerable rate. About 33% of 1,000 people have experienced delivery accidents, and about 41% of the week have experienced damage or damage. In this paper, a deep learning model capable of detecting a parcel was created to detect a damaged parcel. A system that can check the performance of this model and detect and classify parcels during the delivery process using a real-time detection camera was studied.

• Progress in Medical Physics
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• v.18 no.3
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• pp.161-166
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• 2007

A model theory of passive-targeted drug delivery in sphere-shaped solid tumors is introduced on the basis of Fick's law of diffusion, with appropriate boundary and initial conditions. For a uniform initial concentration inside the tumor, the concentration is obtained as a function of time and radial position. The concentration is shown to approach the equilibrium distribution as the time elapses, as is expected by the Gedanken Experiment. The time-evolution rate is found to be determined by the diffusion coefficient of the drug in the tissue, the size of the tumor, the volume of the drug-injected region, and the concentration gradient at the boundary.

• International Journal of Fluid Machinery and Systems
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• v.7 no.4
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• pp.160-173
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• 2014

Surge phenomena in multi-stage axial flow compressors were studied with attention to the frequency behaviors. A new parameter "volume-modified reduced surge frequency" was introduced, which took into consideration the essential surge process, i.e., emptying and filling of the working gas in the delivery plenum. The behaviors of the relative surge frequencies at the stall stagnation boundaries, compared with the corresponding duct resonance frequencies, have demonstrated the existence of two types of surges; i.e., a near-resonant surge and a subharmonic surge. The former, which has fundamentally a near-resonance frequency, occurs predominantly at the stall stagnation boundary for the short -and-fat plenum delivery flow-path and the long-and-narrow delivery duct flow-path, and possibly in the intermediate conditions. The latter, which has a subharmonic frequency of the fundamental near-resonant one and occurs mainly in the intermediate zone, is considered to be caused by the reduced frequency restricted to a limited range. In relation with those dimensionless frequencies at the stall stagnation boundary, the surge frequency behaviors in more general situations away from the boundaries could be estimated, though very roughly.

• 한국디지털정책학회:학술대회논문집
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• 2004.11a
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• pp.435-448
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• 2004

While Internet promises ubiquitous access, it also creates a fundamental challenge to the traditional ownership toward digital assets traded in e-commerce market. Sharing digital information freely through shared networks leads to many untapped business opportunities, but uncontrolled digital asset transaction undermines many electronic business models. Thus, in this Internet age, proper protection and safe delivery of Intellectual Property (IP) and its representation as digital assets would be a crucial ingredient of building trust in upcoming e-business environment. In this paper, we give a general structural diagram of Intellectual Property Management and Protection (IPMP) and implement an IPMP prototype based on the RSA encryption algorithm and XrML (eXtensible rights Markup Language) WORK tags to show how proper protection and safe delivery of the intellectual property is achieved. This study concludes that IPMP mechanism may contribute significantly to the volume and quality of e-commerce market.

• THE INTERNATIONAL COMMERCE & LAW REVIEW
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• v.40
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• pp.147-167
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• 2008

This paper investigates changing business transaction under the e-commerce environment and their implications on freight transport industry with some case studies. It shows that an efficient and reliable delivery system is essential for e-commerce as business industries are faced with the stricter and more diversified demands of customer. In addition, many aspects of business practices such as small batch, customized production and just-in-time distribution in the e-commerce environment, in turn, bring about a number of changes in the volume and service patterns of freight transport. E-commerce requires longer transport distances and often higher delivery frequencies. It also entails to a certain extent a modal shift towards truck and air freight transport modes. On the one hand, the logistical requirements of e-commerce goods may stimulate greater complexity in existing supply chain management, causing higher costs. However it is true that the increased visibility of goods through more efficient information flow allows more efficient and effective transport management in the logistics system.