• Journal of Korean Society of Industrial and Systems Engineering
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• v.44 no.3
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• pp.106-116
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• 2021

This paper considers a joint problem for blood inventory planning at hospitals and blood delivery planning from blood centers to hospitals, in order to alleviate the blood service imbalance between big and small hospitals being occurred in practice. The joint problem is to determine delivery timing, delivery quantity, delivery means such as medical drones and legacy blood vehicles, and inventory level to minimize inventory and delivery costs while satisfying hospitals' blood demand over a planning horizon. This problem is formulated as a mixed integer programming model by considering practical constraints such as blood lifespan and drone specification. To solve the problem, this paper employs a Lagrangian relaxation technique and suggests a time efficient Lagrangian heuristic algorithm. The performance of the suggested heuristic is evaluated by conducting computational experiments on randomly-generated problem instances, which are generated by mimicking the real data of Korean Red Cross in Seoul and other reliable sources. The results of computational experiments show that the suggested heuristic obtains near-optimal solutions in a shorter amount of time. In addition, we discuss the effect of changes in the length of blood lifespan, the number of planning periods, the number of hospitals, and drone specifications on the performance of the suggested Lagrangian heuristic.

• Journal of Pharmaceutical Investigation
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• v.40 no.spc
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• pp.75-82
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• 2010

Specific diseases like cancer and acquired immune deficiency syndrome (AIDS) occur at various organs including lymphatics and spread through lymphatic system. Thus, if therapeutic agents for such diseases are more distributed or targeted to lymphatic system, we can obtain several advantages like reduction of systemic side effect and increase of efficacy. For these reasons, much interest has been focused on the nature of lymphatics and a lot of studies for lymphatic delivery of drugs have been carried out. Because lymphatics consist of single layer endothelium and have high permeability compared with blood capillaries, especially, the studies using nano-sized carriers have been performed. Polymeric nano-particle, liposome, and lipid-based vehicle have been adopted for lymphatic delivery as carriers. According to the administration route and the kind of carrier, the extent of lymphatic delivery efficiency of nano-sized carriers has been changed and influenced by several factors such as size, charge, hydrophobicity and surface feature of carrier. In this review, we summarized the key factors which affect lymphatic uptake and the major features of carriers for achieving the lymphatic delivery. Lymphatic delivery of drug using nano-sized carriers has many fold improved ability of lymphatic delivery compared with that of conventional dosage forms, but it has not shown whole lymph selectivity yet. Even though nano-sized carriers still have the potential and worth to study as lymphatic drug delivery technology as before, full understanding of delivery mechanism and influencing factors, and setting of pharmacokinetic model are required for more ideal lymphatic delivery of drug.

• Journal of Information Technology Services
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• v.21 no.5
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• pp.15-28
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• 2022

Recently, government agencies are actively adopting the platform model as a means of public policy. However, existing studies on the public platform are minimal and have focused on user experiences or the possibility of public usage of the platform model. Now the research concerning building governance structure and utilizing network effects of the platform after adopting the platform model in the public sector is keenly required. This study intended to ignite academic dialogue on the governance of public platforms in the context of digital transformation. This study focused on a case of the 'Special delivery,' a public delivery app established by Gyeonggi-do. In order to analyze the characteristics of the public platform and its governance structure, data were collected from press releases, policy reports, and news articles. Data was analyzed using the frame of Hagui's platform design factors and Ansell & Gash's collaborative governance model. The results of the public platform analyses showed 1) incompleteness in the value trade-off accounting, which was designed for platform business based on general cost-benefit analysis, and 2) a closed governance structure that limits direct participation of diverse user groups(i.e., service provider, customer) in order to enhance providers' utility by preventing customers' excessive online activities. The results of this study provided theoretical and policy implications regarding designing the strategy for accounting for value trade-offs and functioning governance structure for public platforms.

• Journal of Pharmaceutical Investigation
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• v.25 no.3
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• pp.33-35
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• 1995

Microspheres containing tetracaine or bupivacaine with poly-lactic-glycolic acid were prepared with a range of compositions. Using the rat scicatic nerve model in vivo it was found that prolonged blockade for periods of 2-7 days. depending on composition variables. Polymer-local anesthetics microspheres are feasible delivery vehicle for prolonged regional nerve blockade.

• Journal of Korean Society of Industrial and Systems Engineering
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• v.9 no.13
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• pp.29-32
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• 1986

A decision procedure to determine when computer software should be released after testing is described. This paper extends optimum release policies minimizing the total expected software cost with a scheduled software delivery time under reliability requirement constraint. Such cost considerations enable us to make a release decision as to when transfer a software system from testing phase to operational phase. The underlying model is software reliability growth model described by a nonhomogeneous poisson process. It is assumed that the penalty cost function due to delay for a scheduled software delivery time is linearly proportional to time. Numerical examples are shown to illustrate the results.

• Journal of the Korean Operations Research and Management Science Society
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• v.26 no.4
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• pp.143-153
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• 2001

In this study we develop a computer simulation model to evaluate the effects of various production and order processing policies measured in terms of on-time delivery rate and average waiting time of job orders. Policies considered include : eliminating inflated due date, lot splitting, loss time reduction, attaining full flexibility in production lines, and selective order promising scheme. Actual order-production data from a chemical company were used in the simulation model. Based on the simulation results, we make several suggestions that can significantly reduce the production lead time and increase the on-time delivery rate.

• Communications for Statistical Applications and Methods
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• v.11 no.3
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• pp.631-641
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• 2004

In this paper, a model for an inventory whose stock decreases with time is considered. When a deliveryman arrives, if the level of the inventory exceeds a threshold $\alpha$, no stock is delivered, otherwise a delivery is made. It is assumed that the size of a delivery is a random variable Y which is exponentially distributed. After assigning various costs to the model, we calculate the long-run average cost and show that there exist unique value of arrival rate of deliveryman $\alpha$, unique value of threshold $\alpha$ and unique value of average delivery m which minimize the long-run average cost.

• Journal of Convergence for Information Technology
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• v.8 no.5
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• pp.243-249
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• 2018

This study is to verify the accommodation attitudes and intention of use of the end-users to use the drone distribution delivery service that is to be introduced in Korea. For a research purpose, the research model and hypothesis in this study have been set based on by using the SPSS 22.0. Upon these, the extended technology acceptance model has been used to verify the correlation service of new technology, and the result has shown that the user of drone distribution delivery service has a causal relationship with individual innovation and that the accommodation behavior and intention of use have a causal relationship with economic efficiency and convenience. However, there was no causal relation from a perceived risk. Hence, based on the results of study about accommodation behaviors and intention of use of the end users of drone distribution delivery service, the marketing implications have been provided for commercialization of drone delivery service.

• International conference on construction engineering and project management
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• 2013.01a
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• pp.338-343
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• 2013

Integrated Project Delivery (IPD) as a delivery method fully capitalizes on an integrated project team that takes advantage of the knowledge of all team members to maximize project outcomes. IPD is currently the highest form of collaboration available because all three core project stakeholders, owner, designer and contractor, are aligned to the same purpose. Compared with traditional project delivery approaches such as Design-Bid-Build (DBB), Design-Build (DB), and CM at-Risk, IPD is distinguished in that it eliminates the adversarial nature of the business by encouraging transparency, open communication, honesty and collaboration among all project stakeholders. The team appropriately shares the project risk and reward. Sharing reward is easy, while it is hard to fairly share a failure. So the compensation structure and the contingency in IPD are very different from those in traditional delivery methods and they are expected to encourage motivation, inspiration and creativity of all project stakeholders to achieve project success. This paper investigates the compensation structure in IPD and provides a method to determine the proper level of contingency allocation to reduce the risk of cost overrun. It also proposes a method in which contingency could be used as a functional monetary incentive when established to produce the desired level of collaboration in IPD. Based on the compensation structure scenario discovered, a probabilistic contingency calculation model was created by evaluating the random nature of changes and various risk drivers. The model can be used by the IPD team to forecast the probability of the cost overrun and equip the IPD team with confidence to really enjoy the benefits of collaborative team work.

• Journal of the Korean Operations Research and Management Science Society
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• v.41 no.3
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• pp.75-96
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• 2016

This paper investigates the usefulness of drones in an urban delivery system. We define the vehicle and drone routing problem with time window (VDRPTW) and present a model that can describe a dual mode delivery system consisting of drones and vehicles in the metropolitan area. Drones are relatively free from traffic congestion but have limited flight range and capacity. Vehicles are not free from traffic congestion, and the complexity of urban road network reduces the efficiency of vehicles. Using drones and vehicles together can reduce inefficiency of the urban delivery system because of their complementary cooperation. In this paper, we assume that drones operate in a point-to-point manner between the depot and customers, and that customers in the need of fast delivery are willing to pay additional charges. For the experiment datasets, we use instances of Solomon (1987), which are well known in the Vehicle Routing Problem society. Moreover, to mirror the urban logistics demand trend, customers who want fast delivery are added to the Solomon's instances. We propose a hybrid evolutionary algorithm for solving VDRPTW. The experiment results provide different useful insights according to the geographical distributions of customers. In the instances where customers are randomly located and in instances where some customers are randomly located while others form some clusters, the dual mode delivery system displays lower total cost and higher customer satisfaction. In instances with clustered customers, the dual mode delivery system exhibits narrow competition for the total cost with the delivery system that uses only vehicles. In this case, using drones and vehicles together can reduce the level of dissatisfaction of customers who take their cargo over the time-window. From the view point of strategic flexibility, the dual mode delivery system appears to be more interesting. In meeting the objective of maximizing customer satisfaction, the use of drones and vehicles incurs less cost and requires fewer resources.