• Journal of Pharmaceutical Investigation
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• v.38 no.6
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• pp.405-412
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• 2008

Six ester analogues of Ketorolac were synthesized as potential enhancer prodrugs for transdermal delivery. Solubility of these esters was determined in 10% propylene glycol (PG)/isotonic phosphate buffer (IPB) at room temperature while lipophilicity was obtained as partition coefficients (log P) and capacity factors (k') using HPLC. Stability of the prodrugs in skin extract and in plasma was investigated at $37^{\circ}C$. The lipophilicity of the potential prodrugs increased in proportion to their alkyl chain length. Good linear relationship between partition coefficients (log P) and capacity factors (log k') was observed ($R^2=0.9961$). All of the analogues were fairly stable but slowly degraded in IPB over a 12 hour period. However, their stability in skin extract and in plasma varied with most compounds gradually decomposing over a 12 hour period. Although unsaturation of the alkyl ester chain did not alter the over all lipophilicity of the compound, the half-life was significantly affected. In plasma, degradation of the esters was slower than in the skin extract, which is a desirable trait for enhancer-prodrugs. However, the overall hydrolysis in the skin extract needs to be facilitated for the development of an effective enhancer prodrug. The analogue with the shortest half life in the skin extract was the unsaturated C-12 analogue of 0.96 hr.

• Journal of Communications and Networks
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• v.13 no.2
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• pp.132-141
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• 2011

IEEE 802.15.4 networks are a feasible platform candidate for connecting all health-care-related equipment dispersed across a hospital room to collect critical time-sensitive data about patient health state, such as the heart rate and blood pressure. To meet the quality of service requirements of health-care systems, this paper proposes a multi-priority queue system that differentiates between various types of frames. The effect of the proposed system on the average delay and throughput is explored herein. By employing different contention window parameters, as in IEEE 802.11e, this multi-queue system prioritizes frames on the basis of priority classes. Performance under both saturated and unsaturated traffic conditions was evaluated using a novel analytical model that comprehensively integrates two legacy models for 802.15.4 and 802.11e. To improve the accuracy, our model also accommodates the transmission retries and deferment algorithms that significantly affect the performance of IEEE 802.15.4. The multi-queue scheme is predicted to separate the average delay and throughput of two different classes by up to 48.4% and 46%, respectively, without wasting bandwidth. These outcomes imply that the multi-queue system should be employed in health-care systems for prompt allocation of synchronous channels and faster delivery of urgent information. The simulation results validate these model's predictions with a maximum deviation of 7.6%.

• Women's Health Nursing
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• v.11 no.4
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• pp.265-272
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• 2005

Purpose: To investigate the effect of infant massage on stress, immune function and self-confidence in postpartum mothers. Method: From September, 2003 to February, 2004, 65 women who had delivered babies and were enrolled in the postpartum clinic were assigned to the experimental group or control group. In the experimental group, infant massage was given for 20 minute sessions twice a day from 4 days to 14 days after delivery. The instruments were Parental Stress Index, serum cortisol levels, WBCs, lymphocytes, and Self Confidence Scale. Results: Stress scores, WBCs and lymphocytes showed significant differences by the time, but there weren't significant differences according to the group and interactions between the group and the time. Cortisol and self-confidence scores showed significant differences by the time and the group. Conclusions: Applying massage to their newborn baby influenced cortisol levels of postpartum mothers. Therefore stress, cortisol, and immune functions in postpartum mothers should be generally screened and follow up studies are needed for the effective application of massage in postpartum mothers.

• Bulletin of the Korean Chemical Society
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• v.33 no.12
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• pp.4035-4040
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• 2012

Presented study describes the synthesis of photo cross-linkable and water soluble hydroxyethyl starch hydroxyethyl methacrylate (HESHEMA) samples with different degree of substitution (DS) by functionalization of hydroxyethyl starch (HES) with hydroxyethyl methacrylate (HEMA) or hydroxyethyl methacrylate carbonylimidazole (HEMACI) in DMSO using two different routes. It was revealed that the reaction time for HESHEMA synthesis can be reduced from 5 days to 24 h by conducting the reaction at $80^{\circ}C$ instead of at room temperature. Solubility of HESHEMA was found to be dependent on DS which in turn was dependent on ratio between HES and HEMA or HEMACI. HESHEMA samples with DS > 0.24 depicted insoluble in water, whereas the samples with DS < 0.05 did not form appreciable gel. HESHEMA samples with appropriate DS were converted into hydrogels by cross-linking polymer chains under UV radiations and resulting HESHEMA hydrogels showed swelling up to 1200%. Application of HESHEMA in controlled drug delivery was investigated by diffusion based encapsulation of Ondansetron, a serotonin 5-$HT_3$ receptor antagonist drug, mainly used for nausea and vomiting treatment.

• Proceedings of the Korean Society for Technology of Plasticity Conference
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• 2008.05a
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• pp.273-276
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• 2008

Thermoplastic resin takes place stress relaxation and creep according to temperature and time. In room temperature, time dependent deformation (TDD) of polymer was carried out at previous study. In this study, it evaluates time dependent deformation to relate temperature. Nanoscale indents can be used as cells for molecular electronics and drug delivery, slots for integration into nanodevices, and defects for tailoring the structure and properties. Therefore, it is important to control pattern depth for change of indent depth by creep when using Nanoindenter. For evaluating TDD at high temperature, it is occurred thermal-nanoindentation test by changing hold time at maximum load. Temperature is putted at $90^{\circ}C$, hold time at maximum loads are putted at 1, 10, 50, 100, 200, 300 and 500s.

• Molecular & Cellular Toxicology
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• v.2 no.1
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• pp.1-6
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• 2006

Photodynamic therapy (PDT), a newly established treatment for solid tumors, involves the systemic administration of a tumor localizing photosensitizer that is only activated when exposed to light of appropriate wavelength. Photoactivation of photosensitizer in the presence of oxygen results in the formation of highly cytotoxic molecular species, which precipitates necrosis. PDT has now become a promising means for the treatment of cancer due to its specificity, relatively minimal side effects, and inexpensive. However, the application of PDT has been restricted to the treatment of superficial lesions or the use of interstitial light delivery. A single photon generally activates the photochemical reaction in traditional PDT. However the use of multi photon excitation, where two or more photons simultaneously excite a photosensitizer, allows for the use of wavelengths twice as long. Such wavelengths exhibit better transmittance through tissue and thereby deeper penetration is achieved. This paper will review theoretical principles of multi photon excitation, challenges associated with multi photon PDT and update the current and future role of multi photon PDT in cancer.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2004.11a
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• pp.550-553
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• 2004

Recently, the demand for the Floating, Production, Storage, and Offloading facility (FPSO) which has some economic and technical advantages, has increased in offshore oil production areas. The 36,8000 DWT class FPSO was built in Hyundai Heavy Industries and will be installed in Offshore Angola. She dose not have self-propulsion system, but has additional facilities for oil production and positioning system. Main noise sources are contributing to the cabin noise of the accommodation are classified into three classes such as the machinery in the engine room and the deckhouse, HVAC system, and the topside equipments. In general, the noise regulation for the offshore structure is severer than that of the cargo ship and acceptable noise limit of cabin is specified as 45 dB(A). This paper describes the procedure of noise analysis, the countermeasures of noise control, and the measurement results of the quay trial. In order to minimize the noise levels, careful attention have to be paid by the special committee of experts from the initial design stage to the delivery. Proper countermeasures, considering the characteristics of sources and receiver spaces, were applied from the noise prediction and various experiment results. Finally, this ship was successfully delivered with excellent noise properties. The technology to minimize the noise levels for FPSO has been established throughout the construction of this ship.

• Journal of Animal Environmental Science
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• v.7 no.1
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• pp.13-20
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• 2001

This study was conducted to investigate the actual conditions on housing and facilities for goat. This investigation of the actual conditions was investigated by the style of farm which was divided into sideline scale and speciality scale included 47 farms. The results are summarized as follows: Rearing scale was 48.9% for 50-100 heads per farm. Rearing type was 46.8% for grazing type and 53.2% for barn type. Housing type was 27.7% for simple frame housing and 72.3% for permanent housing. Pipe was used 80.8% with Pillar and Girder as the housing frame at farm. For the pipe used in farm, 27.7% of them was used for simple frame housing. Side wall was composed of cement and winch curtain to be 29.8%, slate roof to be 40.4%, pipe partition to be 38.3%, and cement floor to be 51.1%. Materials of feeding trough were wood and Zinc grater to be 41.5%, respectively. Type of feeding trough was square to be 70.2%. The feeding trough was located in barn to be 48.9%. Material of water supply facilities was plastic to be 87.2%. Type of water supply facilities was mostly square to be 76.6%. Water-trough was located in playground to be 48.9%. Parturition facilities were consisted of partition structure by group to be 42.5% and were mainly composed of pipe and wood. 46.8% of the barn did not have delivery room in the farm.

• Women's Health Nursing
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• v.6 no.1
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• pp.46-53
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• 2000

The purpose of this study was to explore the structure of nursing needs during labor pain as perceived by women who have given birth. The phenomenological perspective of qualitative research theory guided the approach to the study. The sample consisted of 20 women who had undergone normal labor and had delivered a healthy baby at term. Collection of data was by means of in-depth interviews conducted 1-2 days after delivery in the admission room from March to may 1998. On average, the interviews lasted for about 30 minutes. Interviews were taken with the consent of the subjects. Data were analyzed by means of Giorgi's method and categorized according to the similarities of their contents. The investigator read the data repeatedly to identify themes and categories. Four categories were : 1) a sense of security 2) self esteem 3) willingness to learn 4) a sense of comfort. Under these categories there were twelve themes. I. A sense of security : (a) presence (b) conversation (c) touching II. Self esteem : (a) praise (b) encouragement (c) treating the women with respect (d) caregiver with good character III. Willingness to learn : (a) teaching (b) information IV. A sense of comfort : (a) self controlled pain relief (b) artificially controlled pain relief (c) skillfulness of caregiver The findings should sensitize nurses to the various needs of women in labor who are under their care. Further research should focus on developing instruments to assess the nursing needs of parturients. Researchers also need to identify ways to assess women's satisfaction with nursing needs.

• Journal of Korean Academy of Nursing
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• v.4 no.1
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• pp.95-106
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• 1974

The Purpose of this study was to observe the body temperature changes of newborn infants in general crib and electric heat crib after birth for the period required to reach the optimum body temperature. Forty-seven newborn infants who were delivered at Seoul National University Hospital during the period from June 12 to September 13, 1973 were chosen as Subjects for this study. The criteria for the choice of subjects were the babies with normal spontaneous delivery; body weight 2.5kg and over at birth; Apgar so ore seven and over and gestation period over thirty-six weeks. Of these subjects, by random sampling thirty-one newborn infants were placed in the general crib and sixteen in the electric-heat crib. The rectal body temperature of these newborn infants were taken and recorded at fifteen-minute interval for the first one hour period after birth, at thirty minute interval for the next two hours and at one hour interval for the remaining period up to eight hours. The results of the study were as follows: 1. The mean body temperature of the newborn infants on admission to nursery ranged from 98.7℉. to 99℉. irrespective of the body weight and the room temperature. 2. There was a significant difference in the body temperature changes of the newborn infants as a total between the general crib and the electric-heat crib from three to eight hours after birth. It was found that the body temperature of the newborn infants in the electric-heat crib was significantly higher than that of the newborn infants in the general crib. 3. In comparison with the body temperature changes of the newborn infants in the general crib, the newborn infants in the electric- heat crib exhibited significantly higher body temperatures in all three body weight groups; from four to eight hours after birth in the 2.5-2.9kg body weight group; from three to seven hours after birth in the 3.0-3.4kg body weight group; from two and half to six hours after birth in the group with body weight over 3.5kg. 4. Time required to reach 98℉. of body temperature was four hours in the 3.5-2.9kg body weight group, three hours in the 3.0-3.4kg. body weight group and two and half hours in the group with body weight over 3.5kg in the electric- heat crib. In the general crib, it took over eight hours in the 2.5-2.9kg body weight group and five hors in both the 3.0-3.4kg and over 3.5kg body weight group to reach 98℉ of body temperature. 5. The lowest mean body temperature of newborn infants in both general and electric- heat crib appeared in forty-five minute after birth and the temperature ranged from 96.4℉ to 96.5℉. 6. The mean body temperature of the newborn infants in the general crib was increased as the room temperature. 7. The body weight, the room temperature and the time elapsed after birth fore proved to be significant factors influencing the body temperature changes of newborn infants. From tile above results, the three hypotheses were positively accepted.